Behdad Zarnegar
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View article: Matrix-M adjuvant triggers inflammasome activation and enables antigen cross-presentation through induction of lysosomal membrane permeabilization
Matrix-M adjuvant triggers inflammasome activation and enables antigen cross-presentation through induction of lysosomal membrane permeabilization Open
Matrix-M® adjuvant, containing saponins, delivers a potent adjuvant effect and good safety profile. Given that Matrix-M is composed of Matrix-A and Matrix-C particles, comprising different saponin fractions, understanding their …
View article: Matrix-M® adjuvant triggers inflammasome activation and enables antigen cross-presentation through induction of lysosomal membrane permeabilization
Matrix-M® adjuvant triggers inflammasome activation and enables antigen cross-presentation through induction of lysosomal membrane permeabilization Open
Matrix-M ® adjuvant, containing saponins, delivers a potent adjuvant effect and good safety profile. Given that Matrix-M is composed of Matrix-A and Matrix-C particles, comprising different saponin fractions, understanding their distinct r…
View article: The Matrix-M™ adjuvant: A critical component of vaccines for the 21 <sup>st</sup> century
The Matrix-M™ adjuvant: A critical component of vaccines for the 21 <sup>st</sup> century Open
Matrix-M™ adjuvant is a key component of several novel vaccine candidates. The Matrix-M adjuvant consists of two distinct fractions of saponins purified from the Quillaja saponaria Molina tree, combined with cholesterol and phosphol…
View article: Innate Immunity Induces the Accumulation of Lung Mast Cells During Influenza Infection
Innate Immunity Induces the Accumulation of Lung Mast Cells During Influenza Infection Open
Mast cells release disease-causing mediators and accumulate in the lung of asthmatics. The most common cause of exacerbations of asthma is respiratory virus infections such as influenza. Recently, we demonstrated that influenza infection i…
View article: SLC10A4 regulates IgE-mediated mast cell degranulation in vitro and mast cell-mediated reactions in vivo
SLC10A4 regulates IgE-mediated mast cell degranulation in vitro and mast cell-mediated reactions in vivo Open
View article: Influenza Infection in Mice Induces Accumulation of Lung Mast Cells through the Recruitment and Maturation of Mast Cell Progenitors
Influenza Infection in Mice Induces Accumulation of Lung Mast Cells through the Recruitment and Maturation of Mast Cell Progenitors Open
Mast cells (MCs) are powerful immune cells that mature in the peripheral tissues from bone marrow (BM)-derived mast cell progenitors (MCp). Accumulation of MCs in lung compartments where they are normally absent is thought to enhance sympt…
View article: Mechanisms triggering the recruitment of mast cell progenitors to the lung and regulation of mast cell degranulation
Mechanisms triggering the recruitment of mast cell progenitors to the lung and regulation of mast cell degranulation Open
Mast cells stem from the bone marrow and migrate via the blood as mast cell progenitors. Upon arrival in peripheral tissues, they develop into mast cells. These rare immune cells have numerous granules that contain large amounts of pro-inf…