Beihui He
YOU?
Author Swipe
View article: RSA‐KG: A Graph‐Based Rag Enhanced AI Knowledge Graph for Recurrent Spontaneous Abortions Diagnosis and Clinical Decision Support
RSA‐KG: A Graph‐Based Rag Enhanced AI Knowledge Graph for Recurrent Spontaneous Abortions Diagnosis and Clinical Decision Support Open
Recurrent spontaneous abortion (RSA), affecting 1%–5% of reproductive‐aged women, presents diagnostic challenges due to its complex multifactorial causes. Conventional guidelines are inadequate for idiopathic cases and emerging biomarkers,…
View article: Role of short-chain fatty acids in non-alcoholic fatty liver disease and potential therapeutic targets
Role of short-chain fatty acids in non-alcoholic fatty liver disease and potential therapeutic targets Open
Non-alcoholic fatty liver disease (NAFLD) is increasing worldwide and has become the greatest potential risk for cirrhosis and hepatocellular carcinoma. The metabolites produced by the gut microbiota act as signal molecules that mediate th…
View article: Bioactive flavonoids metabolites in citrus species: their potential health benefits and medical potentials
Bioactive flavonoids metabolites in citrus species: their potential health benefits and medical potentials Open
Citrus flavonoids are naturally occurring phytochemicals widely present in the peels and pulps of citrus fruits. They exhibit a wide range of biological activities, including antioxidant, anti-inflammatory, hypoglycemic, lipid-lowering, an…
View article: Taraxasterol Acetate From <i>Taraxacum officinale</i> Ameliorates Dextran Sulfate Sodium–Induced Ulcerative Colitis in Mice in Association With Changes of the Metabolism and Structure of Gut Microbiota
Taraxasterol Acetate From <i>Taraxacum officinale</i> Ameliorates Dextran Sulfate Sodium–Induced Ulcerative Colitis in Mice in Association With Changes of the Metabolism and Structure of Gut Microbiota Open
Ulcerative colitis (UC) is closely associated with the structural and metabolic disorders of gut microbiota. Taraxasterol acetate (TSA) from Taraxacum officinale (TO) has anti‐inflammatory activity. In this study, to investigate the therap…
View article: Association between serum vitamin D, uric acid, C-reactive protein, and disease severity in ulcerative colitis: A retrospective study
Association between serum vitamin D, uric acid, C-reactive protein, and disease severity in ulcerative colitis: A retrospective study Open
Ulcerative colitis (UC) is an inflammatory disease of the intestinal mucosa, and immunodeficiency is the main cause. Vitamin D (VD) has been shown to regulate many immune diseases, and studies have found that the level of uric acid (UA) an…
View article: Diagnostic indicators and lifestyle interventions of metabolic-associated fatty liver disease
Diagnostic indicators and lifestyle interventions of metabolic-associated fatty liver disease Open
MAFLD has become a major global health problem and is the leading cause of liver disease worldwide. The disease progresses from a simple fatty liver to gradual fibrosis, which progresses to cirrhosis and even hepatocellular liver cancer. H…
View article: Exploring the interactions between metabolic dysfunction-associated fatty liver disease and micronutrients: from molecular mechanisms to clinical applications
Exploring the interactions between metabolic dysfunction-associated fatty liver disease and micronutrients: from molecular mechanisms to clinical applications Open
Metabolic (dysfunction)-associated fatty liver disease (MAFLD) has emerged as a significant global health concern, representing a major cause of liver disease worldwide. This condition spans a spectrum of histopathologic stages, beginning …
View article: Biological activities, Molecular mechanisms, and Clinical application of Naringin in Metabolic syndrome
Biological activities, Molecular mechanisms, and Clinical application of Naringin in Metabolic syndrome Open
Metabolic syndrome has become major health problems in recent decades, and natural compounds receive considerable attention in the management of metabolic syndrome. Among them, naringin is abundant in citrus fruits and tomatoes. Many studi…
View article: Application of natural compounds in the treatment and prevention of prediabetes
Application of natural compounds in the treatment and prevention of prediabetes Open
Prediabetes is an intermediate stage in the development of type 2 diabetes mellitus characterized by impaired fasting glucose and/or impaired glucose tolerance. Prediabetes generally has no obvious clinical symptoms, and most patients are …
View article: Bioactive components, pharmacological effects, and drug development of traditional herbal medicine Rubus chingii Hu (Fu-Pen-Zi)
Bioactive components, pharmacological effects, and drug development of traditional herbal medicine Rubus chingii Hu (Fu-Pen-Zi) Open
Rubus chingii Hu (Chinese Raspberry), known as Fu-Pen-Zi in Chinese, a woody perennial plant of the genus Rubus in the Rosaceae family, has specific nutritional and medicinal values, which is considered food-medicine herb in China for thou…
View article: Current progress of <i>Atractylodes macrocephala</i> Koidz.: A review of its biogeography, PAO-ZHI processing, biological activities, biosynthesis pathways, and technology applications
Current progress of <i>Atractylodes macrocephala</i> Koidz.: A review of its biogeography, PAO-ZHI processing, biological activities, biosynthesis pathways, and technology applications Open
