Beatriz Millare
YOU?
Author Swipe
View article: Zetomipzomib (KZR-616) attenuates lupus in mice via modulation of innate and adaptive immune responses
Zetomipzomib (KZR-616) attenuates lupus in mice via modulation of innate and adaptive immune responses Open
Zetomipzomib (KZR-616) is a selective inhibitor of the immunoproteasome currently undergoing clinical investigation in autoimmune disorders. Here, we characterized KZR-616 in vitro and in vivo using multiplexed cytokine analysis, lymphocyt…
View article: 207 Small molecule inhibitors of Sec61 cotranslational translocation regulate the phagocytosis checkpoint molecule CD47
207 Small molecule inhibitors of Sec61 cotranslational translocation regulate the phagocytosis checkpoint molecule CD47 Open
Background Many tumor cells escape immune cell clearance by overexpressing CD47, a multi-pass transmembrane protein, which binds signal regulatory protein α (SIRPα) on macrophages leading to decreased phagocytic activity. Blockade of CD47/…
View article: Non-progressing cancer patients have persistent B cell responses expressing shared antibody paratopes that target public tumor antigens
Non-progressing cancer patients have persistent B cell responses expressing shared antibody paratopes that target public tumor antigens Open
There is significant debate regarding whether B cells and their antibodies contribute to effective anti-cancer immune responses. Here we show that patients with metastatic but non-progressing melanoma, lung adenocarcinoma, or renal cell ca…