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View article: Epithelial cells provide immunocompetence to the early embryo for bacterial clearance
Epithelial cells provide immunocompetence to the early embryo for bacterial clearance Open
Early embryos are exposed to environmental perturbations that may influence their development, including bacteria. Despite lacking a proper immune system, the surface epithelium of early embryos (trophectoderm in mammals) can phagocytose d…
View article: iPSC-based merlin-deficient Schwann cell-like spheroids as an in vitro system for studying NF2 pathogenesis
iPSC-based merlin-deficient Schwann cell-like spheroids as an in vitro system for studying NF2 pathogenesis Open
View article: Generation of the CTRL EiPS J9 mR6F-8 iPSC line derived from healthy human outgrowth blood endothelial cells (BOECs) using mRNA reprogramming methodology
Generation of the CTRL EiPS J9 mR6F-8 iPSC line derived from healthy human outgrowth blood endothelial cells (BOECs) using mRNA reprogramming methodology Open
mRNA reprogramming is a technology for generating iPSCs with high efficiency and safety. However, it is not suitable for reprogramming non-adherent cells, the primary cell type in blood. An alternative is to obtain adherent cells from bloo…
View article: The pluripotency state of human embryonic stem cells derived from single blastomeres of eight-cell embryos
The pluripotency state of human embryonic stem cells derived from single blastomeres of eight-cell embryos Open
View article: Unlocking the full potential of human induced pluripotent stem cells from haplo-selected cord blood samples—the how and the why
Unlocking the full potential of human induced pluripotent stem cells from haplo-selected cord blood samples—the how and the why Open
There is a critical need worldwide for tissue for transplantation in patients with organ failure and with degenerative diseases with no treatments available. Cell therapy can represent an alternative to organ transplantation and for the tr…
View article: Generation of a bank of clinical-grade, HLA-homozygous iPSC lines with high coverage of the Spanish population
Generation of a bank of clinical-grade, HLA-homozygous iPSC lines with high coverage of the Spanish population Open
Background Induced pluripotent stem cell (iPSC)-derived cell therapies are an interesting new area in the field of regenerative medicine. One of the approaches to decrease the costs of iPSC-derived therapies is the use of allogenic homozyg…
View article: Generation of the induced pluripotent stem cell line ESi108-A from a familial atrial fibrillation patient
Generation of the induced pluripotent stem cell line ESi108-A from a familial atrial fibrillation patient Open
Tissue-specific cells differentiated from patient-derived human induced pluripotent stem cells (hiPSC) are a relevant cellular model to study several diseases. We obtained a hiPSC line from skin fibroblasts of a patient affected by familia…
View article: 151 Type-2 inflammation transcript expression in cystic fibrosis
151 Type-2 inflammation transcript expression in cystic fibrosis Open
View article: Generation of an induced pluripotent stem cell line (ESi107-A) from a transthyretin amyloid cardiomyopathy (ATTR-CM) patient carrying a p.Ser43Asn mutation in the TTR gene
Generation of an induced pluripotent stem cell line (ESi107-A) from a transthyretin amyloid cardiomyopathy (ATTR-CM) patient carrying a p.Ser43Asn mutation in the TTR gene Open
Transthyretin (TTR) amyloid cardiomyopathy (ATTR-CM) is a life-threatening disease caused by the abnormal production of misfolded TTR protein by liver cells, which is then released systemically. Its amyloid deposition in the heart is linke…
View article: Generation of a bank of clinical-grade, HLA homozygous iPSC lines with high coverage of the Spanish population
Generation of a bank of clinical-grade, HLA homozygous iPSC lines with high coverage of the Spanish population Open
Background: Induced Pluripotent Stem Cells (iPSC) derived cell therapies are an interesting new area in the field of regenerative medicine. One of the approaches to decrease costs of iPSC derived therapies is the use of allogenic homozygou…
View article: MERLIN-DEFICIENT iPSCs AS AN<i>IN VITRO</i>MODEL SYSTEM FOR STUDIYNG<i>NF2</i>PATHOGENESIS
