Benjamin H. Brinkmann
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Tracking seizure cycles beats a prospective moving average: Commentary on "Rigorous evaluation of five e‐diary alone seizure forecasting tools" Open
There is debate on the predictive value of multiday seizure cycles versus simple statistical baselines. Multidien seizure cyclicity is a prevalent, patient‐specific phenomenon with promise for epilepsy management. We challenge the assertio…
View article: Clinical 7T MRI for Epilepsy: A Retrospective Review of 50 Cases
Clinical 7T MRI for Epilepsy: A Retrospective Review of 50 Cases Open
In clinical practice, 7T MRI revealed additional epileptogenic lesions in 36% of nonlesional 3T MRI cases.
View article: 7T MRI Automated Software Segmentation of the Hippocampus for Epilepsy: Prospective Performance Evaluation
7T MRI Automated Software Segmentation of the Hippocampus for Epilepsy: Prospective Performance Evaluation Open
Computerized volume measurement of the hippocampus at 7T correlates poorly with volumes obtained through manual segmentation and suboptimally with matched 3T examination measurements, but is highly reproducible at 7T within the same partic…
View article: Stimulation of the Thalamus for Arousal Restoral in Temporal Lobe Epilepsy (START) Clinical Trial: Modulation of Natural Sleep and Focal Seizures
Stimulation of the Thalamus for Arousal Restoral in Temporal Lobe Epilepsy (START) Clinical Trial: Modulation of Natural Sleep and Focal Seizures Open
Thalamic stimulation has emerged as a promising neuromodulation target for treating disorders of consciousness. Impaired consciousness, a debilitating outcome in temporal lobe epilepsy (TLE) remains a central problem for patients whose sei…
Detecting Diverse Seizure Types with Wrist-Worn Wearable Devices: A Comparison of Machine Learning Approaches Open
Objective: To evaluate the feasibility and effectiveness of wrist-worn wearable devices combined with machine learning (ML) approaches for detecting a diverse array of seizure types beyond generalized tonic–clonic (GTC), including focal, g…
Diagnostic screening for epilepsy, functional neurological disorder, and other paroxysmal disorders: A clinical survey study Open
The results validate the diagnostic utility of general questions about event duration, related symptoms and comorbidities in a meaningfully sampled patient cohort that was representative of people presenting with seizures or seizure-like e…
View article: Real‐world epilepsy monitoring with ultra‐long‐term subcutaneous electroencephalography: A 15‐month prospective study
Real‐world epilepsy monitoring with ultra‐long‐term subcutaneous electroencephalography: A 15‐month prospective study Open
Objective Novel subcutaneous electroencephalography (sqEEG) systems enable prolonged, near‐continuous cerebral monitoring in real‐world conditions. Nevertheless, the feasibility, acceptability and overall clinical utility of these systems …
Low and high frequency signatures of impaired consciousness in temporal lobe seizures Open
Impaired consciousness is a debilitating and unpredictable outcome of mesial temporal lobe seizures whose mechanisms to date remain unclear. Moreover, questions about the relationship between impaired consciousness and lateralization, hemi…
Forecasting epileptic seizures with wearable devices: A hybrid short‐ and long‐horizon pseudo‐prospective approach Open
Objective Seizure unpredictability can be debilitating and dangerous for people with epilepsy. Accurate seizure forecasters could improve quality of life for those with epilepsy but must be practical for long‐term use. This study presents …
Thalamocortical seizure onset patterns in drug resistant focal epilepsy Open
Drug-resistant epilepsy affects tens of millions of people worldwide and is associated with considerable morbidity and mortality. Thalamic deep brain stimulation and cortical responsive neurostimulation are proven treatments for focal epil…
View article: Automated Detection of Faciobrachial Dystonic Seizures Related Events in LGI1 Autoimmune Encephalitis Patients with Wearables
Automated Detection of Faciobrachial Dystonic Seizures Related Events in LGI1 Autoimmune Encephalitis Patients with Wearables Open
Objective To evaluate the potential of wrist-worn wearable devices to detect and quantify Faciobrachial Dystonic Seizures (FBDS) and related events associated with leucine-rich glioma Inactivated-1 (LGI1)-IgG autoimmune encephalitis (LGI1 …
View article: Post-Ictal Sleep Changes in Human Focal Epilepsy
Post-Ictal Sleep Changes in Human Focal Epilepsy Open
Bidirectional interactions between sleep, seizures, and epilepsy remain incompletely understood. Evidence from animal models and people with focal epilepsy suggest that seizures may engage mechanisms of memory consolidation to reinforce an…
