Basil Khuder
YOU?
Author Swipe
View article: Novel Method for Predicting Lp(a) From Genomic Testing Identifies ASCVD Risk Across a Diverse Cohort
Novel Method for Predicting Lp(a) From Genomic Testing Identifies ASCVD Risk Across a Diverse Cohort Open
Lipoprotein(a) (Lp[a]) is a genetic and often unmeasured contributor to atherosclerotic cardiovascular disease (ASCVD) risk. In this study, Lp(a) was estimated from exome data by quantifying Kringle IV subtype 2 repeats alongside a single-…
View article: Population genomic screening leads to improved lipid management in patients with familial hypercholesterolemia
Population genomic screening leads to improved lipid management in patients with familial hypercholesterolemia Open
Background The Helix Research Network TM program is a large population genomics initiative that screens an all-comers population of patients for CDC Tier 1 genetic conditions, including familial hypercholesterolemia (FH). We evaluated chan…
View article: P583: Improved breast cancer screening adherence among participants receiving a negative result from a multi-health system population genomics screening program
P583: Improved breast cancer screening adherence among participants receiving a negative result from a multi-health system population genomics screening program Open
View article: P617: Impact of population genomic screening on patient behavior and care: Changes in preventive screening behaviors among HBOC positive individuals
P617: Impact of population genomic screening on patient behavior and care: Changes in preventive screening behaviors among HBOC positive individuals Open
View article: P580: Comparing automated vs ACMG/AMP-based variant interpretation for the CDC Tier 1 conditions in a clinicogenomic cohort from US-based health systems
P580: Comparing automated vs ACMG/AMP-based variant interpretation for the CDC Tier 1 conditions in a clinicogenomic cohort from US-based health systems Open
View article: P293: A novel method for predicting Lp(a) levels from routine outpatient genomic testing identifies those at risk of cardiovascular disease
P293: A novel method for predicting Lp(a) levels from routine outpatient genomic testing identifies those at risk of cardiovascular disease Open
View article: Underestimated risk of secondary complications in pathogenic and glucose-elevating GCK variant carriers with type 2 diabetes
Underestimated risk of secondary complications in pathogenic and glucose-elevating GCK variant carriers with type 2 diabetes Open
This population-level assessment shows secondary complications in individuals with pathogenic and glucose-elevating GCK variants and T2D and suggests that genotyping for these variants should be considered in a precision medicine approach …
View article: A novel method for predicting Lp(a) levels from routine outpatient genomic testing identifies those at risk of cardiovascular disease across a diverse cohort
A novel method for predicting Lp(a) levels from routine outpatient genomic testing identifies those at risk of cardiovascular disease across a diverse cohort Open
Background Lipoprotein(a) (Lp(a)) levels are a largely genetically determined and often an unmeasured predictor of future Atherosclerotic Cardiovascular Disease (ASCVD). With the increased use of exome sequencing in the clinical setting, t…
View article: Mitochondrial integrated stress response controls lung epithelial cell fate
Mitochondrial integrated stress response controls lung epithelial cell fate Open
View article: A Novel MIP-1–Expressing Macrophage Subtype in BAL Fluid from Healthy Volunteers
A Novel MIP-1–Expressing Macrophage Subtype in BAL Fluid from Healthy Volunteers Open
Tissue availability remains an important limitation of single-cell genomic technologies for investigating cellular heterogeneity in human health and disease. BAL represents a minimally invasive approach to assessing an individual's lung ce…
View article: Determinants of expression of SARS‐CoV‐2 entry‐related genes in upper and lower airways
Determinants of expression of SARS‐CoV‐2 entry‐related genes in upper and lower airways Open
Funder: Dutch Research Council (NWO)
View article: Mortality from COVID-19 in Patients with COPD: A US Study in the N3C Data Enclave
Mortality from COVID-19 in Patients with COPD: A US Study in the N3C Data Enclave Open
Daniel Meza, Basil Khuder, Joseph I Bailey, Sharon R Rosenberg, Ravi Kalhan, Paul A Reyfman Northwestern University, Feinberg School of Medicine, Division of Pulmonary and Critical Care Medicine, Chicago, IL, USACorrespondence: Paul A Reyf…
View article: Urban–Rural Mortality Disparities from Chronic Lower Respiratory Diseases in the United States, 1999–2019
Urban–Rural Mortality Disparities from Chronic Lower Respiratory Diseases in the United States, 1999–2019 Open
"Urban–Rural Mortality Disparities from Chronic Lower Respiratory Diseases in the United States, 1999–2019." American Journal of Respiratory and Critical Care Medicine, 203(11), pp. 1435–1437
View article: The proteostatic network chaperome is downregulated in F508del homozygote cystic fibrosis
The proteostatic network chaperome is downregulated in F508del homozygote cystic fibrosis Open
View article: Determinants of SARS-CoV-2 receptor gene expression in upper and lower airways
Determinants of SARS-CoV-2 receptor gene expression in upper and lower airways Open
