Bee‐Ha Gan
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View article: β-Lactamase cleavable antimicrobial peptide–drug conjugates
β-Lactamase cleavable antimicrobial peptide–drug conjugates Open
From a series of peptides, the most promising was developed into a stapled conjugate, with a ciprofloxacin prodrug attached to the staple via a cephalosporin linker. Factors influencing antibacterial activity and drug release were investig…
View article: Stereorandomized Oncocins with Preserved Ribosome Binding and Antibacterial Activity
Stereorandomized Oncocins with Preserved Ribosome Binding and Antibacterial Activity Open
We recently showed that solid-phase peptide synthesis using racemic amino acids yields stereorandomized peptides comprising all possible diastereomers as homogeneous, single-mass products that can be purified by HPLC and that stereorandomi…
View article: Highly Potent Cationic Chitosan Derivatives Coupled to Antimicrobial Peptide Dendrimers to Combat <i>Pseudomonas aeruginosa</i>
Highly Potent Cationic Chitosan Derivatives Coupled to Antimicrobial Peptide Dendrimers to Combat <i>Pseudomonas aeruginosa</i> Open
The burden of bacterial wound infections has considerably increased due to antibiotic resistance to most of the currently available antimicrobial drugs. Herein, for the first time, a chemical coupling of two cationic N ‐aryl (pyridyl and a…
View article: Antimicrobial Peptide–Peptoid Hybrids with and without Membrane Disruption
Antimicrobial Peptide–Peptoid Hybrids with and without Membrane Disruption Open
Among synthetic analogues of antimicrobial peptides (AMPs) under investigation to address antimicrobial resistance, peptoids (N-alkylated oligoglycines) have been reported to act both by membrane disruption and on intracellular targets. He…
View article: Correction: The multifaceted nature of antimicrobial peptides: current synthetic chemistry approaches and future directions
Correction: The multifaceted nature of antimicrobial peptides: current synthetic chemistry approaches and future directions Open
Correction for ‘The multifaceted nature of antimicrobial peptides: current synthetic chemistry approaches and future directions’ by Bee Ha Gan et al. , Chem. Soc. Rev. , 2021, 50 , 7820–7880, DOI: 10.1039/D0CS00729C.
View article: Dataset for: Stereorandomization as a Method to Probe Peptide Bioactivity
Dataset for: Stereorandomization as a Method to Probe Peptide Bioactivity Open
The upload contains additional primary data associated with the publication, including raw data in the original file format whenever possible. Data content: HRMS, HPLC-MS, CD, MD, TEM, Serum stability, Vesicle leakage assay, Cytotoxicity, …
View article: Dataset for: Stereorandomization as a Method to Probe Peptide Bioactivity
Dataset for: Stereorandomization as a Method to Probe Peptide Bioactivity Open
The upload contains additional primary data associated with the publication, including raw data in the original file format whenever possible. Data content: HRMS, HPLC-MS, CD, MD, TEM, Serum stability, Vesicle leakage assay, Cytotoxicity, …
View article: Dataset for: The antibacterial activity of peptide dendrimers and polymyxin B increases sharply above pH 7.4
Dataset for: The antibacterial activity of peptide dendrimers and polymyxin B increases sharply above pH 7.4 Open
The upload contains additional primary data associated with the publication, including raw data in the original file format whenever possible. Data content: HRMS, HPLC-MS, pH titration, CD, MD, TEM
View article: Dataset for: The antibacterial activity of peptide dendrimers and polymyxin B increases sharply above pH 7.4
Dataset for: The antibacterial activity of peptide dendrimers and polymyxin B increases sharply above pH 7.4 Open
The upload contains additional primary data associated with the publication, including raw data in the original file format whenever possible. Data content: HRMS, HPLC-MS, pH titration, CD, MD, TEM
View article: A Study with Peptide Dendrimers Reveals an Extreme pH Dependence of Antibiotic Activity Above pH 7.4
A Study with Peptide Dendrimers Reveals an Extreme pH Dependence of Antibiotic Activity Above pH 7.4 Open
The presence of ionizable groups in antimicrobial peptides (AMPs) often induces a pH-dependent activity. Herein we report that removing eight low p K a amino termini in antimicrobial peptide dendrimer (AMPD) G3KL provides dendrimer XC1 wit…
View article: A Study with Peptide Dendrimers Reveals an Extreme pH Dependence of Antibiotic Activity Above pH 7.4
A Study with Peptide Dendrimers Reveals an Extreme pH Dependence of Antibiotic Activity Above pH 7.4 Open
In our efforts to develop peptide dendrimers as a new class of antimicrobial peptides (AMPs) against Gram-negative bacteria, we investigated their activity at acidic and basic pH, which correspond to the conditions of the site of bacterial…
View article: A Study with Peptide Dendrimers Reveals an Extreme pH Dependence of Antibiotic Activity Above pH 7.4
A Study with Peptide Dendrimers Reveals an Extreme pH Dependence of Antibiotic Activity Above pH 7.4 Open
In our efforts to develop peptide dendrimers as a new class of antimicrobial peptides (AMPs) against Gram-negative bacteria, we investigated their activity at acidic and basic pH, which correspond to the conditions of the site of bacterial…
View article: A Study with Peptide Dendrimers Reveals an Extreme pH Dependence of Antibiotic Activity Above pH 7.4
A Study with Peptide Dendrimers Reveals an Extreme pH Dependence of Antibiotic Activity Above pH 7.4 Open
The presence of ionizable groups in antimicrobial peptides (AMPs) often induces a pH-dependent activity. Herein we report that removing eight low pKa amino termini in antimicrobial peptide dendrimer (AMPD) G3KL provides dendrimer XC1 with …
View article: Stereorandomization as a Method to Probe Peptide Bioactivity
Stereorandomization as a Method to Probe Peptide Bioactivity Open
Solid-phase peptide synthesis (SPPS) is usually performed with optically pure building blocks to prepare peptides as single enantiomers. Herein we report that SPPS using racemic amino acids provides stereorandomized (sr) peptides, containi…
View article: The antibacterial activity of peptide dendrimers and polymyxin B increases sharply above pH 7.4
The antibacterial activity of peptide dendrimers and polymyxin B increases sharply above pH 7.4 Open
A previously unknown pH-effect on the antimicrobial activity of peptide dendrimers and polymyxin B against Klebsiella pneumoniae and MRSA is reported.