MERLIN-DEFICIENT iPSCs AS AN<i>IN VITRO</i>MODEL SYSTEM FOR STUDIYNG<i>NF2</i>PATHOGENESIS Open
NF2-related schwannomatosis is an autosomal dominant syndrome that predisposes to the development of benign tumors of the nervous system. Schwannomas, particularly bilateral vestibular schwannomas (VS), are the most characteristic features…
View article: Generation of four induced pluripotent stem cell lines from a family harboring a single nucleotide variant in SCN5A
Generation of four induced pluripotent stem cell lines from a family harboring a single nucleotide variant in SCN5A Open
View article: Generation of an induced pluripotent stem cell line from a healthy Caucasian male
Generation of an induced pluripotent stem cell line from a healthy Caucasian male Open
The effects of genetic mutations on protein function can be studied in a physiologically relevant environment using tissue-specific cells differentiated from patient-derived induced pluripotent stem cells (iPSC). However, it is crucial to …
View article: Transplantation of Human Induced Pluripotent Stem Cell-Derived Retinal Pigment Epithelium in a Swine Model of Geographic Atrophy
Transplantation of Human Induced Pluripotent Stem Cell-Derived Retinal Pigment Epithelium in a Swine Model of Geographic Atrophy Open
Background: The aim of this study was to test the feasibility and safety of subretinal transplantation of human induced pluripotent stem cell (hiPSC)-derived retinal pigment epithelium (RPE) cells into the healthy margins and within areas …
View article: Derivation of induced pluripotent stem cells (iPSCs) by retroviral transduction of skin fibroblasts from four patients suffering 7q11.23 microduplication syndrome
Derivation of induced pluripotent stem cells (iPSCs) by retroviral transduction of skin fibroblasts from four patients suffering 7q11.23 microduplication syndrome Open
View article: Generation of induced pluripotent stem cells (iPSCs) by retroviral transduction of skin fibroblasts from four patients suffering Williams-Beuren syndrome (7q11.23 deletion)
Generation of induced pluripotent stem cells (iPSCs) by retroviral transduction of skin fibroblasts from four patients suffering Williams-Beuren syndrome (7q11.23 deletion) Open
Skin fibroblasts were obtained from four patients with Williams-Beuren syndrome (WBS) carrying the typical 1.5 Mb or 1.8 Mb deletion at the 7q11.23 genomic region. Induced pluripotent stem cells (iPSCs) were generated by retroviral infecti…
View article: Pluripotent stem cell regulation in Spain and the Spanish National Stem Cell Bank
Pluripotent stem cell regulation in Spain and the Spanish National Stem Cell Bank Open
The Spanish National Stem Cell Bank (Banco Nacional de Líneas Celulares, BNLC) was established in 2006 thanks to a change in the legislative framework in Spain. The Law 14/2006 updated the previous Assisted Reproduction Techniques Law (Law…
View article: Access to stem cell data and registration of pluripotent cell lines: The Human Pluripotent Stem Cell Registry (hPSCreg)
Access to stem cell data and registration of pluripotent cell lines: The Human Pluripotent Stem Cell Registry (hPSCreg) Open
View article: Two decades of embryonic stem cells: a historical overview
Two decades of embryonic stem cells: a historical overview Open
Not applicable.ESHRE Pages are not externally peer reviewed. This article has been approved by the Executive Committee of ESHRE.
View article: Integration-free induced pluripotent stem cells derived from a patient with autosomal recessive Alport syndrome (ARAS)
Integration-free induced pluripotent stem cells derived from a patient with autosomal recessive Alport syndrome (ARAS) Open
View article: Generation of integration-free induced pluripotent stem cell lines derived from two patients with X-linked Alport syndrome (XLAS)
Generation of integration-free induced pluripotent stem cell lines derived from two patients with X-linked Alport syndrome (XLAS) Open
Skin biopsies were obtained from two male patients with X-linked Alport syndrome (XLAS) with hemizygous COL4A5 mutations in exon 41 or exon 46. Dermal fibroblasts were extracted and reprogrammed by nucleofection with episomal plasmids carr…
View article: Generation of six multiple sclerosis patient-derived induced pluripotent stem cell lines
Generation of six multiple sclerosis patient-derived induced pluripotent stem cell lines Open