Beatrice Cavina
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View article: Combining circulating tumor cell and circulating cell free DNA analyses enhances liquid biopsy sensitivity in detecting high grade serous tubo-ovarian carcinoma
Combining circulating tumor cell and circulating cell free DNA analyses enhances liquid biopsy sensitivity in detecting high grade serous tubo-ovarian carcinoma Open
Background Liquid biopsy is a promising strategy for detecting and monitoring neoplastic diseases, with circulating tumor cells (CTCs) and circulating tumor DNA (ctDNA) being the most common objects of investigation. Most analyses have foc…
View article: Immunomagnetic enrichment coupled to PAX8/TP53 molecular pathology approach increases sensitivity in the detection of ovarian cancer cells in ascites
Immunomagnetic enrichment coupled to PAX8/TP53 molecular pathology approach increases sensitivity in the detection of ovarian cancer cells in ascites Open
High-grade serous ovarian carcinoma (HGSOC) is one of the deadliest malignancies in female population and the cause of 70% of all ovarian cancer-related deaths. Among its hallmarks, the fluid accumulation in the peritoneal cavity, or ascit…
View article: Mitochondrial chaperonin DNAJC15 promotes vulnerability to ferroptosis of chemoresistant ovarian cancer cells
Mitochondrial chaperonin DNAJC15 promotes vulnerability to ferroptosis of chemoresistant ovarian cancer cells Open
DNAJC15 is a mitochondrial TIMM23-related co-chaperonin known for its role in regulating oxidative phosphorylation efficiency, oxidative stress response and lipid metabolism. Recently, it has been proposed that the loss of DNAJC15 correlat…
View article: Lightweight CNN efficiently discriminates ovarian cancer cells from a tumor microenvironment via holographic imaging flow cytometry
Lightweight CNN efficiently discriminates ovarian cancer cells from a tumor microenvironment via holographic imaging flow cytometry Open
Holographic imaging flow cytometry (HIFC) can generate 2D quantitative phase maps of flowing cells in microchannels. When combined with convolutional neural networks (CNNs), HIFC could provide a promising stain-free approach for identifyin…
View article: Clinically Informed Intelligent Classification of Ovarian Cancer Cells by Label‐Free Holographic Imaging Flow Cytometry
Clinically Informed Intelligent Classification of Ovarian Cancer Cells by Label‐Free Holographic Imaging Flow Cytometry Open
Liquid biopsy, intended as the detection of circulating tumor cells (CTCs) in hematic specimens, is an emerging tool for both early cancer detection and estimation of prognosis. Herein, the strength of quantitative phase imaging (QPI) is i…
View article: Dysregulation of a Subset of Circulating and Vesicle-Associated miRNA in Pancreatic Cancer
Dysregulation of a Subset of Circulating and Vesicle-Associated miRNA in Pancreatic Cancer Open
Pancreatic ductal adenocarcinoma (PDAC) is one of the most aggressive neoplasia, characterized by early metastasis, low diagnostic rates at early stages, resistance to drugs, and poor prognosis. There is an urgent need to better characteri…
View article: Unlocking the promise of liquid biopsies in precision oncology
Unlocking the promise of liquid biopsies in precision oncology Open
Liquid biopsies have emerged as a promising and minimally invasive alternative to traditional tissue biopsies for detecting and monitoring cancer. Liquid biopsies offer a comprehensive analysis of cancer genetics and tumor burden by examin…
View article: NDUFS3 knockout cancer cells and molecular docking reveal specificity and mode of action of anti-cancer respiratory complex I inhibitors
NDUFS3 knockout cancer cells and molecular docking reveal specificity and mode of action of anti-cancer respiratory complex I inhibitors Open
Inhibition of respiratory complex I (CI) is becoming a promising anti-cancer strategy, encouraging the design and the use of inhibitors, whose mechanism of action, efficacy and specificity remain elusive. As CI is a central player of cellu…
View article: On monocytes and lymphocytes biolens clustering by in flow holographic microscopy
On monocytes and lymphocytes biolens clustering by in flow holographic microscopy Open
Live cells act as biological lenses and can be employed as real‐world optical components in bio‐hybrid systems. Imaging at nanoscale, optical tweezers, lithography and also photonic waveguiding are some of the already proven functionalitie…
View article: Finding intracellular lipid droplets from the single-cell biolens’ signature in a holographic flow-cytometry assay
Finding intracellular lipid droplets from the single-cell biolens’ signature in a holographic flow-cytometry assay Open
In recent years, intracellular LDs have been discovered to play an important role in several pathologies. Therefore, detection of LDs would provide an in-demand diagnostic tool if coupled with flow-cytometry to give significant statistical…
View article: Inducing respiratory complex I impairment elicits an increase in PGC1α in ovarian cancer
Inducing respiratory complex I impairment elicits an increase in PGC1α in ovarian cancer Open