Explanipedia

Calcium signaling dysregulation in rheumatoid arthritis: a comparative perspective with osteoarthritis Open

Thuy Duong Nguyen, Hugo Abreu, Nunziatina De Tommasi, Luigi Azzarone, Rita Maria Concetta Di Martino , et al. · 2025

Rheumatoid arthritis and osteoarthritis are among the most prevalent chronic diseases worldwide, imposing a significant burden on both patients and healthcare systems. Despite their distinct etiology and progression, emerging evidence sugg…

Paclitaxel activates SOCE/ICRAC in dorsal root ganglion neurons: implications for paclitaxel-induced peripheral neuropathy Open

Marta Delconti, Tiziana Ravasenga, Marianna Dionisi, Tiziana Romanazzi, Fausto Chiazza , et al. · 2025

Paclitaxel (PTX) is one of the most widely used antineoplastic drugs for the treatment of solid cancers. Its mechanism of action involves binding to β-tubulin subunits, leading to the stabilization of microtubule polymers and subsequent ce…

POST–ENDOCARDITIS MOBILE THROMBUS IN PULMONARY VALVE: A UNIQUE CASE REPORT OF ACUTE PULMONARY EMBOLISM Open

C Ciampi, P Ossola, Sebastiano Massaro, Emanuela Tavasci, Elisabetta Lobiati , et al. · 2024

Background Infective endocarditis results from a complex interplay among bacterial virulence factors, coagulation, and hemodynamics.Native pulmonary valve endocarditis is a very rare phenomenon. Similarly, the development of a thrombus on …

Bitter taste receptor (TAS2R) 46 in human skeletal muscle: expression and activity Open

Maria Talmon, Erika Massara, Martina Quaregna, Marta De Battisti, Francesca Boccafoschi , et al. · 2023

Bitter taste receptors are involved not only in taste perception but in various physiological functions as their anatomical location is not restricted to the gustatory system. We previously demonstrated expression and activity of the subty…

Inhibition of NHE1 transport activity and gene transcription in DRG neurons in oxaliplatin-induced painful peripheral neurotoxicity Open

Marianna Dionisi, Beatrice Riva, Marta Delconti, C Meregalli, A Chiorazzi , et al. · 2023

CIC-39Na reverses the thrombocytopenia that characterizes tubular aggregate myopathy Open

Celia Cordero-Sánchez, Emanuela Pessolano, Beatrice Riva, Mauro Vismara, Silvia Maria Grazia Trivigno , et al. · 2022

Store-operated Ca2+-entry is a cellular mechanism that governs the replenishment of intracellular stores of Ca2+ upon depletion caused by the opening of intracellular Ca2+-channels. Gain-of-function mutations of the 2 key proteins of store…

STIM1 and ORAI1 mutations leading to tubular aggregate myopathies are sensitive to the Store-operated Ca2+-entry modulators CIC-37 and CIC-39 Open

Beatrice Riva, Emanuela Pessolano, Edoardo Quaglia, Celia Cordero-Sánchez, Irene Preet Bhela , et al. · 2022

Dissecting the Mechanism of Action of Spiperone—A Candidate for Drug Repurposing for Colorectal Cancer Open

Annamaria Antona, Marco Varalda, Konkonika Roy, Francesco Favero, Eleonora Mazzucco , et al. · 2022

Approximately 50% of colorectal cancer (CRC) patients still die from recurrence and metastatic disease, highlighting the need for novel therapeutic strategies. Drug repurposing is attracting increasing attention because, compared to tradit…

1,2,4-Oxadiazole-Bearing Pyrazoles as Metabolically Stable Modulators of Store-Operated Calcium Entry Open

Silvio Aprile, Beatrice Riva, Irene Preet Bhela, Celia Cordero-Sánchez, Giulia Avino , et al. · 2021

Store-operated calcium entry (SOCE) is a pivotal mechanism in calcium homeostasis, and, despite still being under investigation, its dysregulation is known to be associated with severe human disorders. SOCE modulators are therefore needed …

Store-Operated Calcium Entry as a Therapeutic Target in Acute Pancreatitis: Discovery and Development of Drug-Like SOCE Inhibitors Open

