Beinan Wang
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View article: Author response: Regulative synthesis of capsular polysaccharides in the pathogenesis of Streptococcus suis
Author response: Regulative synthesis of capsular polysaccharides in the pathogenesis of Streptococcus suis Open
View article: Regulative synthesis of capsular polysaccharides in the pathogenesis of Streptococcus suis
Regulative synthesis of capsular polysaccharides in the pathogenesis of Streptococcus suis Open
Streptococcus suis ( S. suis ) is an important zoonotic pathogen causing substantial economic losses in the swine industry. S. suis serotype 2 (SS2) is often isolated from the diseased. S. suis expresses capsular polysaccharide (CPS), a vi…
View article: Regulative synthesis of capsular polysaccharides in the pathogenesis of Streptococcus suis
Regulative synthesis of capsular polysaccharides in the pathogenesis of Streptococcus suis Open
Streptococcus suis (S. suis) is an important zoonotic pathogen causing substantial economic losses in the swine industry. S. suis serotype 2 (SS2) is often isolated from the diseased. S. suis expresses capsular polysaccharide (CPS), a viru…
View article: Author response: Regulative synthesis of capsular polysaccharides in the pathogenesis of Streptococcus suis
Author response: Regulative synthesis of capsular polysaccharides in the pathogenesis of Streptococcus suis Open
View article: Regulative synthesis of capsular polysaccharides in the pathogenesis of Streptococcus suis
Regulative synthesis of capsular polysaccharides in the pathogenesis of Streptococcus suis Open
Streptococcus suis (S. suis) is an important zoonotic pathogen causing substantial economic losses in the swine industry. S. suis serotype 2 (SS2) is often isolated from the diseased. S. suis expresses capsular polysaccharide (CPS), a viru…
View article: Regulative synthesis of capsular polysaccharides in the pathogenesis of Streptococcus suis
Regulative synthesis of capsular polysaccharides in the pathogenesis of Streptococcus suis Open
Streptococcus suis ( S. suis ) is an important zoonotic pathogen causing substantial economic losses in the swine industry. S. suis serotype 2 (SS2) is often isolated from the diseased. S. suis expresses capsular polysaccharide (CPS), a vi…
View article: Regulative synthesis of capsular polysaccharides in the pathogenesis of <i>Streptococcus suis</i>
Regulative synthesis of capsular polysaccharides in the pathogenesis of <i>Streptococcus suis</i> Open
Streptococcus suis ( S. suis ) is an important zoonotic pathogen causing substantial economic losses in the swine industry. S. suis serotype 2 (SS2) is often isolated from the diseased. S. suis expresses capsular polysaccharide (CPS), a vi…
View article: Data Caching for Enterprise-Grade Petabyte-Scale OLAP
Data Caching for Enterprise-Grade Petabyte-Scale OLAP Open
With the exponential growth of data and evolving use cases, petabyte-scale OLAP data platforms are increasingly adopting a model that decouples compute from storage. This shift, evident in organizations like Uber and Meta, introduces opera…
View article: Rethinking the Cloudonomics of Efficient I/O for Data-Intensive Analytics Applications
Rethinking the Cloudonomics of Efficient I/O for Data-Intensive Analytics Applications Open
This paper explores a prevailing trend in the industry: migrating data-intensive analytics applications from on-premises to cloud-native environments. We find that the unique cost models associated with cloud-based storage necessitate a mo…
View article: Immunization with Multiple Virulence Factors Provides Maternal and Neonatal Protection against Group B Streptococcus Serotypes
Immunization with Multiple Virulence Factors Provides Maternal and Neonatal Protection against Group B Streptococcus Serotypes Open
Group B streptococcus (GBS) commonly colonizes the vaginal tract and is a leading cause of life-threatening neonatal infections and adverse pregnancy outcomes. No effective vaccine is clinically available. Conserved bacterial virulence fac…
View article: Coevolution of <i>furA</i> -Regulated Hyper-Inflammation and Mycobacterial Resistance to Oxidative Killing through Adaptation to Hydrogen Peroxide
