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Microheterogeneity of therapeutic monoclonal antibodies is governed by changes in the surface charge of the protein Open
It has previously been shown for individual antibodies, that the microheterogenity pattern can have a significant impact on various key characteristics of the product. The aim of this study to get a more generalized understanding of the im…
Charge heterogeneity: Basic antibody charge variants with increased binding to Fc receptors Open
We identified active isoforms of the chimeric anti-GD2 antibody, ch14.18, a recombinant antibody produced in Chinese hamster ovary cells, which is already used in clinical trials. 1,2,3 We separated the antibody by high resolution ion-exch…