Beibei Du
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View article: Frailty and cardiovascular disease: a bidirectional relationship with clinical implications
Frailty and cardiovascular disease: a bidirectional relationship with clinical implications Open
Background Frailty and cardiovascular disease (CVD) are increasingly recognized as interconnected conditions that significantly impact aging populations. This review synthesizes evidence from studies published between 2000 and 2025, identi…
View article: A systematic review and meta-analysis on the efficacy and safety of finerenone in the progression of heart failure
A systematic review and meta-analysis on the efficacy and safety of finerenone in the progression of heart failure Open
Aims Finerenone, a kind of mineralocorticoid receptor antagonist (MRA), may benefit heart failure (HF) patients as MRAs are established effective therapies for HF. Many studies have confirmed the drug’s effectiveness in treating kidney dis…
View article: Extracorporeal membrane oxygenation-supported one-stop surgery for transcatheter aortic valve replacement and percutaneous coronary intervention in high-risk complex coronary artery and aortic valvular disease: a case report
Extracorporeal membrane oxygenation-supported one-stop surgery for transcatheter aortic valve replacement and percutaneous coronary intervention in high-risk complex coronary artery and aortic valvular disease: a case report Open
Aortic stenosis (AS) is frequently associated with coronary artery disease (CAD), particularly in high-risk patients for whom treatment strategies lack standardized clinical guidelines. We report a case of a patient with severe AS and high…
View article: Long-term effects of SGLT2 inhibitors on arrhythmias: a systematic review and meta-analysis
Long-term effects of SGLT2 inhibitors on arrhythmias: a systematic review and meta-analysis Open
Aims Sodium-glucose co-transporter 2 (SGLT2) inhibitors are novel oral hypoglycemic agents strongly endorsed in the treatment guidelines for heart failure due to their cardioprotective benefits. However, their specific impact of SGLT2 inhi…
View article: Epidemiology, clinical characteristics and potential mechanism of ibrutinib-induced ventricular arrhythmias
Epidemiology, clinical characteristics and potential mechanism of ibrutinib-induced ventricular arrhythmias Open
The Bruton’s Tyrosine Kinase Inhibitor, ibrutinib, has been widely employed due to its significant efficacy in B-cell lymphoma. However, the subsequent cardiac complications, notably atrial fibrillation (AF) and ventricular arrhythmias (VA…
View article: A retrospective study on the efficacy of pegfilgrastim-filgrastim combination regimen in the mobilization for autologous stem cell transplantation in lymphoma patients
A retrospective study on the efficacy of pegfilgrastim-filgrastim combination regimen in the mobilization for autologous stem cell transplantation in lymphoma patients Open
Compared to conventional filgrastim mobilization, the combination of pegfilgrastim and filgrastim schedule has high efficacy, non-inferior safety, and superior health economic benefits during auto-HSCT.
View article: Impaired Cardiac AMPK (5′‐Adenosine Monophosphate‐Activated Protein Kinase) and Ca <sup>2+</sup> ‐Handling, and Action Potential Duration Heterogeneity in Ibrutinib‐Induced Ventricular Arrhythmia Vulnerability
Impaired Cardiac AMPK (5′‐Adenosine Monophosphate‐Activated Protein Kinase) and Ca <sup>2+</sup> ‐Handling, and Action Potential Duration Heterogeneity in Ibrutinib‐Induced Ventricular Arrhythmia Vulnerability Open
Background We recently demonstrated that acute administration of ibrutinib, a Bruton's tyrosine kinase inhibitor used in chemotherapy for blood malignancies, increases ventricular arrhythmia (VA) vulnerability. A pathway of ibrutinib‐induc…
View article: IL-6 and D-dimer Levels at Admission Predict Cardiac Injury and Early Mortality during SARS-CoV-2 Infection
IL-6 and D-dimer Levels at Admission Predict Cardiac Injury and Early Mortality during SARS-CoV-2 Infection Open
Background: We previously described the mortality associated with cardiac injury in patients with coronavirus disease 2019 (COVID-19). The activation of immune and thrombotic biomarkers at admission, and their ability to predict cardiac in…
