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View article: Freiburg Neuropathology Case Conference:
Freiburg Neuropathology Case Conference: Open
Case ReportA 68-year-old male patient had been experiencing double vision and dizziness for approximately 14 days.He presented with an increasing gait disturbance and slurred speech.Subsequent computed tomography (CT) and magnetic resonanc…
View article: Data from Epidermal Growth Factor Receptor Variant III (EGFRvIII) Positivity in <i>EGFR</i>-Amplified Glioblastomas: Prognostic Role and Comparison between Primary and Recurrent Tumors
Data from Epidermal Growth Factor Receptor Variant III (EGFRvIII) Positivity in <i>EGFR</i>-Amplified Glioblastomas: Prognostic Role and Comparison between Primary and Recurrent Tumors Open
Purpose: Approximately 40% of all glioblastomas have amplified the EGFR gene, and about half of these tumors express the EGFRvIII variant. The prognostic role of EGFRvIII in EGFR-amplified glioblastoma patients and cha…
View article: Data from Epidermal Growth Factor Receptor Variant III (EGFRvIII) Positivity in <i>EGFR</i>-Amplified Glioblastomas: Prognostic Role and Comparison between Primary and Recurrent Tumors
Data from Epidermal Growth Factor Receptor Variant III (EGFRvIII) Positivity in <i>EGFR</i>-Amplified Glioblastomas: Prognostic Role and Comparison between Primary and Recurrent Tumors Open
Purpose: Approximately 40% of all glioblastomas have amplified the EGFR gene, and about half of these tumors express the EGFRvIII variant. The prognostic role of EGFRvIII in EGFR-amplified glioblastoma patients and cha…
View article: Supplementary Materials from Epidermal Growth Factor Receptor Variant III (EGFRvIII) Positivity in <i>EGFR</i>-Amplified Glioblastomas: Prognostic Role and Comparison between Primary and Recurrent Tumors
Supplementary Materials from Epidermal Growth Factor Receptor Variant III (EGFRvIII) Positivity in <i>EGFR</i>-Amplified Glioblastomas: Prognostic Role and Comparison between Primary and Recurrent Tumors Open
Supplementary Table 1. Overview of the individual survival times, MGMT promoter methylation status and results of EGFRvIII testing by immunohistochemistry (IHC) or reverse transcription-PCR (RT-PCR) in primary tumors (PT) and recurrent tum…
View article: Supplementary Materials from Epidermal Growth Factor Receptor Variant III (EGFRvIII) Positivity in <i>EGFR</i>-Amplified Glioblastomas: Prognostic Role and Comparison between Primary and Recurrent Tumors
Supplementary Materials from Epidermal Growth Factor Receptor Variant III (EGFRvIII) Positivity in <i>EGFR</i>-Amplified Glioblastomas: Prognostic Role and Comparison between Primary and Recurrent Tumors Open
Supplementary Table 1. Overview of the individual survival times, MGMT promoter methylation status and results of EGFRvIII testing by immunohistochemistry (IHC) or reverse transcription-PCR (RT-PCR) in primary tumors (PT) and recurrent tum…
View article: Defining activities in neurovascular microsurgery training: entrustable professional activities for vascular neurosurgery
Defining activities in neurovascular microsurgery training: entrustable professional activities for vascular neurosurgery Open
Background Entrustable professional activities (EPAs) represent an assessment framework with an increased focus on competency-based assessment. Originally developed and adopted for undergraduate medical education, concerns over resident ab…
View article: Primary cilia contribute to the aggressiveness of atypical teratoid/rhabdoid tumors
Primary cilia contribute to the aggressiveness of atypical teratoid/rhabdoid tumors Open
View article: Virtual auscultation course via video chat in times of COVID-19 improves cardiac auscultation skills compared to literature self-study in third-year medical students: a prospective randomized controlled cross-over study
Virtual auscultation course via video chat in times of COVID-19 improves cardiac auscultation skills compared to literature self-study in third-year medical students: a prospective randomized controlled cross-over study Open
Background: Cardiac auscultation is a core clinical skill taught in medical school. Due to contact restrictions during the SARS-CoV-2 pandemic, interaction with patients was very limited. Therefore, a peer-to-peer virtual case-based auscul…
View article: Droplet digital PCR-based analyses for robust, rapid, and sensitive molecular diagnostics of gliomas
Droplet digital PCR-based analyses for robust, rapid, and sensitive molecular diagnostics of gliomas Open
Classification of gliomas involves the combination of histological features with molecular biomarkers to establish an integrated histomolecular diagnosis. Here, we report on the application and validation of a set of molecular assays for g…
View article: Intratumoral heterogeneity of MYC drives medulloblastoma metastasis and angiogenesis
Intratumoral heterogeneity of MYC drives medulloblastoma metastasis and angiogenesis Open
Background Intratumoral heterogeneity is crucially involved in metastasis, resistance to therapy, and cancer relapse. Amplifications of the proto-oncogene MYC display notable heterogeneity at the single-cell level and are associated with a…
View article: First-line high-dose therapy and autologous blood stem cell transplantation in patients with primary central nervous system non-Hodgkin lymphomas—a single-centre experience in 61 patients
