Beatrix Elsberger
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View article: Genomic tests to guide management of breast cancer in Europe: regulation, reimbursement, adoption, and challenges
Genomic tests to guide management of breast cancer in Europe: regulation, reimbursement, adoption, and challenges Open
The integration of genomic tests such as the Oncotype DX Breast Recurrence Score® test, into routine clinical practice represents a significant advance in personalized breast cancer care. By supporting more tailored therapeutic decisions, …
View article: A compendium of adipocyte morphologies across different breast pathologies
A compendium of adipocyte morphologies across different breast pathologies Open
Adipocytes are abundant in the breast tissue microenvironment. In breast cancer, they can change morphologically according to their proximity to tumour cells, with the closest becoming cancer-associated adipocytes (CAAs). It remains unclea…
View article: Feasibility of the omission of axillary surgery in node-negative early breast cancer: a systematic review and meta-analysis
Feasibility of the omission of axillary surgery in node-negative early breast cancer: a systematic review and meta-analysis Open
View article: Safe and transparent introduction and evaluation of targeted axillary dissection in patients with node-positive breast cancer undergoing primary surgery: international consensus process
Safe and transparent introduction and evaluation of targeted axillary dissection in patients with node-positive breast cancer undergoing primary surgery: international consensus process Open
Background Axillary node clearance is the current standard of care in patients with node-positive breast cancer undergoing primary surgery, despite a lack of evidence to demonstrate survival benefit and high rates of life-changing morbidit…
View article: A compendium of adipocyte morphologies across different breast pathologies
A compendium of adipocyte morphologies across different breast pathologies Open
Adipocytes are abundant in the breast tissue microenvironment. In breast cancer, they can change morphologically according to their proximity to tumour cells, with the closest becoming cancer-associated adipocytes (CAAs). It remains unclea…
View article: SMALL: open surgery versus minimally invasive vacuum-assisted excision for small screen-detected breast cancer—protocol for a phase III randomised multicentre trial
SMALL: open surgery versus minimally invasive vacuum-assisted excision for small screen-detected breast cancer—protocol for a phase III randomised multicentre trial Open
Introduction Mammographic screening identifies many women with small breast cancers with favourable biological features, which have an excellent prognosis. Some of these may never have become clinically apparent without screening and are c…
View article: Feasibility of the Omission of Axillary Surgery in Node-Negative Early Breast Cancer: A Systematic Review and Meta-Analysis
Feasibility of the Omission of Axillary Surgery in Node-Negative Early Breast Cancer: A Systematic Review and Meta-Analysis Open
View article: Web-based interventions for fear of cancer recurrence: A scoping review with a focus on suggestions for the development and evaluation of future interventions
Web-based interventions for fear of cancer recurrence: A scoping review with a focus on suggestions for the development and evaluation of future interventions Open
Purpose The objective of this scoping review is to provide an overview of the available evidence on the effectiveness of web-based interventions for fear of cancer recurrence (FCR) and a discussion of drawbacks and possible improvements fo…
View article: Insomnia prehabilitation in newly diagnosed breast cancer patients: Protocol for a pilot, multicentre, randomised controlled trial comparing nurse delivered sleep restriction therapy to sleep hygiene education (INVEST trial)
Insomnia prehabilitation in newly diagnosed breast cancer patients: Protocol for a pilot, multicentre, randomised controlled trial comparing nurse delivered sleep restriction therapy to sleep hygiene education (INVEST trial) Open
Introduction Insomnia is a prevalent sleep disorder that negatively impacts daytime functioning and quality of life. Breast cancer patients report higher rates of insomnia and more circadian disruption than other cancer groups. Approximate…
