Beatriz Beamud
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View article: Unlocking data in Klebsiella lysogens to predict capsular type-specificity of phage depolymerases
Unlocking data in Klebsiella lysogens to predict capsular type-specificity of phage depolymerases Open
Viral entry is a critical step in the infection process. Klebsiella spp. and other clinically relevant bacteria often express complex polysaccharide capsules that act as a barrier to phage entry. In turn, most lytic phages targeting Klebsi…
View article: Genomic surveillance reveals different transmission patterns between third-generation cephalosporin and carbapenem resistance in Klebsiella pneumoniae in the Comunidad Valenciana (Spain), 2018–2020
Genomic surveillance reveals different transmission patterns between third-generation cephalosporin and carbapenem resistance in Klebsiella pneumoniae in the Comunidad Valenciana (Spain), 2018–2020 Open
View article: Incomplete lytic cycle of a widespread Bacteroides bacteriophage leads to the formation of defective viral particles
Incomplete lytic cycle of a widespread Bacteroides bacteriophage leads to the formation of defective viral particles Open
Advances in metagenomics have led to the identification of new intestinal temperate bacteriophages. However, their experimental characterization remains challenging due to a limited understanding of their lysogenic-lytic cycle and the comm…
View article: Incomplete lytic cycle of a widespread<i>Bacteroides</i>bacteriophage leads to the formation of defective viral particles
Incomplete lytic cycle of a widespread<i>Bacteroides</i>bacteriophage leads to the formation of defective viral particles Open
Advances in metagenomics have led to the identification of new intestinal temperate bacteriophages. However, their experimental characterization remains challenging due to a limited understanding of their lysogenic-lytic cycle and the comm…
View article: Unlocking data in<i>Klebsiella</i>lysogens to predict capsular type-specificity of phage depolymerases
Unlocking data in<i>Klebsiella</i>lysogens to predict capsular type-specificity of phage depolymerases Open
Viral entry is a critical step in the infection process. Klebsiella spp. and other clinically relevant bacteria often express a complex polysaccharide capsule that acts as a barrier to phage entry. In turn, most Klebsiella phages encode de…
View article: Systematic interrogation of CRISPR antimicrobials in <i>Klebsiella pneumoniae</i> reveals nuclease-, guide- and strain-dependent features influencing antimicrobial activity
Systematic interrogation of CRISPR antimicrobials in <i>Klebsiella pneumoniae</i> reveals nuclease-, guide- and strain-dependent features influencing antimicrobial activity Open
CRISPR-Cas systems can be utilized as programmable-spectrum antimicrobials to combat bacterial infections. However, how CRISPR nucleases perform as antimicrobials across target sites and strains remains poorly explored. Here, we address th…
View article: Different Transmission Patterns between Third Generation Cephalosporin and Carbapenem Resistance in Klebsiella Pneumoniae
Different Transmission Patterns between Third Generation Cephalosporin and Carbapenem Resistance in Klebsiella Pneumoniae Open
View article: Inference of the Life Cycle of Environmental Phages from Genomic Signature Distances to Their Hosts
Inference of the Life Cycle of Environmental Phages from Genomic Signature Distances to Their Hosts Open
The environmental impact of uncultured phages is shaped by their preferred life cycle (lytic or lysogenic). However, our ability to predict it is very limited. We aimed to discriminate between lytic and lysogenic phages by comparing the si…
View article: Human Anelloviruses: Influence of Demographic Factors, Recombination, and Worldwide Diversity
Human Anelloviruses: Influence of Demographic Factors, Recombination, and Worldwide Diversity Open
Anelloviruses are the most common human infectious viruses and are considered essentially harmless. Compared to other human viruses, they are characterized by enormous diversity, and recombination is suggested to play an important role in …
View article: Tracking the Emergence and Dissemination of a <i>bla</i> <sub>NDM-23</sub> Gene in a Multidrug Resistance Plasmid of Klebsiella pneumoniae