First-line high-dose therapy and autologous blood stem cell transplantation in patients with primary central nervous system non-Hodgkin lymphomas—a single-centre experience in 61 patients Open
View article: Proposed definition of competencies for surgical neuro-oncology training
Proposed definition of competencies for surgical neuro-oncology training Open
View article: Undergraduate medical education amid COVID-19: a qualitative analysis of enablers and barriers to acquiring competencies in distant learning using focus groups
Undergraduate medical education amid COVID-19: a qualitative analysis of enablers and barriers to acquiring competencies in distant learning using focus groups Open
Due to comprehensive social distancing measures related to the COVID-19 pandemic, medical faculties worldwide have made a virtue of necessity in resorting to online teaching. Medical faculties grapple with how to convey clinical competenci…
View article: Virtual auscultation course for medical students via video chat in times of COVID-19
Virtual auscultation course for medical students via video chat in times of COVID-19 Open
Introduction: Auscultation skills are among the basic techniques to be learned in medical school. Such skills are achieved through supervised examination of patients often supported by simulator-based learning. The emergence of COVID-19 ha…
View article: Age-stratified clinical performance and survival of patients with IDH-wildtype glioblastoma homogeneously treated by radiotherapy with concomitant and maintenance temozolomide
Age-stratified clinical performance and survival of patients with IDH-wildtype glioblastoma homogeneously treated by radiotherapy with concomitant and maintenance temozolomide Open
Objective Isocitrate dehydrogenase (IDH)-wildtype glioblastomas are the most malignant glial tumours. Median survival is only 14–16 months after diagnosis, with patients aged ≥ 65 years reportedly showing worse outcome. This study aimed to…
View article: ATRT-07. TARGETING PRIMARY CILIOGENESIS IN ATYPICAL TERATOID/RHABDOID TUMORS
ATRT-07. TARGETING PRIMARY CILIOGENESIS IN ATYPICAL TERATOID/RHABDOID TUMORS Open
Atypical teratoid/rhabdoid tumors (AT/RT) are among the most common malignant brain tumors in infants. Comprehensive genomic studies revealed three distinct molecular subgroups (AT/RT-TYR, -MYC and -SHH). As primary cilia (PC) have already…
View article: <i>MiR‐16‐5p</i> is frequently down‐regulated in astrocytic gliomas and modulates glioma cell proliferation, apoptosis and response to cytotoxic therapy
<i>MiR‐16‐5p</i> is frequently down‐regulated in astrocytic gliomas and modulates glioma cell proliferation, apoptosis and response to cytotoxic therapy Open
Aims Aberrant expression of microRNAs (miRNAs) is frequent in various cancers including gliomas. We aimed to characterize the role of miR‐16‐5p as a candidate tumour suppressor miRNA in gliomas. Methods Real‐time PCR‐based approaches were …
View article: ATRT-34. TARGETING PRIMARY CILIOGENESIS IN ATYPICAL TERATOID/RHABDOID TUMORS
ATRT-34. TARGETING PRIMARY CILIOGENESIS IN ATYPICAL TERATOID/RHABDOID TUMORS Open
Atypical teratoid/rhabdoid tumors (AT/RT) are among the most common malignant brain tumors in infants. Comprehensive genomic studies revealed three distinct molecular subgroups (AT/RT-TYR, -MYC and -SHH). As primary cilia (PC) have already…
View article: Epidermal Growth Factor Receptor Variant III (EGFRvIII) Positivity in <i>EGFR</i> -Amplified Glioblastomas: Prognostic Role and Comparison between Primary and Recurrent Tumors
Epidermal Growth Factor Receptor Variant III (EGFRvIII) Positivity in <i>EGFR</i> -Amplified Glioblastomas: Prognostic Role and Comparison between Primary and Recurrent Tumors Open
Purpose: Approximately 40% of all glioblastomas have amplified the EGFR gene, and about half of these tumors express the EGFRvIII variant. The prognostic role of EGFRvIII in EGFR-amplified glioblastoma patients and cha…
View article: Molecular Diagnostics of Gliomas Using Next Generation Sequencing of a Glioma‐Tailored Gene Panel
Molecular Diagnostics of Gliomas Using Next Generation Sequencing of a Glioma‐Tailored Gene Panel Open
Current classification of gliomas is based on histological criteria according to the World Health Organization (WHO) classification of tumors of the central nervous system. Over the past years, characteristic genetic profiles have been ide…
View article: Progressive multifokale Leukenzephalopathie
Progressive multifokale Leukenzephalopathie Open
Progressive multifocal leukoencephalopathy (PML) is a demyelinating disease of the central nervous system following reactivation of the John-Cunningham-Virus (JVC) in an immunocompromised host. This rare condition is characterized by rapid…
View article: Molecular diagnostics of malignant gliomas using next-generation sequencing
Molecular diagnostics of malignant gliomas using next-generation sequencing Open
Background: Molecular genetic approaches are becoming increasingly important in brain tumor diagnostics to assess for diagnostic, prognostic and predictive markers. Frequent genetic alterations detectable in adult glioma patients include m…
View article: Role of micro<scp>RNA</scp>s Located on Chromosome Arm 10q in Malignant Gliomas
Role of micro<span>RNA</span>s Located on Chromosome Arm 10q in Malignant Gliomas Open
Deletions of chromosome arm 10q are found in most glioblastomas and subsets of lower grade gliomas. Mutations in the PTEN gene at 10q23.3 are restricted to less than half of the 10q‐deleted gliomas, suggesting additional glioma‐associated …