View article: The multifaceted nature of antimicrobial peptides: current synthetic chemistry approaches and future directions
The multifaceted nature of antimicrobial peptides: current synthetic chemistry approaches and future directions Open
This review discusses the diversity of structure and physicochemical properties of antimicrobial peptides and their derivatives, various chemical synthetic strategies that have been applied in their development, and how this links to their…
View article: Stereorandomization as a Method to Probe Peptide Bioactivity
Stereorandomization as a Method to Probe Peptide Bioactivity Open
Solid-phase peptide synthesis (SPPS) is usually performed with optically pure building blocks to prepare peptides as single enantiomers. Herein we report that SPPS using racemic amino acids provides stereorandomized (sr) peptides, containi…
View article: Stereorandomization as a Method to Probe Peptide Bioactivity
Stereorandomization as a Method to Probe Peptide Bioactivity Open
Solid-phase peptide synthesis (SPPS) is usually performed with optically pure building blocks to prepare peptides as single enantiomers. Herein we report that SPPS using racemic amino acids provides stereorandomized ( sr ) peptides, contai…
View article: Synergistic Effect of Propidium Iodide and Small Molecule Antibiotics with the Antimicrobial Peptide Dendrimer G3KL against Gram-Negative Bacteria
Synergistic Effect of Propidium Iodide and Small Molecule Antibiotics with the Antimicrobial Peptide Dendrimer G3KL against Gram-Negative Bacteria Open
There is an urgent need to develop new antibiotics against multidrug-resistant bacteria. Many antimicrobial peptides (AMPs) are active against such bacteria and often act by destabilizing membranes, a mechanism that can also be used to per…
View article: Chemo-enzymatic synthesis of lipid-linked GlcNAc2Man5 oligosaccharides using recombinant Alg1, Alg2 and Alg11 proteins
Chemo-enzymatic synthesis of lipid-linked GlcNAc2Man5 oligosaccharides using recombinant Alg1, Alg2 and Alg11 proteins Open
The biosynthesis of eukaryotic lipid-linked oligosaccharides (LLOs) that act as donor substrates in eukaryotic protein N-glycosylation starts on the cytoplasmic side of the endoplasmic reticulum and includes the sequential addition of five…
View article: Characterization of the single-subunit oligosaccharyltransferase STT3A from Trypanosoma brucei using synthetic peptides and lipid-linked oligosaccharide analogs
Characterization of the single-subunit oligosaccharyltransferase STT3A from Trypanosoma brucei using synthetic peptides and lipid-linked oligosaccharide analogs Open
The initial transfer of a complex glycan in protein N-glycosylation is catalyzed by oligosaccharyltransferase (OST), which is generally a multisubunit membrane protein complex in the endoplasmic reticulum but a single-subunit enzyme (ssOST…
View article: Chemical space guided discovery of antimicrobial bridged bicyclic peptides against Pseudomonas aeruginosa and its biofilms
Chemical space guided discovery of antimicrobial bridged bicyclic peptides against Pseudomonas aeruginosa and its biofilms Open
Here we used a new strategy for exploring the peptide chemical space to discover bicyclic antimicrobial peptides.
View article: Design, crystal structure and atomic force microscopy study of thioether ligated<scp>d</scp>,<scp>l</scp>-cyclic antimicrobial peptides against multidrug resistant Pseudomonas aeruginosa
Design, crystal structure and atomic force microscopy study of thioether ligated<span>d</span>,<span>l</span>-cyclic antimicrobial peptides against multidrug resistant Pseudomonas aeruginosa Open
A new family of cyclic antimicrobial peptides is reported targeting multidrug resistantPseudomonas aeruginosaby membrane disruption.