Bassem Refaat
YOU?
Author Swipe
View article: Increased protein expression of interleukin-10 and its signalling molecules in colon cancer progression: potential prognostic and therapeutic targets
Increased protein expression of interleukin-10 and its signalling molecules in colon cancer progression: potential prognostic and therapeutic targets Open
IL-10 and its signalling molecules increased in CRC progression, particularly in RSCs, suggesting their potential oncogenic roles and prognostic significance. Furthermore, targeting IL-10 signalling pathways could offer a promising avenue …
View article: Prevalence of Hypertension Risk Factors Among Young Female Students of Umm Al-Qura University, Makkah, Saudi Arabia: A Cross-Sectional Study
Prevalence of Hypertension Risk Factors Among Young Female Students of Umm Al-Qura University, Makkah, Saudi Arabia: A Cross-Sectional Study Open
Background: Conditions concerning high blood pressure create substantial health risks both worldwide and within the Gulf nations because of accelerated changes in lifestyles and expanding young demographic statistics. Objective: The curren…
View article: IL-10-Directed Cancer Immunotherapy: Preclinical Advances, Clinical Insights, and Future Perspectives
IL-10-Directed Cancer Immunotherapy: Preclinical Advances, Clinical Insights, and Future Perspectives Open
Interleukin-10 (IL-10) is a dimeric cytokine encoded by the IL-10 gene on chromosome 1 [...]
View article: Exploring potential additive effects of 5-fluorouracil, thymoquinone, and coenzyme Q10 triple therapy on colon cancer cells in relation to glycolysis and redox status modulation
Exploring potential additive effects of 5-fluorouracil, thymoquinone, and coenzyme Q10 triple therapy on colon cancer cells in relation to glycolysis and redox status modulation Open
Background To investigate the anticancer effects of 5-Fluorouracil (5-FU), thymoquinone (TQ), and/or coenzyme Q10 (CQ10), alone and combined, in HT29, SW480, and SW620 human colorectal cancer (CRC) cell lines. Methods Cell cycle progressio…
View article: Cytotoxic activity, selectivity, and clonogenicity of fruits and resins of Saudi medicinal plants against human liver adenocarcinoma
Cytotoxic activity, selectivity, and clonogenicity of fruits and resins of Saudi medicinal plants against human liver adenocarcinoma Open
Background: Edible fruits and resins provide various benefits to mankind including potential medicinal applications. This study aimed to determine the cytotoxicity, selectivity, and clonogenicity of fruits and exudates of certain Saudi med…
View article: Enhanced hepatoprotective effects of empagliflozin and vitamin D dual therapy against metabolic dysfunction‐associated steatohepatitis in mice by boosted modulation of metabolic, oxidative stress, and inflammatory pathways
Enhanced hepatoprotective effects of empagliflozin and vitamin D dual therapy against metabolic dysfunction‐associated steatohepatitis in mice by boosted modulation of metabolic, oxidative stress, and inflammatory pathways Open
Although single treatment with sodium‐glucose cotransporter‐2 inhibitors (SGLT2i) or vitamin D 3 (VD 3 ) inhibited metabolic dysfunction‐associated steatohepatitis (MASH) development in diabetic patients, their combination has not been exp…
View article: The anticancer properties, cell-cycle cytotoxicity and apoptosis of cissus rotundifolia, trema orientalis, and buddleja polystachya with ocular applications
The anticancer properties, cell-cycle cytotoxicity and apoptosis of cissus rotundifolia, trema orientalis, and buddleja polystachya with ocular applications Open
Background: Buddleja polystachya, Trema orientalis, and Cissus rotundifolia were applied locally for various ocular purposes, while receiving few scientific evaluations. Purpose: This study aimed to screen the anticancer properties and det…
View article: Saffron (Crocus Sativus Linnaeus) based protection against Aflatoxin B1 induced organ damage in rats
Saffron (Crocus Sativus Linnaeus) based protection against Aflatoxin B1 induced organ damage in rats Open
Saffron is well-known for its anti-apoptotic, anti-inflammatory, and antioxidant properties. Saffron's nutritional and medicinal properties support its numerous uses as a flavouring and herbal remedy. This study investigated the protective…
View article: Seroprevalence of transfusion-transmitted infections among blood donors in Makkah, Saudi Arabia
Seroprevalence of transfusion-transmitted infections among blood donors in Makkah, Saudi Arabia Open
Introduction: Blood donation is vital for healthcare; however, transfusion-transmitted infections (TTIs) pose a serious risk. This study investigated the seroprevalence of TTIs among Saudi blood donors. Methodology: This retrospective stud…
View article: In-vitro Cytotoxicity Investigations for Phytoconstituents of Saudi Medicinal Plants With Putative Ocular Effects
In-vitro Cytotoxicity Investigations for Phytoconstituents of Saudi Medicinal Plants With Putative Ocular Effects Open
