Ravi V. Bellamkonda
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View article: EXTH-95. <i>In vivo</i> electrotaxis of glioblastoma in a rodent model
EXTH-95. <i>In vivo</i> electrotaxis of glioblastoma in a rodent model Open
The treatment of glioblastoma (GBM) continues to be a major clinical challenge, in great part due to the diffusely invasive nature of tumor spread, including into the eloquent regions of the brain. This limits complete surgical resection, …
View article: TIP-27. An assessment of the Tumor Monorail Device (TMD) for repeated sampling as part of a trial evaluating the combination of D2C7-IT and an Fc-engineered anti-CD40 monoclonal antibody (2141-V11) administered intratumorally via convection-enhanced delivery (CED) and cervical perilymphatic injections (CPLIs) of 2141-V11 in recurrent glioblastoma (rGBM) patients
TIP-27. An assessment of the Tumor Monorail Device (TMD) for repeated sampling as part of a trial evaluating the combination of D2C7-IT and an Fc-engineered anti-CD40 monoclonal antibody (2141-V11) administered intratumorally via convection-enhanced delivery (CED) and cervical perilymphatic injections (CPLIs) of 2141-V11 in recurrent glioblastoma (rGBM) patients Open
BACKGROUND The TMD is a surgically implanted catheter system that remains in place after tumor resection. The TMD is not used to deliver therapy but serves as a platform to monitor changes in the tumor environment post-treatment, potential…
View article: Finite element analysis of a neural implant for cytostatic hypothermia and a novel heat management system
Finite element analysis of a neural implant for cytostatic hypothermia and a novel heat management system Open
The treatment of glioblastoma (GBM) presents significant challenges, with median survival rates remaining low despite standard-of-care therapies. A novel approach, cytostatic hypothermia (CH), is under development against GBM; it is a wind…
View article: Device-assisted strategies for drug delivery across the blood-brain barrier to treat glioblastoma
Device-assisted strategies for drug delivery across the blood-brain barrier to treat glioblastoma Open
View article: Finite element analysis of a neural implant for cytostatic hypothermia and a novel heat management system
Finite element analysis of a neural implant for cytostatic hypothermia and a novel heat management system Open
The treatment of glioblastoma (GBM) presents significant challenges, with median survival rates remaining low despite standard-of-care therapies. This study expands upon the findings of a novel approach to managing GBM, namely cytostatic h…
View article: A neural tract-inspired conduit for facile, on-demand biopsy of glioblastoma
A neural tract-inspired conduit for facile, on-demand biopsy of glioblastoma Open
Background A major hurdle to effectively treating glioblastoma (GBM) patients is the lack of longitudinal information about tumor progression, evolution, and treatment response. Methods In this study, we report the use of a neural tract-in…
View article: EXTH-04. CYTOSTATIC HYPOTHERMIA AGAINST GLIOBLASTOMA AND THE DEVELOPMENT OF A NEURAL IMPLANT FOR RODENTS AND SWINE
EXTH-04. CYTOSTATIC HYPOTHERMIA AGAINST GLIOBLASTOMA AND THE DEVELOPMENT OF A NEURAL IMPLANT FOR RODENTS AND SWINE Open
Survival rates for patients with glioblastoma (GBM) remain discouraging due to the near-impossibility of eradicating all tumor cells, resulting in frequent recurrence. However, studies have shown that recurrence is predominantly localized …
View article: Supplemental Video 1 from Interstitial Flow in a 3D Microenvironment Increases Glioma Invasion by a CXCR4-Dependent Mechanism
Supplemental Video 1 from Interstitial Flow in a 3D Microenvironment Increases Glioma Invasion by a CXCR4-Dependent Mechanism Open
Supplemental Video 1 AVI file - 2214K, Glioma in static
View article: Data from Interstitial Flow in a 3D Microenvironment Increases Glioma Invasion by a CXCR4-Dependent Mechanism
Data from Interstitial Flow in a 3D Microenvironment Increases Glioma Invasion by a CXCR4-Dependent Mechanism Open
Brain tumor invasion leads to recurrence and resistance to treatment. Glioma cells invade in distinct patterns, possibly determined by microenvironmental cues including chemokines, structural heterogeneity, and fluid flow. We hypothesized …
View article: Supplemental Video 1 from Interstitial Flow in a 3D Microenvironment Increases Glioma Invasion by a CXCR4-Dependent Mechanism
