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View article: Data from The Tumor Immune Microenvironment Drives a Prognostic Relevance That Correlates with Bladder Cancer Subtypes
Data from The Tumor Immune Microenvironment Drives a Prognostic Relevance That Correlates with Bladder Cancer Subtypes Open
Muscle-invasive bladder cancer (MIBC) represents approximately two-thirds of invasive urothelial bladder cancers (UBC) and has high morbidity and mortality. Men are over 3-fold more frequently affected by UBC than women. Despite intensive …
View article: Table S4 from The Tumor Immune Microenvironment Drives a Prognostic Relevance That Correlates with Bladder Cancer Subtypes
Table S4 from The Tumor Immune Microenvironment Drives a Prognostic Relevance That Correlates with Bladder Cancer Subtypes Open
Inflammation gene signature TCGA: Full table of included genes.
View article: Table S1 from The Tumor Immune Microenvironment Drives a Prognostic Relevance That Correlates with Bladder Cancer Subtypes
Table S1 from The Tumor Immune Microenvironment Drives a Prognostic Relevance That Correlates with Bladder Cancer Subtypes Open
Clinico-pathological features of analyzed cohorts and subgroups.
View article: Table S6 from The Tumor Immune Microenvironment Drives a Prognostic Relevance That Correlates with Bladder Cancer Subtypes
Table S6 from The Tumor Immune Microenvironment Drives a Prognostic Relevance That Correlates with Bladder Cancer Subtypes Open
Multivariable Survival Models.
View article: Table S2 from The Tumor Immune Microenvironment Drives a Prognostic Relevance That Correlates with Bladder Cancer Subtypes
Table S2 from The Tumor Immune Microenvironment Drives a Prognostic Relevance That Correlates with Bladder Cancer Subtypes Open
Reference Sequences - Nanostring analysis for subtyping (CCC-EMN cohort).
View article: Table S5 from The Tumor Immune Microenvironment Drives a Prognostic Relevance That Correlates with Bladder Cancer Subtypes
Table S5 from The Tumor Immune Microenvironment Drives a Prognostic Relevance That Correlates with Bladder Cancer Subtypes Open
Distribution of stromal tumor infiltrating lymphocytes in analyzed cohorts and subgroups.
View article: Supplementary Figure S1-S7 from The Tumor Immune Microenvironment Drives a Prognostic Relevance That Correlates with Bladder Cancer Subtypes
Supplementary Figure S1-S7 from The Tumor Immune Microenvironment Drives a Prognostic Relevance That Correlates with Bladder Cancer Subtypes Open
Figure S1. Selected images of different sTILs amounts, illustration of applied scoring method and images of IHC stainings. Figure S2. TLS in MIBC Figure S3. Subtyping of the CCC-EMN cohort and the TCGA-Cohort according to the MDACC-subtypi…
View article: Table S3 from The Tumor Immune Microenvironment Drives a Prognostic Relevance That Correlates with Bladder Cancer Subtypes
Table S3 from The Tumor Immune Microenvironment Drives a Prognostic Relevance That Correlates with Bladder Cancer Subtypes Open
CIBERSORT - Spearman rank correlations between predicted immune cell populations in the TCGA cohort.
View article: Table S2 from The Tumor Immune Microenvironment Drives a Prognostic Relevance That Correlates with Bladder Cancer Subtypes
Table S2 from The Tumor Immune Microenvironment Drives a Prognostic Relevance That Correlates with Bladder Cancer Subtypes Open
Reference Sequences - Nanostring analysis for subtyping (CCC-EMN cohort).
View article: Table S1 from The Tumor Immune Microenvironment Drives a Prognostic Relevance That Correlates with Bladder Cancer Subtypes
Table S1 from The Tumor Immune Microenvironment Drives a Prognostic Relevance That Correlates with Bladder Cancer Subtypes Open
Clinico-pathological features of analyzed cohorts and subgroups.
View article: Table S4 from The Tumor Immune Microenvironment Drives a Prognostic Relevance That Correlates with Bladder Cancer Subtypes
Table S4 from The Tumor Immune Microenvironment Drives a Prognostic Relevance That Correlates with Bladder Cancer Subtypes Open
Inflammation gene signature TCGA: Full table of included genes.
