Leticia Moreira
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View article: Supplementary Figure from Evaluating the Potential of Polygenic Risk Score to Improve Colorectal Cancer Screening
Supplementary Figure from Evaluating the Potential of Polygenic Risk Score to Improve Colorectal Cancer Screening Open
Supplementary Figure from Evaluating the Potential of Polygenic Risk Score to Improve Colorectal Cancer Screening
View article: Targetable pathways for drug repurposing in gastric cancer
Targetable pathways for drug repurposing in gastric cancer Open
Gastric cancer (GC) is both the fifth most common cancer worldwide and the fifth in mortality. Owing to a lack of symptoms in the early stages and unspecific clinical presentation in the later stages, GC is usually diagnosed at advanced st…
View article: Familial Non-Hereditary Gastric Cancer: Diagnosis, Management, Molecular Characteristics and Future Perspective
Familial Non-Hereditary Gastric Cancer: Diagnosis, Management, Molecular Characteristics and Future Perspective Open
Background/Objectives: Gastric cancer (GC) remains a leading cause of cancer mortality worldwide. While most cases are sporadic, approximately 10% show familial clustering with only a minority explained by known hereditary syndromes. The r…
View article: Hereditary diffuse gastric cancer spectrum associated with germline <i>CTNNA1</i> loss of function revealed by clinical and molecular data from 351 carrier families and over 37 000 non-carrier controls
Hereditary diffuse gastric cancer spectrum associated with germline <i>CTNNA1</i> loss of function revealed by clinical and molecular data from 351 carrier families and over 37 000 non-carrier controls Open
Background Diffuse gastric cancer (DGC) is the most common manifestation in germline CTNNA1 variant carriers, with one study estimating a 49–57% lifetime risk by age 80. Knowledge on CTNNA1 -associated hereditary diffuse gastric cancer (HD…
View article: Empirical Rescue Eradication Therapy for <scp> <i>Helicobacter pylori</i> </scp> Infection in Second and Subsequent Treatment Lines: Experience From 500 Cases of the Brazilian Registry on <scp> <i>H. pylori</i> </scp> Management (Hp‐ <scp>BrazilReg</scp> )
Empirical Rescue Eradication Therapy for <span> <i>Helicobacter pylori</i> </span> Infection in Second and Subsequent Treatment Lines: Experience From 500 Cases of the Brazilian Registry on <span> <i>H. pylori</i> </span> Management (Hp‐ <span>BrazilReg</span> ) Open
Background The effectiveness of anti ‐ H. pylori treatment diminishes with therapy failure, making regional performance understanding crucial. Objective To evaluate the effectiveness of empirical therapy in second‐line and subsequent treat…
View article: Prospective validation of the Barcelona scale for the assessment of mucosal cleanliness during upper gastrointestinal endoscopy
Prospective validation of the Barcelona scale for the assessment of mucosal cleanliness during upper gastrointestinal endoscopy Open
Background: Some validated scales for assessing upper gastrointestinal (UGI) cleanliness have been developed, though none have been widely implemented. Objectives: To evaluate the association between the presence of clinically significant …
View article: Effectiveness and safety of first-line empirical Helicobacter pylori eradication regimens in Switzerland: an interim analysis from a prospective multicentre registry (Hp-EuReg)
Effectiveness and safety of first-line empirical Helicobacter pylori eradication regimens in Switzerland: an interim analysis from a prospective multicentre registry (Hp-EuReg) Open
BACKGROUND: Helicobacter pylori infection remains prevalent globally. Despite the relatively low reported prevalence in Switzerland, the actual burden is thought to be higher, primarily due to migration. To date, limited evidence is availa…
View article: <scp> Performance of upper gastrointestinal endoscopy in <i>CDH1</i> germline pathogenic variant carriers </scp> : A multicenter study
<span> Performance of upper gastrointestinal endoscopy in <i>CDH1</i> germline pathogenic variant carriers </span> : A multicenter study Open
Hereditary diffuse gastric cancer (HDGC) is a syndrome primarily caused by pathogenic variants in the CDH1 gene, characterized histologically by the presence of signet ring cell carcinoma (SRCC). This observational multicenter study aimed …
View article: First-Line Prescriptions and Effectiveness of Helicobacter pylori Eradication Treatment in Ireland over a 10-Year Period: Data from the European Registry on Helicobacter pylori Management (Hp-EuReg)
First-Line Prescriptions and Effectiveness of Helicobacter pylori Eradication Treatment in Ireland over a 10-Year Period: Data from the European Registry on Helicobacter pylori Management (Hp-EuReg) Open
Background: Local audits of Helicobacter pylori (H. pylori) prescriptions and outcomes are necessary to assess guideline awareness among clinicians and treatment effectiveness. Aims: The aims were to investigate first-line prescriptions an…