Background The recent outbreak of the severe acute respiratory syndrome coronavirus-2 (SARS-CoV-2), which causes coronavirus disease 2019 (COVID-19), has led to a worldwide pandemic. A subset of COVID-19 patients progresses to severe disea…
View article: DNA methylation and gene expression signatures are associated with ataxia-telangiectasia phenotype
DNA methylation and gene expression signatures are associated with ataxia-telangiectasia phenotype Open
People with ataxia-telangiectasia (A-T) display phenotypic variability with regard to progression of immunodeficiency, sino-pulmonary disease, and neurologic decline. To determine the association between differential gene expression, epige…
View article: Intricacies in arrangement of SNP haplotypes suggest “Great Admixture” that created modern humans
Intricacies in arrangement of SNP haplotypes suggest “Great Admixture” that created modern humans Open
View article: Additional file 1: SD1. of Intricacies in arrangement of SNP haplotypes suggest â Great Admixtureâ that created modern humans
Additional file 1: SD1. of Intricacies in arrangement of SNP haplotypes suggest â Great Admixtureâ that created modern humans Open
Complete set of our pipeline of Perl programs to characterize human haplotypes and Denisovan diplotypes is presented in this file. All the output files which contain information about every GV with MAF >0.25 (identifier, location, alleles)…
View article: Additional file 6: Table S2. of Intricacies in arrangement of SNP haplotypes suggest â Great Admixtureâ that created modern humans
Additional file 6: Table S2. of Intricacies in arrangement of SNP haplotypes suggest â Great Admixtureâ that created modern humans Open
A prototype of one of the output files generated in Step II. The name of the file is CORE_HAPS_New_140 which is for chromosome 1 segment 140. The file is transferred from UNIX to pc environment in MS Excel format. (XLSX 23 kb)
View article: Additional file 4: of Intricacies in arrangement of SNP haplotypes suggest â Great Admixtureâ that created modern humans
Additional file 4: of Intricacies in arrangement of SNP haplotypes suggest â Great Admixtureâ that created modern humans Open
Complete table presenting the characteristics of Yin, Yang, Mosaic, and all other CHs in all the 22 human autosomes. (XLSX 1667 kb)
View article: Additional file 9: Table S5. of Intricacies in arrangement of SNP haplotypes suggest â Great Admixtureâ that created modern humans
Additional file 9: Table S5. of Intricacies in arrangement of SNP haplotypes suggest â Great Admixtureâ that created modern humans Open
A prototype of one of the output files generated in Step II. The name of the file is Combined_STATS_YY_Mos_1 which is the output file for chromosome 1. The file is transferred from UNIX to pc environment in MS Excel format. (XLSX 140 kb)
View article: Additional file 1: SD1. of Intricacies in arrangement of SNP haplotypes suggest â Great Admixtureâ that created modern humans
Additional file 1: SD1. of Intricacies in arrangement of SNP haplotypes suggest â Great Admixtureâ that created modern humans Open
Complete set of our pipeline of Perl programs to characterize human haplotypes and Denisovan diplotypes is presented in this file. All the output files which contain information about every GV with MAF >0.25 (identifier, location, alleles)…
View article: Additional file 10: Table S6. of Intricacies in arrangement of SNP haplotypes suggest â Great Admixtureâ that created modern humans
Additional file 10: Table S6. of Intricacies in arrangement of SNP haplotypes suggest â Great Admixtureâ that created modern humans Open
A prototype of one of the output files generated in Step V. The name of the file is CORE_HAPS_with_DENI_Pinky_10 which is the output file for chromosome 1 segment 10. The file is transferred from UNIX to pc environment in MS Excel format. …
View article: Additional file 7: Table S3. of Intricacies in arrangement of SNP haplotypes suggest â Great Admixtureâ that created modern humans
Additional file 7: Table S3. of Intricacies in arrangement of SNP haplotypes suggest â Great Admixtureâ that created modern humans Open
A prototype of one of the output files generated in Step II. The name of the file is STAT_FOR_Yin_Yang_New_1 which is for chromosome 1. The file is transferred from UNIX to pc environment in MS Excel format. (XLSX 50 kb)
View article: Additional file 3: Table ST1. of Intricacies in arrangement of SNP haplotypes suggest â Great Admixtureâ that created modern humans
Additional file 3: Table ST1. of Intricacies in arrangement of SNP haplotypes suggest â Great Admixtureâ that created modern humans Open
Distribution of CHs has been examined among all human autosomes in 5398 segments, and these data are shown in the Additional file 2: Table ST1. (XLSX 643 kb)
View article: Additional file 8: Table S4. of Intricacies in arrangement of SNP haplotypes suggest â Great Admixtureâ that created modern humans
Additional file 8: Table S4. of Intricacies in arrangement of SNP haplotypes suggest â Great Admixtureâ that created modern humans Open
A prototype of one of the output files generated in Step II. The name of the file is STAT_FOR_Mos_New_1 which is for chromosome 1. The file is transferred from UNIX to pc environment in MS Excel format. (XLSX 98 kb)