Ben E. Biesterveld
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View article: Nodular regenerative hyperplasia and liver transplantation: a systematic review
Nodular regenerative hyperplasia and liver transplantation: a systematic review Open
Nodular regenerative hyperplasia (NRH) is a primary disease of the liver that may cause noncirrhotic portal hypertension. Common causes include autoimmune, hematologic, immune deficiency, and myeloproliferative disorders. Given the limited…
View article: Prediction of Postoperative Deterioration in Cardiac Surgery Patients Using Electronic Health Record and Physiologic Waveform Data
Prediction of Postoperative Deterioration in Cardiac Surgery Patients Using Electronic Health Record and Physiologic Waveform Data Open
Background Postoperative hemodynamic deterioration among cardiac surgical patients can indicate or lead to adverse outcomes. Whereas prediction models for such events using electronic health records or physiologic waveform data are previou…
View article: Prediction of postoperative cardiac events in multiple surgical cohorts using a multimodal and integrative decision support system
Prediction of postoperative cardiac events in multiple surgical cohorts using a multimodal and integrative decision support system Open
Postoperative patients are at risk of life-threatening complications such as hemodynamic decompensation or arrhythmia. Automated detection of patients with such risks via a real-time clinical decision support system may provide opportuniti…
View article: Validation of intraosseous delivery of valproic acid in a swine model of polytrauma
Validation of intraosseous delivery of valproic acid in a swine model of polytrauma Open
Background Intraosseous (IO) drug delivery may be necessary in emergency situations when intravenous access is unattainable. Valproic acid (VPA) is a histone deacetylase inhibitor that has previously been shown to improve survival in precl…
View article: Brain proteomic changes by histone deacetylase inhibition after traumatic brain injury
Brain proteomic changes by histone deacetylase inhibition after traumatic brain injury Open
Background Traumatic brain injury (TBI) is a leading cause of morbidity and mortality. There are currently no cytoprotective treatments for TBI. There is growing evidence that the histone deacetylase inhibitor valproic acid (VPA) may be be…
View article: A single dose of valproic acid improves neurologic recovery and decreases brain lesion size in swine subjected to an isolated traumatic brain injury
A single dose of valproic acid improves neurologic recovery and decreases brain lesion size in swine subjected to an isolated traumatic brain injury Open
BACKGROUND We lack specific treatments for traumatic brain injury (TBI), which remains the leading cause of trauma-related morbidity and mortality. Treatment with valproic acid (VPA) improves outcomes in models of severe TBI with concurren…
View article: Multimodal tensor-based method for integrative and continuous patient monitoring during postoperative cardiac care
Multimodal tensor-based method for integrative and continuous patient monitoring during postoperative cardiac care Open
Patients recovering from cardiovascular surgeries may develop life-threatening complications such as hemodynamic decompensation, making the monitoring of patients for such complications an essential component of postoperative care. However…
View article: Development of a large animal model of lethal polytrauma and intra-abdominal sepsis with bacteremia
Development of a large animal model of lethal polytrauma and intra-abdominal sepsis with bacteremia Open
Background Trauma and sepsis are individually two of the leading causes of death worldwide. When combined, the mortality is greater than 50%. Thus, it is imperative to have a reproducible and reliable animal model to study the effects of p…
View article: Practical Guidance for Early Identification of Barriers in Surgical Telehealth Clinics
Practical Guidance for Early Identification of Barriers in Surgical Telehealth Clinics Open
Early identification of and response to barriers in telehealth settings will help patients receive optimal care. Here, the authors, based on institutional experience, provide advice on such strategies. This guidance focuses on standardizin…