Background: Metastatic secondary ocular tumors spread from systemic malignancies, including breast cancer. This study aimed to evaluate the cytotoxicity of extracts from 5 medicinal plants native to Saudi Arabia. Methods: For preliminary a…
View article: Comparative impacts of Saudi Arabian and Egyptian Aspergillus flavus-associated Aflatoxin B1 on rats
Comparative impacts of Saudi Arabian and Egyptian Aspergillus flavus-associated Aflatoxin B1 on rats Open
Aflatoxin B1 (AFB1) is a carcinogenic secondary metabolite of filamentous Aspergillus species. This study investigated the effects of Saudi Arabian (local) and Egyptian (imported) Aspergillus flavus-associated AFB1 on rats (hematological p…
View article: Improved Glycaemic Control and Nephroprotective Effects of Empagliflozin and Paricalcitol Co-Therapy in Mice with Type 2 Diabetes Mellitus
Improved Glycaemic Control and Nephroprotective Effects of Empagliflozin and Paricalcitol Co-Therapy in Mice with Type 2 Diabetes Mellitus Open
Herein, we measured the antidiabetic and nephroprotective effects of the sodium–glucose cotransporter-2 inhibitor (empagliflozin; SGLT2i) and synthetic active vitamin D (paricalcitol; Pcal) mono- and co-therapy against diabetic nephropathy…
View article: Antioxidative and Anti-Inflammatory Protective Effects of Fucoxanthin against Paracetamol-Induced Hepatotoxicity in Rats
Antioxidative and Anti-Inflammatory Protective Effects of Fucoxanthin against Paracetamol-Induced Hepatotoxicity in Rats Open
Paracetamol or acetaminophen (PAC) is a commonly used analgesic and antipyretic drug. It has been shown that overdoses beyond the therapeutic range can cause hepatotoxicity and acute liver injury. The most common cause of drug-induced live…
View article: The protective effects of Vitamin D against Cadmium-induced nephrotoxicity
The protective effects of Vitamin D against Cadmium-induced nephrotoxicity Open
Background: Cadmium (Cd) is retained in the kidneys in large amounts thus inducing oxidative damage. Vitamin D (VD) is a potent antioxidant that is postulated to reverse the Cd-induced oxidative effects. Aim: The present study aimed at inv…
View article: The Quality of Blood Donation Services and Its Association with Blood Donors’ Trust and Loyalty at Makkah Blood Donation Centers in Saudi Arabia: A Cross-Sectional Study
The Quality of Blood Donation Services and Its Association with Blood Donors’ Trust and Loyalty at Makkah Blood Donation Centers in Saudi Arabia: A Cross-Sectional Study Open
The current cross-sectional study was conducted to determine the quality of blood donation services and its association with blood donors’ trust and loyalty at Makkah blood donation centers in Saudi Arabia. A total of 373 healthy blood don…
View article: Vitamin D3 alleviates nonalcoholic fatty liver disease in rats by inhibiting hepatic oxidative stress and inflammation via the SREBP-1-c/ PPARα-NF-κB/IR-S2 signaling pathway
Vitamin D3 alleviates nonalcoholic fatty liver disease in rats by inhibiting hepatic oxidative stress and inflammation via the SREBP-1-c/ PPARα-NF-κB/IR-S2 signaling pathway Open
Introduction: Nonalcoholic fatty liver disease (NAFLD) is a chronic disease characterized by fat deposits in liver cells, which can lead to hepatitis and fibrosis. This study attempted to explore the protective effect of vitamin D3 (VitD) …
View article: Profiling estrogen, progesterone, and androgen receptors in colorectal cancer in relation to gender, menopausal status, clinical stage, and tumour sidedness
Profiling estrogen, progesterone, and androgen receptors in colorectal cancer in relation to gender, menopausal status, clinical stage, and tumour sidedness Open
Background Although estrogen (ERα/ERβ), progesterone (PGR), and androgen (AR) receptors are pathologically altered in colorectal cancer (CRC), their simultaneous expression within the same cohort of patients was not previously measured. Me…
View article: Cymbopogon citratus and Citral Overcome Doxorubicin Resistance in Cancer Cells via Modulating the Drug’s Metabolism, Toxicity, and Multidrug Transporters
Cymbopogon citratus and Citral Overcome Doxorubicin Resistance in Cancer Cells via Modulating the Drug’s Metabolism, Toxicity, and Multidrug Transporters Open
Multidrug resistance (MDR) is the major complex mechanism that causes the failure of chemotherapy, especially with drugs of natural origin such as doxorubicin (DOX). Intracellular drug accumulation and detoxification are also involved in c…
View article: Hepatoprotective and Neuroprotective Effects of Naringenin against Lead-Induced Oxidative Stress, Inflammation, and Apoptosis in Rats
Hepatoprotective and Neuroprotective Effects of Naringenin against Lead-Induced Oxidative Stress, Inflammation, and Apoptosis in Rats Open
Naringenin (NRG) is one of the most important naturally occurring flavonoids, predominantly found in some edible fruits, such as citrus species and tomatoes. It has several biological activities, such as antioxidant, antitumor, antiviral, …
View article: Insights from the molecular docking analysis of EGFR antagonists
