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View article: Dietary protein source mediates colitis pathogenesis through bacterial modulation of bile acids
Dietary protein source mediates colitis pathogenesis through bacterial modulation of bile acids Open
Introductory paragraph Evidence-based dietary recommendations for individuals with inflammatory bowel diseases (IBD) are limited. Red meat consumption is associated with increased IBD incidence and relapse in patients, suggesting that swit…
View article: A CONSORTIA OF CLINICAL <i>E. COLI</i> STRAINS WITH DISTINCT IN-VITRO ADHERENT/INVASIVE PROPERTIES ESTABLISH THEIR OWN CO-COLONIZATION NICHE AND SHAPE THE INTESTINAL MICROBIOTA IN INFLAMMATION-SUSCEPTIBLE MICE
A CONSORTIA OF CLINICAL <i>E. COLI</i> STRAINS WITH DISTINCT IN-VITRO ADHERENT/INVASIVE PROPERTIES ESTABLISH THEIR OWN CO-COLONIZATION NICHE AND SHAPE THE INTESTINAL MICROBIOTA IN INFLAMMATION-SUSCEPTIBLE MICE Open
Mucosal colonization with adherent-invasive Escherichia coli (AIEC) are believed to perpetuate intestinal inflammation and associated inflammatory bowel disease (IBD). However, it remains unclear if the 24-year-old AIEC in-vitro definition…
View article: VARIOUS ADHERENT-INVASIVE <i>E. COLI</i> (AIEC) AND NON-AIEC STRAINS ISOLATED FROM CROHN’S DISEASE PATIENTS GROW DIFFERENTLY WITH <i>RUMINOCOCCUS GNAVUS</i> PRE-DIGESTED MUCUS AND <i>R. GNAVUS</i>-RELEASED PRE-DIGESTED ILEAL AND COLONIC MUCUS MONOSACCHARIDES
VARIOUS ADHERENT-INVASIVE <i>E. COLI</i> (AIEC) AND NON-AIEC STRAINS ISOLATED FROM CROHN’S DISEASE PATIENTS GROW DIFFERENTLY WITH <i>RUMINOCOCCUS GNAVUS</i> PRE-DIGESTED MUCUS AND <i>R. GNAVUS</i>-RELEASED PRE-DIGESTED ILEAL AND COLONIC MUCUS MONOSACCHARIDES Open
BACKGROUND Mucus-digesting Ruminococcus gnavus (R. gnavus), adherent-invasive E. coli (AIEC), and hydrogen sulfide (H2S) are enriched in active Crohn’s disease (CD) patients compared to healthy subjects. Dual colonization of R. gnavus and …
View article: A consortia of clinical E. coli strains with distinct in vitro adherent/invasive properties establish their own co-colonization niche and shape the intestinal microbiota in inflammation-susceptible mice
A consortia of clinical E. coli strains with distinct in vitro adherent/invasive properties establish their own co-colonization niche and shape the intestinal microbiota in inflammation-susceptible mice Open
Background Inflammatory bowel disease (IBD) patients experience recurrent episodes of intestinal inflammation and often follow an unpredictable disease course. Mucosal colonization with adherent-invasive Escherichia coli (AIEC) are believe…
View article: A consortia of clinical E. coli strains with distinct in-vitro adherent/invasive properties establish their own co-colonization niche and shape the intestinal microbiota in inflammation-susceptible mice
A consortia of clinical E. coli strains with distinct in-vitro adherent/invasive properties establish their own co-colonization niche and shape the intestinal microbiota in inflammation-susceptible mice Open
Background Inflammatory bowel disease (IBD) patients experience recurrent episodes of intestinal inflammation and often follow an unpredictable disease course. Mucosal colonization with adherent-invasive Escherichia coli (AIEC) are believe…
View article: Agr2-associated ER stress promotes adherent-invasive E. coli dysbiosis and triggers CD103+ dendritic cell IL-23-dependent ileocolitis
Agr2-associated ER stress promotes adherent-invasive E. coli dysbiosis and triggers CD103+ dendritic cell IL-23-dependent ileocolitis Open
Endoplasmic reticulum (ER) stress is associated with Crohn's disease (CD), but its impact on host-microbe interaction in disease pathogenesis is not well defined. Functional deficiency in the protein disulfide isomerase anterior gradient 2…
View article: Mucosal metabolites fuel the growth and virulence of E. coli linked to Crohn’s disease
Mucosal metabolites fuel the growth and virulence of E. coli linked to Crohn’s disease Open
Elucidating how resident enteric bacteria interact with their hosts to promote health or inflammation is of central importance to diarrheal and inflammatory bowel diseases across species. Here, we integrated the microbial and chemical micr…
