Begoña Aguado
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View article: Microbial Complexes in Subgingival Plaque: A Bacterial Meta‐Taxonomic Study
Microbial Complexes in Subgingival Plaque: A Bacterial Meta‐Taxonomic Study Open
Aim To leverage technological advances to propose a more accurate representation of subgingival microbiota diversity and dynamics across health and disease, 25 years after the seminal and still authoritative contribution of Socransky and h…
View article: The expanding avian influenza panzootic: skua die-off in Antarctica
The expanding avian influenza panzootic: skua die-off in Antarctica Open
High pathogenicity avian influenza virus of subtype H5 (H5 HPAIV), clade 2.3.4.4b, invaded Antarctica in 2023. Here we show that H5 HPAIV caused high mortality in a breeding colony of skuas at one of ten sites we visited in March 2024. By …
View article: Loss of Cldn5 -and increase in Irf7-in the hippocampus and cerebral cortex of diabetic mice at the early symptomatic stage
Loss of Cldn5 -and increase in Irf7-in the hippocampus and cerebral cortex of diabetic mice at the early symptomatic stage Open
Analyzing changes in gene expression within specific brain regions of individuals with Type 2 Diabetes (T2DM) who do not exhibit significant cognitive deficits can yield valuable insights into the mechanisms underlying the progression towa…
View article: A Proteogenomic Approach to Unravel New Proteins Encoded in the Leishmania donovani (HU3) Genome
A Proteogenomic Approach to Unravel New Proteins Encoded in the Leishmania donovani (HU3) Genome Open
The high-throughput proteomics data generated by increasingly more sensible mass spectrometers greatly contribute to our better understanding of molecular and cellular mechanisms operating in live beings. Nevertheless, proteomics analyses …
View article: Datasets of Iso-Seq transcripts for decoding transcriptome complexity in four Leishmania species
Datasets of Iso-Seq transcripts for decoding transcriptome complexity in four Leishmania species Open
The Iso-Seq technology, based on PacBio sequencing, enables the generation of high-quality, full-length transcripts, providing insights into transcriptome complexity. In this study, total RNA from promastigotes of four Leishmania sp…
View article: LOSS OF CLDN5 -AND INCREASE IN IRF7- IN THE HIPPOCAMPUS AND CEREBRAL CORTEX OF DIABETIC MICE AT THE EARLY SYMPTOMATIC STAGE
LOSS OF CLDN5 -AND INCREASE IN IRF7- IN THE HIPPOCAMPUS AND CEREBRAL CORTEX OF DIABETIC MICE AT THE EARLY SYMPTOMATIC STAGE Open
Analyzing changes in gene expression within specific brain regions of individuals with Type 2 Diabetes (T2DM) who do not exhibit significant cognitive deficits can yield valuable insights into the mechanisms that may underlie the progressi…
View article: Refinement of Leishmania donovani Genome Annotations in the Light of Ribosome-Protected mRNAs Fragments (Ribo-Seq Data)
Refinement of Leishmania donovani Genome Annotations in the Light of Ribosome-Protected mRNAs Fragments (Ribo-Seq Data) Open
Advances in next-generation sequencing methodologies have facilitated the assembly of an ever-increasing number of genomes. Gene annotations are typically conducted via specialized software, but the most accurate results require additional…
View article: Cognitive decline in diabetic mice predisposed to Alzheimer’s disease is greater than in wild type
Cognitive decline in diabetic mice predisposed to Alzheimer’s disease is greater than in wild type Open
In this work, we tested the hypothesis that the development of dementia in individuals with type 2 diabetes (T2DM) requires a genetic background of predisposition to neurodegenerative disease. As a proof of concept, we induced T2DM in midd…
View article: Leishmania infantum (JPCM5) Transcriptome, Gene Models and Resources for an Active Curation of Gene Annotations
Leishmania infantum (JPCM5) Transcriptome, Gene Models and Resources for an Active Curation of Gene Annotations Open
Leishmania infantum is one of the causative agents of visceral leishmaniases, the most severe form of leishmaniasis. An improved assembly for the L. infantum genome was published five years ago, yet delineation of its transcriptome remaine…
