Basil Sharrack
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View article: Employment status in people with multiple sclerosis: profile, dynamic changes and determinants over time
Employment status in people with multiple sclerosis: profile, dynamic changes and determinants over time Open
View article: Digital assessment of real-world walking in people with impaired mobility: How many hours and days are needed?
Digital assessment of real-world walking in people with impaired mobility: How many hours and days are needed? Open
Background Impaired mobility increases falls and mortality risk. However, guidelines to reliably assess real-world walking activity and gait remain undefined. We aimed to (i) determine the minimum daily wear time during waking hours (7:00–…
View article: Effect of repurposed simvastatin on disability progression in secondary progressive multiple sclerosis (MS-STAT2): a phase 3, randomised, double-blind, placebo-controlled trial
Effect of repurposed simvastatin on disability progression in secondary progressive multiple sclerosis (MS-STAT2): a phase 3, randomised, double-blind, placebo-controlled trial Open
National Institute for Health and Care Research Health Technology Assessment Programme, UK Multiple Sclerosis Society, and the US National Multiple Sclerosis Society.
View article: BEAM/ATG or cyclophosphamide/ATG as conditioning regimen in autologous haemopoietic stem cell transplantation for multiple sclerosis: a retrospective analysis of the EBMT autoimmune diseases working party
BEAM/ATG or cyclophosphamide/ATG as conditioning regimen in autologous haemopoietic stem cell transplantation for multiple sclerosis: a retrospective analysis of the EBMT autoimmune diseases working party Open
Multiple Sclerosis (MS) is the most frequent autoimmune disease (AD) treated with autologous hematopoietic stem cell transplantation (HSCT). There are no prospective trials comparing the most used conditioning regimens, BEAM/Anti-thymocyte…
View article: Autologous haematopoietic stem cell transplantation for multiple sclerosis in the <scp>UK</scp>: A 20‐year retrospective analysis of activity and haematological outcomes from the British Society of Blood and Marrow Transplantation and Cellular Therapy (<scp>BSBMTCT</scp>)
Autologous haematopoietic stem cell transplantation for multiple sclerosis in the <span>UK</span>: A 20‐year retrospective analysis of activity and haematological outcomes from the British Society of Blood and Marrow Transplantation and Cellular Therapy (<span>BSBMTCT</span>) Open
Summary Autologous haematopoietic stem cell transplantation (AHSCT) has been developed as a treatment for multiple sclerosis (MS) since 1995. The United Kingdom is one of the most active countries performing AHSCT for MS in Europe. We repo…
View article: Clinical and socio-demographic characteristics of people with multiple sclerosis at the time of diagnosis: Influences on outcome trajectories
Clinical and socio-demographic characteristics of people with multiple sclerosis at the time of diagnosis: Influences on outcome trajectories Open
MS care must be personalised from diagnosis; service design should account for those people with MS experiencing poor health status from diagnosis. Basing capacity planning on average trajectories would be misleading. Furthermore, this evi…
View article: Determinants and progression of stigma in amyotrophic lateral sclerosis/motor neuron disease
Determinants and progression of stigma in amyotrophic lateral sclerosis/motor neuron disease Open
Objective: Stigma in amyotrophic lateral sclerosis/motor neurone disease (ALS/MND) may be felt or enacted; felt stigma covers feeling devalued by the illness, whereas enacted stigma refers to being treated differently because of it.…
View article: Author Correction: Mobilise-D insights to estimate real-world walking speed in multiple conditions with a wearable device
Author Correction: Mobilise-D insights to estimate real-world walking speed in multiple conditions with a wearable device Open
View article: Physical and psychological aspects of multiple sclerosis: Revisiting the Multiple Sclerosis Impact Scale (MSIS-29)
Physical and psychological aspects of multiple sclerosis: Revisiting the Multiple Sclerosis Impact Scale (MSIS-29) Open