Tracking the Emergence and Dissemination of a <i>bla</i> <sub>NDM-23</sub> Gene in a Multidrug Resistance Plasmid of Klebsiella pneumoniae Open
At a time when antimicrobial resistance has become one of the biggest concerns worldwide, the emergence of novel alleles and extremely drug-resistant plasmids is a threat to public health worldwide, especially when they produce carbapenem …
View article: Genetic determinants of host tropism in Klebsiella phages
Genetic determinants of host tropism in Klebsiella phages Open
View article: Tracking the emergence and dissemination of a <i>bla</i><sub>NDM-23</sub> Gene in a Multi-Drug Resistance Plasmid of <i>Klebsiella pneumoniae</i>
Tracking the emergence and dissemination of a <i>bla</i><sub>NDM-23</sub> Gene in a Multi-Drug Resistance Plasmid of <i>Klebsiella pneumoniae</i> Open
Objectives Since the discovery of bla NDM-1 , NDM beta-lactamases have become one of the most widespread carbapenemases worldwide. To date, 28 different NDM variants have been reported but some, such as bla NDM-23 , have not been character…
View article: Genetic determinants of host tropism in<i>Klebsiella</i>phages
Genetic determinants of host tropism in<i>Klebsiella</i>phages Open
Bacteriophages play key roles in bacterial ecology and evolution and are potential antimicrobials. However, the determinants of phage-host specificity remain elusive. Here, we used 46 newly-isolated phages to challenge 138 representative c…
View article: Learning From Mistakes: The Role of Phages in Pandemics
Learning From Mistakes: The Role of Phages in Pandemics Open
The misuse of antibiotics is leading to the emergence of multidrug-resistant (MDR) bacteria, and in the absence of available treatments, this has become a major global threat. In the middle of the recent severe acute respiratory coronaviru…
View article: One is not enough: On the effects of reference genome for the mapping and subsequent analyses of short-reads
One is not enough: On the effects of reference genome for the mapping and subsequent analyses of short-reads Open
Mapping of high-throughput sequencing (HTS) reads to a single arbitrary reference genome is a frequently used approach in microbial genomics. However, the choice of a reference may represent a source of errors that may affect subsequent an…
View article: Isolation and Characterization of Two Klebsiella pneumoniae Phages Encoding Divergent Depolymerases
Isolation and Characterization of Two Klebsiella pneumoniae Phages Encoding Divergent Depolymerases Open
The emergence of multidrug-resistant bacteria is a major global health concern. The search for new therapies has brought bacteriophages into the spotlight, and new phages are being described as possible therapeutic agents. Among the bacter…
View article: One is not enough: on the effects of reference genome for the mapping and subsequent analyses of short-reads
One is not enough: on the effects of reference genome for the mapping and subsequent analyses of short-reads Open
Mapping of high-throughput sequencing (HTS) reads to a single arbitrary reference genome is a frequently used approach in microbial genomics. However, the choice of a reference may represent a source of errors that may affect subsequent an…
View article: Isolation of Four Lytic Phages Infecting Klebsiella pneumoniae K22 Clinical Isolates from Spain
Isolation of Four Lytic Phages Infecting Klebsiella pneumoniae K22 Clinical Isolates from Spain Open
The emergence of multi-drug-resistant bacteria represents a major public-health threat. Phages constitute a promising alternative to chemical antibiotics due to their high host specificity, abundance in nature, and evolvability. However, p…
View article: Characterization of New Recombinant Forms of HIV-1 From the Comunitat Valenciana (Spain) by Phylogenetic Incongruence
Characterization of New Recombinant Forms of HIV-1 From the Comunitat Valenciana (Spain) by Phylogenetic Incongruence Open
Recombination is one of the main processes shaping the evolution of HIV-1, with relevant consequences for its epidemiology. In fact, Circulating and Unique Recombinant Forms (CRFs and URFs) cause 23% of current infections. The routine anal…