View article: Datasets of Iso-Seq Transcripts for Decoding Transcriptome Complexity in Four Leishmania Species
Datasets of Iso-Seq Transcripts for Decoding Transcriptome Complexity in Four Leishmania Species Open
View article: Assembly of a Large Collection of Maxicircle Sequences and Their Usefulness for Leishmania Taxonomy and Strain Typing
Assembly of a Large Collection of Maxicircle Sequences and Their Usefulness for Leishmania Taxonomy and Strain Typing Open
Parasites of medical importance, such as Leishmania and Trypanosoma, are characterized by the presence of thousands of circular DNA molecules forming a structure known as kinetoplast, within the mitochondria. The maxicircles, which are equ…
View article: The Astonishing Large Family of HSP40/DnaJ Proteins Existing in Leishmania
The Astonishing Large Family of HSP40/DnaJ Proteins Existing in Leishmania Open
Abrupt environmental changes are faced by Leishmania parasites during transmission from a poikilothermic insect vector to a warm-blooded host. Adaptation to harsh environmental conditions, such as nutrient deprivation, hypoxia, oxidative s…
View article: Gene Annotation and Transcriptome Delineation on a De Novo Genome Assembly for the Reference Leishmania major Friedlin Strain
Gene Annotation and Transcriptome Delineation on a De Novo Genome Assembly for the Reference Leishmania major Friedlin Strain Open
Leishmania major is the main causative agent of cutaneous leishmaniasis in humans. The Friedlin strain of this species (LmjF) was chosen when a multi-laboratory consortium undertook the objective of deciphering the first genome sequence fo…
View article: Gene Annotation and Transcriptome Delineation on a <em>de novo</em> Genome Assembly for the Reference <em>Leishmania major</em> Friedlin Strain
Gene Annotation and Transcriptome Delineation on a <em>de novo</em> Genome Assembly for the Reference <em>Leishmania major</em> Friedlin Strain Open
Leishmania major is the main causative agent of cutaneous leishmaniasis in humans. The Friedlin strain of this species (LmjF) was chosen when a multi-laboratory consortium undertook the objective of deciphering the first genome sequence fo…
View article: Variability of the Pr77 sequence of L1Tc retrotransposon among six T. cruzi strains belonging to different discrete typing units (DTUs)
Variability of the Pr77 sequence of L1Tc retrotransposon among six T. cruzi strains belonging to different discrete typing units (DTUs) Open
View article: ARAMIS: From systematic errors of NGS long reads to accurate assemblies
ARAMIS: From systematic errors of NGS long reads to accurate assemblies Open
NGS long-reads sequencing technologies (or third generation) such as Pacific BioSciences (PacBio) have revolutionized the sequencing field over the last decade improving multiple genomic applications like de novo genome assemblies. However…
View article: Proteins interacting with Leishmania major PUF1: A proteomic dataset
Proteins interacting with Leishmania major PUF1: A proteomic dataset Open
View article: The Experimental Proteome of Leishmania infantum Promastigote and Its Usefulness for Improving Gene Annotations
The Experimental Proteome of Leishmania infantum Promastigote and Its Usefulness for Improving Gene Annotations Open
Leishmania infantum causes visceral leishmaniasis (kala-azar), the most severe form of leishmaniasis, which is lethal if untreated. A few years ago, the re-sequencing and de novo assembling of the L. infantum (JPCM5 strain) genome was acco…
View article: The Experimental Proteome of Leishmania infantum promastigote and Its Usefulness for Improving Gene Annotations
The Experimental Proteome of Leishmania infantum promastigote and Its Usefulness for Improving Gene Annotations Open
Leishmania infantum is causative of visceral leishmaniasis (kala-azar), the most severe form of leishmaniasis, lethal if untreated. Few years ago, re-sequencing and de novo assembling of the L. infantum (strain JPCM5) genome was accomplish…
