Explanipedia

Severe osteoarthritis in aged PANX3 knockout mice: implications for a novel primary osteoarthritis model Open

Brent Wakefield, Justin Tang, Julián Balanta Melo, Jeffrey L. Hutchinson, Rehanna Kanji , et al. · 2025

Osteoarthritis (OA) is a multifactorial disease associated with aging. As the molecular mechanisms underpinning the pathogenesis of this disease are unclear, there are no disease-modifying drugs to combat OA. Pannexin 3 (PANX3) has been sh…

Changes and associations between synovial fluid and magnetic resonance imaging markers of osteoarthritis after high tibial osteotomy Open

Jenna M Schulz, Trevor B. Birmingham, Holly T. Philpott, C. Thomas Appleton, Hayden F. Atkinson , et al. · 2024

Decreased aberrant knee mechanical loading in patients with OA is associated with decreased biological and imaging measures of inflammation (measured in synovial fluid and on MRI) and increased anabolic processes. These exploratory finding…

Pannexin 3 deletion in mice results in knee osteoarthritis and intervertebral disc degeneration after forced treadmill running Open

Brent Wakefield, Justin Tang, Jeffrey L. Hutchinson, Rehanna Kanji, Courtney Brooks , et al. · 2024

Pannexin 3 ( Panx3 ) is a glycoprotein that forms mechanosensitive channels expressed in chondrocytes and annulus fibrosus cells of the intervertebral disc (IVD). Evidence suggests Panx3 plays contrasting roles in traumatic versus aging os…

Comparative histopathological analysis of age‐associated intervertebral disc degeneration in CD‐1 and C57BL/6 mice: Anatomical and sex‐based differences Open

Jeffrey L. Hutchinson, Matthew A. Veras, Meghan E. Serjeant, Matthew R. McCann, Ashley L. Kelly , et al. · 2023

Background Intervertebral disc (IVD) degeneration is a major contributor to back pain and disability. The cause of IVD degeneration is multifactorial, with no disease‐modifying treatments. Mouse models are commonly used to study IVD degene…

Adseverin, an actin-binding protein, modulates hypertrophic chondrocyte differentiation and osteoarthritis progression Open

Byron Chan, Michael Glogauer, Yongqiang Wang, Jeffrey L. Wrana, Kin Chan , et al. · 2023

In osteoarthritis (OA), a disease characterized by progressive articular cartilage degradation and calcification, the articular chondrocyte phenotype changes and this correlates with actin cytoskeleton alterations suggesting that it regula…

Anabolic phenotype in cartilage-specific mitogen-inducible gene-6 knockout mice is independent of transforming growth factor-α Open

Ermina Hadzic, Bethia To, M.A. Pest, Ling Qin, Frank Beier · 2023

Severe Osteoarthritis in Aged PANX3 Knockout Mice: Implications for a Novel Primary Osteoarthritis Model Open

Brent Wakefield, Justin Tang, Julián Balanta Melo, Jeffrey L. Hutchinson, Rehanna Kanji , et al. · 2023

Osteoarthritis (OA) is a multi-factorial disease associated with aging. As the molecular mechanisms underpinning the pathogenesis of this disease are unclear, there are no disease-modifying drugs to combat OA. Pannexin 3 (PANX3) has been s…

First-in-human phase Ib trial of M9241 (NHS-IL12) plus avelumab in patients with advanced solid tumors, including dose expansion in patients with advanced urothelial carcinoma Open

Julius Strauss, Jean‐Laurent Deville, Mario Sznol, Alain Ravaud, Marco Maruzzo , et al. · 2023

Background In preclinical studies, combining M9241 (a novel immunocytokine containing interleukin (IL)-12 heterodimers) with avelumab (anti-programmed death ligand 1 antibody) resulted in additive or synergistic antitumor effects. We repor…

Pannexin 3deletion in mice results in knee osteoarthritis and intervertebral disc degeneration after forced treadmill running Open

Brent Wakefield, Jeffrey L. Hutchinson, Justin Tang, Rehanna Kanji, Courtney Brooks , et al. · 2023

Pannexin 3 ( Panx3 ) is a glycoprotein that forms mechanosensitive channels expressed in chondrocytes and annulus fibrosus cells of the intervertebral disc (IVD). Evidence suggests Panx3 plays contrasting roles in traumatic versus aging os…

Anabolic phenotype in cartilage-specific Mitogen-inducible gene-6 knockout mice is independent of Transforming growth factor-α Open

Ermina Hadzic, Bethia To, M.A. Pest, Ling Qin, Frank Beier · 2023

Background/Objective Osteoarthritis (OA) is a whole joint disorder with no disease modifying treatment currently available. The Epidermal Growth Factor Receptor (EGFR) signaling pathway plays an important role in cartilage/bone development…

A Na+/K+ ATPase Pump Regulates Chondrocyte Differentiation and Bone Length Variation in Mice Open

Marta Marchini, Mitchell R. Ashkin, Melina Bellini, Margaret Man‐Ger Sun, Matthew L. Workentine , et al. · 2021

