Explanipedia

Socio-Demographic Characteristics and Clinical profile in Sickle Cell Disease Patients Open

G.R. Joshi, Sher Bahadur Kamar, Pradip Mishra, Hem Raj Pandey, Yogendra Shah , et al. · 2025

Background: Sickle cell disease (SCD) is a significant public health issue in Nepal, predominantly affecting the Tharu community in the Mid-Western and Sudurpaschim province. This study was design to understand the socio-demographic charac…

Potential Risk of Local Transmission of Mpox in Nepal: An Emerging Public Health Concern Open

Yogendra Shah, Ankit Kumar Singh, Bipin Kumar Acharya, Mandira Lamichhane Dhimal, Ram Singh Dhami , et al. · 2025

Background and Aims Monkeypox (Mpox) is a zoonotic disease caused by the monkeypox virus, a double‐stranded DNA virus of the Orthopoxvirus genus with two major clades (Clades I and II), with Clade IIb responsible for most global cases repo…

Pakistan on the road to zero leprosy transmission by 2030 Open

Basu Dev Pandey, Mya Myat Ngwe Tun, E Kita, Wim H. van Brakel, Kouichi Morita · 2025

Emergence of Dengue Virus Serotypes 1 and 3 in Mahottari and Adjacent Areas of Southern Nepal Open

Sabin Shrestha, Sandesh Rimal, Anjana Kharbuja, Manoj Ray, Sanjay Shrestha , et al. · 2025

Dengue has been a serious public health concern in Nepal since the past few years, with concurrent big outbreaks occurring in 2022–2024. This cross-sectional study was conducted among febrile patients visiting hospitals in Mahottari distri…

Detection of Dengue and Chikungunya Viruses in Mosquitoes from Nepal Open

Maurine Mumo Mutua, Sandesh Rimal, Sabin Shrestha, Anjana Kharbuja, Anjali Dulal , et al. · 2025

The dengue virus (DENV) and chikungunya virus (CHIKV) infection present with similar symptoms and are transmitted by Aedes mosquitoes. Until now, there have been no reported cases of DENV and CHIKV being detected in mosquitoes in Nepal. Th…

A regression-based approach to modelling recurrent outbreaks: a case study of dengue fever in Nepal (2006–2022) Open

Jessie Jane Khaki, Bipin Kumar Acharya, Kouichi Morita, Basu Dev Pandey, Emanuele Giorgi · 2025

Understanding the temporal and spatial dynamics of dengue fever outbreaks is essential for effective public health planning. In this study, we develop a novel, data-driven approach to characterise dengue outbreaks in Nepal from 2006 to 202…

Current Landscape and Future Directions for Dengue Vaccines: Addressing a Global Health Challenge Open

Basu Dev Pandey, Yogendra Shah, Mya Myat Ngwe Tun, Kouichi Morita · 2025

Dengue is the most common arboviral infection, causing significant morbidity and mortality. Currently, more than half of the world’s population is at risk, particularly in tropical and subtropical regions of Asia, with the virus now spread…

Healthcare performance of leprosy management in peripheral health facilities of Dhanusa and Mahottari, Nepal Open

Ram Kumar Mahato, Uttam Ghimire, Bijay Bajracharya, K. C. Binod, Deepak Bam , et al. · 2025

Overall leprosy care median performance was low (53%) and can be improved by evidenced-based training, onsite coaching, monitoring, and supervision to facilitate leprosy transmission elimination. The results highlight many of the challenge…

Seroprevalence of Hepatitis A and E virus Antibodies in Dhanusha, Madhesh Province, Nepal Open

Sandesh Rimal, Sabin Shrestha, Anjana Khadka, Mami Matsuda, Ryosuke Suzuki , et al. · 2025

Hepatitis A virus (HAV) and hepatitis E virus (HEV) are believed to have similar routes of transmission and epidemiology in developing countries. This study investigated the seroprevalence of these pathogens among healthy individuals from …

Prevalence and types of lower limb conditions in Nepal Open

Lucy Gates, Andrew Amos Channon, Alex Dickinson, Basu Dev Pandey, Abhinav Vaidya , et al. · 2025

Background Understanding the burden of lower limb conditions (LLCs) is essential for effective health planning, yet data in low-resource settings like Nepal is scarce. LLCs, encompassing diverse issues such as pain, injuries and amputation…

