Beatrix Steer
YOU?
Author Swipe
View article: A Mouse Model to Study the Pathogenesis of γ-herpesviral Infections in Germinal Center B Cells
A Mouse Model to Study the Pathogenesis of γ-herpesviral Infections in Germinal Center B Cells Open
CD30-positive germinal center (GC)-derived B cell lymphomas are frequently linked to Epstein–Barr Virus (EBV) infection. However, a suitable animal model for the investigation of the interplay between γ-herpesvirus and host cells in B cell…
View article: Pollen induces reactivation of latent herpesvirus and differentially affects infected and uninfected murine macrophages
Pollen induces reactivation of latent herpesvirus and differentially affects infected and uninfected murine macrophages Open
Aeroallergens including plant pollen are continuously inhaled and deposited in the respiratory tract and, together with their soluble components, actively interact with a variety of cells in the airways.1 Besides epithelial cells, B cells,…
View article: B cells latently infected with murine gammaherpesvirus 68 (MHV‐68) are present in the mouse thymus–A step toward immune evasion?
B cells latently infected with murine gammaherpesvirus 68 (MHV‐68) are present in the mouse thymus–A step toward immune evasion? Open
We show that latently gammaherpesvirus-infected B cells are present in the thymus. This could result in a functional T-cell tolerance against certain viral epitopes. It is conceivable that also antigens from other viruses or pathogens may …
View article: S100a4 Is Secreted by Alternatively Activated Alveolar Macrophages and Promotes Activation of Lung Fibroblasts in Pulmonary Fibrosis
S100a4 Is Secreted by Alternatively Activated Alveolar Macrophages and Promotes Activation of Lung Fibroblasts in Pulmonary Fibrosis Open
Idiopathic pulmonary fibrosis (IPF) is a devastating interstitial lung disease, characterized by damage of lung epithelial cells, excessive deposition of extracellular matrix in the lung interstitium, and enhanced activation and proliferat…
View article: Nanoparticle exposure reactivates latent herpesvirus and restores a signature of acute infection
Nanoparticle exposure reactivates latent herpesvirus and restores a signature of acute infection Open
Our results indicate that NP-exposure of persistently herpesvirus-infected cells - murine or human - restores molecular signatures found in acute virus infection, boosts production of lytic viral proteins, and induces an inflammatory respo…
View article: Additional file 2: of Nanoparticle exposure reactivates latent herpesvirus and restores a signature of acute infection
Additional file 2: of Nanoparticle exposure reactivates latent herpesvirus and restores a signature of acute infection Open
Supplementary Material (XLSX 7772Â kb)
View article: The small noncoding RNAs (sncRNAs) of murine gammaherpesvirus 68 (MHV-68) are involved in regulating the latent-to-lytic switch in vivo
The small noncoding RNAs (sncRNAs) of murine gammaherpesvirus 68 (MHV-68) are involved in regulating the latent-to-lytic switch in vivo Open
The human gammaherpesviruses Epstein-Barr virus (EBV) and Kaposi’s sarcoma-associated herpesvirus (KSHV), which are associated with a variety of diseases including tumors, produce various small noncoding RNAs (sncRNAs) such as microRNAs (m…
View article: Virus replication in vitro.
Virus replication in vitro. Open
MOVAS (A), MHEC (B), SVEC 4–10 (C), TCMK-1 (D), MH-S (E) and CS16 stromal cells (F) were infected with the indicated viruses at an MOI of 0.01 (MOVAS, MHEC, SVEC 4–10, TCMK-1, CS16) or 1 (MH-S). Cells and cell culture supernatants were har…
View article: Analysis of the influence of Rbbp4 on lytic virus replication.
Analysis of the influence of Rbbp4 on lytic virus replication. Open
To analyze lytic growth of recombinant viruses expressing Rbbp4, TCMK-1 cells were plated and after 24 hours infected with the indicated viruses at an MOI of 0.01 for 1 hour. After removing the inoculum, cells were incubated with fresh med…
View article: Lytic replication in the lungs after i.n. inoculation.
Lytic replication in the lungs after i.n. inoculation. Open
C57BL/6 mice were inoculated i.n. with 1x 103 PFU of the indicated viruses. Lungs of mice were harvested at day 3 after infection (parental virus or mutant viruses) and at day 6 after infection (parental or mutant viruses and ectopic rever…
View article: Multiple Lytic Origins of Replication Are Required for Optimal Gammaherpesvirus Fitness In Vitro and In Vivo
Multiple Lytic Origins of Replication Are Required for Optimal Gammaherpesvirus Fitness In Vitro and In Vivo Open
An unresolved question in herpesvirus biology is why some herpesviruses contain more than one lytic origin of replication (oriLyt). Using murine gammaherpesvirus 68 (MHV-68) as model virus containing two oriLyts, we demonstrate that loss o…