View article: Resolving the developmental mechanisms of coagulation abnormalities characteristic of SARS-CoV2 based on single-cell transcriptome analysis
Resolving the developmental mechanisms of coagulation abnormalities characteristic of SARS-CoV2 based on single-cell transcriptome analysis Open
The COVID-19 outbreak caused by the SARS-CoV-2 virus has developed into a global health emergency. In addition to causing respiratory symptoms following SARS-CoV-2 infection, COVID-19-associated coagulopathy (CAC) is the main cause of deat…
View article: S1PR1/S1PR3-YAP signaling and S1P-ALOX15 signaling contribute to an aggressive behavior in obesity-lymphoma
S1PR1/S1PR3-YAP signaling and S1P-ALOX15 signaling contribute to an aggressive behavior in obesity-lymphoma Open
Background Excess body weight has been found to associate with an increased risk of lymphomas and some metabolic pathways are currently recognized in lymphomagenesis. Bioactive lipid metabolites such as sphingosine-1-phosphate (S1P) have b…
View article: Nilotinib related acute myocardial infarction with nonobstructive coronary arteries: a case report and literature review
Nilotinib related acute myocardial infarction with nonobstructive coronary arteries: a case report and literature review Open
Background Myocardial Ischemia with No Obstructive Coronary Artery Disease (MINOCA) is a common cause of type 2 acute myocardial infarction (AMI) which requires careful differential diagnosis. Coronary artery spasm (CAS) syndrome is one et…
View article: Cardioprotective effects of dantrolene in doxorubicin-induced cardiomyopathy in mice
Cardioprotective effects of dantrolene in doxorubicin-induced cardiomyopathy in mice Open
Dantrolene prevents cardiac contractile dysfunction following doxorubicin treatment by mitigating dysregulation of calcium dynamics.
View article: Concomitant acute myocardial infarction and acute pulmonary embolism caused by paradoxical embolism: a case report
Concomitant acute myocardial infarction and acute pulmonary embolism caused by paradoxical embolism: a case report Open
View article: IL-6 and D-Dimer at Admission Predicts Cardiac Injury and Early Mortality during SARS-CoV-2 Infection
IL-6 and D-Dimer at Admission Predicts Cardiac Injury and Early Mortality during SARS-CoV-2 Infection Open
BACKGROUND We recently described mortality of cardiac injury in COVID-19 patients. Admission activation of immune, thrombotic biomarkers and their ability to predict cardiacinjury and mortality patterns in COVID-19 is unknown. METHODS This…
View article: Cardiovascular syphilis-associated acute myocardial infarction
Cardiovascular syphilis-associated acute myocardial infarction Open
Rationale: In recent decades, the incidence of advanced syphilis has declined due to early recognition and the application of effective antibiotics. Advanced syphilis often manifests in the cardiovascular system as simple aortitis, aortic …
View article: Aspirin Positively Contributes to <i>Drosophila</i> Intestinal Homeostasis and Delays Aging through Targeting Imd
Aspirin Positively Contributes to <i>Drosophila</i> Intestinal Homeostasis and Delays Aging through Targeting Imd Open
The intestine, a high-turnover tissue, plays a critical role in regulating aging and health in both vertebrates and invertebrates. Maintaining the epithelial barrier function of the intestine by preserving innate immune homeostasis signifi…
View article: Mortalité, congé et arythmie chez les patients ayant la COVID-19 et une atteinte cardiaque
Mortalité, congé et arythmie chez les patients ayant la COVID-19 et une atteinte cardiaque Open
CONTEXTE: Les atteintes cardiaques sont fréquentes dans les cas graves de maladie à coronavirus 2019 (COVID-19) et sont associées à un mauvais pronostic. Notre étude portait sur les facteurs prédictifs de mortalité intrahospitalière, les c…
View article: Important factors affecting COVID-19 transmission and fatality in metropolises
Important factors affecting COVID-19 transmission and fatality in metropolises Open
View article: Acute Effects of Ibrutinib on Ventricular Arrhythmia in Spontaneously Hypertensive Rats
Acute Effects of Ibrutinib on Ventricular Arrhythmia in Spontaneously Hypertensive Rats Open
Ibrutinib-induced VA is associated with old age in SHR. Acute dysregulation of calcium and repolarization dynamics play important roles in ibrutinib-induced VF.