The Atractylodes macrocephala Koidz. is a traditional Chinese rhizome herb, consumed for its well-known medicinal value. This review summarizes the recent research findings on biological activities, main biosynthesis pathways, PAO-ZHI proc…
View article: Natural flavonoids: Potential therapeutic strategies for non-alcoholic fatty liver disease
Natural flavonoids: Potential therapeutic strategies for non-alcoholic fatty liver disease Open
The incidence of non-alcoholic fatty liver disease (NAFLD) is increasing rapidly worldwide; however, there are currently limited treatments for NAFLD. The disease spectrum includes simple fatty liver, non-alcoholic steatohepatitis (NASH), …
View article: Exploring and Verifying the Mechanism and Targets of Shenqi Pill in the Treatment of Nonalcoholic Steatohepatitis via Network Pharmacology and Experiments
Exploring and Verifying the Mechanism and Targets of Shenqi Pill in the Treatment of Nonalcoholic Steatohepatitis via Network Pharmacology and Experiments Open
Shenqi pill (SQP), a famous traditional Chinese medicine (TCM) herbal formula derived from Jinguiyaolue (Synopsis of Prescriptions of the Golden Chamber), has long been used to treat kidney yang deficiency syndrome. According to the TCM tr…
View article: Yiqi-Bushen-Tiaozhi Recipe Attenuated High-Fat and High-Fructose Diet Induced Nonalcoholic Steatohepatitis in Mice via Gut Microbiota
Yiqi-Bushen-Tiaozhi Recipe Attenuated High-Fat and High-Fructose Diet Induced Nonalcoholic Steatohepatitis in Mice via Gut Microbiota Open
Aim To investigate the treating effect of Yiqi-Bushen-Tiaozhi (YBT) recipe on nonalcoholic steatohepatitis (NASH) mice, determine whether the outcome was associated with gut microbiota, and clarify the regulating mechanism. Methods NASH mi…
View article: Bioinformatics analysis of an animal model of diet-induced nonalcoholic fatty liver disease with rapid progression
Bioinformatics analysis of an animal model of diet-induced nonalcoholic fatty liver disease with rapid progression Open
Nonalcoholic fatty liver disease (NAFLD) develops rapidly in high-fat diet (HFD) fed Mongolian gerbil ( Meriones unguiculatus). Here, we aim to explore the gene expression characteristics of Mongolian gerbil to better understand the underl…
View article: Long Non-Coding RNA: A Potential Strategy for the Diagnosis and Treatment of Colorectal Cancer
Long Non-Coding RNA: A Potential Strategy for the Diagnosis and Treatment of Colorectal Cancer Open
Colorectal cancer (CRC), being one of the most commonly diagnosed cancers worldwide, endangers human health. Because the pathological mechanism of CRC is not fully understood, there are many challenges in the prevention, diagnosis, and tre…
View article: Emodin inhibits the progression of acute pancreatitis via regulation of lncRNA TUG1 and exosomal lncRNA TUG1
Emodin inhibits the progression of acute pancreatitis via regulation of lncRNA TUG1 and exosomal lncRNA TUG1 Open
Acute pancreatitis (AP) is one of the most frequent gastrointestinal diseases and has no specific treatment. It has been shown that dysfunction of pancreatic acinar cells can lead to AP progression. Emodin is a natural product, which can a…
View article: Predicting Target Genes of San-Huang-Chai-Zhu Formula in Treating ANIT-Induced Acute Intrahepatic Cholestasis Rat Model via Bioinformatics Analysis Combined with Experimental Validation
Predicting Target Genes of San-Huang-Chai-Zhu Formula in Treating ANIT-Induced Acute Intrahepatic Cholestasis Rat Model via Bioinformatics Analysis Combined with Experimental Validation Open
Background. San-Huang-Chai-Zhu formula (SHCZF) has been used to improve cholestasis for many years. This study aims to predict the possible gene targets of SHCZF in treating acute intrahepatic cholestasis (AIC) in rats. Materials and Metho…
View article: Hp-Positive Chinese Patients Should Undergo Colonoscopy Earlier and More Frequently: The Result of a Cross-Sectional Study Based on 13,037 Cases of Gastrointestinal Endoscopy
Hp-Positive Chinese Patients Should Undergo Colonoscopy Earlier and More Frequently: The Result of a Cross-Sectional Study Based on 13,037 Cases of Gastrointestinal Endoscopy Open
Background In China, the prevalence and mortality of colorectal cancer (CRC) have always been high, and more than 95% of CRC cases have evolved from colorectal polyps (CPs), especially adenoma. Early detection and treatment of CPs through …
View article: Potential Roles of Exosomal lncRNAs in the Intestinal Mucosal Immune Barrier
Potential Roles of Exosomal lncRNAs in the Intestinal Mucosal Immune Barrier Open
The intestinal mucosal immune barrier protects the host from the invasion of foreign pathogenic microorganisms. Immune cells and cytokines in the intestinal mucosa maintain local and systemic homeostasis by participating in natural and ada…
View article: Probiotics Alleviated Nonalcoholic Fatty Liver Disease in High-Fat Diet-Fed Rats via Gut Microbiota/FXR/FGF15 Signaling Pathway
Probiotics Alleviated Nonalcoholic Fatty Liver Disease in High-Fat Diet-Fed Rats via Gut Microbiota/FXR/FGF15 Signaling Pathway Open
Gut microbiota (GM) dysbiosis and bile acid (BA) metabolism disorder play an important role in the pathogenesis of nonalcoholic fatty liver disease (NAFLD). Probiotics had a beneficial effect on NAFLD, but further study is needed to explor…
View article: Natural Compounds: A Potential Treatment for Alcoholic Liver Disease?