View article: ADHERENT-INVASIVE E. COLI PROMOTE ER STRESS TO SUPPORT IL23R-DRIVEN AGR2-DEPENDENT ILEOCOLITIS
ADHERENT-INVASIVE E. COLI PROMOTE ER STRESS TO SUPPORT IL23R-DRIVEN AGR2-DEPENDENT ILEOCOLITIS Open
View article: Long-read sequencing to interrogate strain-level variation among adherent-invasive Escherichia coli isolated from human intestinal tissue
Long-read sequencing to interrogate strain-level variation among adherent-invasive Escherichia coli isolated from human intestinal tissue Open
Adherent-invasive Escherichia coli (AIEC) is a pathovar linked to inflammatory bowel diseases (IBD), especially Crohn’s disease, and colorectal cancer. AIEC are genetically diverse, and in the absence of a universal molecular signature, ar…
View article: <i>Escherichia coli</i>‐associated granulomatous colitis in dogs treated according to antimicrobial susceptibility profiling
<i>Escherichia coli</i>‐associated granulomatous colitis in dogs treated according to antimicrobial susceptibility profiling Open
Background Eradication of intramucosal Escherichia coli correlates with remission of periodic acid‐Schiff‐positive E coli ‐associated granulomatous colitis (GC). Treatment failures attributed to multidrug resistant (MDR) bacteria necessita…
View article: Dietary Fructose Alters the Composition, Localization, and Metabolism of Gut Microbiota in Association With Worsening Colitis
Dietary Fructose Alters the Composition, Localization, and Metabolism of Gut Microbiota in Association With Worsening Colitis Open
Excess dietary fructose consumption has a pro-colitic effect that can be explained by changes in the composition, distribution, and metabolic function of resident enteric microbiota.
View article: Molecular and Phenotypic Characterization of Escherichia coli Associated with Granulomatous Colitis of Boxer Dogs
Molecular and Phenotypic Characterization of Escherichia coli Associated with Granulomatous Colitis of Boxer Dogs Open
Invasive Escherichia coli is causally associated with granulomatous colitis (GC) of Boxer dogs and French Bulldogs. The virulence determinants of GC E. coli are unclear. E. coli isolated from 16 GC (36 strains) and 17 healthy control (HC: …
View article: Defined microbiota transplant restores Th17/RORγt <sup>+</sup> regulatory T cell balance in mice colonized with inflammatory bowel disease microbiotas
Defined microbiota transplant restores Th17/RORγt <sup>+</sup> regulatory T cell balance in mice colonized with inflammatory bowel disease microbiotas Open
Significance Composition of gut microbiota is altered in many human diseases, including inflammatory bowel disease. Some hope that restoring microbiota to a healthy state could help treat such diseases. We have used mice colonized with mic…
View article: Short Chain Fatty Acids Modulate the Growth and Virulence of Pathosymbiont Escherichia coli and Host Response
Short Chain Fatty Acids Modulate the Growth and Virulence of Pathosymbiont Escherichia coli and Host Response Open
Short chain fatty acids (SCFA), principally acetate, propionate, and butyrate, are produced by fermentation of dietary fibers by the gut microbiota. SCFA regulate the growth and virulence of enteric pathogens, such as enterohemorrhagic E. …
View article: Long-read sequencing to interrogate strain-level variation among adherent-invasive<i>Escherichia coli</i>isolated from human intestinal tissue
Long-read sequencing to interrogate strain-level variation among adherent-invasive<i>Escherichia coli</i>isolated from human intestinal tissue Open
Adherent-invasive Escherichia coli (AIEC) is a pathovar linked to inflammatory bowel diseases (IBD), especially Crohn’s disease, and colorectal cancer. AIEC are genetically diverse, and in the absence of a universal molecular signature, ar…
View article: Dietary l-serine confers a competitive fitness advantage to Enterobacteriaceae in the inflamed gut
Dietary l-serine confers a competitive fitness advantage to Enterobacteriaceae in the inflamed gut Open
