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View article: Corrigendum: MicroRNAs as potential regulators of immune response networks in asthma and chronic obstructive pulmonary disease
Corrigendum: MicroRNAs as potential regulators of immune response networks in asthma and chronic obstructive pulmonary disease Open
[This corrects the article DOI: 10.3389/fimmu.2020.608666.].
View article: Selective miRNA inhibition in CD8+ cytotoxic T lymphocytes enhances HIV-1 specific cytotoxic responses
Selective miRNA inhibition in CD8+ cytotoxic T lymphocytes enhances HIV-1 specific cytotoxic responses Open
miRNAs dictate relevant virus-host interactions, offering new avenues for interventions to achieve an HIV remission. We aimed to enhance HIV-specific cytotoxic responses—a hallmark of natural HIV control— by miRNA modulation in T cells. We…
View article: Nasal Tslp and Periostin in Infants With Severe Bronchiolitis and Risk of Asthma at 4 Years of Age
Nasal Tslp and Periostin in Infants With Severe Bronchiolitis and Risk of Asthma at 4 Years of Age Open
Background. Severe bronchiolitis is often associated with subsequent respiratory morbidity, mainly recurrent wheezing and asthma. However, the underlying immune mechanisms remain unclear. The aim of this study was to investigate the associ…
View article: Reduced miR-146a-5p Is a Biomarker of Infant Respiratory Diseases Contributing to Immune Dysregulation in Small Airway Epithelial Cells
Reduced miR-146a-5p Is a Biomarker of Infant Respiratory Diseases Contributing to Immune Dysregulation in Small Airway Epithelial Cells Open
Respiratory diseases such as bronchiolitis, and those with wheezing episodes, are highly important during infancy due to their potential chronicity. Immune response dysregulation is critical in perpetuating lung damage. Epigenetic modifica…
View article: FILAGGRIN AND CYTOKINES IN RESPIRATORY SAMPLES OF PRETERM INFANTS AT VIRAL RESPIRATORY INFECTION RISK
FILAGGRIN AND CYTOKINES IN RESPIRATORY SAMPLES OF PRETERM INFANTS AT VIRAL RESPIRATORY INFECTION RISK Open
Background: Respiratory viral infections (RVIs) are frequent in preterm infants and may have long-term impact on respiratory morbidity, especially those with bronchopulmonary dysplasia (BDP). The immune response and respiratory are key def…
View article: Role of miR‐185‐5p as modulator of periostin synthesis and smooth muscle contraction in asthma
Role of miR‐185‐5p as modulator of periostin synthesis and smooth muscle contraction in asthma Open
Asthma is a chronic respiratory disease produced by an aberrant immune response that originates with breathing difficulties and cough, through airway remodeling. The above pathophysiological events of asthma emerge the regulators of effect…
View article: Serum microRNAs Catalog Asthma Patients by Phenotype
Serum microRNAs Catalog Asthma Patients by Phenotype Open
Background: Asthma is a chronic inflammatory condition of the airways with a complex pathophysiology. Stratification of asthma subtypes into phenotypes and endotypes should move the field forward, making treatment more effective and person…
View article: Emerging Evidence for Pleiotropism of Eosinophils
Emerging Evidence for Pleiotropism of Eosinophils Open
Eosinophils are complex granulocytes with the capacity to react upon diverse stimuli due to their numerous and variable surface receptors, which allows them to respond in very different manners. Traditionally believed to be only part of pa…
View article: Changes in Serum MicroRNAs after Anti-IL-5 Biological Treatment of Severe Asthma
Changes in Serum MicroRNAs after Anti-IL-5 Biological Treatment of Severe Asthma Open
There is currently enough evidence to think that miRNAs play a role in several key points in asthma, including diagnosis, severity of the disease, and response to treatment. Cells release different types of lipid double-membrane vesicles i…
View article: Clinical and inflammatory characteristics of patients with asthma in the Spanish MEGA project cohort
Clinical and inflammatory characteristics of patients with asthma in the Spanish MEGA project cohort Open
Introduction The MEGA (MEchanism underlying the Genesis and evolution of Asthma) project is a multicenter cohort study carried out in eight Spanish hospitals, gathering clinical, physiological, and molecular data from patients with asthma …
View article: Serum microRNAs as Tool to Predict Early Response to Benralizumab in Severe Eosinophilic Asthma
Serum microRNAs as Tool to Predict Early Response to Benralizumab in Severe Eosinophilic Asthma Open
Severe eosinophilic asthma poses a serious health and economic problem, so new therapy approaches have been developed to control it, including biological drugs such as benralizumab, which is a monoclonal antibody that binds to IL-5 recepto…
View article: Exosomes: A Key Piece in Asthmatic Inflammation
Exosomes: A Key Piece in Asthmatic Inflammation Open
Asthma is a chronic disease of the airways that has an important inflammatory component. Multiple cells are implicated in asthma pathogenesis (lymphocytes, eosinophils, mast cells, basophils, neutrophils), releasing a wide variety of cytok…
View article: MicroRNAs as Potential Regulators of Immune Response Networks in Asthma and Chronic Obstructive Pulmonary Disease
MicroRNAs as Potential Regulators of Immune Response Networks in Asthma and Chronic Obstructive Pulmonary Disease Open
Chronic respiratory diseases (CRDs) are an important factor of morbidity and mortality, accounting for approximately 6% of total deaths worldwide. The main CRDs are asthma and chronic obstructive pulmonary disease (COPD). These complex dis…
View article: The excellent biocompatibility and negligible immune response of the titanium heterometallic MOF MUV-10
The excellent biocompatibility and negligible immune response of the titanium heterometallic MOF MUV-10 Open
MUV-10 exhibits slow physiological degradation kinetics, good dispersibility, high biomolecular loading and excellent immune system biocompatibility.