View article: The Value of Normal Interictal EEGs in Epilepsy Diagnosis and Treatment Planning: A Retrospective Cohort Study using Population-level Spectral Power and Connectivity Patterns
The Value of Normal Interictal EEGs in Epilepsy Diagnosis and Treatment Planning: A Retrospective Cohort Study using Population-level Spectral Power and Connectivity Patterns Open
Introduction Scalp electroencephalography (EEG) is a cornerstone in the diagnosis and treatment of epilepsy, but routine EEG is often interpreted as normal without identification of epileptiform activity during expert visual review. The ab…
View article: Thalamocortical network neuromodulation for epilepsy
Thalamocortical network neuromodulation for epilepsy Open
Despite the growing interest in network-guided neuromodulation for epilepsy, uncertainty about the safety and long-term efficacy of thalamocortical stimulation persists. Our evaluation focused on the use of a four-lead open-loop implantabl…
Modulating limbic circuits in temporal lobe epilepsy: impacts on seizures, memory, mood and sleep Open
Temporal lobe epilepsy is a common neurological disease characterized by recurrent seizures that often originate within limbic networks involving amygdala and hippocampus. The limbic network is involved in crucial physiologic functions inv…
Real-world epilepsy monitoring with ultra long-term subcutaneous EEG: a 15-month prospective study Open
Objective Novel subcutaneous electroencephalography (sqEEG) systems enable prolonged, near-continuous cerebral monitoring in real-world conditions. Nevertheless, the feasibility, acceptability and overall clinical utility of these systems …
Effects of epileptic seizures on the quality of biosignals recorded from wearables Open
Objective Wearable nonelectroencephalographic biosignal recordings captured from the wrist offer enormous potential for seizure monitoring. However, signal quality remains a challenging factor affecting data reliability. Models trained for…
M${}^2$NuFFT: A Computationally Efficient Suboptimal Power Spectrum Estimator for Fast Exploration of Nonuniformly Sampled Time Series Open
Nonuniformly sampled signals are prevalent in real-world applications. However, estimating their power spectra from finite samples poses a significant challenge. The optimal solution-Bronez Generalized Prolate Spheroidal Sequence (GPSS) by…
User experience of a seizure risk forecasting app: A mixed methods investigation Open
Preliminary results suggest that seizure risk forecasting can be a useful tool for people with epilepsy to make lifestyle changes, such as scheduling daily events, and experience greater feelings of control. These improvements may be attri…
How accurate do self‐reported seizures need to be for effective medication management in epilepsy? Open
Studies suggest that self‐reported seizure diaries suffer from 50% under‐reporting on average. It is unknown to what extent this impacts medication management. This study used simulation to predict the seizure outcomes of a large heterogen…
View article: Acute to long-term characteristics of impedance recordings during neurostimulation in humans
Acute to long-term characteristics of impedance recordings during neurostimulation in humans Open
Objective. This study aims to characterize the time course of impedance, a crucial electrophysiological property of brain tissue, in the human thalamus (THL), amygdala-hippocampus, and posterior hippocampus over an extended period. Approac…
Minimum clinical utility standards for wearable seizure detectors: A simulation study Open
Objective Epilepsy management employs self‐reported seizure diaries, despite evidence of seizure underreporting. Wearable and implantable seizure detection devices are now becoming more widely available. There are no clear guidelines about…
High and low frequency anterior nucleus of thalamus deep brain stimulation: Impact on memory and mood in five patients with treatment resistant temporal lobe epilepsy Open
High frequency anterior nucleus of the thalamus deep brain stimulation (ANT DBS) is an established therapy for treatment resistant focal epilepsies. Although high frequency-ANT DBS is well tolerated, patients are rarely seizure free and th…
View article: Thalamocortical network neuromodulation for epilepsy
Thalamocortical network neuromodulation for epilepsy Open
Objectives Despite the growing interest in network-guided neuromodulation for epilepsy, uncertainty about the safety and long-term efficacy of thalamocortical stimulation persist. Our evaluation focused on the use of a 4-lead open-loop imp…
A platform for brain network sensing and stimulation with quantitative behavioral tracking: Application to limbic circuit epilepsy Open
Temporal lobe epilepsy is a common neurological disease characterized by recurrent seizures. These seizures often originate from limbic networks and people also experience chronic comorbidities related to memory, mood, and sleep (MMS). Dee…