Bassem M. Mohammed
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View article: Cryo-EM structure of coagulation factor Va bound to activated protein C
Cryo-EM structure of coagulation factor Va bound to activated protein C Open
Coagulation factor Va (FVa) is the cofactor component of the prothrombinase complex required for rapid generation of thrombin from prothrombin in the penultimate step of the coagulation cascade. In addition, FVa is a target for proteolytic…
View article: A model of zymogen factor XII: insights into protease activation
A model of zymogen factor XII: insights into protease activation Open
In plasma, the zymogens factor XII (FXII) and prekallikrein reciprocally convert each other to the proteases FXIIa and plasma kallikrein (PKa). PKa cleaves high-molecular-weight kininogen (HK) to release bradykinin, which contributes to re…
View article: Replacement of a single residue changes the primary specificity of thrombin
Replacement of a single residue changes the primary specificity of thrombin Open
D189 in the S1 pocket confers thrombin "trypsin-like" specificity for Arg at P1. However, the S1 pocket is wide enough to also enable "chymotrypsin-like" specificity for Phe at P1. Consistent with these structural features, a single amino …
View article: Maturation of germinal center B cells after influenza virus vaccination in humans
Maturation of germinal center B cells after influenza virus vaccination in humans Open
Germinal centers (GC) are microanatomical lymphoid structures where affinity-matured memory B cells and long-lived bone marrow plasma cells are primarily generated. It is unclear how the maturation of B cells within the GC impacts the brea…
View article: Cryo-EM structure of coagulation factor V short
Cryo-EM structure of coagulation factor V short Open
Coagulation factor V (fV) is the inactive precursor of fVa, an essential component of the prothrombinase complex required for rapid activation of prothrombin in the penultimate step of the coagulation cascade. In addition, fV regulates the…
View article: A mechanism for hereditary angioedema caused by a lysine 311–to–glutamic acid substitution in plasminogen
A mechanism for hereditary angioedema caused by a lysine 311–to–glutamic acid substitution in plasminogen Open
Patients with hereditary angioedema (HAE) experience episodes of bradykinin (BK)-induced swelling of skin and mucosal membranes. The most common cause is reduced plasma activity of C1 inhibitor, the main regulator of the proteases plasma k…
View article: Model for surface-dependent factor XII activation: the roles of factor XII heavy chain domains
Model for surface-dependent factor XII activation: the roles of factor XII heavy chain domains Open
Factor XII (FXII) is the zymogen of a plasma protease (FXIIa) that contributes to bradykinin generation by converting prekallikrein to the protease plasma kallikrein (PKa). FXII conversion to FXIIa by autocatalysis or PKa-mediated cleavage…
View article: Neutralizing Monoclonal Antibodies That Target the Spike Receptor Binding Domain Confer Fc Receptor-Independent Protection against SARS-CoV-2 Infection in Syrian Hamsters
Neutralizing Monoclonal Antibodies That Target the Spike Receptor Binding Domain Confer Fc Receptor-Independent Protection against SARS-CoV-2 Infection in Syrian Hamsters Open
The severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) spike protein is the main target for neutralizing antibodies. These antibodies can be elicited through immunization or passively transferred as therapeutics in the form of co…
View article: Patency and Clinico-Haematological Pathologies Sequel to Trypanosoma brucei and Trypanosoma evansi Induced Infections in Yankasa Sheep I
Patency and Clinico-Haematological Pathologies Sequel to Trypanosoma brucei and Trypanosoma evansi Induced Infections in Yankasa Sheep I Open
Trypanosomosis remains one of the most deadly protozoan diseases that pose a significant impact on livestock health in the tropics. Sixteen (16) rams aged between 24 to 30 months and weighed between 22-25kg were acclimatized under standard…
View article: Clinicopathological and Microscopic Features of Trypanosoma brucei and Trypanosoma evansi Induced Infections in Sheep II
Clinicopathological and Microscopic Features of Trypanosoma brucei and Trypanosoma evansi Induced Infections in Sheep II Open
The present study elucidates further on clinical, gross, and microscopic pathologies induced by single or mixed infections with Trypanosoma evansi and Trypanosoma brucei in sheep. Briefly, the experimental animals were divided into four gr…
View article: Polyclonal epitope cartography reveals the temporal dynamics and diversity of human antibody responses to H5N1 vaccination
Polyclonal epitope cartography reveals the temporal dynamics and diversity of human antibody responses to H5N1 vaccination Open
SUMMARY Novel influenza A virus (IAV) strains elicit recall immune responses to conserved epitopes, making them favorable antigenic choices for universal influenza virus vaccines. Evaluating these immunogens requires a thorough understandi…
View article: Mouse models of hemostasis
Mouse models of hemostasis Open
Hemostasis is the normal process that produces a blood clot at a site of vascular injury. Mice are widely used to study hemostasis and abnormalities of blood coagulation because their hemostatic system is similar in most respects to that o…
Protease activity in single-chain prekallikrein Open
Prekallikrein (PK) is the precursor of the trypsin-like plasma protease kallikrein (PKa), which cleaves kininogens to release bradykinin and converts the protease precursor factor XII (FXII) to the enzyme FXIIa. PK and FXII undergo recipro…
View article: Phenotype of ribonuclease 1 deficiency in mice
Phenotype of ribonuclease 1 deficiency in mice Open
Biological roles for extracellular RNA (eRNA) have become apparent. For example, eRNA can induce contact activation in blood via activation of the plasma proteases factor XII (FXII) and factor XI (FXI). We sought to reveal the biological r…
View article: A mechanism for hereditary angioedema with normal C1 inhibitor: an inhibitory regulatory role for the factor XII heavy chain
A mechanism for hereditary angioedema with normal C1 inhibitor: an inhibitory regulatory role for the factor XII heavy chain Open
The plasma proteins factor XII (FXII) and prekallikrein (PK) undergo reciprocal activation to the proteases FXIIa and kallikrein by a process that is enhanced by surfaces (contact activation) and regulated by the serpin C1 inhibitor. Kalli…
View article: Effect of Intramuscular Administration of Trypadim, Trypamidium and Novidium on Body Temperature, Body Weight and Hematological Parameters of Wistar Rats Infected with <em>Trypanosoma brucei brucei</em> (Federe Strain)
Effect of Intramuscular Administration of Trypadim, Trypamidium and Novidium on Body Temperature, Body Weight and Hematological Parameters of Wistar Rats Infected with <em>Trypanosoma brucei brucei</em> (Federe Strain) Open
Effect of intramuscular administration of Trypanocides on body temperature, body weight and hematological parameters of Wistar rats infected with Trypanosoma brucei brucei was investigated. Twenty-five adult Wistar rats were randomly divid…
View article: Factor <scp>XI</scp> and pulmonary infections
Factor <span>XI</span> and pulmonary infections Open
The glycoprotein factor XI (FXI) and its active protease form factor XIa (FXIa) are undergoing evaluation as therapeutic targets based on mounting evidence that they contribute to thrombotic disease.1 FXI serves a modest role in haemostasi…