View article: Peptidylarginine Deiminase Inhibition by Cl-Amidine Improves Survival and Attenuates Kidney Injury in a Model of Endotoxic Shock in Rabbits
Peptidylarginine Deiminase Inhibition by Cl-Amidine Improves Survival and Attenuates Kidney Injury in a Model of Endotoxic Shock in Rabbits Open
Siddiqui, Ali BA; Williams, Aaron M. MD; Bhatti, Umar F. MD; Biesterveld, Ben MD; Tian, Yuzi MD; Wu, Zhenyu MD; Liu, Baoling MD; Li, Yongqing MD, PhD; Badre Alam, Hasan MBBS FACS Author Information
View article: Factors Associated with Increased Risk of Patient No-Show in Telehealth and Traditional Surgery Clinics
Factors Associated with Increased Risk of Patient No-Show in Telehealth and Traditional Surgery Clinics Open
Several factors are associated with increased odds of no-show, including the visit being in eClinic. County-level analysis suggests no-show variation is not dependent on geographic location. Understanding these patterns allows for prospect…
View article: Valproic acid treatment rescues injured tissues after traumatic brain injury
Valproic acid treatment rescues injured tissues after traumatic brain injury Open
BACKGROUND No agents that are specifically neuroprotective are currently approved to emergently treat patients with traumatic brain injury (TBI). The histone deacetylase inhibitor, high-dose valproic acid (VPA) has been shown to have cytop…
View article: Not Dying Alone — Modern Compassionate Care in the Covid-19 Pandemic
Not Dying Alone — Modern Compassionate Care in the Covid-19 Pandemic Open
Not Dying Alone When the wife of a severely ill patient with Covid-19 is told she can’t visit him, her anger quickly gives way to pleading — “What if I only spent 5 minutes and left?” How can we ha...
View article: Frailty Is Associated With Increased Rates of Acute Cellular Rejection Within 3 Months After Liver Transplantation
Frailty Is Associated With Increased Rates of Acute Cellular Rejection Within 3 Months After Liver Transplantation Open
Peer Reviewed
View article: Comparative analysis of isoform-specific and non-selective histone deacetylase inhibitors in attenuating the intestinal damage after hemorrhagic shock
Comparative analysis of isoform-specific and non-selective histone deacetylase inhibitors in attenuating the intestinal damage after hemorrhagic shock Open
Background Isoform-specific histone deacetylase inhibitors (HDACIs) MC1568 and ACY1083 are comparable to the non-selective HDACI valproic acid (VPA) in improving survival in rodents undergoing lethal hemorrhage. However, the organ-specific…
View article: Post-traumatic intercostal and diaphragm hernias following a sneezing episode
Post-traumatic intercostal and diaphragm hernias following a sneezing episode Open
Trauma and sneeze-induced or cough-induced intercostal and diaphragm hernias are both rare phenomena, especially in combination. Management of these hernias is not well described, and there is no good evidence to guide operative management…
View article: Valproic acid improves survival and decreases resuscitation requirements in a swine model of prolonged damage control resuscitation
Valproic acid improves survival and decreases resuscitation requirements in a swine model of prolonged damage control resuscitation Open
BACKGROUND Although damage control resuscitation (DCR) is routinely performed for short durations, prolonged DCR may be required in military conflicts as a component of prolonged field care. Valproic acid (VPA) has been shown to have benef…
View article: The impact of intraoperative fluid management during laparoscopic donor nephrectomy on donor and recipient outcomes
The impact of intraoperative fluid management during laparoscopic donor nephrectomy on donor and recipient outcomes Open
Background Intraoperative fluid management during laparoscopic donor nephrectomy (LDN) may have a significant effect on donor and recipient outcomes. We sought to quantify variability in fluid management and investigate its impact on donor…
View article: Histone Deacetylase Inhibitors: A Novel Strategy in Trauma and Sepsis
Histone Deacetylase Inhibitors: A Novel Strategy in Trauma and Sepsis Open
Trauma remains a leading cause of morbidity and mortality among all age groups in the United States. Hemorrhagic shock and traumatic brain injury (TBI) are major causes of preventable death in trauma. Initial treatment involves fluid resus…