View article: Yersiniabactin-Producing Adherent/Invasive Escherichia coli Promotes Inflammation-Associated Fibrosis in Gnotobiotic <i> Il10 <sup>−/−</sup> </i> Mice
Yersiniabactin-Producing Adherent/Invasive Escherichia coli Promotes Inflammation-Associated Fibrosis in Gnotobiotic <i> Il10 <sup>−/−</sup> </i> Mice Open
Fibrosis is a significant complication of intestinal disorders associated with microbial dysbiosis and pathobiont expansion, notably Crohn’s disease (CD). Mechanisms that favor fibrosis are not well understood, and therapeutic strategies a…
View article: Yersiniabactin producing AIEC promote inflammation-associated fibrosis in gnotobiotic<i>Il10<sup>−/−</sup></i>mice
Yersiniabactin producing AIEC promote inflammation-associated fibrosis in gnotobiotic<i>Il10<sup>−/−</sup></i>mice Open
Fibrosis is a significant complication of intestinal disorders associated with microbial dysbiosis and pathobiont expansion, notably Crohn’s disease (CD). Mechanisms that favor fibrosis are not well understood and therapeutic strategies ar…
Murine Adherent and Invasive<i>E. coli</i>Induces Chronic Inflammation and Immune Responses in the Small and Large Intestines of Monoassociated IL-10-/- Mice Independent of Long Polar Fimbriae Adhesin A Open
View article: Microbiome‐within‐a‐Membrane: A Microfluidic‐Based Model for Spatially Constrained Culture of Intestinal Microbiota (Adv. Funct. Mater. 48/2018)
Microbiome‐within‐a‐Membrane: A Microfluidic‐Based Model for Spatially Constrained Culture of Intestinal Microbiota (Adv. Funct. Mater. 48/2018) Open
Inflammatory bowel disease is linked to complex interactions with the intestinal microbiome. In article number 1805568, Alireza Abbaspourrad and co-workers introduce a microfluidic approach to embed viable bacteria in microfiber for co-cul…
View article: Evaluation of Escherichia coli pathotypes associated with Irritable Bowel Syndrome
Evaluation of Escherichia coli pathotypes associated with Irritable Bowel Syndrome Open
Irritable bowel syndrome (IBS) affects 10%-20% of people. Increased numbers of Escherichia coli (E. coli) correlate with symptoms, and patients respond to antimicrobials targeting E. coli. We examined whether specific E. coli strains, phyl…
View article: Rifaximin decreases virulence of Crohn’s disease-associated Escherichia coli and epithelial inflammatory responses
Rifaximin decreases virulence of Crohn’s disease-associated Escherichia coli and epithelial inflammatory responses Open
View article: IgA-coated <i>E. coli</i> enriched in Crohn’s disease spondyloarthritis promote T <sub>H</sub> 17-dependent inflammation
IgA-coated <i>E. coli</i> enriched in Crohn’s disease spondyloarthritis promote T <sub>H</sub> 17-dependent inflammation Open
IgA-reactive E. coli in Crohn’s disease–associated spondyloarthritis link mucosal immunity and systemic inflammation.
View article: Solar-thermal complex sample processing for nucleic acid based diagnostics in limited resource settings
Solar-thermal complex sample processing for nucleic acid based diagnostics in limited resource settings Open
The use of point-of-care (POC) devices in limited resource settings where access to commonly used infrastructure, such as water and electricity, can be restricted represents simultaneously one of the best application fits for POC systems a…
View article: Inflammation drives dysbiosis, Gram negative proliferation and <i>E. coli</i> invasion.
Inflammation drives dysbiosis, Gram negative proliferation and <i>E. coli</i> invasion. Open
Independent of genotype, ileitis induces a progressive decrease in microbial diversity, a shift from Firmicutes (Gram+) to Proteobacteria (Gram−), and proliferation of AIEC. Superimposition of genetic susceptibility ca…
View article: Genome Based Phylogeny and Comparative Genomic Analysis of Intra-Mammary Pathogenic Escherichia coli
Genome Based Phylogeny and Comparative Genomic Analysis of Intra-Mammary Pathogenic Escherichia coli Open
Escherichia coli is an important cause of bovine mastitis and can cause both severe inflammation with a short-term transient infection, as well as less severe, but more chronic inflammation and infection persistence. E. coli is a highly di…