Bowen Zhang
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View article: Prognostic assessment of sepsis-induced acute respiratory distress syndrome in older patients using clinical and CT-based radiomic features
Prognostic assessment of sepsis-induced acute respiratory distress syndrome in older patients using clinical and CT-based radiomic features Open
The nomogram developed from the fusion model demonstrated superior predictive performance for 28-day mortality in older patients with SI-ARDS compared to conventional scoring systems, though multicenter validation is required to confirm cl…
View article: A unified language model bridging <i>de novo</i> and fragment-based 3D molecule design delivers potent CBL-B inhibitors for cancer treatment
A unified language model bridging <i>de novo</i> and fragment-based 3D molecule design delivers potent CBL-B inhibitors for cancer treatment Open
The rational design of small molecules is central to drug discovery, yet current artificial intelligence (AI) methodologies for generating three-dimensional (3D) molecules are often siloed, focusing on either de novo design or fragment-bas…
View article: Detection and genetic diversity of Cryptosporidium in yaks in Xinjiang, China
Detection and genetic diversity of Cryptosporidium in yaks in Xinjiang, China Open
Cryptosporidium spp. is an important protozoan parasite that can cause diarrhea in both humans and animals worldwide. In the present study, a total of 826 yak fecal samples were collected from six counties in Xinjiang and tested for…
View article: Pocket-based molecule generation with an SE(3)-equivariant language model leads to a potent and selective HPK1 inhibitor with <i>in vivo</i> efficacy
Pocket-based molecule generation with an SE(3)-equivariant language model leads to a potent and selective HPK1 inhibitor with <i>in vivo</i> efficacy Open
Deep learning shows promise in structure-based drug discovery, yet challenges persist in generating pharmacologically plausible molecules with valid 3D conformation and decent binding mode in the pocket. We introduce SE3-BiLingoMol, an SE(…
View article: Temporal Glycemic Patterns in Type 1 and Type 2 Diabetes: Insights From Extended Continuous Glucose Monitoring
Temporal Glycemic Patterns in Type 1 and Type 2 Diabetes: Insights From Extended Continuous Glucose Monitoring Open
Background: Achieving optimal glycemic control for persons with diabetes remains difficult. Real-world continuous glucose monitoring (CGM) data can illuminate previously underrecognized glycemic fluctuations. We aimed to characterize gluco…
View article: Correction: Lactobacillus acidophilus extracellular vesiclescoated UiO-66-NH2@siRNA nanoparticles for ulcerative colitis targeted gene therapy and gut microbiota modulation
Correction: Lactobacillus acidophilus extracellular vesiclescoated UiO-66-NH2@siRNA nanoparticles for ulcerative colitis targeted gene therapy and gut microbiota modulation Open
View article: Lactobacillus acidophilus extracellular vesicles-coated UiO-66-NH2@siRNA nanoparticles for ulcerative colitis targeted gene therapy and gut microbiota modulation
Lactobacillus acidophilus extracellular vesicles-coated UiO-66-NH2@siRNA nanoparticles for ulcerative colitis targeted gene therapy and gut microbiota modulation Open
Ulcerative colitis (UC) is a complex and chronic inflammatory bowel disease whose pathogenesis involves genetic and environmental factors, which poses a challenge for treatment. Here, we have designed an innovative integrated therapeutic s…
View article: The dual-function of HSP70 in immune response and tumor immunity: from molecular regulation to therapeutic innovations
The dual-function of HSP70 in immune response and tumor immunity: from molecular regulation to therapeutic innovations Open
Heat shock protein 70 (HSP70) is a highly conserved molecular chaperone that plays a core role in assisting protein folding and maintaining cellular homeostasis. In recent years, studies have revealed that HSP70 has dual functions in immun…
View article: Lipid metabolism analysis reveals that DGAT1 regulates Th17 survival by controlling lipid peroxidation in uveitis
