Beatrice Grabner
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View article: A Mouse Model to Assess STAT3 and STAT5A/B Combined Inhibition in Health and Disease Conditions
A Mouse Model to Assess STAT3 and STAT5A/B Combined Inhibition in Health and Disease Conditions Open
Genetically-engineered mouse models (GEMMs) lacking diseased-associated gene(s) globally or in a tissue-specific manner represent an attractive tool with which to assess the efficacy and toxicity of targeted pharmacological inhibitors. Sta…
View article: PS1436 IFN‐Α TREATMENT NORMALIZES THE PLATELET COUNTS AND REDUCES QUIESCENT STEM CELLS IN A CALR‐DEL52 TRANSGENIC MOUSE MODEL, IN VIVO
PS1436 IFN‐Α TREATMENT NORMALIZES THE PLATELET COUNTS AND REDUCES QUIESCENT STEM CELLS IN A CALR‐DEL52 TRANSGENIC MOUSE MODEL, IN VIVO Open
Background: Treatment options for Myeloproliferative Neoplasms (MPN) have mainly been limited to disease managing risk of thromboembolic events and long‐term transformation to acute myelogenous leukemia and myelofibrosis. To date, type I i…
View article: CDK6 coordinates JAK2V617F mutant MPN via NF-κB and apoptotic networks
CDK6 coordinates JAK2V617F mutant MPN via NF-κB and apoptotic networks Open
Over 80% of patients with myeloproliferative neoplasms (MPNs) harbor the acquired somatic JAK2V617F mutation. JAK inhibition is not curative and fails to induce a persistent response in most patients, illustrating the need for the developm…
View article: Afatinib restrains K-RAS–driven lung tumorigenesis
Afatinib restrains K-RAS–driven lung tumorigenesis Open
K-RAS –mutated lung adenocarcinomas depend on ERBB signaling, and pan-ERBB inhibitors impair K-RAS–driven lung tumorigenesis.
View article: PO-211 KRAS driven lung adenocarcinoma depends on ERBB signalling
PO-211 KRAS driven lung adenocarcinoma depends on ERBB signalling Open
Introduction Several clinical trials using first generation EGFR Tyrosine Kinase Inhibitors (TKIs, erlotinib and gefitinib) in patients suffering of lung adenocarcinoma (AC) harbouring activating mutations in the KRAS gene have shown disa…
View article: <scp>AKT</scp>3 drives adenoid cystic carcinoma development in salivary glands
<span>AKT</span>3 drives adenoid cystic carcinoma development in salivary glands Open
Salivary gland cancer is an aggressive and painful cancer, but a rare tumor type accounting for only ~0.5% of cancer cases. Tumors of the salivary gland exhibit heterogeneous histologic and genetic features and they are subdivided into dif…
View article: Unexpected oncosuppressive role for STAT3 in KRAS-induced lung tumorigenesis
Unexpected oncosuppressive role for STAT3 in KRAS-induced lung tumorigenesis Open
Signal transducer and activator of transcription 3 (STAT3) plays a critical role in the pathogenesis of several diseases and is considered a therapeutic target in solid cancers, including lung cancer. However, we recently demonstrated a tu…
View article: Heterologous protein production using euchromatin-containing expression vectors in mammalian cells
Heterologous protein production using euchromatin-containing expression vectors in mammalian cells Open
Upon stable cell line generation, chromosomal integration site of the vector DNA has a major impact on transgene expression. Here we apply an active gene environment, rather than specified genetic elements, in expression vectors used for r…
View article: Disruption of STAT3 signalling promotes KRAS-induced lung tumorigenesis
Disruption of STAT3 signalling promotes KRAS-induced lung tumorigenesis Open
STAT3 is considered to play an oncogenic role in several malignancies including lung cancer; consequently, targeting STAT3 is currently proposed as therapeutic intervention. Here we demonstrate that STAT3 plays an unexpected tumour-suppres…
View article: Myeloid<i>STAT3</i>promotes formation of colitis-associated colorectal cancer in mice
Myeloid<i>STAT3</i>promotes formation of colitis-associated colorectal cancer in mice Open
Myeloid cells lacking STAT3 promote antitumor responses of NK and T cells but it is unknown if this crosstalk affects development of autochthonous tumors. We deleted STAT3 in murine myeloid cells (STAT3Δm) and examined the effect on the de…