M. Teresa Serafini, Celia Cordero-Sánchez, Rosanna Di Paola, Irene Preet Bhela, Silvio Aprile , et al. · 2020

Store-operated calcium entry (SOCE) is important in the maintenance of calcium homeostasis and alterations in this mechanism are responsible for several pathological conditions, including acute pancreatitis. Since the discovery of SOCE, ma…

Early Stimulation of TREK Channel Transcription and Activity Induced by Oxaliplatin-Dependent Cytosolic Acidification Open

Marianna Dionisi, Federico Alessandro Ruffinatti, Beatrice Riva, Dmitry Lim, A Canta , et al. · 2020

Oxaliplatin-induced peripheral neuropathy is characterized by an acute hyperexcitability syndrome triggered/exacerbated by cold. The mechanisms underlying oxaliplatin-induced peripheral neuropathy are unclear, but the alteration of ion cha…

A luminal EF-hand mutation in STIM1 in mice causes the clinical hallmarks of tubular aggregate myopathy Open

Celia Cordero-Sánchez, Beatrice Riva, Simone Reano, Nausicaa Clemente, Ivan Zaggia , et al. · 2019

STIM and ORAI proteins play a fundamental role in calcium signaling, allowing for calcium influx through the plasma membrane upon depletion of intracellular stores, in a process known as store-operated Ca2+ entry. Point mutations that lead…

Pyrtriazoles, a Novel Class of Store-Operated Calcium Entry Modulators: Discovery, Biological Profiling, and in Vivo Proof-of-Concept Efficacy in Acute Pancreatitis Open

Beatrice Riva, Alessia Griglio, M. Teresa Serafini, Celia Cordero-Sánchez, Silvio Aprile , et al. · 2018

In recent years, channels that mediate store-operated calcium entry (SOCE, i.e., the ability of cells to sense a decrease in endoplasmic reticulum luminal calcium and induce calcium entry across the plasma membrane) have been associated wi…

Oxaliplatin induces pH acidification in dorsal root ganglia neurons Open

Beatrice Riva, Marianna Dionisi, Alberto Potenzieri, A Chiorazzi, Celia Cordero-Sánchez , et al. · 2018

Oxaliplatin induced peripheral neurotoxicity is characterized by an acute cold-induced syndrome characterized by cramps, paresthesias/dysesthesias in the distal limbs and perioral region, that develops rapidly and lasts up to one week affe…

SiO2 nanoparticles modulate the electrical activity of neuroendocrine cells without exerting genomic effects Open

Carla Distasi, Federico Alessandro Ruffinatti, Marianna Dionisi, Susanna Antoniotti, Alessandra Gilardino , et al. · 2018

Engineered silica nanoparticles (NPs) have attracted increasing interest in several applications, and particularly in the field of nanomedicine, thanks to the high biocompatibility of this material. For their optimal and controlled use, th…

Susceptibility of different mouse strains to oxaliplatin peripheral neurotoxicity: Phenotypic and genotypic insights Open

P Marmiroli, Beatrice Riva, E Pozzi, E Ballarini, Dmitry Lim , et al. · 2017

Peripheral neurotoxicity is one of the most distressing side effects of oxaliplatin therapy for cancer. Indeed, most patients that received oxaliplatin experience acute and/or chronic severe sensory peripheral neuropathy. However, despite …

investigating the functionalization of colloidal nanoparticles with small molecules of biological interest Open

Beatrice Riva · 2017

1) Developement of radio-labelled SNPs for the targeted detection and treatment of Her2-positive breast cancer.Aim of this work was to develop a SNP-based system loaded with radioactive/fluorescent probes and functionalized with the half-c…

Celecoxib inhibits proliferation and survival of chronic myelogeous leukemia (CML) cells via AMPK-dependent regulation of β-catenin and mTORC1/2 Open

Beatrice Riva, Marco De Dominici, Ilaria Gnemmi, Samanta A. Mariani, Alberto Minassi , et al. · 2016

CML is effectively treated with tyrosine kinase inhibitors (TKIs). However, the efficacy of these drugs is confined to the chronic phase of the disease and development of resistance to TKIs remains a pressing issue. The anti-inflammatory C…

Functionalized silica nanoparticles in the detection and treatment of Her2-positive breast cancer Open

Paolo Rainone, Beatrice Riva, Silvana Belloli, F. Sudati, Marilena Ripamonti , et al. · 2015

Beatrice Riva YOU? Author Swipe