Béla Kocsis
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View article: Gut Microbiome and Intestinal Colonization with Multidrug-Resistant Strains of Enterobacterales: An Interplay Between Microbial Communities
Gut Microbiome and Intestinal Colonization with Multidrug-Resistant Strains of Enterobacterales: An Interplay Between Microbial Communities Open
Background: The intestinal tract is a host to a high number of diverse bacteria, and the presence of multidrug-resistant (MDR) Enterobacterales strains acts as a reservoir and a source of infection. The interactions between the intestinal …
View article: Variable In Vitro Efficacy of Delafloxacin on Multidrug-Resistant Pseudomonas aeruginosa and the Detection of Delafloxacin Resistance Determinants
Variable In Vitro Efficacy of Delafloxacin on Multidrug-Resistant Pseudomonas aeruginosa and the Detection of Delafloxacin Resistance Determinants Open
Background: In this study, molecular mechanisms contributing to delafloxacin resistance in Pseudomonas aeruginosa strains were investigated. Delafloxacin is a recently approved fluoroquinolone currently introduced to clinical applications.…
View article: Efficacy of lavender essential oil against respiratory tract bacteria is influenced by harvesting time
Efficacy of lavender essential oil against respiratory tract bacteria is influenced by harvesting time Open
Antibiotic resistance can be largely associated with the biofilm-forming properties of bacteria, since in this form pathogens show increased resistance to antibiotics and disinfectants. Pathogens, for example the airway colonizing Pseudomo…
View article: Synergistic Antibiofilm Effects of Chestnut and Linden Honey with Lavender Essential Oil Against Multidrug-Resistant Otitis Media Pathogens
Synergistic Antibiofilm Effects of Chestnut and Linden Honey with Lavender Essential Oil Against Multidrug-Resistant Otitis Media Pathogens Open
Background/Objectives: Bacterial resistance to antibiotics is a major problem in healthcare, complicated by the ability of bacteria to form biofilms. Complementary therapy for infectious diseases can rely on natural substances with antibac…
View article: Detection of Delafloxacin Resistance Mechanisms in Multidrug-Resistant Klebsiella pneumoniae
Detection of Delafloxacin Resistance Mechanisms in Multidrug-Resistant Klebsiella pneumoniae Open
Background: In this study, the mechanisms implicated in delafloxacin resistance in Klebsiella pneumoniae strains were investigated. Delafloxacin is a novel, broad-spectrum fluoroquinolone that has been approved for clinical application. Me…
View article: Genomic Investigation and Comparative Analysis of European High-Risk Clone of Acinetobacter baumannii ST2
Genomic Investigation and Comparative Analysis of European High-Risk Clone of Acinetobacter baumannii ST2 Open
Multidrug-resistant Acinetobacter baumannii is a major concern in healthcare institutions worldwide. Several reports described the dissemination of A. baumannii high-risk clones that are responsible for a high number of difficult-to-treat …
View article: Complete Test Suites for Automata in Monoidal Closed Categories
Complete Test Suites for Automata in Monoidal Closed Categories Open
Conformance testing of automata is about checking the equivalence of a known specification and a black-box implementation. An important notion in conformance testing is that of a complete test suite, which guarantees that if an implementat…
View article: Risk Assessment and Recommended Approaches to Optimize Infection Control and Antibiotic Stewardship to Reduce External Ventricular Drain Infection: A Single-Center Study
Risk Assessment and Recommended Approaches to Optimize Infection Control and Antibiotic Stewardship to Reduce External Ventricular Drain Infection: A Single-Center Study Open
Background: An external ventricular drain (EVD) is used to release elevated intracranial pressure by draining cerebrospinal fluid (CSF) from the brain’s ventricles. The establishment of an EVD is one of the most commonly performed neurosur…
View article: Biofilm Inhibition Activity of Fennel Honey, Fennel Essential Oil and Their Combination
Biofilm Inhibition Activity of Fennel Honey, Fennel Essential Oil and Their Combination Open
The eradication of bacterial biofilms remains a persistent challenge in medicine, particularly because an increasing number of biofilms exhibit resistance to conventional antibiotics. This underscores the importance of searching for novel …
View article: Analysis of molecular mechanisms of delafloxacin resistance in Escherichia coli
Analysis of molecular mechanisms of delafloxacin resistance in Escherichia coli Open