Coevolution of <i>furA</i> -Regulated Hyper-Inflammation and Mycobacterial Resistance to Oxidative Killing through Adaptation to Hydrogen Peroxide Open
Mycobacterium tuberculosis ( Mtb ) causes human tuberculosis (TB), which has killed more people in human history than any other microorganism. However, the mechanisms underlying Mtb pathogenesis and related genes have not yet been fully el…
View article: Diversification of Sinorhizobium populations associated with Medicago polymorpha and Medicago lupulina in purple soil of China
Diversification of Sinorhizobium populations associated with Medicago polymorpha and Medicago lupulina in purple soil of China Open
The double selection of environment adaptation and host specificity forced the diversification of rhizobia in nature. In the tropical region of China, Medicago polymorpha and Medicago lupulina are widely distributed, particularly in purple…
View article: Metadata Caching in Presto: Towards Fast Data Processing
Metadata Caching in Presto: Towards Fast Data Processing Open
Presto is an open-source distributed SQL query engine for OLAP, aiming for "SQL on everything". Since open-sourced in 2013, Presto has been consistently gaining popularity in large-scale data analytics and attracting adoption from a wide r…
View article: CWcollab: Presenting multimedia with web-based context-aware collaboration
CWcollab: Presenting multimedia with web-based context-aware collaboration Open
View article: Serving Hybrid-Cloud SQL Interactive Queries at Twitter
Serving Hybrid-Cloud SQL Interactive Queries at Twitter Open
The demand for data analytics has been consistently increasing in the past years at Twitter. In order to fulfill the requirements and provide a highly scalable and available query experience, a large-scale in-house SQL system is heavily re…
View article: A Parallel Implementation of Computing Mean Average Precision
A Parallel Implementation of Computing Mean Average Precision Open
Mean Average Precision (mAP) has been widely used for evaluating the quality of object detectors, but an efficient implementation is still absent. Current implementations can only count true positives (TP's) and false positives (FP's) for …
View article: Differential Effects of Toll-Like Receptor Signaling on the Activation of Immune Responses in the Upper Respiratory Tract
Differential Effects of Toll-Like Receptor Signaling on the Activation of Immune Responses in the Upper Respiratory Tract Open
Agonists of TLRs are potential adjuvant candidates for mucosal vaccination. We demonstrated that the TLR-mediated inflammatory and antibody responses in the URT of SPF mice exposed to extracellular TLR agonists were substantially restricte…
View article: Immunity to Sda1 Protects against Infection by Sda1+ and Sda1− Serotypes of Group A Streptococcus
Immunity to Sda1 Protects against Infection by Sda1+ and Sda1− Serotypes of Group A Streptococcus Open
Group A Streptococcus (GAS) causes a variety of diseases globally. The DNases in GAS promote GAS evasion of neutrophil killing by degrading neutrophil extracellular traps (NETs). Sda1 is a prophage-encoded DNase associated with virulent GA…
View article: Forecasting SQL Query Cost at Twitter
Forecasting SQL Query Cost at Twitter Open
With the advent of the Big Data era, it is usually computationally expensive\nto calculate the resource usages of a SQL query with traditional DBMS\napproaches. Can we estimate the cost of each query more efficiently without any\ncomputati…
View article: CWcollab: A Context-Aware Web-Based Collaborative Multimedia System
CWcollab: A Context-Aware Web-Based Collaborative Multimedia System Open
Remote collaboration tools for conferencing and presentation are gaining significant popularity during the COVID-19 pandemic period. Most prior work has issues, such as a) limited support for media types, b) lack of interactivity, for exam…
View article: Induction of cyclophilin A by influenza A virus infection facilitates group A Streptococcus coinfection
Induction of cyclophilin A by influenza A virus infection facilitates group A Streptococcus coinfection Open
