Beatrice A. Brugger
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View article: CHIASMA: Advancing chemicals and materials safety and sustainability assessments through innovative integration of in vitro and in silico (new approach) methodologies
CHIASMA: Advancing chemicals and materials safety and sustainability assessments through innovative integration of in vitro and in silico (new approach) methodologies Open
View article: Catalytically Active Ti‐Based Nanomaterials for Hydroxyl Radical Mediated Clinical X‐Ray Enhancement
Catalytically Active Ti‐Based Nanomaterials for Hydroxyl Radical Mediated Clinical X‐Ray Enhancement Open
Nanoparticle radioenhancement offers a promising strategy for augmenting radiotherapy by locally increasing radiation damage to tumor tissue. While past research has predominantly focused on nanomaterials with high atomic numbers, such as …
View article: The chicken chorioallantoic membrane assay revisited – A face-lifted approach for new perspectives in placenta research
The chicken chorioallantoic membrane assay revisited – A face-lifted approach for new perspectives in placenta research Open
The study of very early human placentation is largely limited due to ethical restrictions on the use of embryonic tissue and the fact that the placental anatomy of common laboratory animal models varies considerably from that of humans. In…
View article: Fluid shear stress induces a shift from glycolytic to amino acid pathway in human trophoblasts
Fluid shear stress induces a shift from glycolytic to amino acid pathway in human trophoblasts Open
Background The human placenta, a tissue with a lifespan limited to the period of pregnancy, is exposed to varying shear rates by maternal blood perfusion depending on the stage of development. In this study, we aimed to investigate the eff…
View article: CD39 abrogates platelet-derived factors induced IL-1β expression in the human placenta
CD39 abrogates platelet-derived factors induced IL-1β expression in the human placenta Open
Tissue insults in response to inflammation, hypoxia and ischemia are accompanied by the release of ATP into the extracellular space. There, ATP modulates several pathological processes, including chemotaxis, inflammasome induction and plat…
View article: Platelet-derived factors dysregulate placental sphingosine-1-phosphate receptor 2 in human trophoblasts
Platelet-derived factors dysregulate placental sphingosine-1-phosphate receptor 2 in human trophoblasts Open
This study suggests that the placental S1PR repertoire is differentially expressed across gestation. S1PR2 expression in villous trophoblasts is negatively influenced by platelet-derived factors, which could contribute to down-regulation o…
View article: A novel protein truncating mutation in L2HGDH causes L-2-hydroxyglutaric aciduria in a consanguineous Pakistani family
A novel protein truncating mutation in L2HGDH causes L-2-hydroxyglutaric aciduria in a consanguineous Pakistani family Open
View article: Maternal platelets pass interstices of trophoblast columns and are not activated by HLA-G in early human pregnancy
Maternal platelets pass interstices of trophoblast columns and are not activated by HLA-G in early human pregnancy Open
In early human gestation, maternal arterial blood flow into the intervillous space of the developing placenta is obstructed by invaded trophoblasts, which form cellular plugs in uterine spiral arteries. These trophoblast plugs have recentl…
View article: Go with the Flow—Trophoblasts in Flow Culture
Go with the Flow—Trophoblasts in Flow Culture Open
With establishment of uteroplacental blood flow, the perfused fetal chorionic tissue has to deal with fluid shear stress that is produced by hemodynamic forces across different trophoblast subtypes. Amongst many other cell types, trophobla…