Beata Franczyk
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View article: Atrial Fibrillation in COVID-19: Mechanisms, Clinical Impact, and Monitoring Strategies
Atrial Fibrillation in COVID-19: Mechanisms, Clinical Impact, and Monitoring Strategies Open
The coronavirus disease 2019 (COVID-19) pandemic has revealed a close and multifaceted relationship between viral infection, systemic inflammation, and cardiovascular health. Among the cardiac complications of severe acute respiratory synd…
View article: The Mediterranean Diet in Primary and Secondary Prevention of Coronary Heart Disease: Evidence and Mechanisms
The Mediterranean Diet in Primary and Secondary Prevention of Coronary Heart Disease: Evidence and Mechanisms Open
Cardiovascular disease is a major cause of mortality, and its global reach places it as an object of interest for many researchers worldwide. Steps are being actively taken to combat this disease. Current trends focus on non-invasive preve…
View article: Endothelial Dysfunction as the Common Pathway Linking Obesity, Hypertension and Atherosclerosis
Endothelial Dysfunction as the Common Pathway Linking Obesity, Hypertension and Atherosclerosis Open
Endothelial dysfunction plays a central role in the pathogenesis of cardiovascular diseases, driven by a complex interplay of oxidative stress, metabolic imbalances, and adipokine dysregulation. Excessive reactive oxygen species reduce nit…
View article: Inflammaging and Senescence-Driven Extracellular Matrix Remodeling in Age-Associated Cardiovascular Disease
Inflammaging and Senescence-Driven Extracellular Matrix Remodeling in Age-Associated Cardiovascular Disease Open
Cardiovascular aging is a multifactorial and systemic process that contributes significantly to the global burden of cardiovascular disease, particularly in older populations. This review explores the molecular and cellular mechanisms unde…
View article: Baxdrostat: A Next-Generation Aldosterone Synthase Inhibitor Offering New Hope in Resistant Hypertension
Baxdrostat: A Next-Generation Aldosterone Synthase Inhibitor Offering New Hope in Resistant Hypertension Open
Hypertension is a leading global cause of cardiovascular disease and mortality, with resistant hypertension (RH) posing treatment challenges. Aldosterone synthase inhibitors (ASIs) are a novel drug class that reduce blood pressure by lower…
View article: Vitamin D and Chronic Disorders: A Review of Metabolic and Cardiovascular Diseases
Vitamin D and Chronic Disorders: A Review of Metabolic and Cardiovascular Diseases Open
Vitamin D, long recognized for its essential role in calcium–phosphate balance and bone health, has increasingly been identified as a pleiotropic regulator of metabolic, cardiovascular, and renal function. Deficiency of vitamin D is widesp…
View article: Obesity as a Multifactorial Chronic Disease: Molecular Mechanisms, Systemic Impact, and Emerging Digital Interventions
Obesity as a Multifactorial Chronic Disease: Molecular Mechanisms, Systemic Impact, and Emerging Digital Interventions Open
Obesity is a multifactorial chronic disease resulting from complex genetic, molecular, environmental, and behavioral interactions. Its prevalence rises worldwide, affecting cardiovascular, metabolic, oncological, hepatic, respiratory, and …
View article: Environmental Insults to Glucose Metabolism: The Role of Pollutants in Insulin Resistance
Environmental Insults to Glucose Metabolism: The Role of Pollutants in Insulin Resistance Open
Insulin resistance is a condition of impaired tissue reactivity to insulin. This state is primarily associated with obesity and the lifestyle of modern Western societies, which favors abnormalities of glucose and lipid homeostasis. As a re…
View article: Creatine Supplementation Combined with Exercise in the Prevention of Type 2 Diabetes: Effects on Insulin Resistance and Sarcopenia
Creatine Supplementation Combined with Exercise in the Prevention of Type 2 Diabetes: Effects on Insulin Resistance and Sarcopenia Open
Type 2 diabetes (T2D) is a chronic metabolic disorder marked by insulin resistance and impaired glucose metabolism, with skeletal muscle being a major site of systemic glucose disposal. This review examines the bidirectional relationship b…
View article: High-density lipoproteins. Part 2. Impact of disease states on functionality
