Ben Glampson
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View article: Characterisation of People Living With Chronic Hepatitis B Virus Infection in England and Stratification by <scp>HBsAg</scp> Levels: A Cross‐Sectional Study
Characterisation of People Living With Chronic Hepatitis B Virus Infection in England and Stratification by <span>HBsAg</span> Levels: A Cross‐Sectional Study Open
Characterisation of people with hepatitis B (PwHB) remains limited, particularly regarding treatment status, disease severity and biomarker profiles. Quantitative hepatitis B surface antigen (qHBsAg) is a key predictor of response to emerg…
View article: Hepatitis B Virus ( <scp>HBV</scp> ) Treatment Eligibility in the <scp>UK</scp> : Retrospective Longitudinal Cohort Data to Explore the Impact of Changes in Clinical Guidelines
Hepatitis B Virus ( <span>HBV</span> ) Treatment Eligibility in the <span>UK</span> : Retrospective Longitudinal Cohort Data to Explore the Impact of Changes in Clinical Guidelines Open
Nucleos/tide analogue (NA) drugs are used for long‐term treatment of chronic hepatitis B virus (HBV) infection, with treatment eligibility criteria changing rapidly amidst globally evolving clinical guidelines. We aimed to quantify the pre…
View article: ABO blood group antigens influence host–microbe interactions and risk of early spontaneous preterm birth
ABO blood group antigens influence host–microbe interactions and risk of early spontaneous preterm birth Open
The mechanisms by which vaginal microbiota shape spontaneous preterm birth (sPTB) risk remain poorly defined. Using electronic clinical records data from 74,913 maternities in conjunction with metaxanomic ( n = 596) and immune profiling ( …
View article: Supporting cancer research on real-world data: extracting colorectal cancer status and explicitly written TNM stages from free-text imaging and histopathology reports
Supporting cancer research on real-world data: extracting colorectal cancer status and explicitly written TNM stages from free-text imaging and histopathology reports Open
Objectives The ‘tumour, node, metastasis’ (TNM) classification of colorectal cancer (CRC) predicts prognosis and so is vital to consider in analyses of patterns and outcomes of care when using electronic health records. Unfortunately, it i…
View article: Improving transparency in data access processes: Developing best practice standards and promoting system-wide change through a competitive funding call
Improving transparency in data access processes: Developing best practice standards and promoting system-wide change through a competitive funding call Open
IntroductionTransparency in the use of data for research benefits the public and researchers by fostering trust and enabling efficient data sharing. Public support for access to their data for research depends on robust data security, the …
View article: Understanding and Addressing Challenges With Electronic Health Record Use in Gynecological Oncology: Cross-Sectional Survey of Multidisciplinary Professionals in the United Kingdom and Co-Design of an Integrated Informatics Platform to Support Clinical Decision-Making
Understanding and Addressing Challenges With Electronic Health Record Use in Gynecological Oncology: Cross-Sectional Survey of Multidisciplinary Professionals in the United Kingdom and Co-Design of an Integrated Informatics Platform to Support Clinical Decision-Making Open
Background Electronic health records (EHRs) are a cornerstone of modern health care delivery, but their current configuration often fragments information across systems, impeding timely and effective clinical decision-making. In gynecologi…
View article: Systematic curation and analysis of ovarian cancer data across multiple electronic record systems held within the UK National Health Service: a tertiary referral centre experience
Systematic curation and analysis of ovarian cancer data across multiple electronic record systems held within the UK National Health Service: a tertiary referral centre experience Open
Background: Manual curation of real-world data (RWD) for patients with ovarian cancer is complex and costly. We set up a novel collaboration between informatics and clinical teams generating automated data curation at scale. This enabled i…
View article: The sepsis journey and where digital alerts can help: a qualitative, interview study with survivors and family members in England
The sepsis journey and where digital alerts can help: a qualitative, interview study with survivors and family members in England Open