View article: Data from The Tumor Immune Microenvironment Drives a Prognostic Relevance That Correlates with Bladder Cancer Subtypes
Data from The Tumor Immune Microenvironment Drives a Prognostic Relevance That Correlates with Bladder Cancer Subtypes Open
Muscle-invasive bladder cancer (MIBC) represents approximately two-thirds of invasive urothelial bladder cancers (UBC) and has high morbidity and mortality. Men are over 3-fold more frequently affected by UBC than women. Despite intensive …
View article: Table S5 from The Tumor Immune Microenvironment Drives a Prognostic Relevance That Correlates with Bladder Cancer Subtypes
Table S5 from The Tumor Immune Microenvironment Drives a Prognostic Relevance That Correlates with Bladder Cancer Subtypes Open
Distribution of stromal tumor infiltrating lymphocytes in analyzed cohorts and subgroups.
View article: Supplementary Figure S1-S7 from The Tumor Immune Microenvironment Drives a Prognostic Relevance That Correlates with Bladder Cancer Subtypes
Supplementary Figure S1-S7 from The Tumor Immune Microenvironment Drives a Prognostic Relevance That Correlates with Bladder Cancer Subtypes Open
Figure S1. Selected images of different sTILs amounts, illustration of applied scoring method and images of IHC stainings. Figure S2. TLS in MIBC Figure S3. Subtyping of the CCC-EMN cohort and the TCGA-Cohort according to the MDACC-subtypi…
View article: Table S6 from The Tumor Immune Microenvironment Drives a Prognostic Relevance That Correlates with Bladder Cancer Subtypes
Table S6 from The Tumor Immune Microenvironment Drives a Prognostic Relevance That Correlates with Bladder Cancer Subtypes Open
Multivariable Survival Models.
View article: Table S7 from The Tumor Immune Microenvironment Drives a Prognostic Relevance That Correlates with Bladder Cancer Subtypes
Table S7 from The Tumor Immune Microenvironment Drives a Prognostic Relevance That Correlates with Bladder Cancer Subtypes Open
Antigen presenting cell signature TCGA: Full table of included genes.
View article: Table S7 from The Tumor Immune Microenvironment Drives a Prognostic Relevance That Correlates with Bladder Cancer Subtypes
Table S7 from The Tumor Immune Microenvironment Drives a Prognostic Relevance That Correlates with Bladder Cancer Subtypes Open
Antigen presenting cell signature TCGA: Full table of included genes.
View article: Table S3 from The Tumor Immune Microenvironment Drives a Prognostic Relevance That Correlates with Bladder Cancer Subtypes
Table S3 from The Tumor Immune Microenvironment Drives a Prognostic Relevance That Correlates with Bladder Cancer Subtypes Open
CIBERSORT - Spearman rank correlations between predicted immune cell populations in the TCGA cohort.
View article: Supplementary figure S8 from Molecular Markers Increase Precision of the European Association of Urology Non–Muscle-Invasive Bladder Cancer Progression Risk Groups
Supplementary figure S8 from Molecular Markers Increase Precision of the European Association of Urology Non–Muscle-Invasive Bladder Cancer Progression Risk Groups Open
Supplementary figure S8. Progression-free survival curve in patients with EAU high risk tumors of a combination of FGFR3 and GATA2 status. Blue: good status (hypomethylated GATA2 and mutated FGFR3), green; moderate status (either hypermeth…
View article: Supplementary table S3 from Molecular Markers Increase Precision of the European Association of Urology Non–Muscle-Invasive Bladder Cancer Progression Risk Groups
Supplementary table S3 from Molecular Markers Increase Precision of the European Association of Urology Non–Muscle-Invasive Bladder Cancer Progression Risk Groups Open
Supplementary Table S3. Distribution of the EAU category and administration of intravesical instillations per country. Between brackets the percentage (%) within each country is given.
View article: Supplementary figure S8 from Molecular Markers Increase Precision of the European Association of Urology Non–Muscle-Invasive Bladder Cancer Progression Risk Groups
Supplementary figure S8 from Molecular Markers Increase Precision of the European Association of Urology Non–Muscle-Invasive Bladder Cancer Progression Risk Groups Open
Supplementary figure S8. Progression-free survival curve in patients with EAU high risk tumors of a combination of FGFR3 and GATA2 status. Blue: good status (hypomethylated GATA2 and mutated FGFR3), green; moderate status (either hypermeth…
View article: Supplementary figure S5 from Molecular Markers Increase Precision of the European Association of Urology Non–Muscle-Invasive Bladder Cancer Progression Risk Groups
Supplementary figure S5 from Molecular Markers Increase Precision of the European Association of Urology Non–Muscle-Invasive Bladder Cancer Progression Risk Groups Open
Supplementary figure S5. Progression-free survival curves in all patients for (A) EAU risk category, (B) FGFR3, (C) GATA2 and (D) TBX3. Progressive disease is defined as progression to stage T2 or higher stage disease. P-values (log-rank t…
View article: Supplementary table S3 from Molecular Markers Increase Precision of the European Association of Urology Non–Muscle-Invasive Bladder Cancer Progression Risk Groups
Supplementary table S3 from Molecular Markers Increase Precision of the European Association of Urology Non–Muscle-Invasive Bladder Cancer Progression Risk Groups Open
Supplementary Table S3. Distribution of the EAU category and administration of intravesical instillations per country. Between brackets the percentage (%) within each country is given.
