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View article: Photoisomerization of Azobenzene‐Extended Charybdotoxin for the Optical Control of K<sub>v</sub>1.2 Potassium Channel Activity
Photoisomerization of Azobenzene‐Extended Charybdotoxin for the Optical Control of K<sub>v</sub>1.2 Potassium Channel Activity Open
Natural peptides from animal venoms effectively modulate ion channel activity. While photoswitches regulate small compound pharmacology, their application to natural peptides rich in disulfide bridges and active on ion channels is novel du…
View article: Photoisomerization of Azobenzene‐Extended Charybdotoxin for the Optical Control of K<sub>v</sub>1.2 Potassium Channel Activity
Photoisomerization of Azobenzene‐Extended Charybdotoxin for the Optical Control of K<sub>v</sub>1.2 Potassium Channel Activity Open
Natural peptides from animal venoms effectively modulate ion channel activity. While photoswitches regulate small compound pharmacology, their application to natural peptides rich in disulfide bridges and active on ion channels is novel du…
View article: Cross-linking teichoic acids by click chemistry prevents bacterial cell growth
Cross-linking teichoic acids by click chemistry prevents bacterial cell growth Open
A new mechanism to stop bacterial growth has been identified by artificial cross-linking of teichoic acid in Streptococcus pneumoniae .
View article: Specific ATP-metric kit for bacterial identification and quantification
Specific ATP-metric kit for bacterial identification and quantification Open
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View article: To click or not to click for short pulse-labeling of the bacterial cell wall
To click or not to click for short pulse-labeling of the bacterial cell wall Open
Clicking fluorescent dyes to live bacteria at the right time enables high-intensity fluorescence, and high spatial and temporal resolution.
View article: Characterization of Potent ABCG2 Inhibitor Derived from Chromone: From the Mechanism of Inhibition to Human Extracellular Vesicles for Drug Delivery
Characterization of Potent ABCG2 Inhibitor Derived from Chromone: From the Mechanism of Inhibition to Human Extracellular Vesicles for Drug Delivery Open
Inhibition of ABC transporters is a promising approach to overcome multidrug resistance in cancer. Herein, we report the characterization of a potent ABCG2 inhibitor, namely, chromone 4a (C4a). Molecular docking and in vitro assays using A…
View article: Resorcinol-based hemiindigoid derivatives as human tyrosinase inhibitors and melanogenesis suppressors in human melanoma cells
Resorcinol-based hemiindigoid derivatives as human tyrosinase inhibitors and melanogenesis suppressors in human melanoma cells Open
Human tyrosinase (hsTYR) catalyzes the key steps of melanogenesis, making it a privileged target for reducing melanin production in vivo. However, very few hsTYR inhibitors have been reported so far in the literature, whereas thousands of …
View article: Resorcinol-based hemiindigoid derivatives as human tyrosinase inhibitors and melanogenesis suppressors in human melanoma cells
Resorcinol-based hemiindigoid derivatives as human tyrosinase inhibitors and melanogenesis suppressors in human melanoma cells Open
Human tyrosinase (hsTYR) catalyzes the key steps of melanogenesis, making it a privileged target for reducing melanin production in vivo. However, very few hsTYR inhibitors have been reported so far in the literature, whereas thousands of …
View article: Crossing of the Cystic Barriers of Toxoplasma gondii by the Fluorescent Coumarin Tetra-Cyclopeptide
Crossing of the Cystic Barriers of Toxoplasma gondii by the Fluorescent Coumarin Tetra-Cyclopeptide Open
FR235222 is a natural tetra-cyclopeptide with a strong inhibition effect on histone deacetylases, effective on mammalian cells as well as on intracellular apicomplexan parasites, such as Toxoplasma gondii, in the tachyzoite and bradyzoite …
View article: Advances in the Design of Genuine Human Tyrosinase Inhibitors for Targeting Melanogenesis and Related Pigmentations
Advances in the Design of Genuine Human Tyrosinase Inhibitors for Targeting Melanogenesis and Related Pigmentations Open
Human tyrosinase (hsTYR) is the key enzyme ensuring the conversion of l-tyrosine to dopaquinone, thereby initiating melanin synthesis, i.e., melanogenesis. Although the protein has long been familiar, knowledge about its three-dimensional …
View article: Molecular analysis of the massive GSH transport mechanism mediated by the human Multidrug Resistant Protein 1/ABCC1
Molecular analysis of the massive GSH transport mechanism mediated by the human Multidrug Resistant Protein 1/ABCC1 Open
The transporter Multidrug Resistance Protein 1 (MRP1, ABCC1) is implicated in multidrug resistant (MDR) phenotype of cancer cells. Glutathione (GSH) plays a key role in MRP1 transport activities. In addition, a ligand-stimulated GSH transp…