Background: The MSIS-29 measures the physical and psychological impact of MS. Objective: The associations between MSIS-29 domains and demographic/clinical aspects were examined and trajectories analysed over time. Methods: Data were collec…
View article: Self-supervised learning of wrist-worn daily living accelerometer data improves the automated detection of gait in older adults
Self-supervised learning of wrist-worn daily living accelerometer data improves the automated detection of gait in older adults Open
View article: Brain reserve and physical disability in secondary progressive multiple sclerosis
Brain reserve and physical disability in secondary progressive multiple sclerosis Open
Background The brain reserve hypothesis posits that larger maximal lifetime brain growth (MLBG) may confer protection against physical disability in multiple sclerosis (MS). Larger MLBG as a proxy for brain reserve, has been associated wit…
View article: Evaluating the effectiveness of simvastatin in slowing the progression of disability in secondary progressive multiple sclerosis (MS-STAT2): protocol for a multicentre, randomised controlled, double-blind, phase 3 clinical trial in the UK
Evaluating the effectiveness of simvastatin in slowing the progression of disability in secondary progressive multiple sclerosis (MS-STAT2): protocol for a multicentre, randomised controlled, double-blind, phase 3 clinical trial in the UK Open
Introduction There remains a high unmet need for disease-modifying therapies that can impact disability progression in secondary progressive multiple sclerosis (SPMS). Following positive results of the phase 2 MS-STAT study, the MS-STAT2 p…
View article: ATG and other serotherapy in conditioning regimens for autologous HSCT in autoimmune diseases: a survey on behalf of the EBMT Autoimmune Diseases Working Party (ADWP)
ATG and other serotherapy in conditioning regimens for autologous HSCT in autoimmune diseases: a survey on behalf of the EBMT Autoimmune Diseases Working Party (ADWP) Open
View article: The Role of Chimeric Antigen Receptor T‐Cell Therapy in Immune‐Mediated Neurological Diseases
The Role of Chimeric Antigen Receptor T‐Cell Therapy in Immune‐Mediated Neurological Diseases Open
Despite the use of ‘high efficacy’ disease‐modifying therapies, disease activity and clinical progression of different immune‐mediated neurological diseases continue for some patients, resulting in accumulating disability, deteriorating so…
View article: Patient-reported outcomes in HSCT for autoimmune diseases: Considerations on behalf of the EBMT ADWP, PAC, and Nurses Group
Patient-reported outcomes in HSCT for autoimmune diseases: Considerations on behalf of the EBMT ADWP, PAC, and Nurses Group Open
View article: Correction: Assessing real-world gait with digital technology? Validation, insights and recommendations from the Mobilise-D consortium
Correction: Assessing real-world gait with digital technology? Validation, insights and recommendations from the Mobilise-D consortium Open
View article: Real-World Gait Detection Using a Wrist-Worn Inertial Sensor: Validation Study
Real-World Gait Detection Using a Wrist-Worn Inertial Sensor: Validation Study Open
Background Wrist-worn inertial sensors are used in digital health for evaluating mobility in real-world environments. Preceding the estimation of spatiotemporal gait parameters within long-term recordings, gait detection is an important st…
View article: Effectiveness of autologous haematopoietic stem cell transplantation versus natalizumab in progressive multiple sclerosis
Effectiveness of autologous haematopoietic stem cell transplantation versus natalizumab in progressive multiple sclerosis Open
Background Natalizumab was not shown to modify disability in progressive multiple sclerosis (MS). This matched observational study compared the effectiveness of autologous haematopoietic stem cell transplantation (AHSCT) with natalizumab i…
View article: Automated Gait Detection in Older Adults during Daily-Living using Self-Supervised Learning of Wrist- Worn Accelerometer Data: Development and Validation of ElderNet
Automated Gait Detection in Older Adults during Daily-Living using Self-Supervised Learning of Wrist- Worn Accelerometer Data: Development and Validation of ElderNet Open
View article: Innovative cellular therapies for autoimmune diseases: expert-based position statement and clinical practice recommendations from the EBMT practice harmonization and guidelines committee