Lipid metabolism analysis reveals that DGAT1 regulates Th17 survival by controlling lipid peroxidation in uveitis Open
Lipid metabolism is closely linked with antitumor immunity and autoimmune disorders. However, the precise role of lipid metabolism in uveitis pathogenesis is not clear. In our study, we analyzed the single-cell RNA-Seq (scRNA-Seq) data fro…
View article: Audio Deepfake Detection: What Has Been Achieved and What Lies Ahead
Audio Deepfake Detection: What Has Been Achieved and What Lies Ahead Open
Advancements in audio synthesis and manipulation technologies have reshaped applications such as personalised virtual assistants, voice cloning for creative content, and language learning tools. However, the misuse of these technologies to…
View article: Molecular evidence of host range expansion of Enterocytozoon bieneusi in captive wildlife at Beijing Zoo, China
Molecular evidence of host range expansion of Enterocytozoon bieneusi in captive wildlife at Beijing Zoo, China Open
View article: The association between rs2228226 and postoperative clinical outcomes in gastric adenocarcinoma: a retrospective study
The association between rs2228226 and postoperative clinical outcomes in gastric adenocarcinoma: a retrospective study Open
Background This study aims to investigate the differences in postoperative prognosis associated with the single nucleotide polymorphism (SNP) rs2228226 (G > C) in gastric adenocarcinoma (GAC) patients. Methods This study enrolled 661 patie…
View article: Genetic Diversity and Host Specificity of Blastocystis in Yaks in Xinjiang, Northwest China
Genetic Diversity and Host Specificity of Blastocystis in Yaks in Xinjiang, Northwest China Open
View article: Genetic Diversity and Host Specificity of Blastocystis in Yaks in Xinjiang, Northwest China
Genetic Diversity and Host Specificity of Blastocystis in Yaks in Xinjiang, Northwest China Open
View article: Public and Philanthropic Research Funding, Publications and Research Networks for Cancer in the Commonwealth and Globally in 2016-2023: Comparative Analysis
Public and Philanthropic Research Funding, Publications and Research Networks for Cancer in the Commonwealth and Globally in 2016-2023: Comparative Analysis Open
View article: Deep Learning Research on Smart Home Compatibility
Deep Learning Research on Smart Home Compatibility Open
In recent years, with the rapid development of technology, the concept of Smart Home has gradually emerged into people's view., Because of its remarkable convenience, it has won the favor of many consumers in the present era. However, as t…
View article: Serine Hydroxymethyltransferase 2 Deficiency in the Hematopoietic System Disrupts Erythropoiesis and Induces Anemia in Murine Models
Serine Hydroxymethyltransferase 2 Deficiency in the Hematopoietic System Disrupts Erythropoiesis and Induces Anemia in Murine Models Open
Serine and folate metabolism play critical roles in erythroid development in both embryonic and adult mice; however, the precise roles of these metabolic pathways in erythropoiesis and the pathophysiology of anemia remain inadequately char…
View article: Gut microbiota dysbiosis is associated with altered tryptophan metabolism and dysregulated inflammatory response in COVID-19
Gut microbiota dysbiosis is associated with altered tryptophan metabolism and dysregulated inflammatory response in COVID-19 Open
View article: Therapeutic potential of the secreted Kazal-type serine protease inhibitor SPINK4 in colitis
Therapeutic potential of the secreted Kazal-type serine protease inhibitor SPINK4 in colitis Open
View article: Establishment of human hematopoietic organoids for evaluation of hematopoietic injury and regeneration effect
Establishment of human hematopoietic organoids for evaluation of hematopoietic injury and regeneration effect Open
View article: Pu‐erh tea reduces the transmission of CRD‐mediated alopecia risk to offspring
Pu‐erh tea reduces the transmission of CRD‐mediated alopecia risk to offspring Open
Circadian rhythm disorder (CRD) is closely associated with hair regression and shedding, but whether this risk can be transmitted to the offspring is unknown. Whether Pu‐erh tea, with alleviating effects of CRD‐mediated syndrome, can act o…