Insights from the molecular docking analysis of EGFR antagonists Open
Overexpression of the epidermal growth factor receptor (EGFR) has been shown to be a critical factor in tumor development and cancer progression. Although established EGFR inhibitors have been effective in the treatment of cancer, they are…
View article: Patterns of acute poisoning for children during outbreak of Corona virus in Makkah region Saudi Arabia
Patterns of acute poisoning for children during outbreak of Corona virus in Makkah region Saudi Arabia Open
Background Poisoning occurs when a person is exposed to an external substance at a too high dose for them. It is possible for young children to be exposed to chemicals. Lungs, the heart, CNS, the digestive tract, and kidneys can be poisone…
View article: Green-synthesized nanoparticles and their therapeutic applications: A review
Green-synthesized nanoparticles and their therapeutic applications: A review Open
Antibiotic-resistant microorganisms are a rising issue when it comes to human health. Microbial pathogens that cause harmful infections are quickly becoming resistant to the antimicrobial action of traditional antibiotics. Nanotechnology, …
View article: Enhanced anti-cancer effects of oestrogen and progesterone co-therapy against colorectal cancer in males
Enhanced anti-cancer effects of oestrogen and progesterone co-therapy against colorectal cancer in males Open
Although ovarian sex steroids could have protective roles against colorectal cancer (CRC) in women, little is currently known about their potential anti-tumorigenic effects in men. Hence, this study measured the therapeutic effects of 17β-…
View article: Associations of Clinical Factors and Blood Groups With the Severity of COVID-19 Infection in Makkah City, Saudi Arabia
Associations of Clinical Factors and Blood Groups With the Severity of COVID-19 Infection in Makkah City, Saudi Arabia Open
Context The possible associations between the different blood groups and clinical factors with COVID-19 infection among patients in Makkah city. Objective To investigate the relationship between ABO blood groups and COVID-19 infection in p…
View article: Hydrogel films of methanolic <i>Mentha piperita</i> extract and silver nanoparticles enhance wound healing in rats with diabetes Type I
Hydrogel films of methanolic <i>Mentha piperita</i> extract and silver nanoparticles enhance wound healing in rats with diabetes Type I Open
Poor wound healing is considered an obstacle in diabetics, which requires effective therapy. Our goal was to investigate the combined effect of mint and silver nanoparticle hydrogel films as wound-healing agents in diabetic rats. Thirty ra…
View article: In Vivo and In Vitro Enhanced Tumoricidal Effects of Metformin, Active Vitamin D3, and 5-Fluorouracil Triple Therapy against Colon Cancer by Modulating the PI3K/Akt/PTEN/mTOR Network
In Vivo and In Vitro Enhanced Tumoricidal Effects of Metformin, Active Vitamin D3, and 5-Fluorouracil Triple Therapy against Colon Cancer by Modulating the PI3K/Akt/PTEN/mTOR Network Open
Chemoresistance to 5-fluorouracil (5-FU) is common during colorectal cancer (CRC) treatment. This study measured the chemotherapeutic effects of 5-FU, active vitamin D3 (VD3), and/or metformin single/dual/triple regimens as complementary/a…
View article: Protective antioxidative and anti-inflammatory actions of β-caryophyllene against sulfasalazine-induced nephrotoxicity in rat
Protective antioxidative and anti-inflammatory actions of β-caryophyllene against sulfasalazine-induced nephrotoxicity in rat Open
The pathogenesis of sulfasalazine (SFZ)-induced nephrotoxicity is unclear. Moreover, there are no reports on the protective effects of β-caryophyllene (BCP) against SFZ-induced renal injury. Hence, in this study, we measured several oxidat…
View article: Metformin and Calcitriol Enhance 5-Fluorouracil Tumoricidal Effects in Colon Cancer By Modulating The PI3K/Akt/PTEN/mTOR Network
Metformin and Calcitriol Enhance 5-Fluorouracil Tumoricidal Effects in Colon Cancer By Modulating The PI3K/Akt/PTEN/mTOR Network Open
Purpose: Chemoresistance to 5-Fluorouracil (5-FU) is common during colorectal cancer (CRC) treatment. This study measured the chemotherapeutic effects of 5-FU, calcitriol, and/or metformin single/dual/triple regimens as complementary/alter…
View article: Antioxidative and Anti‐Inflammatory Protective Effects of <i>β</i>‐Caryophyllene against Amikacin‐Induced Nephrotoxicity in Rat by Regulating the Nrf2/AMPK/AKT and NF‐<i>κ</i>B/TGF‐<i>β</i>/KIM‐1 Molecular Pathways
Antioxidative and Anti‐Inflammatory Protective Effects of <i>β</i>‐Caryophyllene against Amikacin‐Induced Nephrotoxicity in Rat by Regulating the Nrf2/AMPK/AKT and NF‐<i>κ</i>B/TGF‐<i>β</i>/KIM‐1 Molecular Pathways Open
Herein, the molecular pathogenic pathways implicated in renal injury triggered by amikacin (AK), together with the alleviating actions of β ‐caryophyllene (BCP), were investigated. Adult male Wistar rats ( n = 32) were disseminated to the …