Innovative cellular therapies for autoimmune diseases: expert-based position statement and clinical practice recommendations from the EBMT practice harmonization and guidelines committee Open
View article: Efficacy and safety of autologous haematopoietic stem cell transplantation versus alemtuzumab, ocrelizumab, ofatumumab or cladribine in relapsing remitting multiple sclerosis (StarMS): protocol for a randomised controlled trial
Efficacy and safety of autologous haematopoietic stem cell transplantation versus alemtuzumab, ocrelizumab, ofatumumab or cladribine in relapsing remitting multiple sclerosis (StarMS): protocol for a randomised controlled trial Open
Introduction Autologous haematopoietic stem cell transplantation (aHSCT) is increasingly used as treatment for patients with active multiple sclerosis (MS), typically after failure of disease-modifying therapies (DMTs). A recent phase III …
View article: Mobilise-D insights to estimate real-world walking speed in multiple conditions with a wearable device
Mobilise-D insights to estimate real-world walking speed in multiple conditions with a wearable device Open
View article: Neurological Complications
Neurological Complications Open
Neurological complications of allogeneic hematopoietic cell transplantation are frequent and often highly challenging to manage. These complications can stem from various causes, including neurotoxic drugs, infectious pathogens, cerebrovas…
View article: Autoimmune Disease
Autoimmune Disease Open
Autoimmune diseases (ADs) are a heterogeneous group of diseases affecting 8–10% of the Western population, which constitute a heavy burden to society and are often debilitating and disabling for affected individuals. ADs are defined as an …
View article: Correlates and trajectories of relapses in relapsing–remitting multiple sclerosis
Correlates and trajectories of relapses in relapsing–remitting multiple sclerosis Open
Background and aims In people with relapsing–remitting multiple sclerosis (pwRRMS), data from studies on non-pharmacological factors which may influence relapse risk, other than age, are inconsistent. There is a reduced risk of relapses wi…
View article: Ecological validity of a deep learning algorithm to detect gait events from real-life walking bouts in mobility-limiting diseases
Ecological validity of a deep learning algorithm to detect gait events from real-life walking bouts in mobility-limiting diseases Open
Introduction The clinical assessment of mobility, and walking specifically, is still mainly based on functional tests that lack ecological validity. Thanks to inertial measurement units (IMUs), gait analysis is shifting to unsupervised mon…
View article: O.5.2-7 Listening to the patients’ voice: a conceptual framework of the walking experience
O.5.2-7 Listening to the patients’ voice: a conceptual framework of the walking experience Open
Purpose Walking is crucial for an active and healthy ageing, but it changes with age and in the presence of diverse health conditions, such as non-communicable diseases and injuries. So far, conceptual frameworks of walking have not includ…
View article: Measuring disability in multiple sclerosis: the WHODAS 2.0
Measuring disability in multiple sclerosis: the WHODAS 2.0 Open
View article: Real-World Gait Detection Using a Wrist-Worn Inertial Sensor: Validation Study (Preprint)
Real-World Gait Detection Using a Wrist-Worn Inertial Sensor: Validation Study (Preprint) Open
BACKGROUND Wrist-worn inertial sensors are used in digital health for evaluating mobility in real-world environments. Preceding the estimation of spatiotemporal gait parameters within long-term recordings, gait detection is an important s…
View article: Estimating real-world walking speed from a single wearable device: analytical pipeline, results and lessons learnt from the Mobilise-D technical validation study
Estimating real-world walking speed from a single wearable device: analytical pipeline, results and lessons learnt from the Mobilise-D technical validation study Open
Background: Estimation of walking speed from wearable devices requires combining a set of algorithms in a single analytical pipeline. The aim of this study was to validate a pipeline for walking speed estimation and assess its performance …