View article: Molecular detection of Cryptosporidium in alpine musk deer (Moschus chrysogaster) in Gansu Province, Northwest China
Molecular detection of Cryptosporidium in alpine musk deer (Moschus chrysogaster) in Gansu Province, Northwest China Open
Cryptosporidium spp. are protozoa commonly found in domestic and wild animals. Limited information is available on Cryptosporidium in deer worldwide. In this study, 201 fecal samples were collected from alpine musk deer on three farms in G…
View article: <i>CellDemux:</i>coherent genetic demultiplexing in single-cell and single-nuclei experiments
<i>CellDemux:</i>coherent genetic demultiplexing in single-cell and single-nuclei experiments Open
Multiplexed single-cell experiment designs are superior in terms of reduced batch effects, increased cost-effectiveness, throughput and statistical power. However, current computational strategies using genetics to demultiplex single-cell …
View article: Gut microbiota dysbiosis is associated with altered tryptophan metabolism and dysregulated inflammatory response in severe COVID-19
Gut microbiota dysbiosis is associated with altered tryptophan metabolism and dysregulated inflammatory response in severe COVID-19 Open
The clinical course of COVID-19 is variable and often unpredictable. To test the hypothesis that disease progression and inflammatory responses associate with alterations in the microbiome and metabolome, we analyzed metagenome, metabolome…
View article: Editorial: Tumor immune microenvironment topographies for prediction and evaluation: unlock the mystery of the therapeutic effects and adverse events of tumor immunotherapy
Editorial: Tumor immune microenvironment topographies for prediction and evaluation: unlock the mystery of the therapeutic effects and adverse events of tumor immunotherapy Open
EDITORIAL article Front. Oncol., 01 November 2023Sec. Cancer Immunity and Immunotherapy Volume 13 - 2023 | https://doi.org/10.3389/fonc.2023.1301340
View article: Differential DNA damage repair and PARP inhibitor vulnerability of the mammary epithelial lineages
Differential DNA damage repair and PARP inhibitor vulnerability of the mammary epithelial lineages Open
View article: Differential DNA damage repair and PARP inhibitor vulnerability of the mammary epithelial lineages
Differential DNA damage repair and PARP inhibitor vulnerability of the mammary epithelial lineages Open
It is widely assumed that all normal somatic cells can equally perform homologous recombination (HR) and non-homologous end joining in the DNA damage response (DDR). Here, we show that the DDR in normal mammary gland inherently depends on …
View article: Molecular evaluation of Cryptosporidium spp. in sheep in southern Xinjiang, China
Molecular evaluation of Cryptosporidium spp. in sheep in southern Xinjiang, China Open
Cryptosporidium spp. are diarrhoeagenic intestinal parasites with multiple hosts worldwide. A total of 1252 fresh faecal samples of sheep were collected from 10 large-scale farms in southern Xinjiang. Based on the small subunit ribosomal (…
View article: A single-cell view on host immune transcriptional response to in vivo BCG-induced trained immunity
A single-cell view on host immune transcriptional response to in vivo BCG-induced trained immunity Open
Bacillus Calmette-Guérin (BCG) vaccination is a prototype model for the study of trained immunity (TI) in humans, and results in a more effective response of innate immune cells upon stimulation with heterologous stimuli. Here, we investig…
View article: Baffled‐flow culture system enables the mass production of megakaryocytes from human embryonic stem cells by enhancing mitochondrial function
Baffled‐flow culture system enables the mass production of megakaryocytes from human embryonic stem cells by enhancing mitochondrial function Open
Human embryonic stem cells (hESCs) have become an ideal cell source for the ex vivo generation of megakaryocyte (MK) and platelet products for clinical applications. However, an ongoing challenge is to establish scalable culture systems to…