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View article: Social context restructures behavioral syntax in mice
Social context restructures behavioral syntax in mice Open
Introduction The study of social behavior in mice has grown increasingly relevant for unraveling associated brain circuits and advancing the development of treatments for psychiatric symptoms involving social withdrawal or social anxiety. …
View article: Evidence for reduced synaptic protein SNAP-25 in cerebrospinal fluid in major depressive disorder and schizophrenia
Evidence for reduced synaptic protein SNAP-25 in cerebrospinal fluid in major depressive disorder and schizophrenia Open
Background Decreased cerebrospinal fluid (CSF) levels of synaptic proteins, possibly reflecting impaired synaptic function, have been observed in major depressive disorder (MDD). Objective To investigate the diagnostic utility of the solub…
View article: Social Context Restructures Behavioral Syntax in Mice
Social Context Restructures Behavioral Syntax in Mice Open
The study of social behavior in mice has grown increasingly relevant for unraveling associated brain circuits and advancing the development of treatments for psychiatric symptoms involving social withdrawal or social anxiety. However, a da…
View article: Glucocorticoid receptors mediate reprogramming of astrocytes in depression
Glucocorticoid receptors mediate reprogramming of astrocytes in depression Open
Psychiatric disorders are among the most pressing problems of the modern society, with various forms of depression affecting more than 300 millions of people worldwide. Dysfunction of glial cells has consistently been reported in major dep…
View article: Chronic social stress induces generalized hyper-sensitivity to aversion: A mouse model with translational validity for understanding and treating negative valence disorders
Chronic social stress induces generalized hyper-sensitivity to aversion: A mouse model with translational validity for understanding and treating negative valence disorders Open
The RDoC framework focuses on neurobehavioral processes often dysfunctional in mental disorders and commensurate with translational research. Generalized hyper-sensitivity to aversion/threat is common in various stress-related emotional di…
View article: Molecularly Responsive Aptamer-Functionalized Hydrogel for Continuous Plasmonic Biomonitoring
Molecularly Responsive Aptamer-Functionalized Hydrogel for Continuous Plasmonic Biomonitoring Open
Continuous in vivo monitoring of small molecule biomarkers requires biosensors with reversibility, sensitivity in physiologically relevant ranges, and biological stability. Leveraging the real-time, label-free detection capability of surfa…
View article: Modulation of negative affective biases in male rats may predict the rapid and sustained antidepressant effects of different NMDA antagonists
Modulation of negative affective biases in male rats may predict the rapid and sustained antidepressant effects of different NMDA antagonists Open
Affective biases influence cognitive and emotional behaviour and play a significant role in major depressive disorder. We have shown that the NMDA antagonist and rapid-acting antidepressant, ketamine, selectively modulates affective biases…
View article: A molecular mechanism mediating clozapine-enhanced sensorimotor gating
A molecular mechanism mediating clozapine-enhanced sensorimotor gating Open
The atypical antipsychotic clozapine targets multiple receptor systems beyond the dopaminergic pathway and influences prepulse inhibition (PPI), a critical translational measure of sensorimotor gating. Since PPI is modulated by atypical an…
View article: Identification and characterization of human <i>KALRN</i> mRNA and Kalirin protein isoforms
Identification and characterization of human <i>KALRN</i> mRNA and Kalirin protein isoforms Open
Kalirin is a multidomain protein with important roles in neurite outgrowth, and synaptic spine formation and remodeling. Genetic and pathophysiological links with various neuropsychiatric disorders associated with synaptic dysfunction and …
View article: Real-time monitoring of vancomycin using a split-aptamer surface plasmon resonance biosensor
Real-time monitoring of vancomycin using a split-aptamer surface plasmon resonance biosensor Open
The split-aptamer assay exploits the balance between aptamer affinity and structure for real-time monitoring of vancomycin on SPR. Further optimization improved sensitivity, while retaining repeatability under physiologically relevant cond…
View article: Orphan receptor-GPR52 inverse agonist efficacy in ameliorating chronic stress-related deficits in reward motivation and phasic accumbal dopamine activity in mice
Orphan receptor-GPR52 inverse agonist efficacy in ameliorating chronic stress-related deficits in reward motivation and phasic accumbal dopamine activity in mice Open
Reward processing dysfunctions e.g., anhedonia, apathy, are common in stress-related neuropsychiatric disorders including depression and schizophrenia, and there are currently no established therapies. One potential therapeutic approach is…
View article: Neural effects of dopaminergic compounds revealed by multi-site electrophysiology and interpretable machine-learning
Neural effects of dopaminergic compounds revealed by multi-site electrophysiology and interpretable machine-learning Open
Background Neuropsychopharmacological compounds may exert complex brain-wide effects due to an anatomically and genetically broad expression of their molecular targets and indirect effects via interconnected brain circuits. Electrophysiolo…
View article: Orphan receptor-GPR52 inverse agonist efficacy in ameliorating chronic stress-related deficits in reward motivation and phasic accumbal dopamine activity in mice
Orphan receptor-GPR52 inverse agonist efficacy in ameliorating chronic stress-related deficits in reward motivation and phasic accumbal dopamine activity in mice Open
