Beiling Li
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View article: Human cytomegalovirus reactivation in cirrhosis patients with acute decompensation
Human cytomegalovirus reactivation in cirrhosis patients with acute decompensation Open
Background/Aims: The role of reactivation of human cytomegalovirus (HCMV) in determining outcomes of cirrhotic patients with acute decompensation (AD) is unknown. We aimed to investigate HCMV incidence and potential correlation with hepati…
View article: Serum Creatinine of 1.1 mg/dL Can Indicate Disease Deterioration and 90‐day Mortality in Hospitalized Patients With Cirrhosis in Chinese Population
Serum Creatinine of 1.1 mg/dL Can Indicate Disease Deterioration and 90‐day Mortality in Hospitalized Patients With Cirrhosis in Chinese Population Open
Aims Increased serum creatinine (sCR) is associated with increased mortality in cirrhotic patients, while there remains a lack of evidence‐based sCR cutoffs for indicating disease deterioration and predicting 90‐day liver transplantation (…
View article: Nomograms for predicting short-term mortality in acute-on-chronic liver disease caused by the combination of hepatitis B virus and alcohol
Nomograms for predicting short-term mortality in acute-on-chronic liver disease caused by the combination of hepatitis B virus and alcohol Open
This study aimed to identify predictive factors for the prognosis of acute-on-chronic liver disease (AoCLD) due to both hepatitis B virus (HBV) and alcohol and to develop prognostic models to improve treatment management. AoCLD patients wi…
View article: Evidence-based incorporation of key parameters into MELD score for acute-on-chronic liver failure
Evidence-based incorporation of key parameters into MELD score for acute-on-chronic liver failure Open
Background The model for end-stage liver disease (MELD) score is widely used for the prognostication in end-stage liver disease but has limited performance in acute-on-chronic liver failure (ACLF). In this study, we identified additional p…
View article: Characterization of acute-on-chronic liver diseases: A multicenter prospective cohort study
Characterization of acute-on-chronic liver diseases: A multicenter prospective cohort study Open
BACKGROUND Acute-on-chronic liver disease (AoCLD) accounts for the majority of patients hospitalized in the Department of Hepatology or Infectious Diseases. AIM To explore the characterization of AoCLD to provide theoretical guidance for t…
View article: The clinical courses of HBV-related acute-on-chronic liver failure and a multi-state model to predict disease evolution
The clinical courses of HBV-related acute-on-chronic liver failure and a multi-state model to predict disease evolution Open
Background and Aims: Acute-on-chronic liver failure (ACLF) is a highly dynamic syndrome. The objective of this study was to delineate the clinical course of patients with HBV-ACLF and to develop a model to estimate the temporal evolution o…
View article: Investigation on the short‐term outcome and prognostic impact of predisposition, and precipitants in inpatients with chronic liver disease from Chinese AcuTe on CHronic LIver FailurE (CATCH‐LIFE) cohorts
Investigation on the short‐term outcome and prognostic impact of predisposition, and precipitants in inpatients with chronic liver disease from Chinese AcuTe on CHronic LIver FailurE (CATCH‐LIFE) cohorts Open
Aim The study aimed to investigate the short‐term outcomes of hospitalized patients with chronic liver disease (CLDs) and assess the prognostic impact of predisposition and precipitants, which currently remains unclear. Methods The study i…
View article: Severe anemia is associated with increased short-term and long-term mortality in patients hospitalized with cirrhosis
Severe anemia is associated with increased short-term and long-term mortality in patients hospitalized with cirrhosis Open
Anemia is common in patients with cirrhosis admitted for acute events. Severe anemia was associated with poor 90-day and 1-year prognoses in these patients.
View article: Prognosis prediction performs better in patients with non-cirrhosis hepatitis B virus-related acute-on-chronic liver failure than those with cirrhosis
Prognosis prediction performs better in patients with non-cirrhosis hepatitis B virus-related acute-on-chronic liver failure than those with cirrhosis Open
Background The accurate prediction of the outcome of hepatitis B virus-related acute-on-chronic liver failure (HBV-ACLF) is impeded by population heterogeneity. The study aimed to assess the impact of underlying cirrhosis on the performanc…
View article: Prognostic and therapeutic significance of microbial cell-free DNA in plasma of people with acute decompensation of cirrhosis
Prognostic and therapeutic significance of microbial cell-free DNA in plasma of people with acute decompensation of cirrhosis Open
A non-hepatotropic virus (NHV) signature, which was similar to that in individuals with sepsis and hematological malignancies, was identified in individuals with acute decompensation of cirrhosis. The detected viral signature had clinical …
View article: Prevalence and clinical characteristics of autoimmune liver disease in hospitalized patients with cirrhosis and acute decompensation in China
Prevalence and clinical characteristics of autoimmune liver disease in hospitalized patients with cirrhosis and acute decompensation in China Open
AILD was not rare in hospitalized patients with cirrhosis and AD in China, among which PBC was the most common etiology. 90-d LT-free mortality were independently associated with TB, HE and BUN.
