Beilei Wang
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View article: Correlation of IgE and FeNO with lung function in children with asthma: a retrospective study
Correlation of IgE and FeNO with lung function in children with asthma: a retrospective study Open
Background Although immunoglobulin E (IgE), fractional exhaled nitric oxide (FeNO), and lung function testing are important for asthma diagnosis and assessment, their associations are not fully understood. This study aims to investigate th…
View article: Temporal-spatial evolution analysis of carbon emission efficiency in the logistics industry of coastal provinces in China based on the super-efficiency SBM model
Temporal-spatial evolution analysis of carbon emission efficiency in the logistics industry of coastal provinces in China based on the super-efficiency SBM model Open
This study conducted an in-depth analysis of the temporal-spatial evolution characteristics of LCEE in China's coastal provinces. There are significant differences in LCEE among these provinces. Each province needs to reduce the carbon dio…
View article: The effects of temperature variation on obstructive pulmonary dysfunction and small airway dysfunction in asthmatic children: A continuous eight-year study in Jinan, China
The effects of temperature variation on obstructive pulmonary dysfunction and small airway dysfunction in asthmatic children: A continuous eight-year study in Jinan, China Open
Childhood asthma is increasingly prevalent globally, leading to a significant disease burden with rising incidence and greater healthcare demands. However, previous research has primarily focused on the impact of temperature variation on h…
View article: A large-scale prospective nested case-control study: developing a comprehensive risk prediction model for early detection of pancreatic cancer in the community-based ESPRIT-AI cohort
A large-scale prospective nested case-control study: developing a comprehensive risk prediction model for early detection of pancreatic cancer in the community-based ESPRIT-AI cohort Open
Background: Pancreatic cancer (PC) remains a significant public health concern due to its late diagnosis and limited effective screening methods. This study aimed to develop a robust risk prediction model for early detection, utilizing a l…
View article: In-Situ Constructing S-Scheme Heterojunction of Zif-67 Derived Nano Nico-Ldh Supported on Flower-Like Bi2wo6 for Boosting Photocatalytic Co2 Reduction
In-Situ Constructing S-Scheme Heterojunction of Zif-67 Derived Nano Nico-Ldh Supported on Flower-Like Bi2wo6 for Boosting Photocatalytic Co2 Reduction Open
View article: In-Situ Constructing S-Scheme Heterojunction of Zif-67 Derived Nano Nico-Ldh Supported on Flower-Like Bi2wo6 for Boosting Photocatalytic Co2 Reduction
In-Situ Constructing S-Scheme Heterojunction of Zif-67 Derived Nano Nico-Ldh Supported on Flower-Like Bi2wo6 for Boosting Photocatalytic Co2 Reduction Open
View article: MMD-TSC: An Adaptive Multi-Objective Traffic Signal Control for Energy Saving with Traffic Efficiency
MMD-TSC: An Adaptive Multi-Objective Traffic Signal Control for Energy Saving with Traffic Efficiency Open
Reducing traffic energy consumption is crucial for smart cities, and vehicle carbon emissions are a key energy indicator. Traffic signal control (TSC) is a useful method because it can affect the energy consumption of vehicles on the road …
View article: A Red-Emission Fluorescent Probe with Large Stokes Shift for Detection of Viscosity in Living Cells and Tumor-Bearing Mice
A Red-Emission Fluorescent Probe with Large Stokes Shift for Detection of Viscosity in Living Cells and Tumor-Bearing Mice Open
Abnormal viscosity is closely related to the occurrence of many diseases, such as cancer. Therefore, real-time detection of changes in viscosity in living cells is of great importance. Fluorescent molecular rotors play a critical role in d…
View article: Facile Construction of I-Scheme Biocl/Etched Sic Heterojunction for Boosting Photocatalytic Co2 Reduction to Co
Facile Construction of I-Scheme Biocl/Etched Sic Heterojunction for Boosting Photocatalytic Co2 Reduction to Co Open
View article: Biocl/Sic I-Scheme Heterojunction with Efficient Interfacial Charge Transfer For Enhanced Photocatalytic Co2 Reduction
Biocl/Sic I-Scheme Heterojunction with Efficient Interfacial Charge Transfer For Enhanced Photocatalytic Co2 Reduction Open
View article: Top-down Nanoscavengers for the protection of organophosphate-challenged cells