Introduction The fight against sepsis is an ongoing healthcare challenge, where digital tools are increasingly used with some promising results. The experience of survivors and their family members can help optimize digital alerts for seps…
View article: Co-producing a safe mobility and falls informatics platform to drive meaningful quality improvement in the hospital setting: a mixed-methods protocol for the <i>insightFall</i> study
Co-producing a safe mobility and falls informatics platform to drive meaningful quality improvement in the hospital setting: a mixed-methods protocol for the <i>insightFall</i> study Open
Introduction Manual investigation of falls incidents for quality improvement is time-consuming for clinical staff. Routine care delivery generates a large volume of relevant data in disparate systems, yet these data are seldom integrated a…
View article: Daily stress and worry are additional triggers of symptom fluctuations in individuals living with Long COVID: results from an intensive longitudinal cohort study
Daily stress and worry are additional triggers of symptom fluctuations in individuals living with Long COVID: results from an intensive longitudinal cohort study Open
Background Recent research has shown that exertion in physical, cognitive, social, and self-care activities triggers symptom severity in individuals with Long COVID. Purpose The current study aimed to investigate whether daily emotional ex…
View article: Hepatitis B Virus (HBV) treatment eligibility in the UK: retrospective longitudinal cohort data to explore the impact of changes in clinical guidelines
Hepatitis B Virus (HBV) treatment eligibility in the UK: retrospective longitudinal cohort data to explore the impact of changes in clinical guidelines Open
Objective Nucleos/tide analogue (NA) drugs are used for the long-term treatment of chronic hepatitis B virus (HBV) infection. In a landscape of changing clinical recommendations, we set out to quantify the prescription of NA drugs to date,…
View article: Transformer-based deep learning model for the diagnosis of suspected lung cancer in primary care based on electronic health record data
Transformer-based deep learning model for the diagnosis of suspected lung cancer in primary care based on electronic health record data Open
Cancer Research UK.
View article: Distinct virologic trajectories in chronic hepatitis B identify heterogeneity in response to nucleos(t)ide analogue therapy
Distinct virologic trajectories in chronic hepatitis B identify heterogeneity in response to nucleos(t)ide analogue therapy Open
Treatment recommendations for people living with chronic hepatitis B virus (HBV) infection are becoming less stringent, meaning that more of the population will be eligible to receive therapy with nucleos(t)ide analogue agents. We explored…
View article: Association between kidney function, frailty and receipt of invasive management after acute coronary syndrome
Association between kidney function, frailty and receipt of invasive management after acute coronary syndrome Open
Background Reduced estimated glomerular filtration rate (eGFR) is associated with lower use of invasive management and increased mortality after acute coronary syndrome (ACS). The reasons for this are unclear. Methods A retrospective clini…
View article: Views and Uses of Sepsis Digital Alerts in National Health Service Trusts in England: Qualitative Study With Health Care Professionals
Views and Uses of Sepsis Digital Alerts in National Health Service Trusts in England: Qualitative Study With Health Care Professionals Open
Background Sepsis is a common cause of serious illness and death. Sepsis management remains challenging and suboptimal. To support rapid sepsis diagnosis and treatment, screening tools have been embedded into hospital digital systems to ap…
View article: Prognostic significance of troponin in patients with malignancy (NIHR Health Informatics Collaborative TROP-MALIGNANCY study)
Prognostic significance of troponin in patients with malignancy (NIHR Health Informatics Collaborative TROP-MALIGNANCY study) Open
Background Cardiac troponin is commonly raised in patients presenting with malignancy. The prognostic significance of raised troponin in these patients is unclear. Objectives We sought to investigate the relation between troponin and morta…
View article: Enhancing Transparency, Awareness, Accessibility of Healthcare Data Access for Research: the iCARE website redesign project
Enhancing Transparency, Awareness, Accessibility of Healthcare Data Access for Research: the iCARE website redesign project Open
BackgroundThe iCARE (Imperial Clinical Analytics, Research and Evaluation) Secure Data Environment (SDE) is committed to further enhancing its website to improve awareness of processes and procedures for appropriately accessing the healthc…