View article: Insomnia prehabilitation in newly diagnosed breast cancer patients: protocol for a pilot, multicentre, randomised controlled trial comparing nurse delivered sleep restriction therapy to sleep hygiene education (INVEST trial)
Insomnia prehabilitation in newly diagnosed breast cancer patients: protocol for a pilot, multicentre, randomised controlled trial comparing nurse delivered sleep restriction therapy to sleep hygiene education (INVEST trial) Open
Introduction Insomnia is a prevalent sleep disorder that negatively impacts daytime functioning and quality of life. Breast cancer patients report higher rates of insomnia and more circadian disruption than other cancer groups. Approximate…
View article: Enhancing clinical decision support with genomic tools in breast cancer: A Scottish perspective
Enhancing clinical decision support with genomic tools in breast cancer: A Scottish perspective Open
Genomic assays offer the potential for risk-stratified decision making regarding the use of chemotherapy. They can help reduce unnecessary chemotherapy treatment and identify a subgroup of patients with more adverse genomic tumour biology.…
View article: The MARECA (national study of management of breast cancer locoregional recurrence and oncological outcomes) study: protocol for a prospective, multicentre cohort study
The MARECA (national study of management of breast cancer locoregional recurrence and oncological outcomes) study: protocol for a prospective, multicentre cohort study Open
Background: Despite a UK 5-year breast cancer survival rate of 86.6%, patients may develop breast cancer recurrence within the same breast after breast conserving surgery, as well as in the remaining skin or chest wall after mastectomy or …
View article: Impaired Cardiac and Skeletal Muscle Energetics Following Anthracycline Therapy for Breast Cancer
Impaired Cardiac and Skeletal Muscle Energetics Following Anthracycline Therapy for Breast Cancer Open
Background: Anthracycline-related cardiac toxicity is a recognized consequence of cancer therapies. We assess resting cardiac and skeletal muscle energetics and myocyte, sarcomere, and mitochondrial integrity in patients with breast cancer…
View article: Bridging pre-surgical endocrine therapy for breast cancer during the COVID-19 pandemic: outcomes from the B-MaP-C study
Bridging pre-surgical endocrine therapy for breast cancer during the COVID-19 pandemic: outcomes from the B-MaP-C study Open
View article: ATNEC – Patient Experience Sub-Study (IRSCTN: 36585784): What Patients Think About Taking Part In Breast Cancer Treatment De-Escalation Trials?
ATNEC – Patient Experience Sub-Study (IRSCTN: 36585784): What Patients Think About Taking Part In Breast Cancer Treatment De-Escalation Trials? Open
View article: Enhancing Clinical Decision Support with Genomic Tools in Breast Cancer: A Scottish Perspective
Enhancing Clinical Decision Support with Genomic Tools in Breast Cancer: A Scottish Perspective Open
View article: Energetic and myocellular pathways in cardiac and skeletal muscle following anthracycline chemotherapy
Energetic and myocellular pathways in cardiac and skeletal muscle following anthracycline chemotherapy Open
Background Anthracycline-related cardiac dysfunction is a recognised consequence of cancer therapies. Here we assess resting cardiac and skeletal muscle energic status as an early mechanistic pathway of myocyte derangement and explore mole…
View article: Analysis of the Clinical Advancements for BRCA-Related Malignancies Highlights the Lack of Treatment Evidence for BRCA-Positive Male Breast Cancer
Analysis of the Clinical Advancements for BRCA-Related Malignancies Highlights the Lack of Treatment Evidence for BRCA-Positive Male Breast Cancer Open
Male breast cancer (MBC) is a rare disease that accounts for less than 1% of all breast cancers and male malignancies. Despite recognised clinico-pathological and molecular differences to female breast cancer (FBC), the clinical management…
View article: ATNEC: A multicenter, randomized trial investigating whether axillary treatment can be avoided in patients with T1-3N1M0 breast cancer with no residual cancer in the lymph glands after neoadjuvant chemotherapy.