Top-down Nanoscavengers for the protection of organophosphate-challenged cells Open
Background: Organophosphates (OPs) can directly poison various types of mammalian cells, only with several awkward bottom-up antagonists. A top-down nanoscavenger was developed to radically and etiologically prevent cell damage, while insu…
View article: Drive on a Greener Way: A Case Study on Navigating Cross-Regional Traffic Networks in South China
Drive on a Greener Way: A Case Study on Navigating Cross-Regional Traffic Networks in South China Open
Green navigation presents a challenge to sustainable mobility. Carbon emissions are a key indicator for evaluating the sustainability of a route. Some methods of green navigation consider the fastest and shortest route to be the least carb…
View article: Liver injury monitoring using dynamic fluorescence molecular tomography based on a time-energy difference strategy
Liver injury monitoring using dynamic fluorescence molecular tomography based on a time-energy difference strategy Open
Dynamic fluorescence molecular tomography (DFMT) is a promising molecular imaging technique that offers the potential to monitor fast kinetic behaviors within small animals in three dimensions. Early monitoring of liver disease requires th…
View article: A novel staging system derived from natural language processing of pathology reports to predict prognostic outcomes of pancreatic cancer: a retrospective cohort study
A novel staging system derived from natural language processing of pathology reports to predict prognostic outcomes of pancreatic cancer: a retrospective cohort study Open
Objective: To construct a novel tumor-node-morphology (TNMor) staging system derived from natural language processing (NLP) of pathology reports to predict outcomes of pancreatic ductal adenocarcinoma. Method: This retrospective study with…
View article: Pharmacological inhibiting STAT5 for the treatment of FLT3‐ITD‐positive acute myeloid leukemia with triciribine phosphate monohydrate
Pharmacological inhibiting STAT5 for the treatment of FLT3‐ITD‐positive acute myeloid leukemia with triciribine phosphate monohydrate Open
Approximately 25% of acute myeloid leukemia (AML) patients carry FLT3-ITD oncogenic mutations.1 Due to the essential role of the transcription factor STAT5 for the survival and proliferation of AML cells with this specific mutation, excess…
View article: 3D-deep optical learning: a multimodal and multitask reconstruction framework for optical molecular tomography
3D-deep optical learning: a multimodal and multitask reconstruction framework for optical molecular tomography Open
Optical molecular tomography (OMT) is an emerging imaging technique. To date, the poor universality of reconstruction algorithms based on deep learning for various imaged objects and optical probes limits the development and application of…
View article: AI-Enabled Consensus Algorithm in Human-Centric Collaborative Computing for Internet of Vehicle
AI-Enabled Consensus Algorithm in Human-Centric Collaborative Computing for Internet of Vehicle Open
With the enhanced interoperability of information among vehicles, the demand for collaborative sharing among vehicles increases. Based on blockchain, the classical consensus algorithms in collaborative IoV (Internet of Vehicle), such as Po…
View article: Predicting and overcoming resistance to CDK9 inhibitors for cancer therapy
Predicting and overcoming resistance to CDK9 inhibitors for cancer therapy Open
View article: Discovery of IHMT-MST1-39 as a novel MST1 kinase inhibitor and AMPK activator for the treatment of diabetes mellitus
Discovery of IHMT-MST1-39 as a novel MST1 kinase inhibitor and AMPK activator for the treatment of diabetes mellitus Open
View article: A adaptive parameter selection strategy based on maximizing the probability of data for robust fluorescence molecular tomography reconstruction
A adaptive parameter selection strategy based on maximizing the probability of data for robust fluorescence molecular tomography reconstruction Open
To alleviate the ill-posed of the inverse problem in Fluorescent molecular tomography (FMT), many regularization methods based on L 2 or L 1 norm have been proposed. Whereas, the quality of regularization parameters affect the performance …
View article: Discovery of a highly potent pan-RAF inhibitor IHMT-RAF-128 for cancer treatment
Discovery of a highly potent pan-RAF inhibitor IHMT-RAF-128 for cancer treatment Open