View article: Identifying novel factors associated with COVID-19 transmission and fatality using the machine learning approach
Identifying novel factors associated with COVID-19 transmission and fatality using the machine learning approach Open
View article: D-dimer surge and coagulation disorders in COVID-19 related pneumonia patients with cardiac injury
D-dimer surge and coagulation disorders in COVID-19 related pneumonia patients with cardiac injury Open
D-dimer surge in COVID-19 patients with cardiac injury surely leads to worse in-hospital outcome. D-dimer surge and concomitant DIC can be the leading causes of in-hospital death. Pre-existing cardiovascular or cerebrovascular diseases mig…
View article: Effect of chidamide on treating hepatosplenic T-cell lymphoma: A case report
Effect of chidamide on treating hepatosplenic T-cell lymphoma: A case report Open
The novel agent chidamide can be used in HSTCL to achieve deep remission and improve the duration of response and overall survival.
View article: Modulation of Cardiac Injury by ACE inhibitor/ARB in Patients with Severe COVID-19
Modulation of Cardiac Injury by ACE inhibitor/ARB in Patients with Severe COVID-19 Open
Introduction: Cardiac injury occurs in 7-22% of patient hospitalized with COVID-19 and an elevation in troponin is associated with a 4.2-fold increase in the risk of mortality. Preliminary data showed ACEi/ARB usage might not increase mort…
View article: Death, discharge and arrhythmias among patients with COVID-19 and cardiac injury
Death, discharge and arrhythmias among patients with COVID-19 and cardiac injury Open
Chinese Clinical Trial Registry, No. ChiCTR2000031301.
View article: Identifying novel factors associated with COVID-19 transmission and fatality using the machine learning approach
Identifying novel factors associated with COVID-19 transmission and fatality using the machine learning approach Open
The COVID-19 virus has infected millions of people and resulted in hundreds of thousands of deaths worldwide. By using the logistic regression model, we identified novel critical factors associated with COVID19 cases, death, and case fatal…
View article: Optical coherence tomography guided treatment avoids stenting in an antiphospholipid syndrome patient: A case report
Optical coherence tomography guided treatment avoids stenting in an antiphospholipid syndrome patient: A case report Open
APS can cause acute non-atherosclerosis coronary thrombosis which presents as an AMI in young female patients. Intracoronary OCT findings can guide interventional strategies in this special clinical scenario.
View article: A new peripheral endothelial function measurement improves prediction of symptomatic coronary artery disease
A new peripheral endothelial function measurement improves prediction of symptomatic coronary artery disease Open
Objective This study aimed to determine whether a peripheral artery volume (PAV) test can improve the predictive value of the age-adjusted Framingham risk score (AFRS) for coronary artery disease (CAD) in symptomatic patients. Methods A to…
View article: Rescue treatment and follow-up intervention of a left main acute myocardial infarction with typical carina shift under 3D optical coherence tomography: A case report
Rescue treatment and follow-up intervention of a left main acute myocardial infarction with typical carina shift under 3D optical coherence tomography: A case report Open
3D-OCT can facilitate decision-making for coronary interventions in patients with critical bifurcation lesions.
View article: Treatment of severe upper gastrointestinal bleeding caused by Mallory-Weiss syndrome after primary coronary intervention for acute inferior wall myocardial infarction: A case report
Treatment of severe upper gastrointestinal bleeding caused by Mallory-Weiss syndrome after primary coronary intervention for acute inferior wall myocardial infarction: A case report Open
Bleeding complications after stent implantation can pose a dilemma. MWS is a rare but severe cause of acute UGIB after an AMI that requires an early endoscopic diagnosis and a hemoclip intervention to stop bleeding.
View article: Combined intracoronary assessment and treatment of a patient with coronary plaque rapid progression prior to acute myocardial infarction
Combined intracoronary assessment and treatment of a patient with coronary plaque rapid progression prior to acute myocardial infarction Open
Rational: Plaque rapid progression prior to acute myocardial infarction is not a common phenomenon, and its mechanism remains unknown. Intracoronary imaging may help to assess the plaque characteristics and progression. Patient concern: A …