Reward processing dysfunctions e.g., anhedonia, apathy, are common in stress-related neuropsychiatric disorders including depression and schizophrenia, and there are currently no established therapies. One potential therapeutic approach is…
View article: Chronic stress deficits in reward behaviour are underlain by low nucleus accumbens dopamine activity during reward anticipation specifically
Chronic stress deficits in reward behaviour are underlain by low nucleus accumbens dopamine activity during reward anticipation specifically Open
Whilst reward pathologies e.g., anhedonia and apathy, are major and common in stress-related neuropsychiatric disorders, their neurobiological bases and therefore treatment are poorly understood. Functional imaging studies in humans with r…
View article: Influence of aversive cue detection sensitivity on extinction in adult male rats
Influence of aversive cue detection sensitivity on extinction in adult male rats Open
Threat detection prompts reactions classified either as fear (obvious, predictable, immediate threat) or anxiety (ambiguous, sustained, distant threat). Hypervigilance is a state of sensitivity to threatening stimuli and an attentional bia…
View article: Forceps minor control of social behaviour
Forceps minor control of social behaviour Open
The clinical work package of PRISM, a collaborative research project funded by the EU public-private Innovative Medicine Initiative, identified a transdiagnostic and pathophysiological relationship between default mode network (DMN) integr…
View article: Engagement of basal amygdala‐nucleus accumbens glutamate neurons in the processing of rewarding or aversive social stimuli
Engagement of basal amygdala‐nucleus accumbens glutamate neurons in the processing of rewarding or aversive social stimuli Open
Basal amygdala (BA) neurons projecting to nucleus accumbens (NAc) core/shell are primarily glutamatergic and are integral to the circuitry of emotional processing. Several recent mouse studies have addressed whether neurons in this populat…
View article: Rapid-acting antidepressant drugs modulate affective bias in rats
Rapid-acting antidepressant drugs modulate affective bias in rats Open
How rapid-acting antidepressants (RAADs), such as ketamine, induce immediate and sustained improvements in mood in patients with major depressive disorder (MDD) is poorly understood. A core feature of MDD is the prevalence of cognitive pro…
View article: Engagement of basal amygdala-nucleus accumbens glutamate neurons in the processing of rewarding or aversive social stimuli
Engagement of basal amygdala-nucleus accumbens glutamate neurons in the processing of rewarding or aversive social stimuli Open
Basal amygdala (BA) neurons projecting to nucleus accumbens core/shell (NAc) are primarily glutamatergic and are integral to the circuitry of emotional processing. Several recent mouse studies have addressed whether neurons in this populat…
View article: Functional ultrasound detects frequency-specific acute and delayed S-ketamine effects in the healthy mouse brain
Functional ultrasound detects frequency-specific acute and delayed S-ketamine effects in the healthy mouse brain Open
Introduction S-ketamine has received great interest due to both its antidepressant effects and its potential to induce psychosis when administered subchronically. However, no studies have investigated both its acute and delayed effects usi…
View article: Stress deficits in reward behaviour are associated with and replicated by dysregulated amygdala-nucleus accumbens pathway function in mice
Stress deficits in reward behaviour are associated with and replicated by dysregulated amygdala-nucleus accumbens pathway function in mice Open
Reduced reward interest/learning and reward-to-effort valuation are distinct, common symptoms in neuropsychiatric disorders for which chronic stress is a major aetiological factor. Glutamate neurons in basal amygdala (BA) project to variou…
View article: Three-dimensional co-culture platform of human induced pluripotent stem cell-derived oligodendrocyte lineage cells and neurons for studying myelination
Three-dimensional co-culture platform of human induced pluripotent stem cell-derived oligodendrocyte lineage cells and neurons for studying myelination Open
Developing an in vitro platform to study neuron-oligodendrocyte interaction, particularly myelination, is essential to understand aberrant myelination in neuropsychiatric and neurodegenerative diseases. Here, we provide a controlled, direc…
View article: Stress deficits in reward behaviour are associated with and replicated by dysregulated amygdala-nucleus accumbens pathway function
Stress deficits in reward behaviour are associated with and replicated by dysregulated amygdala-nucleus accumbens pathway function Open
Reduced reward interest/learning and reward-to-effort valuation are distinct, common symptoms in neuropsychiatric disorders for which chronic stress is a major aetiological factor. Glutamate neurons in basal amygdala (BA) project to variou…
View article: Reactivity to conditioned threat cues is distinct from exploratory drive in the elevated plus maze
Reactivity to conditioned threat cues is distinct from exploratory drive in the elevated plus maze Open
Fear and anxiety are adaptive states that allow humans and animals alike to respond appropriately to threatening cues in their environment. Commonly used tasks for studying behaviour akin to fear and anxiety in rodent models are Pavlovian …
View article: Functional ultrasound imaging reveals an aberrant developmental trajectory of functional connectivity in a mouse model of the 15q13.3 copy number variant microdeletion
Functional ultrasound imaging reveals an aberrant developmental trajectory of functional connectivity in a mouse model of the 15q13.3 copy number variant microdeletion Open
The developmental nature of many neuropsychiatric disorders such as schizophrenia necessitates the detection of functional biomarkers during the prodromal phase of disease that can predict symptomatic conversion and outcomes. Structural ch…