ATNEC: A multicenter, randomized trial investigating whether axillary treatment can be avoided in patients with T1-3N1M0 breast cancer with no residual cancer in the lymph glands after neoadjuvant chemotherapy. Open
TPS615 Background: Neoadjuvant chemotherapy (NACT) results in eradication of cancer in the axillary nodes in 40-70% of patients. This raises questions about the benefit of further axillary treatment in patients with no evidence of residual…
View article: 142 Cardiac and skeletal muscle energetic pathways following anthracycline chemotherapy for breast cancer
142 Cardiac and skeletal muscle energetic pathways following anthracycline chemotherapy for breast cancer Open
Background/Introduction Anthracycline-related cardiac dysfunction is a recognised consequence of cancer therapies. Here we assess resting cardiac and skeletal muscle energic status as an early mechanistic pathway of myocyte derangement and…
View article: Loss of breast reconstruction services during the COVID-19 pandemic: Negative impact on patient quality of life and wellbeing
Loss of breast reconstruction services during the COVID-19 pandemic: Negative impact on patient quality of life and wellbeing Open
View article: Current practice and surgical outcomes of neoadjuvant chemotherapy for early breast cancer: UK NeST study
Current practice and surgical outcomes of neoadjuvant chemotherapy for early breast cancer: UK NeST study Open
Neoadjuvant chemotherapy (NACT) is increasingly being used to treat early breast cancer, and offers several advantages, including reducing the extent of breast and axillary surgery, and providing an in vivo assessment of tumour sensitivity…
View article: The MARECA (national study of management of breast cancer locoregional recurrence and oncological outcomes) study: National practice questionnaire of United Kingdom multi-disciplinary decision making
The MARECA (national study of management of breast cancer locoregional recurrence and oncological outcomes) study: National practice questionnaire of United Kingdom multi-disciplinary decision making Open
This survey has highlighted where consistencies and variations exist in the multidisciplinary management of breast cancer LRR. However, further research is required to determine how these management patterns influence patient outcomes, whi…
View article: The Role of redo-Sentinel Lymph Node Biopsy in Patients With Prior Ipsilateral Breast Cancer Surgery
The Role of redo-Sentinel Lymph Node Biopsy in Patients With Prior Ipsilateral Breast Cancer Surgery Open
View article: Not all small HER2 positive breast cancers have the same clinical outcome in the North-East of Scotland
Not all small HER2 positive breast cancers have the same clinical outcome in the North-East of Scotland Open
HER2-positive breast cancers, representing up to 20% of all breast cancers, are more aggressive and have poorer outcomes. Systemic therapy has been proven to prevent disease recurrence and improve survival. Existing literature provides onl…
View article: THE COVID-19 PANDEMIC AND LOSS OF BREAST RECONSTRUCTION SERVICES: HAS IT AFFECTED PATIENT QUALITY OF LIFE AND WELL-BEING?
THE COVID-19 PANDEMIC AND LOSS OF BREAST RECONSTRUCTION SERVICES: HAS IT AFFECTED PATIENT QUALITY OF LIFE AND WELL-BEING? Open
Objective: Breast reconstruction has better postoperative quality of life (QoL) outcomes compared to mastectomy. The COVID-19 pandemic led to restrictions across the National Health Service, including breast reconstruction services. Breast…
View article: Does the gut microbiome environment influence response to systemic breast cancer treatment?
Does the gut microbiome environment influence response to systemic breast cancer treatment? Open
The gut microbiome is a novel player in the pathogenesis and treatment of breast cancer. The term “microbiome” is used to describe the diverse community of micro-organisms existing within the gastrointestinal tract. The gut microbiome play…
View article: Impalpable Breast Cancer and Service Delivery During the COVID-19 Pandemic – the Role of Radiofrequency Tag localization
Impalpable Breast Cancer and Service Delivery During the COVID-19 Pandemic – the Role of Radiofrequency Tag localization Open
Background: Radiofrequency tags are used to localize breast lesions for surgery. During the Covid-19 pandemic, these offered the flexibility of inserting the Tags days or weeks before surgery. This made logistics of planning theatres lists…
View article: P062. The use of radiofrequency tag localization of impalpable breast cancers during the COVID-19 pandemic
P062. The use of radiofrequency tag localization of impalpable breast cancers during the COVID-19 pandemic Open
View article: Axillary tumour burden in women with one abnormal node on ultrasound compared to women with multiple abnormal nodes
Axillary tumour burden in women with one abnormal node on ultrasound compared to women with multiple abnormal nodes Open