Although RAS mutations occur in about 30% of solid tumors, targeting RAS mutations other than KRAS-G12C is still challenging. As an alternative approach, developing inhibitors targeting RAF, the downstream effector of RAS signaling, is cur…
View article: SnSe Nanosheets Mimic Lactate Dehydrogenase to Reverse Tumor Acid Microenvironment Metabolism for Enhancement of Tumor Therapy
SnSe Nanosheets Mimic Lactate Dehydrogenase to Reverse Tumor Acid Microenvironment Metabolism for Enhancement of Tumor Therapy Open
The acidic tumor microenvironment (TME) is unfriendly to the activity and function of immune cells in the TME. Here, we report inorganic nanozymes (i.e., SnSe NSs) that mimic the catalytic activity of lactate dehydrogenase to degrade lacta…
View article: Perspectives of lipid metabolism reprogramming in head and neck squamous cell carcinoma: An overview
Perspectives of lipid metabolism reprogramming in head and neck squamous cell carcinoma: An overview Open
Recent studies showed that lipid metabolism reprogramming contributes to tumorigenicity and malignancy by interfering energy production, membrane formation, and signal transduction in cancers. HNSCCs are highly reliant on aerobic glycolysi…
View article: Application of a Markov chain Monte Carlo method for robust quantification in chemical exchange saturation transfer magnetic resonance imaging
Application of a Markov chain Monte Carlo method for robust quantification in chemical exchange saturation transfer magnetic resonance imaging Open
The MCMC method provided an efficient approach for parameter estimation and CEST effect quantification. The method may therefore be useful in achieving an accurate pathological diagnosis.
View article: PEG-Bottlebrush Stabilizer-Based Worm-like Nanocrystal Micelles with Long-Circulating and Controlled Release for Delivery of a BCR-ABL Inhibitor against Chronic Myeloid Leukemia (CML)
PEG-Bottlebrush Stabilizer-Based Worm-like Nanocrystal Micelles with Long-Circulating and Controlled Release for Delivery of a BCR-ABL Inhibitor against Chronic Myeloid Leukemia (CML) Open
Drug nanocrystals, one of most common drug delivery systems, enable the delivery of poorly water-soluble drugs with high drug loading and enhanced dissolution. The rapid clearance and uncontrolled drug release of drug nanocrystals limit th…
View article: Genetically Engineered Hematopoietic Stem Cells Deliver TGF‐<i>β</i> Inhibitor to Enhance Bone Metastases Immunotherapy
Genetically Engineered Hematopoietic Stem Cells Deliver TGF‐<i>β</i> Inhibitor to Enhance Bone Metastases Immunotherapy Open
Owing to the immune microenvironment of bones and low selectivity of the drug, patients with bone metastases often respond poorly to immunotherapy. In this study, programmed cell death protein 1 (PD1)‐expressing hematopoietic stem cells (H…
View article: Research on Real-Time Communication Algorithm of Substation Based on Time-Sensitive Network
Research on Real-Time Communication Algorithm of Substation Based on Time-Sensitive Network Open
A time-sensitive network (TSN) extends the conventional Ethernet to support time-sensitive data flow. Thus, it enables simultaneous transmission of high reliability (HR) flow, medium reliability (MR) flow, and low reliability (LR) flow on …
View article: Correlation Between Coronavirus Disease 2019 and Olfactory Dysfunction
Correlation Between Coronavirus Disease 2019 and Olfactory Dysfunction Open
A great number of patients with Coronavirus Disease 2019 (COVID-19) experience olfactory dysfunction, typically of a short duration and with a high incidence rate, during the early stages of infection with severe acute respiratory syndrome…
View article: CHMFL-26 is a highly potent irreversible HER2 inhibitor for use in the treatment of HER2-positive and HER2-mutant cancers
CHMFL-26 is a highly potent irreversible HER2 inhibitor for use in the treatment of HER2-positive and HER2-mutant cancers Open
View article: Establishment of a Knowledge‐and‐Data‐Driven Artificial Intelligence System with Robustness and Interpretability in Laboratory Medicine
Establishment of a Knowledge‐and‐Data‐Driven Artificial Intelligence System with Robustness and Interpretability in Laboratory Medicine Open
Laboratory medicine plays an important role in clinical diagnosis. However, no laboratory‐based artificial intelligence (AI) diagnostic system has been applied in current clinical practice due to the lack of robustness and interpretability…