The genetic and developmental mechanisms involved in limb formation are relatively well documented, but how these mechanisms are modulated by changes in chondrocyte physiology to produce differences in limb bone length remains unclear. Her…

Expansion of myeloid-derived suppressor cells contributes to metabolic osteoarthritis through subchondral bone remodeling Open

Lixia Zhang, Cameron L. Kirkwood, Jiho Sohn, Ashley Lau, Mary Bayers-Thering , et al. · 2021

Genetic Deletion of Interleukin-15 Is Not Associated with Major Structural Changes Following Experimental Post-Traumatic Knee Osteoarthritis in Rats Open

Ermina Hadzic, Garth Blackler, Holly Dupuis, Stephen J. Renaud, C. Thomas Appleton , et al. · 2021

Post-traumatic osteoarthritis (PTOA) is a degenerative joint disease, leading to articular cartilage breakdown, osteophyte formation, and synovitis, caused by an initial joint trauma. Pro-inflammatory cytokines increase catabolic activity …

P-111 PERSPECTIVE: Tepotinib plus cetuximab in patients with RAS/BRAF wild-type left-sided metastatic colorectal cancer and acquired resistance to anti-EGFR antibody therapy due to MET amplification Open

Josep Tabernero, Tanios Bekaii‐Saab, M. Safont Aguilera, Antonio Cubillo, Rocio García‐Carbonero , et al. · 2021

Pannexin 3 deletion reduces fat accumulation and inflammation in a sex-specific manner Open

Charles Brent Wakefield, Vanessa R. Lee, Danielle Johnston, Parastoo Boroumand, Nicolas J. Pillon , et al. · 2021

Background Pannexin 3 (PANX3), is a channel-forming glycoprotein that enables nutrient-induced inflammation in vitro , and genetic linkage data suggests it regulates body mass index. Here, we characterized inflammatory and metabolic parame…

Genetic deletion of interleukin-15 is not associated with major structural changes following experimental post-traumatic knee osteoarthritis in rats Open

Ermina Hadzic, Garth Blackler, Holly Dupuis, Stephen J. Renaud, C. Thomas Appleton , et al. · 2021

Post-traumatic Osteoarthritis (PTOA) is a degenerative joint disease, leading to articular cartilage breakdown, osteophyte formation, and synovitis, caused by an initial joint trauma. Pro-inflammatory cytokines increase catabolic activity …

Loss of adseverin, an actin binding protein, in an animal model of osteoarthritis Open

Byron Chan, Michael Glogauer, Frank Beier, Y. Wang, Supinder Kour Bali , et al. · 2021

Associations between surgically-induced changes in knee loading and biochemical markers of knee inflammation Open

Jenna M Schulz, Trevor B. Birmingham, Kristyn M. Leitch, J. Robert Giffin, Frank Beier , et al. · 2021

Diet-induced obesity leads to behavioral indicators of pain preceding structural joint damage in wild-type mice Open

Geoffrey J. Kerr, Bethia To, I. W. C. White, Magali Millecamps, Frank Beier , et al. · 2021

The Role of Panx3 in Age-Associated and Injury-Induced Intervertebral Disc Degeneration Open

Meaghan E. Serjeant, Paxton M. Moon, Diana Quinonez, Silvia Peñuela, Frank Beier , et al. · 2021

Pannexin 3 (Panx3) is a mechanosensitive, channel-forming glycoprotein implicated in the progression of post-traumatic osteoarthritis. Despite evidence for Panx3 expression in the intervertebral disc (IVD), its function in this cartilagino…

Targeting cartilage EGFR pathway for osteoarthritis treatment Open

Yulong Wei, Lijun Luo, Tao Gui, Feifan Yu, Lesan Yan , et al. · 2021

EGFR activation by overexpressing HBEGF in cartilage or intra-articular delivery of TGFα nanoparticles attenuates osteoarthritis development in mice.

Editorial Board Open

Lila M. Gierasch, F. Peter Guengerich, Alex Toker, C.J. Goodman, Ruma Banerjee , et al. · 2020

Activating EGFR Signaling Attenuates Osteoarthritis Development Following Loading Injury in Mice Open

Tao Gui, Yulong Wei, Lijun Luo, Jun Li, Leilei Zhong , et al. · 2020

Posttraumatic osteoarthritis (PTOA) results in joint pain, loss of joint function, and impaired quality of daily life in patients with limited treatment options. We previously demonstrated that epidermal growth factor receptor (EGFR) signa…

Editorial Board Open

Lila M. Gierasch, F. Peter Guengerich, Alex Toker, C.J. Goodman, Ruma Banerjee , et al. · 2020

EGFR Signaling Is Required for Maintaining Adult Cartilage Homeostasis and Attenuating Osteoarthritis Progression Open

Yulong Wei, Xiaoyuan Ma, Hao Sun, Tao Gui, Jun Li , et al. · 2020

The uppermost superficial zone of articular cartilage is the first line of defense against the initiation of osteoarthritis (OA). We previously used Col2-Cre to demonstrate that epidermal growth factor receptor (EGFR), a tyrosine kinase re…

Editorial Board Open