View article: Proton‐pump Inhibitor Response Prediction Using Esophageal microRNAs in Children With Eosinophilic Esophagitis
Proton‐pump Inhibitor Response Prediction Using Esophageal microRNAs in Children With Eosinophilic Esophagitis Open
Objectives: Eosinophilic esophagitis (EoE) is a chronic esophageal disease characterized by eosinophilic inflammation. Proton‐pump inhibitors (PPI) induce disease remission but no predictive factors of PPI‐responsiveness have been identifi…
View article: Bronchiolitis and recurrent wheezing are distinguished by type 2 innate lymphoid cells and immune response
Bronchiolitis and recurrent wheezing are distinguished by type 2 innate lymphoid cells and immune response Open
Background Recurrent wheezing (RW) is frequently developed in infants that have suffered bronchiolitis (BCH) during first months of life, but the immune mechanism underlying is not clear. The goal was to analyze the innate immune response …
View article: Eosinophil Response Against Classical and Emerging Respiratory Viruses: COVID-19
Eosinophil Response Against Classical and Emerging Respiratory Viruses: COVID-19 Open
Eosinophils were discovered more than 140 years ago. These polymorphonuclear leukocytes have a very active metabolism and contain numerous intracellular secretory granules that enable multiple effects on both health and disease status. Cla…
View article: Stability of Asthma Control Implies No Changes in microRNAs Expression
Stability of Asthma Control Implies No Changes in microRNAs Expression Open
Supplementary Table 1.Clinical characteristics of asthmatic patients at baseline and follow-up.Patient Sex Age Ethnicity FeNO baseline IgE total (kU/L) baseline Peripheral blood eosinophils (nº cell/mm 3 ) Atopy Atopic dermatitis ACT basel…
View article: Eosinophils: Old Players in a New Game
Eosinophils: Old Players in a New Game Open
Eosinophils are terminal polymorphonuclear cells with a high number of cytoplasmic granules that originate in bone marrow. Some are exosomes, which contain multiple molecules, such as specific eosinophilic proteins, cytokines, chemokines, …
View article: Maraviroc Is Associated with Latent HIV-1 Reactivation through NF-κB Activation in Resting CD4<sup>+</sup>T Cells from HIV-Infected Individuals on Suppressive Antiretroviral Therapy
Maraviroc Is Associated with Latent HIV-1 Reactivation through NF-κB Activation in Resting CD4<sup>+</sup>T Cells from HIV-Infected Individuals on Suppressive Antiretroviral Therapy Open
Maraviroc is a CCR5 antagonist used in the treatment of HIV-1 infection. We and others have suggested that maraviroc could reactivate latent HIV-1. To test the latency-reversing potential of maraviroc and the mechanisms involved, we perfor…
View article: Novel Modulators of Asthma and Allergy: Exosomes and MicroRNAs
Novel Modulators of Asthma and Allergy: Exosomes and MicroRNAs Open
Intercellular communication is crucial to the immune system response. In the recent years, the discovery of exosomes has changed the way immune response orchestration was understood. Exosomes are able to operate as independent units that a…
View article: Thymic stromal lymphopoietin, IL-33, and periostin in hospitalized infants with viral bronchiolitis
Thymic stromal lymphopoietin, IL-33, and periostin in hospitalized infants with viral bronchiolitis Open
Much attention has recently been focused on thymic stromal lymphopoietin (TSLP), IL-33, and periostin in allergic disease, but less is known about their role in viral bronchiolitis.The aim of the study was to investigate whether infants ex…