View article: Liquid biopsy by NGS: Differential presence of exons (DPE) is related to metastatic potential in a colon-cancer model in the rat
Liquid biopsy by NGS: Differential presence of exons (DPE) is related to metastatic potential in a colon-cancer model in the rat Open
View article: Trypanosoma cruzi Ikiakarora (TcIII) Draft Genome Sequence
Trypanosoma cruzi Ikiakarora (TcIII) Draft Genome Sequence Open
Trypanosoma cruzi shows a genetic diversity that has been associated with the variability of clinical manifestations, geographical distribution, and preferential parasite-vector interactions. In an effort to better understand this genetic …
View article: SO007OVERHYDRATION TREATMENT WITH COMBINED CRYSTALLOID AND COLLOID PD SOLUTION
SO007OVERHYDRATION TREATMENT WITH COMBINED CRYSTALLOID AND COLLOID PD SOLUTION Open
Background and Aims Peritoneal dialysis (PD) fluids used colloid or crystalloid solutions to achieve ultrafiltration. Here we presented our clinical experience with the intraperitoneal (IP) use of mixed solutions (MS) (crystalloid plus col…
View article: Draft Genome Sequence of the Trypanosoma cruzi B. M. López Strain (TcIa), Isolated from a Colombian Patient
Draft Genome Sequence of the Trypanosoma cruzi B. M. López Strain (TcIa), Isolated from a Colombian Patient Open
Trypanosoma cruzi parasite strains are classified into six lineages (discrete typing units TcI to TcVI). The broad genetic diversity of T. cruzi strains has an influence on the development of the host response and pathogenesis, as well as …
View article: Leishmania Mitochondrial Genomes: Maxicircle Structure and Heterogeneity of Minicircles
Leishmania Mitochondrial Genomes: Maxicircle Structure and Heterogeneity of Minicircles Open
The mitochondrial DNA (mtDNA), which is present in almost all eukaryotic organisms, is a useful marker for phylogenetic studies due to its relative high conservation and its inheritance manner. In Leishmania and other trypanosomatids, the …
View article: Analysis by RNA-seq of transcriptomic changes elicited by heat shock in Leishmania major
Analysis by RNA-seq of transcriptomic changes elicited by heat shock in Leishmania major Open
View article: Complete assembly of the Leishmania donovani (HU3 strain) genome and transcriptome annotation
Complete assembly of the Leishmania donovani (HU3 strain) genome and transcriptome annotation Open
View article: Complete and de novo assembly of the Leishmania braziliensis (M2904) genome
Complete and de novo assembly of the Leishmania braziliensis (M2904) genome Open
Leishmania braziliensis is the etiological agent of American mucosal leishmaniasis, one of the most severe clinical forms of leishmaniasis. Here, we report the assembly of the L. braziliensis (M2904) genome into 35 continuous chromosomes. …
View article: Genomic and transcriptomic alterations in Leishmania donovani lines experimentally resistant to antileishmanial drugs
Genomic and transcriptomic alterations in Leishmania donovani lines experimentally resistant to antileishmanial drugs Open
View article: Liquid biopsy by <scp>NGS</scp>: differential presence of exons (<scp>DPE</scp>) in cell‐free <scp>DNA</scp> reveals different patterns in metastatic and nonmetastatic colorectal cancer
Liquid biopsy by <span>NGS</span>: differential presence of exons (<span>DPE</span>) in cell‐free <span>DNA</span> reveals different patterns in metastatic and nonmetastatic colorectal cancer Open
Next‐generation sequencing ( NGS ) has been proposed as a suitable tool for liquid biopsy in colorectal cancer ( CRC ), although most studies to date have focused almost exclusively on sequencing of panels of potential clinically actionabl…
View article: Deep-Sequencing Analysis of the Dynamics of HIV-1 Quasiespecies in Naive Patients during a Short Exposure to Maraviroc
Deep-Sequencing Analysis of the Dynamics of HIV-1 Quasiespecies in Naive Patients during a Short Exposure to Maraviroc Open
In this study, we have characterized quasispecies dynamics and the evolution of viral tropism in naive HIV-1-infected patients treated with a short course of maraviroc monotherapy (ClinicalTrials.gov registration no. NCT01060618) independe…