View article: Supplementary table S1 from Molecular Markers Increase Precision of the European Association of Urology Non–Muscle-Invasive Bladder Cancer Progression Risk Groups
Supplementary table S1 from Molecular Markers Increase Precision of the European Association of Urology Non–Muscle-Invasive Bladder Cancer Progression Risk Groups Open
Supplementary Table S1. Sequences of the primers and probes used in the methylation analyses for the different CpGs in the GATA2, TBX2, TBX3 and ZIC4 genes. All sequences are noted from 5'' to 3''.
View article: Supplementary table S2 from Molecular Markers Increase Precision of the European Association of Urology Non–Muscle-Invasive Bladder Cancer Progression Risk Groups
Supplementary table S2 from Molecular Markers Increase Precision of the European Association of Urology Non–Muscle-Invasive Bladder Cancer Progression Risk Groups Open
Supplementary Table S2. Cut-offs for dichotomization of the methylation marker results were chosen based on the desired sensitivity-specificity trade-off for progression to MIBC as visualized by the receiver-operating characteristic curve …
View article: Supplementary table S2 from Molecular Markers Increase Precision of the European Association of Urology Non–Muscle-Invasive Bladder Cancer Progression Risk Groups
Supplementary table S2 from Molecular Markers Increase Precision of the European Association of Urology Non–Muscle-Invasive Bladder Cancer Progression Risk Groups Open
Supplementary Table S2. Cut-offs for dichotomization of the methylation marker results were chosen based on the desired sensitivity-specificity trade-off for progression to MIBC as visualized by the receiver-operating characteristic curve …
View article: Data from Molecular Markers Increase Precision of the European Association of Urology Non–Muscle-Invasive Bladder Cancer Progression Risk Groups
Data from Molecular Markers Increase Precision of the European Association of Urology Non–Muscle-Invasive Bladder Cancer Progression Risk Groups Open
Purpose: The European Association of Urology (EAU) guidelines for non–muscle-invasive bladder cancer (NMIBC) recommend risk stratification based on clinicopathologic parameters. Our aim was to investigate the added value of biomarke…
View article: Supplementary table S4 from Molecular Markers Increase Precision of the European Association of Urology Non–Muscle-Invasive Bladder Cancer Progression Risk Groups
Supplementary table S4 from Molecular Markers Increase Precision of the European Association of Urology Non–Muscle-Invasive Bladder Cancer Progression Risk Groups Open
Supplementary Table S4. Number of patients progressing to MIBC and person-time per risk group. Suggested risk groups are based on a combination of GATA2 methylation and FGFR3 mutation status for EAU high risk tumors.
View article: Supplementary figure S7 from Molecular Markers Increase Precision of the European Association of Urology Non–Muscle-Invasive Bladder Cancer Progression Risk Groups
Supplementary figure S7 from Molecular Markers Increase Precision of the European Association of Urology Non–Muscle-Invasive Bladder Cancer Progression Risk Groups Open
Supplementary figure S7. Progression-free survival curve in patients with all EAU low risk tumors and EAU high risk patients with a good class tumor (good class: hypomethylated GATA2 and mutated FGFR3). Progressive disease is defined as pr…
View article: Supplementary figure S6 from Molecular Markers Increase Precision of the European Association of Urology Non–Muscle-Invasive Bladder Cancer Progression Risk Groups
Supplementary figure S6 from Molecular Markers Increase Precision of the European Association of Urology Non–Muscle-Invasive Bladder Cancer Progression Risk Groups Open
Supplementary figure S6. Progression-free survival curves in EAU high risk patients for (A) Intravesical instillations, (B) Grade, (C) FGFR3 and (D) GATA2. Progressive disease is defined as progression to stage T2 or higher stage disease. …