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View article: N-Homocysteinylation of HMGB1/2 Promotes Corpus Cavernosum Endothelial Senescence in Erectile Dysfunction
N-Homocysteinylation of HMGB1/2 Promotes Corpus Cavernosum Endothelial Senescence in Erectile Dysfunction Open
Homocysteine (Hcy) is an age-related risk factor for erectile dysfunction (ED), with enhanced vascular toxicity in middle-aged and elderly individuals. However, folate-based Hcy-lowering therapies have shown limited efficacy, necessitating…
View article: Apolipoprotein E promotes primary resistance to AR-targeted therapy via inducing TRIM25-mediated AR ubiquitination and sensitizes immunotherapy in prostate cancer
Apolipoprotein E promotes primary resistance to AR-targeted therapy via inducing TRIM25-mediated AR ubiquitination and sensitizes immunotherapy in prostate cancer Open
Rationale: Prostate cancer (PCa) growth is facilitated by the androgen receptor (AR) and its downstream signaling pathways, making AR-targeted therapy crucial for treating advanced stages. Despite this, the response to AR-targeted t…
View article: Peptide-specific natural killer cell receptors
Peptide-specific natural killer cell receptors Open
Class I and II human leukocyte antigens (HLA-I and HLA-II) present peptide antigens for immunosurveillance by T cells. HLA molecules also form ligands for a plethora of innate, germline-encoded receptors. Many of these receptors engage HLA…
View article: Relaxin‐2 improves type I diabetes mellitus‐induced erectile dysfunction in rats by protecting cavernous endothelial and smooth muscle function, and inhibiting penile fibrosis and apoptosis
Relaxin‐2 improves type I diabetes mellitus‐induced erectile dysfunction in rats by protecting cavernous endothelial and smooth muscle function, and inhibiting penile fibrosis and apoptosis Open
Background Diabetes mellitus‐induced erectile dysfunction (DMED) responds poorly to first‐line treatments, necessitating the development of new therapeutic strategies. Relaxin‐2 (RLX‐2) plays a crucial role in protecting vascular endotheli…
View article: Atractylenolide I inhibits angiogenesis and reverses sunitinib resistance in clear cell renal cell carcinoma through ATP6V0D2-mediated autophagic degradation of EPAS1/HIF2α
Atractylenolide I inhibits angiogenesis and reverses sunitinib resistance in clear cell renal cell carcinoma through ATP6V0D2-mediated autophagic degradation of EPAS1/HIF2α Open
Clear cell renal cell carcinoma (ccRCC) is tightly associated with VHL (von Hippel-Lindau tumor suppressor) mutation and dysregulated angiogenesis. Accumulating evidence indicates that antiangiogenic treatment abolishing tumor angio…
View article: Evaluating the causal effect of circulating proteome on the risk of inflammatory bowel disease-related traits using Mendelian randomization
Evaluating the causal effect of circulating proteome on the risk of inflammatory bowel disease-related traits using Mendelian randomization Open
Objective This study sought to identify circulating proteins causally linked to Inflammatory Bowel Disease (IBD) traits through a Mendelian Randomization (MR) analytical framework. Methods Using a large-scale, two-sample MR approach, we es…
View article: Evaluating the Causal Effect of Circulating Proteome on the Risk of Inflammatory Bowel Disease-Related Traits
Evaluating the Causal Effect of Circulating Proteome on the Risk of Inflammatory Bowel Disease-Related Traits Open
View article: STX4 as a potential biomarker for predicting prognosis and guiding clinical treatment decisions in clear cell renal cell carcinoma
STX4 as a potential biomarker for predicting prognosis and guiding clinical treatment decisions in clear cell renal cell carcinoma Open
View article: Integrating bioinformatic analysis and detailed experiments reveal an <scp>EMT</scp>‐related biomarker for clear cell renal cell carcinoma
Integrating bioinformatic analysis and detailed experiments reveal an <span>EMT</span>‐related biomarker for clear cell renal cell carcinoma Open
Background Epithelial–mesenchymal transition (EMT) is associated with early recurrence and a poor prognosis in clear cell renal cell carcinoma (ccRCC). Studies have shown that EMT‐related genes play an important regulatory role in tumor in…
View article: Peer Review #2 of "A novel gene signature related to oxidative stress predicts the prognosis in clear cell renal cell carcinoma (v0.2)"
Peer Review #2 of "A novel gene signature related to oxidative stress predicts the prognosis in clear cell renal cell carcinoma (v0.2)" Open
Clear cell renal cell carcinoma (ccRCC) is considered to be related to the worse prognosis, which might in part be attributed to the early recurrence and metastasis, compared with other type of kidney cancer.Oxidative stress refers to an i…
View article: Peer Review #1 of "A novel gene signature related to oxidative stress predicts the prognosis in clear cell renal cell carcinoma (v0.1)"
Peer Review #1 of "A novel gene signature related to oxidative stress predicts the prognosis in clear cell renal cell carcinoma (v0.1)" Open
Clear cell renal cell carcinoma (ccRCC) is considered to be related to the worse prognosis, which might in part be attributed to the early recurrence and metastasis, compared with other type of kidney cancer.Oxidative stress refers to an i…
View article: Peer Review #2 of "A novel gene signature related to oxidative stress predicts the prognosis in clear cell renal cell carcinoma (v0.1)"
Peer Review #2 of "A novel gene signature related to oxidative stress predicts the prognosis in clear cell renal cell carcinoma (v0.1)" Open
Clear cell renal cell carcinoma (ccRCC) is considered to be related to the worse prognosis, which might in part be attributed to the early recurrence and metastasis, compared with other type of kidney cancer.Oxidative stress refers to an i…
View article: A novel gene signature related to oxidative stress predicts the prognosis in clear cell renal cell carcinoma
A novel gene signature related to oxidative stress predicts the prognosis in clear cell renal cell carcinoma Open
Clear cell renal cell carcinoma (ccRCC) is considered to be related to the worse prognosis, which might in part be attributed to the early recurrence and metastasis, compared with other type of kidney cancer. Oxidative stress refers to an …
View article: P2Y12 receptor as a new target for electroacupuncture relieving comorbidity of visceral pain and depression of inflammatory bowel disease
P2Y12 receptor as a new target for electroacupuncture relieving comorbidity of visceral pain and depression of inflammatory bowel disease Open