In this study delafloxacin resistance mechanisms in Escherichia coli strains were analyzed. Delafloxacin is a new fluoroquinolone, that is approved for clinical application however, resistance against this agent is scarcely reported. In ou…
View article: What is the current state of patient and family education on infection control? A descriptive study during COVID-19
What is the current state of patient and family education on infection control? A descriptive study during COVID-19 Open
Introduction: With the rise of multidrug-resistant healthcare-associated infections (HAIs) and the recent emergence of coronavirus disease 2019 (COVID-19), patient and family member engagement in infection control (IC) has gained increased…
View article: Complex Infection-Control Measures with Disinfectant Switch Help the Successful Early Control of Carbapenem-Resistant Acinetobacter baumannii Outbreak in Intensive Care Unit
Complex Infection-Control Measures with Disinfectant Switch Help the Successful Early Control of Carbapenem-Resistant Acinetobacter baumannii Outbreak in Intensive Care Unit Open
A carbapenem-resistant Acinetobacter baumannii (CRAB) outbreak in an intensive care unit (ICU) was contained by an improved infection-control measure that included a disinfectant policy. In our retrospective cohort study, we describe the e…
View article: The Roles of a Multidrug-Resistant Klebsiella pneumoniae High-Risk Clone and Its Resistance Plasmids on the Gastrointestinal Colonization and Host-Defense Effectors in the Gut
The Roles of a Multidrug-Resistant Klebsiella pneumoniae High-Risk Clone and Its Resistance Plasmids on the Gastrointestinal Colonization and Host-Defense Effectors in the Gut Open
The asymptomatic gastrointestinal colonization of multidrug-resistant (MDR) bacteria can lead to difficult-to-treat infections. We investigated the role of host factors influencing colonization in an orogastrical murine infection model usi…
View article: Encapsulation protocol for fecal microbiota transplantation
Encapsulation protocol for fecal microbiota transplantation Open
Introduction Clostridioides difficile infections (CDI) continue to pose a challenge for clinicians. Fecal microbiota transplantation (FMT) is an effective treatment option in CDI. Furthermore, recent and ongoing studies suggest potential b…
View article: Antibacterial activity of Hungarian varietal honeys against respiratory pathogens as a function of storage time
Antibacterial activity of Hungarian varietal honeys against respiratory pathogens as a function of storage time Open
View article: Gram-negative rough mutants used as test bacteria can increase sensitivity of direct bioautography
Gram-negative rough mutants used as test bacteria can increase sensitivity of direct bioautography Open
Currently, the antimicrobial activity of essential oils (EOs) is an outstanding research field due to antibiotic resistance of microorganisms. Thin-layer chromatography‒direct bioautography (TLC‒DB) is an effective, fast method to find com…
View article: Antibiotics and probiotics-induced effects on the total fatty acid composition of feces in a rat model
Antibiotics and probiotics-induced effects on the total fatty acid composition of feces in a rat model Open
Fatty acids (FAs) play important roles as membrane components and signal transduction molecules. Changes in short chain FA (SCFA) composition are associated with gut microbiota modifications. However, the effect of bacteria-driven changes …
View article: Chestnut Honey Is Effective against Mixed Biofilms at Different Stages of Maturity
Chestnut Honey Is Effective against Mixed Biofilms at Different Stages of Maturity Open
The irresponsible overuse of antibiotics has increased the occurrence of resistant bacterial strains, which represents one of the biggest patient safety risks today. Due to antibiotic resistance and biofilm formation in bacteria, it is bec…
View article: Antibacterial activity of Hungarian varietal honeys changes over time against respiratory pathogens
Antibacterial activity of Hungarian varietal honeys changes over time against respiratory pathogens Open
Today, antibiotic therapies that previously worked well against certain bacteria due to their natural sensitivity, are becoming less effective. Honey has been proven to inhibit the biofilm formation of some respiratory bacteria, however fe…
View article: Radiation-Detoxified Form of Endotoxin Effectively Activates Th1 Responses and Attenuates Ragweed-Induced Th2-Type Airway Inflammation in Mice
Radiation-Detoxified Form of Endotoxin Effectively Activates Th1 Responses and Attenuates Ragweed-Induced Th2-Type Airway Inflammation in Mice Open