Supplemental Video 1 from Interstitial Flow in a 3D Microenvironment Increases Glioma Invasion by a CXCR4-Dependent Mechanism Open
Supplemental Video 1 AVI file - 2214K, Glioma in static
View article: Supplemental Figures from Interstitial Flow in a 3D Microenvironment Increases Glioma Invasion by a CXCR4-Dependent Mechanism
Supplemental Figures from Interstitial Flow in a 3D Microenvironment Increases Glioma Invasion by a CXCR4-Dependent Mechanism Open
Supplemental Figures PDF file - 346K, Supplementary figures to the main text
View article: Supplemental Figures from Interstitial Flow in a 3D Microenvironment Increases Glioma Invasion by a CXCR4-Dependent Mechanism
Supplemental Figures from Interstitial Flow in a 3D Microenvironment Increases Glioma Invasion by a CXCR4-Dependent Mechanism Open
Supplemental Figures PDF file - 346K, Supplementary figures to the main text
View article: Data from Interstitial Flow in a 3D Microenvironment Increases Glioma Invasion by a CXCR4-Dependent Mechanism
Data from Interstitial Flow in a 3D Microenvironment Increases Glioma Invasion by a CXCR4-Dependent Mechanism Open
Brain tumor invasion leads to recurrence and resistance to treatment. Glioma cells invade in distinct patterns, possibly determined by microenvironmental cues including chemokines, structural heterogeneity, and fluid flow. We hypothesized …
View article: Supplemental Video 2 from Interstitial Flow in a 3D Microenvironment Increases Glioma Invasion by a CXCR4-Dependent Mechanism
Supplemental Video 2 from Interstitial Flow in a 3D Microenvironment Increases Glioma Invasion by a CXCR4-Dependent Mechanism Open
Supplemental Video 2 AVI file - 2041K, Glioma under flow
View article: Supplemental Video 2 from Interstitial Flow in a 3D Microenvironment Increases Glioma Invasion by a CXCR4-Dependent Mechanism
Supplemental Video 2 from Interstitial Flow in a 3D Microenvironment Increases Glioma Invasion by a CXCR4-Dependent Mechanism Open
Supplemental Video 2 AVI file - 2041K, Glioma under flow
View article: Supplemental methods and figure legends from Interstitial Flow in a 3D Microenvironment Increases Glioma Invasion by a CXCR4-Dependent Mechanism
Supplemental methods and figure legends from Interstitial Flow in a 3D Microenvironment Increases Glioma Invasion by a CXCR4-Dependent Mechanism Open
Supplemental Methods and Legends PDF file - 97K, Supplemental methods and figure legends for the supplemental figures
View article: Supplemental methods and figure legends from Interstitial Flow in a 3D Microenvironment Increases Glioma Invasion by a CXCR4-Dependent Mechanism
Supplemental methods and figure legends from Interstitial Flow in a 3D Microenvironment Increases Glioma Invasion by a CXCR4-Dependent Mechanism Open
Supplemental Methods and Legends PDF file - 97K, Supplemental methods and figure legends for the supplemental figures
View article: IL7 and IL7 Flt3L co-expressing CAR T cells improve therapeutic efficacy in mouse EGFRvIII heterogeneous glioblastoma
IL7 and IL7 Flt3L co-expressing CAR T cells improve therapeutic efficacy in mouse EGFRvIII heterogeneous glioblastoma Open
Chimeric antigen receptor (CAR) T cell therapy in glioblastoma faces many challenges including insufficient CAR T cell abundance and antigen-negative tumor cells evading targeting. Unfortunately, preclinical studies evaluating CAR T cells …
View article: Cytostatic hypothermia and its impact on glioblastoma and survival
Cytostatic hypothermia and its impact on glioblastoma and survival Open
Patients with glioblastoma (GBM) have limited options and require novel approaches to treatment. Here, we studied and deployed nonfreezing “cytostatic” hypothermia to stunt GBM growth. This growth-halting method contrasts with ablative, cr…
View article: DIY caging apparatus to facilitate chronic and continuous stimulation or recording in an awake rodent
DIY caging apparatus to facilitate chronic and continuous stimulation or recording in an awake rodent Open
Chronic stimulation of and recording from the brain and brain diseases can require expensive apparatus and tedious cycles of inducing rodents with anesthesia. To resolve this, we have designed and fabricated a low-cost (∼$75 vs. $450) DIY …
View article: Neuromechanobiology: An Expanding Field Driven by the Force of Greater Focus
Neuromechanobiology: An Expanding Field Driven by the Force of Greater Focus Open
