Bassem Youssef
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View article: Chemotherapy-free innovations in locally advanced head and neck cancer: a comprehensive review
Chemotherapy-free innovations in locally advanced head and neck cancer: a comprehensive review Open
The treatment of locally advanced head and neck squamous cell carcinoma (LA-HNSCC) has traditionally relied on a multimodal approach, combining surgery, radiation therapy (RT), and chemotherapy. While chemotherapy plays a critical role in …
View article: Case report: Neoadjuvant-intent pembrolizumab resulted in complete response in a xeroderma pigmentosum patient with locally advanced resectable cutaneous squamous cell carcinoma of the nose
Case report: Neoadjuvant-intent pembrolizumab resulted in complete response in a xeroderma pigmentosum patient with locally advanced resectable cutaneous squamous cell carcinoma of the nose Open
Background Anti-PD1 antibodies have gained popularity in the treatment of skin cancers. These drugs have been FDA approved for treatment of cutaneous melanoma and unresectable/metastatic squamous cell carcinoma of the skin. However, the us…
View article: Neutrophil-to-lymphocyte ratio trend: A novel prognostic predictor in patients with nasopharyngeal carcinoma receiving radiotherapy
Neutrophil-to-lymphocyte ratio trend: A novel prognostic predictor in patients with nasopharyngeal carcinoma receiving radiotherapy Open
Background Peripheral neutrophil-lymphocyte ratio (NLR), reflecting immune-inflammation status, shows great potential for tumor progression and outcome. Pre-treatment NLR does not fully reflect the immune-inflammatory response to treatment…
View article: Radiation-Induced Fibrosis in Patients with Head and Neck Cancer: A Review of Pathogenesis and Clinical Outcomes
Radiation-Induced Fibrosis in Patients with Head and Neck Cancer: A Review of Pathogenesis and Clinical Outcomes Open
Radiotherapy-related fibrosis remains one of the most challenging treatment related side effects encountered by patients with head and neck cancer. Several established and ongoing novel therapies have been studied with paucity of data in h…
View article: Locally advanced lung cancer
Locally advanced lung cancer Open
Mrs. GG is a 76-year-old woman who presented in March 2020 with a 4-month history of middle back pain radiating to the right chest wall. A magnetic resonance image of the thoracic spine on March 11, 2020, revealed the presence of 4.4-cm ri…
View article: Patient Selection for Surgery vs Radiotherapy for Early Stage Oropharyngeal Cancer
Patient Selection for Surgery vs Radiotherapy for Early Stage Oropharyngeal Cancer Open
Surgery and radiation therapy are both commonly used in the treatment of early stage (AJCC stages T1-T2 N0-M0) oropharyngeal squamous cell carcinoma (OPSCC). Transoral robotic surgery (TORS) and intensity modulated radiation therapy (IMRT)…
View article: Outcomes after radiation therapy for<scp>T2N0</scp>/stage<scp>II</scp>glottic squamous cell carcinoma
Outcomes after radiation therapy for<span>T2N0</span>/stage<span>II</span>glottic squamous cell carcinoma Open
Background We report outcomes for patients with T2N0M0 glottic squamous cell carcinoma (SCC) treated with radiation therapy (RT). Methods Patients who received definitive RT for T2 glottic SCC from 2000 through 2013 were retrospectively re…
View article: Predictors of Cardiac Sparing in Deep Inspiration Breath-Hold for Patients With Left Sided Breast Cancer
Predictors of Cardiac Sparing in Deep Inspiration Breath-Hold for Patients With Left Sided Breast Cancer Open
Purpose: The purpose of this study was to evaluate patient-related non-dosimetric predictors of cardiac sparing with the use of deep inspiration breath-hold (DIBH) in patients with left-sided breast cancer undergoing irradiation (RT). Mate…
View article: Trastuzumab Emtansine for the Treatment of HER-2 Positive Carcinoma Ex-pleomorphic Adenoma Metastatic to the Brain: A Case Report
Trastuzumab Emtansine for the Treatment of HER-2 Positive Carcinoma Ex-pleomorphic Adenoma Metastatic to the Brain: A Case Report Open
Background: Carcinoma Ex-pleomorphic adenoma is a malignant transformation of the common benign neoplasm of the salivary glands, "pleomorphic adenoma." Only two cases were ever reported with brain metastases, with absence of good evidence …
View article: Investigation of radiomic signatures for local recurrence using primary tumor texture analysis in oropharyngeal head and neck cancer patients
Investigation of radiomic signatures for local recurrence using primary tumor texture analysis in oropharyngeal head and neck cancer patients Open
Radiomics is one such “big data” approach that applies advanced image refining/data characterization algorithms to generate imaging features that can quantitatively classify tumor phenotypes in a non-invasive manner. We hypothesize that ce…
View article: Supplemental computational phantoms to estimate out-of-field absorbed dose in photon radiotherapy
Supplemental computational phantoms to estimate out-of-field absorbed dose in photon radiotherapy Open
The purpose of this study was to develop a straightforward method of supplementing patient anatomy and estimating out-of-field absorbed dose for a cohort of pediatric radiotherapy patients with limited recorded anatomy. A cohort of nine ch…
View article: Swine Atrioventricular Node Ablation Using Stereotactic Radiosurgery: Methods and In Vivo Feasibility Investigation for Catheter‐Free Ablation of Cardiac Arrhythmias
Swine Atrioventricular Node Ablation Using Stereotactic Radiosurgery: Methods and In Vivo Feasibility Investigation for Catheter‐Free Ablation of Cardiac Arrhythmias Open
Background Linear accelerator–based stereotactic radiosurgery delivered to cardiac arrhythmogenic foci could be a promising catheter‐free ablation modality. We tested the feasibility of in vivo atrioventricular ( AV ) node ablation in swin…
View article: A simple technique for an accurate shielding of the lungs during total body irradiation
A simple technique for an accurate shielding of the lungs during total body irradiation Open
This new technique succeeded in reducing the length of the overall treatment session of the conventional TBI procedure and hence reduced patient discomfort while ensuring accurate shielding of the lungs.
View article: Intraoperative Radiation Therapy: A Promising Treatment Modality in Head and Neck Cancer
Intraoperative Radiation Therapy: A Promising Treatment Modality in Head and Neck Cancer Open
Every year, almost 62,000 are diagnosed with a head and neck cancer (HNC) and 13,000 will succumb to their disease. In the primary setting, intraoperative radiation therapy (IORT) can be used as a boost in select patients in order to optim…
View article: Model for Estimating Power and Downtime Effects on Teletherapy Units in Low-Resource Settings
Model for Estimating Power and Downtime Effects on Teletherapy Units in Low-Resource Settings Open
Purpose More than 6,500 megavoltage teletherapy units are needed worldwide, many in low-resource settings. Cobalt-60 units or linear accelerators (linacs) can fill this need. We have evaluated machine performance on the basis of patient th…