Urbanization with reduced microbial exposure is associated with an increased burden of asthma and atopic symptoms. Conversely, environmental exposure to endotoxins in childhood can protect against the development of allergies. Our study ai…
View article: Pseudomonas aeruginosa antimicrobial susceptibility profiles, resistance mechanisms and international clonal lineages: update from ESGARS-ESCMID/ISARPAE Group
Pseudomonas aeruginosa antimicrobial susceptibility profiles, resistance mechanisms and international clonal lineages: update from ESGARS-ESCMID/ISARPAE Group Open
View article: Hypervirulent Klebsiella pneumoniae: An update on epidemiology, detection and antibiotic resistance
Hypervirulent Klebsiella pneumoniae: An update on epidemiology, detection and antibiotic resistance Open
Klebsiella pneumoniae is a major human pathogen as it is responsible for various infections. In the past years hypervirulent K. pneumoniae (hvKP) emerged and disseminated worldwide. In this review a summary will be given about epidemiology…
View article: Investigation of Delafloxacin Resistance in Multidrug-Resistant Escherichia coli Strains and the Detection of E. coli ST43 International High-Risk Clone
Investigation of Delafloxacin Resistance in Multidrug-Resistant Escherichia coli Strains and the Detection of E. coli ST43 International High-Risk Clone Open
Delafloxacin is a novel fluoroquinolone agent that is approved for clinical application. In this study, we analyzed the antibacterial efficacy of delafloxacin in a collection of 47 Escherichia coli strains. Antimicrobial susceptibility tes…
View article: Flowering phenophases influence the antibacterial and anti-biofilm effects of Thymus vulgaris L. essential oil
Flowering phenophases influence the antibacterial and anti-biofilm effects of Thymus vulgaris L. essential oil Open
View article: Development of a novel, entirely herbal-based mouthwash effective against common oral bacteria and SARS-CoV-2
Development of a novel, entirely herbal-based mouthwash effective against common oral bacteria and SARS-CoV-2 Open
Background Parallel to the growth of the oral healthcare market, there is a constantly increasing demand for natural products as well. Many customers prefer products that contain fewer toxic agents, therefore providing an environmentally f…
View article: Microbiological Studies on the Influence of Essential Oils from Several Origanum Species on Respiratory Pathogens
Microbiological Studies on the Influence of Essential Oils from Several Origanum Species on Respiratory Pathogens Open
Essential oils (EOs) with established and well-known activities against human pathogens might become new therapeutics in multidrug-resistant bacterial infections, including respiratory tract infections. The aim of this study was to evaluat…
View article: Antibacterial and Antibiofilm Effect of Unifloral Honeys against Bacteria Isolated from Chronic Wound Infections
Antibacterial and Antibiofilm Effect of Unifloral Honeys against Bacteria Isolated from Chronic Wound Infections Open
Honey is known as an alternative remedy for the treatment of wounds. To evaluate the potential of five Hungarian honey types against wound-associated bacteria, in vitro microbiological assays were conducted on Pseudomonas aeruginosa, Staph…
View article: Efficacy of lyophilised bacteria-rich faecal sediment and supernatant with reduced bacterial count for treating patients with Clostridioides difficile Infection – A novel method for capsule faecal microbiota transfer
Efficacy of lyophilised bacteria-rich faecal sediment and supernatant with reduced bacterial count for treating patients with Clostridioides difficile Infection – A novel method for capsule faecal microbiota transfer Open
Background and aims Faecal microbiota transfer (FMT) has managed to earn its place in the Clostridioides difficile infection (CDI) guidelines by having comparable efficacy and recurrence rate of fidaxomicin. After more than 100 successful …
View article: Author Correction: Genomic analysis of sewage from 101 countries reveals global landscape of antimicrobial resistance
Author Correction: Genomic analysis of sewage from 101 countries reveals global landscape of antimicrobial resistance Open
View article: Emergence and Dissemination of Extraintestinal Pathogenic High-Risk International Clones of Escherichia coli
Emergence and Dissemination of Extraintestinal Pathogenic High-Risk International Clones of Escherichia coli Open
Multiresistant Escherichia coli has been disseminated worldwide, and it is one of the major causative agents of nosocomial infections. E. coli has a remarkable and complex genomic plasticity for taking up and accumulating genetic elements;…