High-density lipoproteins. Part 2. Impact of disease states on functionality Open
In contrast to low-density lipoproteins which are atherogenic, high-density lipoproteins (HDL) have been conceptualized as beneficial modulators of adverse pathophysiological phenomena along arterial walls. The HDLs are characterized by hi…
View article: Immune Checkpoint Inhibitors in Clear Cell Renal Cell Carcinoma (ccRCC)
Immune Checkpoint Inhibitors in Clear Cell Renal Cell Carcinoma (ccRCC) Open
Renal cell carcinoma (RCC) accounts for about 403,000 new cases and 175,000 deaths worldwide each year. Clear cell RCC (ccRCC), the most prevalent subtype, is often driven by genetic mutations, such as VHL inactivation, leading to angiogen…
View article: The Gut–Brain–Microbiota Connection and Its Role in Autism Spectrum Disorders
The Gut–Brain–Microbiota Connection and Its Role in Autism Spectrum Disorders Open
Autism spectrum disorder (ASD) is a group of complex neurodevelopmental conditions with a heterogeneous and multifactorial etiology that is not yet fully understood. Among the various factors that may contribute to ASD development, alterat…
View article: Nanotechnology and Artificial Intelligence in Dyslipidemia Management—Cardiovascular Disease: Advances, Challenges, and Future Perspectives
Nanotechnology and Artificial Intelligence in Dyslipidemia Management—Cardiovascular Disease: Advances, Challenges, and Future Perspectives Open
This narrative review explores emerging technologies in dyslipidemia management, focusing on nanotechnology and artificial intelligence (AI). It examines the current treatment recommendations and contrasts them with the future prospects en…
View article: Type 2 Diabetes Mellitus: New Pathogenetic Mechanisms, Treatment and the Most Important Complications
Type 2 Diabetes Mellitus: New Pathogenetic Mechanisms, Treatment and the Most Important Complications Open
Type 2 diabetes mellitus (T2DM), a prevalent chronic disease affecting over 400 million people globally, is driven by genetic and environmental factors. The pathogenesis involves insulin resistance and β-cell dysfunction, mediated by mecha…
View article: Renal Outcomes and Other Adverse Effects of Cannabinoid Supplementation
Renal Outcomes and Other Adverse Effects of Cannabinoid Supplementation Open
This narrative review explores the benefits and risks of cannabinoids in kidney health, particularly in individuals with pre-existing renal conditions. It discusses the roles of cannabinoid receptor ligands (phytocannabinoids, synthetic ca…
View article: Gut Microbiota and Gut–Brain Axis in Hypertension: Implications for Kidney and Cardiovascular Health—A Narrative Review
Gut Microbiota and Gut–Brain Axis in Hypertension: Implications for Kidney and Cardiovascular Health—A Narrative Review Open
Introduction: Arterial hypertension is a major contributor to a wide range of health complications, with cardiac hypertrophy and chronic kidney disease being among the most prevalent. Consequently, novel strategies for the treatment and pr…
View article: Hypertrophic Cardiomyopathy with Special Focus on Mavacamten and Its Future in Cardiology
Hypertrophic Cardiomyopathy with Special Focus on Mavacamten and Its Future in Cardiology Open
Hypertrophic cardiomyopathy (HCM) is a heterogeneous group of heart muscle disorders that affects millions, with an incidence from 1 in 500 to 1 in 200. Factors such as genetics, age, gender, comorbidities, and environmental factors may co…
View article: Associations of Microbiota and Nutrition with Cognitive Impairment in Diseases
Associations of Microbiota and Nutrition with Cognitive Impairment in Diseases Open
Background/Objectives: Recent research highlights the growing interest in the impact of nutrition on cognitive health and function in disease, as dietary habits are increasingly recognized as crucial factors in relation to brain function. …
View article: The Role of MicroRNA in the Pathophysiology and Diagnosis of Viral Myocarditis
The Role of MicroRNA in the Pathophysiology and Diagnosis of Viral Myocarditis Open
Myocarditis is a non-ischemic condition with a heterogeneous etiology, clinical course and prognosis. The most common etiology of myocarditis are viral infections, whereas the most severe complications are acute and chronic heart failure a…
View article: Does the Composition of Gut Microbiota Affect Chronic Kidney Disease? Molecular Mechanisms Contributed to Decreasing Glomerular Filtration Rate