During influenza A epidemics, bacterial coinfection is a major cause of increased morbidity and mortality. However, the roles of host factors in regulating influenza A virus (IAV)-triggered bacterial coinfection remain elusive. Cyclophilin…
View article: IFN-γ <sup>–/–</sup> Mice Resist Actinobacillus pleuropneumoniae Infection by Promoting Early Lung IL-18 Release and PMN-I Accumulation
IFN-γ <sup>–/–</sup> Mice Resist Actinobacillus pleuropneumoniae Infection by Promoting Early Lung IL-18 Release and PMN-I Accumulation Open
Porcine pleuropneumonia is a common infectious disease of pigs caused by Actinobacillus pleuropneumoniae . Interferon gamma (IFN-γ) expression increases in the lung of pigs after A. pleuropneumoniae infection, but the role of IFN-γ during …
View article: Flu Virus Attenuates Memory Clearance of Pneumococcus via IFN-γ-Dependent Th17 and Independent Antibody Mechanisms
Flu Virus Attenuates Memory Clearance of Pneumococcus via IFN-γ-Dependent Th17 and Independent Antibody Mechanisms Open
Bacterial coinfection is a major cause of influenza-associated mortality. Most people have experienced infections with bacterial pathogens commonly associated with influenza A virus (IAV) coinfection before IAV exposure; however, bacterial…
View article: Infection of Mycobacterium tuberculosis Promotes Both M1/M2 Polarization and MMP Production in Cigarette Smoke-Exposed Macrophages
Infection of Mycobacterium tuberculosis Promotes Both M1/M2 Polarization and MMP Production in Cigarette Smoke-Exposed Macrophages Open
Pulmonary tuberculosis (PTB) is a risk factor for COPD. Our previous study revealed more severe emphysema in COPD patients (mostly smokers) with prior tuberculosis. However, the mechanisms of interactions between cigarette smoke (CS) and <…
View article: A Multicomponent Vaccine Provides Immunity against Local and Systemic Infections by Group A Streptococcus across Serotypes
A Multicomponent Vaccine Provides Immunity against Local and Systemic Infections by Group A Streptococcus across Serotypes Open
GAS is among the most common human pathogens and causes a wide variety of diseases, likely more than any other microorganism. The diverse clinical manifestations of GAS may be attributable to its large repertoire of virulence factors that …
View article: Feedbackward Decoding for Semantic Segmentation
Feedbackward Decoding for Semantic Segmentation Open
We propose a novel approach for semantic segmentation that uses an encoder in the reverse direction to decode. Many semantic segmentation networks adopt a feedforward encoder-decoder architecture. Typically, an input is first downsampled b…
View article: Intracellular Invasion by <i>Streptococcus pyogenes</i> : Invasins, Host Receptors, and Relevance to Human Disease
Intracellular Invasion by <i>Streptococcus pyogenes</i> : Invasins, Host Receptors, and Relevance to Human Disease Open
The human oral-nasal mucosa is the primary reservoir for Streptococcus pyogenes infections. Although the most common infection of consequence in temperate climates is pharyngitis, the past 25 years have witnessed a dramatic increase in inv…
View article: Protective immune mechanisms of Yifei Tongluo, a Chinese herb formulation, in the treatment of mycobacterial infection
Protective immune mechanisms of Yifei Tongluo, a Chinese herb formulation, in the treatment of mycobacterial infection Open
Yifei Tongluo (YFTL) is a traditional Chinese medicine (TCM) formulation which has been shown clinical efficacy in treatment of patients with multidrug-resistant tuberculosis in China. However, the underlying mechanisms of the effects of Y…
View article: Inhibitors of histone acetyltransferases KAT6A/B induce senescence and arrest tumour growth
Inhibitors of histone acetyltransferases KAT6A/B induce senescence and arrest tumour growth Open
View article: Co-Activation of Th17 and Antibody Responses Provides Efficient Protection against Mucosal Infection by Group A Streptococcus
Co-Activation of Th17 and Antibody Responses Provides Efficient Protection against Mucosal Infection by Group A Streptococcus Open
Conserved protein antigens among serotypes of group A Streptococcus pyogenes (GAS) have been focused for vaccine development because of the diversity of GAS serotypes and risks of autoimmunity post-GAS infection. Precise delineation of pro…