View article: 393MO Overall survival in germline CDH1 pathogenic variant (PV) carriers: A multicenter comparative analysis study
393MO Overall survival in germline CDH1 pathogenic variant (PV) carriers: A multicenter comparative analysis study Open
View article: Experimental Determination of <i>Labidus coecus</i> Army Ant Diet: Novel Evidence for a Feeding Strategy
Experimental Determination of <i>Labidus coecus</i> Army Ant Diet: Novel Evidence for a Feeding Strategy Open
Army ants prey mainly on invertebrates, occasionally attacking vertebrates. However, it remains unclear whether these attacks are defensive or for consumption. By testing the diet of Labidus coecus , we show that they can be attracted to v…
View article: Germline pathogenic variants in <scp><i>HIC1</i> DNA</scp> binding domains are associated with familial serrated polyposis syndrome
Germline pathogenic variants in <span><i>HIC1</i> DNA</span> binding domains are associated with familial serrated polyposis syndrome Open
Serrated polyposis syndrome (SPS) is characterized by multiple and/or large serrated polyps and increased colorectal cancer (CRC) risk. Germline predisposition to SPS is mostly undetermined. We aimed to identify a new inherited SPS predisp…
View article: “The Fish, the Water, That Is Life”
“The Fish, the Water, That Is Life” Open
View article: Influência do uso de telas na qualidade do sono em crianças: Uma revisão da literatura
Influência do uso de telas na qualidade do sono em crianças: Uma revisão da literatura Open
Introdução: O uso excessivo de telas por crianças tem se intensificado significativamente nos últimos anos, gerando preocupações sobre seus impactos no desenvolvimento infantil. Objetivo: Revisar a literatura existente sobre os efeitos do …
View article: Maternal Mortality Due to Abortion in Brazil: A Temporal, Regional, and Sociodemographic Analysis over the Last Three Decades
Maternal Mortality Due to Abortion in Brazil: A Temporal, Regional, and Sociodemographic Analysis over the Last Three Decades Open
Background/Objectives: Maternal mortality due to abortion in Brazil has shown a significant decline of 47.37% between 1996 and 2022. This study aims to analyze temporal trends in maternal mortality due to abortion across regions and sociod…
View article: Discovery and validation of frameshift-derived neopeptides in Lynch syndrome: paving the way for novel cancer prevention strategies
Discovery and validation of frameshift-derived neopeptides in Lynch syndrome: paving the way for novel cancer prevention strategies Open
Background Lynch syndrome (LS), caused by germline pathogenic variants in the mismatch repair genes, leads to high rates of frameshift-derived neopeptide (FSDN) expression due to microsatellite instability (MSI). While colorectal cancer (C…
View article: Metachronous colorectal cancer risks after extended or segmental resection in <i>MLH1</i>, <i>MSH2</i>, and <i>MSH6</i> Lynch syndrome: multicentre study from the Prospective Lynch Syndrome Database
Metachronous colorectal cancer risks after extended or segmental resection in <i>MLH1</i>, <i>MSH2</i>, and <i>MSH6</i> Lynch syndrome: multicentre study from the Prospective Lynch Syndrome Database Open
This first prospective observational study evaluates the impact of extended versus segmental colorectal surgery on the risk of metachronous colorectal cancer (CRC) in patients with Lynch syndrome, analyzing data from the Prospective Lynch …
View article: SÍNDROME PÓS-COVID-19 E RISCO CARDIOVASCULAR: AVALIAÇÃO DO IMPACTO INFLAMATÓRIO CRÔNICO EM PACIENTES RECUPERADOS
SÍNDROME PÓS-COVID-19 E RISCO CARDIOVASCULAR: AVALIAÇÃO DO IMPACTO INFLAMATÓRIO CRÔNICO EM PACIENTES RECUPERADOS Open
A síndrome pós-COVID-19 tem sido amplamente estudada devido aos seus impactos sistêmicos, especialmente no sistema cardiovascular. Evidências sugerem que a infecção pelo SARS-CoV-2 pode desencadear um estado de inflamação crônica persisten…
View article: Regional patterns of early-onset colorectal cancer from the GEOCODE (Global Early-Onset COlorectal Cancer DatabasE)-European consortium: retrospective cohort study
Regional patterns of early-onset colorectal cancer from the GEOCODE (Global Early-Onset COlorectal Cancer DatabasE)-European consortium: retrospective cohort study Open
Background The incidence of early-onset colorectal cancer is increasing, but in Europe this growth shows a heterogeneous pattern in different countries and regions. Methods Patients from six countries who participated in the Global Early-O…
View article: First‐Line Therapy for <scp><i>Helicobacter pylori</i></scp> in Slovenia: Data From 2013 to 2023 of the European Registry on <scp><i>H. pylori</i></scp> Management
First‐Line Therapy for <span><i>Helicobacter pylori</i></span> in Slovenia: Data From 2013 to 2023 of the European Registry on <span><i>H. pylori</i></span> Management Open
