Béla Tóth
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View article: Real-World Experience with Cemiplimab Treatment for Advanced Cutaneous Squamous Cell Carcinoma—A Retrospective Single-Center Study
Real-World Experience with Cemiplimab Treatment for Advanced Cutaneous Squamous Cell Carcinoma—A Retrospective Single-Center Study Open
Background: The systemic treatment of advanced cutaneous squamous cell carcinoma (cSCC) has seen significant developments in recent years. The anti-PD1 inhibitor cemiplimab has demonstrated efficacy in clinical trials, but real-world data …
View article: Cutaneous malignancies in patients with Parkinson’s disease at a dermato-oncological university centre in Hungary
Cutaneous malignancies in patients with Parkinson’s disease at a dermato-oncological university centre in Hungary Open
Background The possible correlation between melanoma and Parkinson’s disease (PD) has been intensively studied. In this work, we aimed to assess the coincidence of skin malignancies and PD at a dermato-oncological university centre in Cent…
View article: Skin affecting adverse events of immunotherapies for the treatment of malignancies
Skin affecting adverse events of immunotherapies for the treatment of malignancies Open
As the fifth pillar of antitumor treatment, immunotherapies have brought a significant breakthrough in oncology. Immune checkpoint inhibitors have been shown to be the most effective modality among immunotherapies by stimulating the antitu…
View article: STIs during the COVID-19 Pandemic in Hungary: Gonorrhea as a Potential Indicator of Sexual Behavior
STIs during the COVID-19 Pandemic in Hungary: Gonorrhea as a Potential Indicator of Sexual Behavior Open
The social distancing measures introduced due to the COVID-19 pandemic may have affected the sexual behavior of the population. We collected data retrospectively from the National STD Center of Hungary. The overall patient influx data of t…
View article: Immunohistochemical Study of the PD-1/PD-L1 Pathway in Cutaneous Lupus Erythematosus
Immunohistochemical Study of the PD-1/PD-L1 Pathway in Cutaneous Lupus Erythematosus Open
The pathomechanism of various autoimmune diseases is known to be associated with the altered function of programmed cell death 1/programmed cell death ligand 1 (PD-1/PD-L1) axis. We aimed to investigate the role of this pathway and inflamm…
View article: Anti-PD-1 Monotherapy in Advanced Melanoma—Real-World Data from a 77-Month-Long Retrospective Observational Study
Anti-PD-1 Monotherapy in Advanced Melanoma—Real-World Data from a 77-Month-Long Retrospective Observational Study Open
Real-world evidence plays an important role in the assessment of efficacy and safety of novel therapies. The increasing use of immune checkpoint inhibitors (ICIs) in patients with advanced melanoma has led to notably improved clinical outc…
View article: Prevalence of HIV and venereal co-infections in the Hungarian National STD Center, the role of dermato-venerologists’
Prevalence of HIV and venereal co-infections in the Hungarian National STD Center, the role of dermato-venerologists’ Open
Incidence of HIV-infection is increasing in Hungary, due to antiretroviral therapy AIDS related mortality remained low. Delayed diagnosis of HIV infection remains a challenge, co-infection of HIV and other STIs is common. Authors present h…
View article: Frequent KIT mutations in skin lesions of patients with BRAF wild-type Langerhans cell histiocytosis
Frequent KIT mutations in skin lesions of patients with BRAF wild-type Langerhans cell histiocytosis Open
Langerhans cell histiocytosis (LCH) is characterized by mutations of the RAS-RAF-MAPK signaling pathway. We analyzed MAP2K1, NRAS and KIT mutation incidence in skin lesions of BRAF wild-type (wt) LCH patients. We evaluated the occurrence o…
View article: Exploring Differential Connexin Expression across Melanocytic Tumor Progression Involving the Tumor Microenvironment
Exploring Differential Connexin Expression across Melanocytic Tumor Progression Involving the Tumor Microenvironment Open
The incidence of malignant melanoma, one of the deadliest cancers, continues to increase. Here we tested connexin (Cx) expression in primary melanocytes, melanoma cell lines and in a common nevus, dysplastic nevus, and thin, thick, and met…