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View article: Evaluation of Equisetin as an Anti-Microbial and Herbicidal Agent from Endophytic Fungus Fusarium sp. JDJR1
Evaluation of Equisetin as an Anti-Microbial and Herbicidal Agent from Endophytic Fungus Fusarium sp. JDJR1 Open
Equisetin was isolated from endophytic fungus Fusarium sp. JDJR1 via bioassay-guided isolation, and it was evaluated as an anti-microbial and herbicidal agent. Bioactivity assessments revealed that equisetin exhibited a broad spectrum of f…
View article: Investigation into the dynamic change pattern of the stress field during integral fracturing in deep reservoirs
Investigation into the dynamic change pattern of the stress field during integral fracturing in deep reservoirs Open
Deep reservoirs have high temperature, high pressure, and high stress. The development of such resources is high cost. Integral fracturing applies one-time well displacement, batch drilling, and batch fracturing. Multiple wells are stimula…
View article: Experimental study on settlement law of multi-particle compound temporary plugging material in rough fracture
Experimental study on settlement law of multi-particle compound temporary plugging material in rough fracture Open
To study the migration and settlement law of temporary plugging particle in fractures, a set of fracture visualization device with controllable pumping rate was built. Based on the experimental device, the influence of the parameters such …
View article: Natural Fractures Characteristics of the Carboniferous Volcanic Reservoir in Northwestern Margin of Junggar Basin
Natural Fractures Characteristics of the Carboniferous Volcanic Reservoir in Northwestern Margin of Junggar Basin Open
Research on the regional fracture’s development is important for reservoir fracturing. This paper takes the Carboniferous volcanic reservoir in the northwestern margin of Junggar Basin as the research object. Based on understanding the reg…
View article: Protein convertase subtilisin/Kexin type 9 inhibits hepatocellular carcinoma growth by interacting with GSTP1 and suppressing the JNK signaling pathway
Protein convertase subtilisin/Kexin type 9 inhibits hepatocellular carcinoma growth by interacting with GSTP1 and suppressing the JNK signaling pathway Open
Background PCSK9 has been found to be closely related to the occurrence and development of a variety of tumors. However, the concrete role of PCSK9 and its relationship with HCC development is largely unknown. Methods The expression levels…
View article: Antibacterial Therapeutic Agents Composed of Functional Biological Molecules
Antibacterial Therapeutic Agents Composed of Functional Biological Molecules Open
Antibacterial agents are a group of materials that selectively destroy bacteria by interfering with bacterial growth or survival. With the emergence of resistance phenomenon of bacterial pathogens to current antibiotics, new drugs are freq…
View article: ETV add-on Peg-interferon therapy plays a positive role in reversing hepatic fibrosis in treatment-naïve chronic hepatitis B patients: a prospective and randomized controlled trial
ETV add-on Peg-interferon therapy plays a positive role in reversing hepatic fibrosis in treatment-naïve chronic hepatitis B patients: a prospective and randomized controlled trial Open
Background and Aim The efficacy of entecavir (ETV) add-on peg-interferon therapy compared with ETV monotherapy in treatment-naïve hepatitis B virus (HBV) patients remains controversial. We investigated whether adding Peg-interferon to ongo…
View article: ETV add-on Peg-interferon therapy plays a positive role in reversing hepatic fibrosis in treatment-naïve chronic hepatitis B patients: a prospective and randomized controlled trial
ETV add-on Peg-interferon therapy plays a positive role in reversing hepatic fibrosis in treatment-naïve chronic hepatitis B patients: a prospective and randomized controlled trial Open
Background and Aim The efficacy of entecavir (ETV) add-on peg-interferon therapy compared with ETV monotherapy in treatment-naïve hepatitis B virus (HBV) patients remains controversial. We investigated whether adding Peg-interferon to ongo…
View article: Formation of G-quadruplex structure in supercoiled DNA under molecularly crowded conditions
Formation of G-quadruplex structure in supercoiled DNA under molecularly crowded conditions Open
It is demonstrated that G-quadruplex generated from G-rich duplex in a circular DNA as a result of quadruplex stabilization and duplex destabilization created by the combined actions of negative DNA supercoiling and molecular crowding cond…
View article: Small DNA circles as bacterial topoisomerase I inhibitors
Small DNA circles as bacterial topoisomerase I inhibitors Open
It is demonstrated that small DNA circles showed high inhibitory effect on the activity of bacterial topoisomerase I and the single-stranded regions associated with bending deformation are believed to be the crucial factor for trapping the…
View article: Transformation of a Thermostable G-Quadruplex Structure into DNA Duplex Driven by Reverse Gyrase
Transformation of a Thermostable G-Quadruplex Structure into DNA Duplex Driven by Reverse Gyrase Open
Reverse gyrase is a topoisomerase that can introduce positive supercoils to its substrate DNA. It is demonstrated in our studies that a highly thermal stable G-quadruplex structure in a mini-plasmid DNA was transformed into its duplex conf…
View article: A Comparison Study of Quetiapine and Risperidone's Effectiveness and Safety on Treating Alcohol-induced Mental Disorder.
A Comparison Study of Quetiapine and Risperidone's Effectiveness and Safety on Treating Alcohol-induced Mental Disorder. Open
Compared with Risperidone, Quetiapine's effectiveness and safety on treating alcohol-induced mental disorder is still unclear.To investigate the clinical effectiveness and safety of Quetiapine on treating alcohol-induced mental disorder.On…
View article: CCDC 1482216: Experimental Crystal Structure Determination
CCDC 1482216: Experimental Crystal Structure Determination Open
An entry from the Cambridge Structural Database, the world’s repository for small molecule crystal structures. The entry contains experimental data from a crystal diffraction study. The deposited dataset for this entry is freely available …
View article: CCDC 1482215: Experimental Crystal Structure Determination
CCDC 1482215: Experimental Crystal Structure Determination Open
An entry from the Cambridge Structural Database, the world’s repository for small molecule crystal structures. The entry contains experimental data from a crystal diffraction study. The deposited dataset for this entry is freely available …
View article: CCDC 1482217: Experimental Crystal Structure Determination
CCDC 1482217: Experimental Crystal Structure Determination Open
An entry from the Cambridge Structural Database, the world’s repository for small molecule crystal structures. The entry contains experimental data from a crystal diffraction study. The deposited dataset for this entry is freely available …
View article: The study of G-quadruplex in supercoiled DNA
The study of G-quadruplex in supercoiled DNA Open
It is demonstrated that DNA gyrase, an essential bacterial enzyme which possesses a unique ability to introduce negative supercoils into DNA, can drive G-quadruplex generation from plasmid DNA under the intracellular concentrations of cati…
View article: The Effect of Dimethyl Sulfoxide on Supercoiled DNA Relaxation Catalyzed by Type I Topoisomerases
The Effect of Dimethyl Sulfoxide on Supercoiled DNA Relaxation Catalyzed by Type I Topoisomerases Open
The effects of dimethyl sulfoxide (DMSO) on supercoiled plasmid DNA relaxation catalyzed by two typical type I topoisomerases were investigated in our studies. It is shown that DMSO in a low concentration (less than 20%, v/v) can induce a …