The brain processes information by transmitting signals through highly connected and dynamic networks of neurons. Neurons use specific cellular structures, including axons, dendrites and synapses, and specific molecules, including cell adh…
View article: Enriching neural stem cell and anti‐inflammatory glial phenotypes with electrical stimulation after traumatic brain injury in male rats
Enriching neural stem cell and anti‐inflammatory glial phenotypes with electrical stimulation after traumatic brain injury in male rats Open
Traumatic brain injury (TBI) by an external physical impact results in compromised brain function via undesired neuronal death. Following the injury, resident and peripheral immune cells, astrocytes, and neural stem cells (NSCs) cooperativ…
View article: Cytostatic hypothermia and its impact on glioblastoma and survival
Cytostatic hypothermia and its impact on glioblastoma and survival Open
Novel therapeutic approaches are needed for patients with glioblastoma (GBM) who otherwise have limited options. Here we studied and deployed non-freezing ‘cytostatic’ hypothermia to stunt GBM growth. This contrasts with ablative, cryogeni…
View article: Liposome-Imipramine Blue Inhibits Sonic Hedgehog Medulloblastoma In Vivo
Liposome-Imipramine Blue Inhibits Sonic Hedgehog Medulloblastoma In Vivo Open
Sonic hedgehog subtype of medulloblastoma (SHH MB) with metastasis or specific clinical or molecular alteration shas a poor prognosis and current therapy results in long-term cognitive impairment in the majority of survivors. Thus, a great…
View article: Engineered glycomaterial implants orchestrate large-scale functional repair of brain tissue chronically after severe traumatic brain injury
Engineered glycomaterial implants orchestrate large-scale functional repair of brain tissue chronically after severe traumatic brain injury Open
Engineered glycomaterial implants orchestrate large-scale repair after severe traumatic brain injury.
View article: Enriching neural stem cell and pro-healing glial phenotypes with electrical stimulation after traumatic brain injury in male rats
Enriching neural stem cell and pro-healing glial phenotypes with electrical stimulation after traumatic brain injury in male rats Open
Traumatic Brain Injury (TBI) by an external physical impact results in compromised brain function via undesired neuronal death. Following the injury, resident and peripheral immune cells, astrocytes, and neural stem cells (NSCs) cooperativ…
View article: EXTH-71. CYTOSTATIC HYPOTHERMIA FOR GLIOBLASTOMA
EXTH-71. CYTOSTATIC HYPOTHERMIA FOR GLIOBLASTOMA Open
As a cancer therapy, hypothermia has been used at sub-zero temperatures to cryosurgically ablate tumors. However, these temperatures can indiscriminately damage both tumorous and healthy cells. Additionally, strategies designed to kill tum…
View article: Neurotrophic Factor-Laden Acellular Chondroitin Sulfate Scaffolds Promote Chronic Functional Recovery After Severe Traumatic Brain Injury
Neurotrophic Factor-Laden Acellular Chondroitin Sulfate Scaffolds Promote Chronic Functional Recovery After Severe Traumatic Brain Injury Open
Severe traumatic brain injury (sTBI) survivors experience permanent functional disabilities due to significant volume loss and the brain’s poor capacity to regenerate. Chondroitin sulfate glycosaminoglycans (CS-GAGs) are key regulators of …
View article: Evaluation of M2-like macrophage enrichment after diffuse traumatic brain injury through transient interleukin-4 expression from engineered mesenchymal stromal cells
Evaluation of M2-like macrophage enrichment after diffuse traumatic brain injury through transient interleukin-4 expression from engineered mesenchymal stromal cells Open
Background Appropriately modulating inflammation after traumatic brain injury (TBI) may prevent disabilities for the millions of those inflicted annually. In TBI, cellular mediators of inflammation, including macrophages and microglia, pos…
View article: Evaluation of M2-like macrophage enrichment after diffuse traumatic brain injury through transient interleukin-4 expression from engineered mesenchymal stromal cells
Evaluation of M2-like macrophage enrichment after diffuse traumatic brain injury through transient interleukin-4 expression from engineered mesenchymal stromal cells Open
Appropriately modulating inflammation after traumatic brain injury (TBI) may prevent disabilities for the millions of those inflicted annually. In TBI, cellular mediators of inflammation, including macrophages and microglia, possess a rang…