Basil Sambou
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View article: Quantitative measures of human <i>Cytomegalovirus</i> infection and their associations with tuberculosis disease progression and <i>Mycobacterium tuberculosis</i> infection
Quantitative measures of human <i>Cytomegalovirus</i> infection and their associations with tuberculosis disease progression and <i>Mycobacterium tuberculosis</i> infection Open
Interactions between human cytomegalovirus (HCMV) and the host immune response to Mycobacterium tuberculosis ( M.tb ) may influence the risk of tuberculosis (TB) disease progression. Data on an association between HCMV and risk of initial …
View article: Assessing the impact of Enhanced-Case-Finding on tuberculosis case notifications and transmission in The Gambia using epidemiological and phylodynamic approaches
Assessing the impact of Enhanced-Case-Finding on tuberculosis case notifications and transmission in The Gambia using epidemiological and phylodynamic approaches Open
Background Most tuberculosis (TB) cases in The Gambia are notified in the Greater Banjul Area (GBA). We conducted an Enhanced-Case-Finding (ECF) intervention in the GBA and determined its effect on TB case notifications and ongoing TB tran…
View article: Acetic Acid Enables Molecular Enumeration of <i>Mycobacterium tuberculosis</i> from Sputum and Eliminates the Need for a Biosafety Level 3 Laboratory
Acetic Acid Enables Molecular Enumeration of <i>Mycobacterium tuberculosis</i> from Sputum and Eliminates the Need for a Biosafety Level 3 Laboratory Open
Background Improved monitoring of Mycobacterium tuberculosis response to treatment is urgently required. We previously developed the molecular bacterial load assay (MBLA), but it is challenging to integrate into the clinical diagnostic lab…
View article: PA-131 The contribution of neutrophils and their soluble markers to lung pathology in tuberculosis disease
PA-131 The contribution of neutrophils and their soluble markers to lung pathology in tuberculosis disease Open
Background Tuberculosis is a leading infectious disease killer. It primarily affects the lung, accompanied by tissue damage from excessive host inflammation. Neutrophils are implicated as primary mediators of this tissue destruction. This …
View article: Exhaled <i>Mycobacterium tuberculosis</i> Predicts Incident Infection in Household Contacts
Exhaled <i>Mycobacterium tuberculosis</i> Predicts Incident Infection in Household Contacts Open
Background Halting transmission of Mycobacterium tuberculosis (Mtb) by identifying infectious individuals early is key to eradicating tuberculosis (TB). Here we evaluate face mask sampling as a tool for stratifying the infection risk of in…
View article: Exhaled Mycobacterium tuberculosis predicts incident infection in household contacts
Exhaled Mycobacterium tuberculosis predicts incident infection in household contacts Open
Background Halting transmission of Mycobacterium tuberculosis (Mtb) by identifying infectious individuals early is key to eradicating Tuberculosis (TB). Here we evaluate face mask sampling as a tool for stratifying infection risk in househ…
View article: Vitamin D in Gambian children with discordant tuberculosis (TB) infection status despite matched TB exposure: a case control study
Vitamin D in Gambian children with discordant tuberculosis (TB) infection status despite matched TB exposure: a case control study Open
Using a matched case control design conducted at MRC Gambia in 2015, we measured vitamin D levels in pairs of asymptomatic children with discordant tuberculin skin test status despite the same sleeping proximity to the same adult TB index …
View article: Vitamin D In Gambian Children With Discordant Tuberculosis Infection Status Despite Matched TB Exposure: A Case Control Study
Vitamin D In Gambian Children With Discordant Tuberculosis Infection Status Despite Matched TB Exposure: A Case Control Study Open
Using a matched case-control design we measured vitamin D levels in pairs of Gambian children with discordant infection status despite the same sleeping proximity to the same adult TB index case. Vitamin D levels were 2.05ng/mL higher in 2…
View article: Monitoring Anti-tuberculosis Treatment Response Using Analysis of Whole Blood Mycobacterium tuberculosis Specific T Cell Activation and Functional Markers
Monitoring Anti-tuberculosis Treatment Response Using Analysis of Whole Blood Mycobacterium tuberculosis Specific T Cell Activation and Functional Markers Open
Background Blood-based biomarkers have been proposed as an alternative to current sputum-based treatment monitoring methods in active tuberculosis (ATB). The aim of this study was to validate previously described phenotypic, activation, an…
View article: Protection against mycobacterial infection: A case-control study of mycobacterial immune responses in pairs of Gambian children with discordant infection status despite matched TB exposure
Protection against mycobacterial infection: A case-control study of mycobacterial immune responses in pairs of Gambian children with discordant infection status despite matched TB exposure Open
Clinical Research Training Fellowship funded under UK Medical Research Council/Department for International Development Concordat agreement and part of EDCTP2 programme supported by European Union (MR/K023446/1). Also MRC Program Grants (M…
View article: Protection Against Mycobacterial Infection: A Case-Control Study of Pairs of Gambian Children with Discordant Infection Status Despite Matched TB Exposure
Protection Against Mycobacterial Infection: A Case-Control Study of Pairs of Gambian Children with Discordant Infection Status Despite Matched TB Exposure Open
View article: An Auto-luminescent Fluorescent BCG Whole Blood Assay to Enable Evaluation of Paediatric Mycobacterial Responses Using Minimal Blood Volumes
An Auto-luminescent Fluorescent BCG Whole Blood Assay to Enable Evaluation of Paediatric Mycobacterial Responses Using Minimal Blood Volumes Open
Introduction: Understanding protective human immunity against mycobacteria is critical to developing and evaluating new vaccines against tuberculosis. Children are the most susceptible population to infection, disease, and death fro…
View article: PO 8414 EVALUATION OF <i>MYCOBACTERIUM TUBERCULOSIS</i> COMPLEX (MTBC) CULTURE METHODS IN <i>MYCOBACTERIUM AFRICANUM</i>-ENDEMIC REGION OF WEST AFRICA
PO 8414 EVALUATION OF <i>MYCOBACTERIUM TUBERCULOSIS</i> COMPLEX (MTBC) CULTURE METHODS IN <i>MYCOBACTERIUM AFRICANUM</i>-ENDEMIC REGION OF WEST AFRICA Open
Background With the endemic Mycobacterium africanum (Maf), West African laboratories use glycerol and pyruvate in separate LJ cultures (LJG and LJP) for isolation of MTBC. The aim of this work is to evaluate if combining both glycerol and …