Bassem Khemakhem
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Novel Coumarin–Hydrazone Hybrids as Potential Antiplatelet Agents: Microwave‐Assisted Synthesis, Characterization, In Vitro and In Silico Biological Evaluations and Toxicity Assessment Open
This work focuses on the synthesis and characterization of a new series of coumarin–hydrazone derivatives, as well as the evaluation of their inhibitory effects on platelet aggregation induced by adenosine diphosphate (ADP), arachidonic ac…
Exploring the Genotoxic Stress Response in Primed Orphan Legume Seeds Challenged with Heat Stress Open
Background/Objectives: The increased frequency of extreme weather events related to climate change, including the occurrence of extreme temperatures, severely affects crop yields, impairing global food security. Heat stress resulting from …
Antiplatelet activity and toxicity profile of novel phosphonium salts derived from Michael reaction Open
In this work, five novel phosphonium salts derived from the Michael reaction were screened for their antiplatelet activity. Our findings revealed that compounds 2a, 2b, 2c, and 2d significantly inhibit platelet aggregation triggered by ADP…
Biochemical and Functional Characterization by Site-Directed Mutagenesis of a Phospholipase A2 from Scorpio maurus Venom Open
The study of amino acid interactions in the active site of scorpion venom phospholipases A2 could help to gain insights into the structure–function relationship and the biological activities of the enzyme. In the secreted phospholipase A2 …
View article: Synthesis, Photophysical Characterization and Evaluation of Biological Properties of C7, a Novel Symmetric Tetra-Imidazolium-Bis-Heterocycle
Synthesis, Photophysical Characterization and Evaluation of Biological Properties of C7, a Novel Symmetric Tetra-Imidazolium-Bis-Heterocycle Open
A novel symmetric tetra-imidazolium-bis-heterocycle, called C7, was designed and synthesized in a quick two-step pathway, with the objective to synthesize biologically active supramolecular assembly. The synthesized compound was then analy…
Apigenin analogues as SARS-CoV-2 main protease inhibitors: <i>In-silico</i> screening approach Open
The COVID-19 new variants spread rapidly all over the world, and until now scientists strive to find virus-specific antivirals for its treatment. The main protease of SARS-CoV-2 (Mpro) exhibits high structural and sequence homology to main…
Antioxidant, Anti-Inflammatory, and Antitumoral Effects of Aqueous Ethanolic Extract from<i>Phoenix dactylifera</i>L. Parthenocarpic Dates Open
The aim of this study was to evaluate the antioxidant, the anti-inflammatory, and the antitumoral activities of the aqueous ethanolic extract from Phoenix dactylifera L. parthenocarpic dates. The antioxidant activity was carried using DPPH…
Optimization, Purification, and Starch Stain Wash Application of Two New<i>α</i>-Amylases Extracted from Leaves and Stems of<i>Pergularia tomentosa</i> Open
A continuous research is attempted to fulfil the highest industrial demands of natural amylases presenting special properties. New α -amylases extracted from stems and leaves of Pergularia tomentosa , which is widespread and growing sponta…