View article: New Algorithm Rules Out Acute-on-chronic Liver Failure Development within 28 Days from Acute Decompensation of Cirrhosis
New Algorithm Rules Out Acute-on-chronic Liver Failure Development within 28 Days from Acute Decompensation of Cirrhosis Open
AD patients with ≤1 organ dysfunction had a significantly lower risk of developing ACLF within 28 days of admission and could be safely ruled out with a pre-ACLF miss rate of <5%.
View article: Hepatitis B Virus Reactivation Increased the Risk of Developing Hepatic Failure and Mortality in Cirrhosis With Acute Exacerbation
Hepatitis B Virus Reactivation Increased the Risk of Developing Hepatic Failure and Mortality in Cirrhosis With Acute Exacerbation Open
Background and Aims Hepatitis B virus (HBV) reactivation is a serious condition and has been extensively described in chemotherapeutic immunosuppressive population. However, little is known about HBV reactivation in immunocompetent patient…
View article: Prevalence and clinical significance of serum sodium variability in patients with acute-on-chronic liver diseases: a prospective multicenter study in China
Prevalence and clinical significance of serum sodium variability in patients with acute-on-chronic liver diseases: a prospective multicenter study in China Open
This study is registered at Shanghai www.clinicaltrials.org (NCT02457637 and NCT03641872).
View article: Back Cover
Back Cover Open
The cover image is based on the Brief Definitive Report Rapid detection for infected ascites in cirrhosis using metagenome next-generation sequencing: A case series by Beiling Li et al., https://doi.org/10.1111/liv.15083.
View article: Increased INR Values Predict Accelerating Deterioration and High Short-Term Mortality Among Patients Hospitalized With Cirrhosis or Advanced Fibrosis
Increased INR Values Predict Accelerating Deterioration and High Short-Term Mortality Among Patients Hospitalized With Cirrhosis or Advanced Fibrosis Open
Background and Objective: An increase in the international normalized ratio (INR) is associated with increased mortality in patients with cirrhosis and other chronic liver diseases, while little is known about the quantitative relationship…
View article: Plasma Exchange-Based Non-bioartificial Liver Support System Improves the Short-Term Outcomes of Patients With Hepatitis B Virus-Associated Acute-on-Chronic Liver Failure: A Multicenter Prospective Cohort Study
Plasma Exchange-Based Non-bioartificial Liver Support System Improves the Short-Term Outcomes of Patients With Hepatitis B Virus-Associated Acute-on-Chronic Liver Failure: A Multicenter Prospective Cohort Study Open
Background and aims: Hepatitis B virus-associated acute-on-chronic liver failure (HBV-ACLF) is a complicated syndrome with extremely high short-term mortality. Whether plasma exchange (PE) improves HBV-ACLF outcomes remains controversial. …
View article: Prognostic Relevance of Anemia In Hospitalized Patients With Cirrhosis:A Multicenter Cohort Study
Prognostic Relevance of Anemia In Hospitalized Patients With Cirrhosis:A Multicenter Cohort Study Open
Background and Aims: Anemia is common in cirrhosis and closely related with adverse outcome in cirrhotic patients, but their clinical features and the effect of variations in hemoglobin levels on mortality or time of death have not yet ful…
View article: Baseline Neutrophil-to-Lymphocyte Ratio Is Independently Associated With 90-Day Transplant-Free Mortality in Patients With Cirrhosis
Baseline Neutrophil-to-Lymphocyte Ratio Is Independently Associated With 90-Day Transplant-Free Mortality in Patients With Cirrhosis Open
Background: Patients with cirrhosis have an increased risk of short-term mortality, however, few studies quantify the association between neutrophil-to-lymphocyte ratio (NLR) and 90-day transplant-free mortality in cirrhotic patients. Meth…
View article: Lower platelet counts were associated with 90-day adverse outcomes in acute-on-chronic liver disease patients
Lower platelet counts were associated with 90-day adverse outcomes in acute-on-chronic liver disease patients Open
NCT02457637, NCT03641872.
View article: Impact of Hepatic Encephalopathy on Clinical Characteristics and Adverse Outcomes in Prospective and Multicenter Cohorts of Patients With Acute-on-Chronic Liver Diseases
Impact of Hepatic Encephalopathy on Clinical Characteristics and Adverse Outcomes in Prospective and Multicenter Cohorts of Patients With Acute-on-Chronic Liver Diseases Open
Importance: Hepatic encephalopathy is a severe complication, and its contribution to clinical adverse outcomes in patients with acute-on-chronic liver diseases from the East is unclear. Objective: We aimed to investigate the impact of hepa…
View article: Different Effects of Total Bilirubin on 90-Day Mortality in Hospitalized Patients With Cirrhosis and Advanced Fibrosis: A Quantitative Analysis
Different Effects of Total Bilirubin on 90-Day Mortality in Hospitalized Patients With Cirrhosis and Advanced Fibrosis: A Quantitative Analysis Open
Introduction: Total bilirubin (TB) is a major prognosis predictor representing liver failure in patients with acute on chronic liver failure (ACLF). However, the cutoff value of TB for liver failure and whether the same cutoff could be app…
View article: Research on Incentive Mode of Post-90s Employees in SMEs
Research on Incentive Mode of Post-90s Employees in SMEs Open
At present, the post-90s employees have become the backbone of all walks of life, and the post-95s are gradually entering the workplace.Their entry has brought great challenges to the management and incentive of enterprises.Reform and open…