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View article: Quantification of the Actin-Binding Protein Flightless-I in Human Serum by Automated Western Blot System and Investigation of Its Diagnostic Potential in Sepsis
Quantification of the Actin-Binding Protein Flightless-I in Human Serum by Automated Western Blot System and Investigation of Its Diagnostic Potential in Sepsis Open
Background: The actin-binding protein Flightless-I (Flii) has not been quantified in the human serum yet. We aimed to determine serum Flii levels in healthy individuals and to investigate Flii as a potential marker in patients with sepsis …
View article: Peripheral thickening of the sarcomeres and pointed end elongation of the thin filaments are both promoted by SALS and its formin interaction partners
Peripheral thickening of the sarcomeres and pointed end elongation of the thin filaments are both promoted by SALS and its formin interaction partners Open
During striated muscle development the first periodically repeated units appear in the premyofibrils, consisting of immature sarcomeres that must undergo a substantial growth both in length and width, to reach their final size. Here we rep…
View article: Cyclophosphamide treatment modifies the thermal stability of profilin bound monomeric and leiomodin2 bound filamentous actin
Cyclophosphamide treatment modifies the thermal stability of profilin bound monomeric and leiomodin2 bound filamentous actin Open
The monomeric (G-actin) and polymer (F-actin) forms of actin play important role in muscle development and contraction, cellular motility, division, and transport processes. Leiomodins 1–3 (Lmod1–3) are crucial for the development of muscl…
View article: Molecular Dissection of DAAM Function during Axon Growth in Drosophila Embryonic Neurons
Molecular Dissection of DAAM Function during Axon Growth in Drosophila Embryonic Neurons Open
Axonal growth is mediated by coordinated changes of the actin and microtubule (MT) cytoskeleton. Ample evidence suggests that members of the formin protein family are involved in the coordination of these cytoskeletal rearrangements, but t…
View article: Urinary actin, as a potential marker of sepsis-related acute kidney injury: A pilot study
Urinary actin, as a potential marker of sepsis-related acute kidney injury: A pilot study Open
Introduction A major complication of sepsis is the development of acute kidney injury (AKI). Recently, it was shown that intracellular actin released from damaged tissues appears in the urine of patients with multiple organ dysfunction syn…
View article: The C-terminal tail extension of myosin 16 acts as a molten globule, including intrinsically disordered regions, and interacts with the N-terminal ankyrin
The C-terminal tail extension of myosin 16 acts as a molten globule, including intrinsically disordered regions, and interacts with the N-terminal ankyrin Open
The lesser-known unconventional myosin 16 protein is essential in proper neuronal functioning and has been implicated in cell cycle regulation. Its longer Myo16b isoform contains a C-terminal tail extension (Myo16Tail), which has been show…
View article: Myosin and gelsolin cooperate in actin filament severing and actomyosin motor activity
Myosin and gelsolin cooperate in actin filament severing and actomyosin motor activity Open
Actin is a major intracellular protein with key functions in cellular motility, signaling, and structural rearrangements. Its dynamic behavior, such as polymerization and depolymerization of actin filaments in response to intracellular and…
View article: The Activities of the Gelsolin Homology Domains of Flightless-I in Actin Dynamics
The Activities of the Gelsolin Homology Domains of Flightless-I in Actin Dynamics Open
Flightless-I is a unique member of the gelsolin superfamily alloying six gelsolin homology domains and leucine-rich repeats. Flightless-I is an established regulator of the actin cytoskeleton, however, its biochemical activities in actin d…
View article: Myosin-gelsolin cooperativity in actin filament severing and actomyosin motor activity
Myosin-gelsolin cooperativity in actin filament severing and actomyosin motor activity Open
Actin is a major intracellular protein with key functions in cellular motility, signalling and structural rearrangements. Its dynamic behavior with actin filaments (F-actin) polymerising and depolymerising in response to intracellular chan…
View article: Myosin XVI in the Nervous System
Myosin XVI in the Nervous System Open
The myosin family is a large inventory of actin-associated motor proteins that participate in a diverse array of cellular functions. Several myosin classes are expressed in neural cells and play important roles in neural functioning. A rec…
View article: ATP competes with PIP2 for binding to gelsolin
ATP competes with PIP2 for binding to gelsolin Open
Gelsolin is a severing and capping protein that targets filamentous actin and regulates filament lengths near plasma membranes, contributing to cell movement and plasma membrane morphology. Gelsolin binds to the plasma membrane via phospha…
View article: Predictive value of serum gelsolin and Gc globulin in sepsis – a pilot study
Predictive value of serum gelsolin and Gc globulin in sepsis – a pilot study Open
Background: Simultaneous determination of the two main actin scavenger proteins in sepsis has not been investigated until now. In our pilot study, we elucidated the predictive values of Gc globulin and gelsolin (GSN) in sepsis by comparing…
View article: Cardiac leiomodin2 binds to the sides of actin filaments and regulates the ATPase activity of myosin
Cardiac leiomodin2 binds to the sides of actin filaments and regulates the ATPase activity of myosin Open
Leiomodin proteins are vertebrate homologues of tropomodulin, having a role in the assembly and maintenance of muscle thin filaments. Leiomodin2 contains an N-terminal tropomodulin homolog fragment including tropomyosin-, and actin-binding…
View article: Validation of an automated immune turbidimetric assay for serum gelsolin and its possible clinical utility in sepsis
Validation of an automated immune turbidimetric assay for serum gelsolin and its possible clinical utility in sepsis Open
Background Studies showing the potential predictive value of the actin‐binding protein gelsolin, in critically ill patients are scarce. Moreover, even up to now a rapid automated measurement of gelsolin has still remained a challenge. Ther…
View article: The activities of the C-terminal regions of the formin protein disheveled-associated activator of morphogenesis (DAAM) in actin dynamics
The activities of the C-terminal regions of the formin protein disheveled-associated activator of morphogenesis (DAAM) in actin dynamics Open
Disheveled-associated activator of morphogenesis (DAAM) is a diaphanous-related formin protein essential for the regulation of actin cytoskeleton dynamics in diverse biological processes. The conserved formin homology 1 and 2 (FH1-FH2) dom…
View article: The formin DAAM is required for coordination of the actin and microtubule cytoskeleton in axonal growth cones
The formin DAAM is required for coordination of the actin and microtubule cytoskeleton in axonal growth cones Open
Directed axonal growth depends on correct coordination of the actin and microtubule cytoskeleton in the growth cone. However, despite the relatively large number of proteins implicated in actin−microtubule crosstalk, the mechanisms whereby…
View article: Biochemical Activities of the Wiskott-Aldrich Syndrome Homology Region 2 Domains of Sarcomere Length Short (SALS) Protein
Biochemical Activities of the Wiskott-Aldrich Syndrome Homology Region 2 Domains of Sarcomere Length Short (SALS) Protein Open
Drosophila melanogaster sarcomere length short (SALS) is a recently identified Wiskott-Aldrich syndrome protein homology 2 (WH2) domain protein involved in skeletal muscle thin filament regulation. SALS was shown to be important for the es…