Sex differences in genotype frequency and the risk of polycythemia associated with rs13419896 and rs2790859 among Tibetan highlanders living in Tsarang, Mustang, Nepal Open

Hiroaki Arima, Takayuki Nishimura, Sweta Koirala, Masayuki Nakano, Hiromu Ito , et al. · 2024

Background Tibetan highlanders have adapted to hypoxic environments through genetic mechanisms that avoid hemoglobin concentration increases and prevent polycythemia. Recently, sex differences in hemoglobin dynamics with age have been repo…

Sero-epidemiological Study of Japanese Encephalitis in Some Selected Hospitals of Nepal Open

Krishna Prasad Pant, Binod Lekhak, Ramesh Pun, Basu Dev Pandey · 2024

Japanese encephalitis is a major public health problem in Nepal, about 1000-3000 cases and 200-300 deaths reported annually, mainly in endemic areas and sporadic cases have also been reported from non-endemic areas such as Kathmandu. The d…

Performance of Fujifilm Dengue NS1 Antigen Rapid Diagnosis Kit Compared to Quantitative Real-Time Polymerase Chain Reaction Open

Mya Myat Ngwe Tun, Merveille Kapandji, Atsuhiko Wada, Ko Yamamoto, Shyam Prakash Dumre , et al. · 2024

Dengue is a viral infection caused by the dengue virus (DENV), transmitted to humans through the bite of infected Aedes mosquitoes. About half of the world’s population is now at risk of dengue, which represents a global public health conc…

The Development of New Primer Sets for the Amplification and Sequencing of the Envelope Gene of All Dengue Virus Serotypes Open

Stefanía Fraenkel, Takeshi Nabeshima, Dalouny Xayavong, Thi Thanh Ngan Nguyen, Qiang Xu , et al. · 2024

Dengue virus (DENV) poses a significant threat to global health, infecting approximately 390 million people annually. This virus comprises four serotypes capable of causing severe disease. Genetic analyses are crucial for understanding the…

Molecular and Entomological Characterization of 2023 Dengue Outbreak in Dhading District, Central Nepal Open

Sandesh Rimal, Sabin Shrestha, Sunita Wagle Paudel, Yogendra Shah, Govinda Bhandari , et al. · 2024

In 2023, Nepal faced its second largest dengue outbreak ever, following a record-breaking number of dengue cases in 2022, characterized by the expansion of infections into areas of higher altitudes. However, the characteristics of the 2023…

Association of RT-qPCR Ct Values and Disease Severity among COVID-19 Patients Visiting a Tertiary Care Hospital in Nepal Open

Jagadish Joshi, O. P. Joshi, Sher Bahadur Kamar, Guna Raj Awasthi, Yogendra Shah , et al. · 2024

COVID-19 pandemic due to SARS-CoV-2 has been one of the major global health issues of this aeon. The aim of this study was to evaluate the association of SARS-CoV-2 cycle threshold (Ct) values with multiple factors among COVID-19 patients …

A Novel, Comprehensive A129 Mouse Model for Investigating Dengue Vaccines and Evaluating Pathogenesis Open

Mya Myat Ngwe Tun, Khine Mya Nwe, Jean Claude Balingit, Yuki Takamatsu, Shingo Inoue , et al. · 2023

In search of a mouse model for use in evaluating dengue vaccines, we assessed A129 mice that lacked IFN-α/β receptors, rendering them susceptible to dengue virus (DENV) infection. To our knowledge, no reports have evaluated dengue vaccine …

Evaluating active leprosy case identification methods in six districts of Nepal Open

Ram Kumar Mahato, Uttam Ghimire, M Lamsal, Bijay Bajracharya, M Poudel , et al. · 2023

Background Nepal has achieved and sustained the elimination of leprosy as a public health problem since 2009, but 17 districts and 3 provinces with 41% (10,907,128) of Nepal’s population have yet to eliminate the disease. Pediatric cases a…

Seroprevalence of SARS‐CoV‐2 infection in the general population of Nepal during the first and second generalized waves of the COVID‐19 pandemic—2020–2021 Open

Krishna Prasad Paudel, Reuben Samuel, Runa Jha, Basu Dev Pandey, Chathura Edirisuriya , et al. · 2023