Natural Compounds: A Potential Treatment for Alcoholic Liver Disease? Open
Excessive alcohol intake is a direct cause of alcoholic liver disease (ALD). ALD usually manifests as fatty liver in the initial stage and then develops into alcoholic hepatitis (ASH), fibrosis and cirrhosis. Severe alcoholism induces exte…
View article: The Roles and Pharmacological Effects of FGF21 in Preventing Aging-Associated Metabolic Diseases
The Roles and Pharmacological Effects of FGF21 in Preventing Aging-Associated Metabolic Diseases Open
With the continuous improvement of living standards but the lack of exercise, aging-associated metabolic diseases such as obesity, type 2 diabetes mellitus (T2DM), and non-alcoholic fatty liver disease (NAFLD) are becoming a lingering dark…
View article: Chemical Activators of the Nrf2 Signaling Pathway in Nonalcoholic Fatty Liver Disease
Chemical Activators of the Nrf2 Signaling Pathway in Nonalcoholic Fatty Liver Disease Open
Nonalcoholic fatty liver disease (NAFLD) is paralleling the insulin resistance and obesity epidemic and is regarded as liver metabolic syndrome, and its prevalence rate is increasing rapidly. The best explanation for the occurrence and dev…
View article: The Role of lncRNAs in Regulating the Intestinal Mucosal Mechanical Barrier
The Role of lncRNAs in Regulating the Intestinal Mucosal Mechanical Barrier Open
lncRNA is a transcript that is more than 200 bp in length. Currently, evidence has shown that lncRNA is of great significance in cell activity, involved in epigenetics, gene transcription, chromatin regulation, etc. The existence of an int…
View article: Pure total flavonoids from citrus attenuate non-alcoholic steatohepatitis via regulating the gut microbiota and bile acid metabolism in mice
Pure total flavonoids from citrus attenuate non-alcoholic steatohepatitis via regulating the gut microbiota and bile acid metabolism in mice Open
PTFC can improve NASH via the the gut microbiota and bile acid metabolism.
View article: The Target MicroRNAs and Potential Underlying Mechanisms of Yiqi-Bushen-Tiaozhi Recipe against‐Non-Alcoholic Steatohepatitis
The Target MicroRNAs and Potential Underlying Mechanisms of Yiqi-Bushen-Tiaozhi Recipe against‐Non-Alcoholic Steatohepatitis Open
MicroRNAs (miRNAs) have emerged as potential therapeutic targets for non-alcoholic fatty liver disease/non-alcoholic steatohepatitis (NAFLD/NASH). Traditional Chineses Medicine (TCM) plays an important role in the prevention or treatment o…
View article: The Function and Role of the Th17/Treg Cell Balance in Inflammatory Bowel Disease
The Function and Role of the Th17/Treg Cell Balance in Inflammatory Bowel Disease Open
Inflammatory bowel disease (IBD) is a chronic, inflammatory, and autoimmune disorder. The pathogenesis of IBD is not yet clear. Studies have shown that the imbalance between T helper 17 (Th17) and regulatory T (Treg) cells, which different…
View article: Small Intestine Protection of Mica Against Non-Steroidal Anti-Inflammatory Drugs-Injury Through ERK1/2 Signal Pathway in Rats
Small Intestine Protection of Mica Against Non-Steroidal Anti-Inflammatory Drugs-Injury Through ERK1/2 Signal Pathway in Rats Open
Objective: The impact of non-steroidal anti-inflammatory drugs (NSAIDs) to damage the small intestine has been well known. Mica, one kind of natural clay, has been widely marketed in China for the treatment of gastric diseases. However, th…