Chaw Yee Beh
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View article: Gut microbiota-derived formate exacerbates pulmonary metastasis in cancer
Gut microbiota-derived formate exacerbates pulmonary metastasis in cancer Open
Rationale: The gut microbiota and its metabolites significantly influence cancer development and metastasis. Among these, formate, the simplest short-chain fatty acid (SCFA), remains underexplored in the context of metastasis. This study i…
View article: Genomic and transcriptomic profiling of radioresistant prostate and head and neck cancers implicate a BAHD1-dependent modification of DNA damage at the heterochromatin
Genomic and transcriptomic profiling of radioresistant prostate and head and neck cancers implicate a BAHD1-dependent modification of DNA damage at the heterochromatin Open
Radiotherapy is an integral modality in treating human cancers, but radioresistance remains a clinical challenge due to the involvement of multiple intrinsic cellular and extrinsic tumour microenvironment factors that govern radiosensitivi…
View article: Depletion of gut microbiota improves the therapeutic efficacy of cancer nanomedicine
Depletion of gut microbiota improves the therapeutic efficacy of cancer nanomedicine Open
Rationale: Gut microbiota plays a crucial role in cancer development and treatment. Studies show that although the gut microbiota is able to promote tumor growth, its presence also improves the efficacy of cancer treatment such as immunoth…
View article: Advances in Biomimetic Nanoparticles for Targeted Cancer Therapy and Diagnosis
Advances in Biomimetic Nanoparticles for Targeted Cancer Therapy and Diagnosis Open
Biomimetic nanoparticles have recently emerged as a novel drug delivery platform to improve drug biocompatibility and specificity at the desired disease site, especially the tumour microenvironment. Conventional nanoparticles often encount…
View article: Immune cell shuttle for precise delivery of nanotherapeutics for heart disease and cancer
Immune cell shuttle for precise delivery of nanotherapeutics for heart disease and cancer Open
Aptamer-based nanovectors that actively bind to circulating monocytes enhance drug delivery to the heart and to cancer.
View article: Enhanced anti-mammary gland cancer activities of tamoxifen-loaded erythropoietin-coated drug delivery system
Enhanced anti-mammary gland cancer activities of tamoxifen-loaded erythropoietin-coated drug delivery system Open
Nanomedicine is an emerging area in the medical field, particularly in the treatment of cancers. Nanostructured lipid carrier (NLC) was shown to be a good nanoparticulated carrier for the delivery of tamoxifen (TAM). In this study, the tam…
View article: Induction of cell cycle arrest and apoptosis by copper complex Cu(SBCM)<sub>2</sub> towards oestrogen-receptor positive MCF-7 breast cancer cells
Induction of cell cycle arrest and apoptosis by copper complex Cu(SBCM)<sub>2</sub> towards oestrogen-receptor positive MCF-7 breast cancer cells Open
Cu(SBCM)2 binds to DNA topoisomerase I, which, in turn, induces cell cycle arrest and apoptosis in MCF-7 breast cancer cells, possibly via p53 signalling pathway.
View article: Zerumbone-Loaded Nanostructured Lipid Carrier Induces Apoptosis of Canine Mammary Adenocarcinoma Cells
Zerumbone-Loaded Nanostructured Lipid Carrier Induces Apoptosis of Canine Mammary Adenocarcinoma Cells Open
Canine mammary gland tumor (CMT) is the most common tumor in intact female dog. Zerumbone (ZER) has promising anticancer properties, but plagued with poor water solubility, poor absorption, bioavailability, and delivery to target tissues. …
View article: Development of erythropoietin receptor-targeted drug delivery system against breast cancer using tamoxifen-loaded nanostructured lipid carriers
Development of erythropoietin receptor-targeted drug delivery system against breast cancer using tamoxifen-loaded nanostructured lipid carriers Open
Tamoxifen (TAM) has been used in the treatment of breast cancers and is supplemented with erythropoietin (EPO) to alleviate the cancer-related anemia. The purported deleterious effects caused by the use of EPO with chemotherapeutic agents …