Few seroprevalence studies have been conducted on coronavirus disease (COVID‐19) in Nepal. Here, we aimed to estimate seroprevalence and assess risk factors for infection in the general population of Nepal by conducting two rounds of sampl…

Healthcare Performance of Leprosy Management in Peripheral Health Facilities of Dhanusa and Mahottari, Nepal Open

Ram Kumar Mahato, Uttam Ghimire, Bijay Bajracharya, Binod KC, Deepak Bam , et al. · 2023

Background The global elimination of leprosy transmission by 2030 is a World Health Organization (WHO) target. Nepal’s leprosy elimination program depends on early case diagnosis and the performance of health workers and facilities. The kn…

Possible high risk of transmission of the Nipah virus in South and South East Asia: a review Open

Jagadish Joshi, Yogendra Shah, Kishor Pandey, Ram Prashad Ojha, Chet Raj Joshi , et al. · 2023

A major dengue epidemic in 2022 in Nepal: need of an efficient early-warning system Open

Bhim Gopal Dhoubhadel, Yumiko Hayashi, Fleurette Mbuyakala Domai, Suraj Bhattarai, Koya Ariyoshi , et al. · 2023

Dengue has become a recurrent and growing threat to public health in Nepal. The epidemic in 2022 was the largest ever reported, with cases being reported in all of the country’s seven provinces and 77 districts. Despite the establishment o…

Ending tuberculosis by 2030: understanding the transmission Open

Basu Dev Pandey, Mya Myat Ngwe Tun, Yogendra Shah, Yasuhiko Suzuki, Kouichi Morita · 2023

AB1718-PARE DISEASE AWARENESS, MANAGEMENT PERCEPTIONS AND CARE SATISFACTION AMONG PATIENTS WITH PSORIATIC ARTHRITIS: A PROSPECTIVE MULTI-CENTRE SURVEY FROM INDIA Open

H.M. Pathak, Manish Goyal, Parthajit Das, Sridhar Santhanam, Aabroo Khan , et al. · 2023

Co-Circulation of Dengue Virus Serotypes 1, 2, and 3 during the 2022 Dengue Outbreak in Nepal: A Cross-Sectional Study Open

Sandesh Rimal, Sabin Shrestha, Kishor Pandey, Thanh Vu Nguyen, Parmananda Bhandari , et al. · 2023

The largest dengue outbreak in the history of Nepal occurred in 2022, with a significant number of casualties. It affected all 77 districts, with the nation’s capital, Kathmandu (altitude 1300 m), being the hardest hit. However, the molecu…

VL Mandua 380: A medium maturing, high yielding and blast tolerant finger millet cultivar for rainfed organic agro-ecology of hills Open

Dinesh Chandra Joshi, Salej Sood, Arun Kumar Gupta, R. K. Khulbe, Basu Dev Pandey , et al. · 2022

The medium duration blast tolerant finger millet variety VL Mandua 380 was developed at ICAR-Vivekananda Parvatiya Krishi Anusandhan Sansthan, Almora from the cross between GEC-440 (blast resistant core collection germplasm line) and VL 14…

How an Outbreak of COVID-19 Circulated Widely in Nepal: A Chronological Analysis of the National Response to an Unprecedented Pandemic Open

Basu Dev Pandey, Mya Myat Ngwe Tun, Kishor Pandey, Shyam Prakash Dumre, Khin Mya Nwe , et al. · 2022

Coronavirus disease 2019 (COVID-19) is caused by the severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2). The first COVID-19 case was reported in Wuhan, China, in December 2019. In March 2020, the World Health Organization (WHO) d…

Twin crises in Nepal: covid-19 and climate change Open

Basu Dev Pandey, Kouichi Morita, Anthony Costello · 2022

High prevalence of rheumatoid arthritis and its risk factors among Tibetan highlanders living in Tsarang, Mustang district of Nepal Open

Hiroaki Arima, Sweta Koirala, Kotaro Nema, Masayuki Nakano, Hiromu Ito , et al. · 2022

Background In Tsarang (at 3560 m), which is located in Mustang, 62.7% of the residents answered that they had a subjective medical history of arthritis, and 41.1% of the residents answered that their families had a subjective medical histo…

Insights into transmission dynamics of Mycobacterium tuberculosis complex in Nepal Open

Yogendra Shah, Sarad Paudel, Kishor Pandey, G.P. Gupta, Eddie Samuneti Solo , et al. · 2022

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