Background Treatment is indicated for all Helicobacter pylori infections. However, the best approach for H. pylori management remains unclear. Methods H. pylori eradication data from Hp‐EuReg on treatment‐naive patients in Slovenia from 20…
View article: Germline structural variant as the cause of Lynch Syndrome in a family from Ecuador
Germline structural variant as the cause of Lynch Syndrome in a family from Ecuador Open
View article: Screening for and surveillance of premalignant conditions of the stomach
Screening for and surveillance of premalignant conditions of the stomach Open
Strategies for population-based screening are thus far only implemented in high incidence countries such as South Korea or Japan with data showing a positive impact on gastric cancer mortality. Screening in most Western countries is deemed…
View article: Effectiveness of First-Line Empirical Treatment in Portugal: Data from the European Registry on Helicobacter pylori Management
Effectiveness of First-Line Empirical Treatment in Portugal: Data from the European Registry on Helicobacter pylori Management Open
Introduction: As Portugal exhibits some of the highest gastric cancer rates in Europe, optimizing the Helicobacter pylori eradication rate is imperative. We aimed to describe H. pylori treatment regimens in Portugal, within a real clinical…
View article: Should We Offer Universal Germline Genetic Testing to All Patients with Pancreatic Cancer? A Multicenter Study
Should We Offer Universal Germline Genetic Testing to All Patients with Pancreatic Cancer? A Multicenter Study Open
Background: Pancreatic ductal adenocarcinoma (PDAC) is associated with a significant percentage of germline pathogenic variants (GPVs). Unlike in the United States, routine universal genetic testing is not performed in Europe. The aim of t…
View article: Gastric Epithelial Polyps: Current Diagnosis, Management, and Endoscopic Frontiers
Gastric Epithelial Polyps: Current Diagnosis, Management, and Endoscopic Frontiers Open
Polyps are defined as luminal lesions that project into the mucosal surface of the gastrointestinal tract and are characterized according to their morphological and histological features [...]
View article: Immigrant Health and Early-Onset Colorectal Cancer Disparities: Results From the Spanish Early-Onset Colorectal Cancer Consortium
Immigrant Health and Early-Onset Colorectal Cancer Disparities: Results From the Spanish Early-Onset Colorectal Cancer Consortium Open
PURPOSE To better understand immigration disparities among a Spanish Early-Onset Colorectal Cancer (SECOC) subset, according to the country of origin. PATIENTS AND METHODS We selected 250 consecutive participants from the SECOC consortium.…
View article: Evolution of the use, effectiveness and safety of bismuth-containing quadruple therapy for <i>Helicobacter pylori</i> infection between 2013 and 2021: results from the European registry on <i>H. pylori</i> management (Hp-EuReg)
Evolution of the use, effectiveness and safety of bismuth-containing quadruple therapy for <i>Helicobacter pylori</i> infection between 2013 and 2021: results from the European registry on <i>H. pylori</i> management (Hp-EuReg) Open
Background Bismuth quadruple therapies (BQTs) including bismuth, a proton pump inhibitor (PPI) and two antibiotics have been shown to be highly effective for treating Helicobacter pylori infection even in areas of high bacterial antibiotic…
View article: Indications of <i>Helicobacter pylori</i> Eradication Treatment and Its Influence on Prescriptions and Effectiveness (Hp‐<scp>EuReg</scp>)
Indications of <i>Helicobacter pylori</i> Eradication Treatment and Its Influence on Prescriptions and Effectiveness (Hp‐<span>EuReg</span>) Open
Background The influence of indications for Helicobacter pylori investigation on prescriptions and effectiveness is unknown. The aim of the study was to assess the impact of indications for H. pylori investigation on prescriptions, effecti…
View article: CTNND1 is involved in germline predisposition to early-onset gastric cancer by affecting cell-to-cell interactions
CTNND1 is involved in germline predisposition to early-onset gastric cancer by affecting cell-to-cell interactions Open
Background CDH1 and CTNNA1 remain as the main genes for hereditary gastric cancer. However, they only explain a small fraction of gastric cancer cases with suspected inherited basis. In this study, we aimed to identify new hereditary genes…
View article: Role of compliance in <i>Helicobacter pylori</i> eradication treatment: Results of the European Registry on <i>H. pylori</i> management
Role of compliance in <i>Helicobacter pylori</i> eradication treatment: Results of the European Registry on <i>H. pylori</i> management Open
Background Adherence to Helicobacter pylori (H. pylori) eradication treatment is a cornerstone for achieving adequate treatment efficacy. Objective To determine which factors influence compliance with treatment. Methods A systematic prospe…