View article: Changes in the investigation and management of suspected myocardial infarction and injury during COVID-19: a multi-centre study using routinely collected healthcare data
Changes in the investigation and management of suspected myocardial infarction and injury during COVID-19: a multi-centre study using routinely collected healthcare data Open
Objective The COVID-19 pandemic was associated with a reduction in the incidence of myocardial infarction (MI) diagnosis, in part because patients were less likely to present to hospital. Whether changes in clinical decision making with re…
View article: Understanding and addressing challenges with Electronic Health Record use in gynaecological oncology: a cross-sectional survey of multidisciplinary professionals in the United Kingdom and co-design of an integrated informatics platform to support clinical decision making. (Preprint)
Understanding and addressing challenges with Electronic Health Record use in gynaecological oncology: a cross-sectional survey of multidisciplinary professionals in the United Kingdom and co-design of an integrated informatics platform to support clinical decision making. (Preprint) Open
BACKGROUND The benefits and challenges of Electronic Health Record (EHR) use may be particularly significant in complex, high-risk specialties such as gynaecological oncology, yet few studies address the experiences of end-users. OBJECT…
View article: Views and Uses of Sepsis Digital Alerts in National Health Service Trusts in England: Qualitative Study With Health Care Professionals (Preprint)
Views and Uses of Sepsis Digital Alerts in National Health Service Trusts in England: Qualitative Study With Health Care Professionals (Preprint) Open
BACKGROUND Sepsis is a common cause of serious illness and death. Sepsis management remains challenging and suboptimal. To support rapid sepsis diagnosis and treatment, screening tools have been embedded into hospital digital systems to a…
View article: Classification of virologic trajectories during nucleos/tide analogue treatment of hepatitis B virus (HBV) infection
Classification of virologic trajectories during nucleos/tide analogue treatment of hepatitis B virus (HBV) infection Open
Background & Aims The dynamics of HBV viral load (VL) in patients with chronic hepatitis B (CHB) on nucleos/tide analogue (NA) treatment and its relationship with liver disease are poorly understood. We aimed to study longitudinal VL patte…
View article: Impact of the COVID-19 pandemic on routine surveillance for adults with chronic hepatitis B virus (HBV) infection in the UK
Impact of the COVID-19 pandemic on routine surveillance for adults with chronic hepatitis B virus (HBV) infection in the UK Open
Background To determine the impact of the COVID-19 pandemic on the population with chronic Hepatitis B virus (HBV) infection under hospital follow-up in the UK, we quantified the coverage and frequency of measurements of biomarkers used fo…
View article: The Relationship Between Cardiac Troponin in People Hospitalised for Exacerbation of COPD and Major Adverse Cardiac Events (MACE) and COPD Readmissions
The Relationship Between Cardiac Troponin in People Hospitalised for Exacerbation of COPD and Major Adverse Cardiac Events (MACE) and COPD Readmissions Open
An elevated troponin level at the time of COPD exacerbation may be a useful tool for predicting MACE in COPD patients. The relationship between degree of troponin elevation and risk of future events is complex and requires further investig…
View article: Exploring Regional Linked Data Capability for Research Phase 2: Exploring Variation in Acute Hospital Admissions
Exploring Regional Linked Data Capability for Research Phase 2: Exploring Variation in Acute Hospital Admissions Open
No existing national data feeds provide detailed and near-real time information on hospital admissions across the UK. Currently available national data feeds are dated, do not include people still in hospital, and lack detailed coding whic…
View article: Exploring Regional Linked Data for Research Phase 1: Detection of vaccine-induced thrombotic thrombocytopenia with regional level data
Exploring Regional Linked Data for Research Phase 1: Detection of vaccine-induced thrombotic thrombocytopenia with regional level data Open
There are no coordinated UK data feeds that provide detailed and near-real time information on hospital admissions or hospital activity to enable research across the UK. Currently, nationally available acute admissions data are only access…