Does the Composition of Gut Microbiota Affect Chronic Kidney Disease? Molecular Mechanisms Contributed to Decreasing Glomerular Filtration Rate Open
Chronic kidney disease (CKD) is a very prevalent and insidious disease, particularly with initially poorly manifested symptoms that progressively culminate in the manifestation of an advanced stage of the condition. The gradual impairment …
View article: Novel Insights into Diabetic Kidney Disease
Novel Insights into Diabetic Kidney Disease Open
Diabetic kidney disease (DKD) is a major complication of diabetes mellitus (DM), affecting over one-third of type 1 and nearly half of type 2 diabetes patients. As the leading cause of end-stage renal disease (ESRD) globally, DKD develops …
View article: The Role of Selected lncRNAs in Lipid Metabolism and Cardiovascular Disease Risk
The Role of Selected lncRNAs in Lipid Metabolism and Cardiovascular Disease Risk Open
Lipid disorders increase the risk for the development of cardiometabolic disorders, including type 2 diabetes, atherosclerosis, and cardiovascular disease. Lipids levels, apart from diet, smoking, obesity, alcohol consumption, and lack of …
View article: The Role of Antioxidants in the Therapy of Cardiovascular Diseases—A Literature Review
The Role of Antioxidants in the Therapy of Cardiovascular Diseases—A Literature Review Open
Antioxidants are endogenous and exogenous substances with the ability to inhibit oxidation processes by interacting with reactive oxygen species (ROS). ROS, in turn, are small, highly reactive substances capable of oxidizing a wide range o…
View article: The Role of Oxidative Stress in Hypertension: The Insight into Antihypertensive Properties of Vitamins A, C and E
The Role of Oxidative Stress in Hypertension: The Insight into Antihypertensive Properties of Vitamins A, C and E Open
Hypertension stands as a pervasive global health challenge, contributing significantly to mortality rates worldwide. Various factors, including lifestyle choices and dietary habits, contribute to the development of hypertension. In recent …
View article: From Atherosclerotic Plaque to Myocardial Infarction—The Leading Cause of Coronary Artery Occlusion
From Atherosclerotic Plaque to Myocardial Infarction—The Leading Cause of Coronary Artery Occlusion Open
Cardiovascular disease (CVD) constitutes the most common cause of death worldwide. In Europe alone, approximately 4 million people die annually due to CVD. The leading component of CVD leading to mortality is myocardial infarction (MI). MI…
View article: Exploring the Significance of Gut Microbiota in Diabetes Pathogenesis and Management—A Narrative Review
Exploring the Significance of Gut Microbiota in Diabetes Pathogenesis and Management—A Narrative Review Open
Type 2 diabetes is a disease with significant health consequences for the individual. Currently, new mechanisms and therapeutic approaches that may affect this disease are being sought. One of them is the association of type 2 diabetes wit…
View article: Role of Uremic Toxins, Oxidative Stress, and Renal Fibrosis in Chronic Kidney Disease
Role of Uremic Toxins, Oxidative Stress, and Renal Fibrosis in Chronic Kidney Disease Open
Affecting millions of people worldwide, chronic kidney disease is a serious medical problem. It results in a decrease in glomerular filtration rate below 60 mL/min/1.73 m, albuminuria, abnormalities in urine sediment and pathologies detect…
View article: Selenium as a Modulator of Redox Reactions in the Prevention and Treatment of Cardiovascular Diseases
Selenium as a Modulator of Redox Reactions in the Prevention and Treatment of Cardiovascular Diseases Open
Cardiovascular diseases stand as the predominant global cause of mortality, exerting a profound impact on both life expectancy and its quality. Given their immense public health burden, extensive efforts have been dedicated to comprehendin…
View article: Influence of Metabolic Dysregulation in the Management of Depressive Disorder—Narrative Review
Influence of Metabolic Dysregulation in the Management of Depressive Disorder—Narrative Review Open
Depressive disorders are heterogeneous in nature, and their global reach makes them the cause of suffering for a million individuals worldwide. Standard treatment does not work for one in three people, and side effects can significantly re…