Ben Hanson
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“Raging Hearts”: Anger Recall Induces Sympathetic Dominance in Men Prone to Anger Open
Excessive anger is linked to adverse health outcomes, including increased cardiovascular disease risk, however, the psychophysiological mechanisms underlying this relationship are not fully understood. Previous studies are sparse and limit…
View article: Validation of the <scp>IDDSI</scp> funnel for liquid flow testing
Validation of the <span>IDDSI</span> funnel for liquid flow testing Open
In 2017, the International Dysphagia Diet Standardisation Initiative (IDDSI) introduced the IDDSI flow test which enables patients, clinicians, caregivers, food service professionals and researchers to classify liquid thickness into five l…
Modernising Orodispersible Film Characterisation to Improve Palatability and Acceptability Using a Toolbox of Techniques Open
Orodispersible films (ODFs) have been widely used in paediatric, geriatric and dysphagic patients due to ease of administration and precise and flexible dose adjustments. ODF fabrication has seen significant advancements with the move towa…
Emerging evidence for a mechanistic link between low-frequency oscillation of ventricular repolarization measured from the electrocardiogram T-wave vector and arrhythmia Open
Strong recent clinical evidence links the presence of prominent oscillations of ventricular repolarization in the low-frequency range (0.04–0.15 Hz) to the incidence of ventricular arrhythmia and sudden death in post-MI patients and patien…
Assessing the ability of substrate mapping techniques to guide ventricular tachycardia ablation using computational modelling Open
Substrate mapping could provide information about the infarct, but the directional dependency on activation should be considered. Activation-repolarization metrics have utility in safely identifying VT targets, even with non-transmural sca…
Self-Abrading Servo Electrode Helmet for Electrical Impedance Tomography Open
Electrical Impedance Tomography (EIT) is a medical imaging technique which has the potential to reduce time to treatment in acute stroke by rapidly differentiating between ischaemic and haemorrhagic stroke. The potential of these methods h…
How Do Orodispersible Tablets Behave in an In Vitro Oral Cavity Model: A Pilot Study Open
Orodispersible tablets (ODTs) offer rapid disintegration of the dosage form when placed on the tongue, which leads to fast release of the active pharmaceutical ingredient. Despite increased use in diverse patient populations, there have be…
Complex Interaction Between Low-Frequency APD Oscillations and Beat-to-Beat APD Variability in Humans Is Governed by the Sympathetic Nervous System Open
Beta-adrenergic blockade reduces LF oscillatory behavior of APD (ARI) in humans in vivo. Our results support the importance of LF oscillations in modulating the response of BVR to beta-adrenergic blockers, suggesting that LF oscillations m…
View article: Evaluation of the reentry vulnerability index to predict ventricular tachycardia circuits using high-density contact mapping
Evaluation of the reentry vulnerability index to predict ventricular tachycardia circuits using high-density contact mapping Open
RVI identifies vulnerable regions closest to VT sites of origin. Activation-repolarization metrics may improve VT substrate delineation and inform novel ablation strategies.
Experimental and Computational Investigation of the IDDSI Flow Test of Liquids Used in Dysphagia Management Open
The International Dysphagia Diet Standardisation Initiative (IDDSI) flow test, using a standard 10-mL syringe, is being adopted in many countries for clinical measurement of the consistency of drinks. The working hypothesis is that thicken…
Modulation of Tongue Pressure According to Liquid Flow Properties in Healthy Swallowing Open
Purpose During swallowing, the tongue generates the primary propulsive forces that transport material through the oral cavity toward the pharynx. Previous literature suggests that higher tongue pressure amplitudes are generated for extreme…
Mechanistic insights from targeted molecular profiling of repolarization alternans in the intact human heart Open
Combined intact heart and cellular electrophysiology show that regions of myocardium in the in vivo human heart exhibiting APD alternans are associated with greater expression of CSQN and RyR and show no difference in restitution propertie…
Flow-dependent tongue pressure modulation (Steele et al., 2019) Open
Purpose: During swallowing, the tongue generates the primary propulsive forces that transport material through the oral cavity toward the pharynx. Previous literature suggests that higher tongue pressure amplitudes are generated for extrem…
Optimization of a Novel Activation-Repolarization Metric to Identify Targets for Catheter Ablation Open
Identification of targets for catheter ablation of arrhythmias remains a significant challenge. Traditional mapping techniques often neglect the tissue repolarization, hampering the detection of pro-arrhythmic regions. We have recently dev…
Sequential Electro-Anatomical Mapping Methodology and Preliminary Results for Reentry Vulnerability Index Estimation Open
Ventricular tachycardia (VT) recurrence after catheter ablation remains frequent and improved ablation strategies are needed. The re-entry vulnerability index (RVI) is an activation-repolarization marker to localize critical sites for VT i…
A study of dysphagia symptoms and esophageal body function in children undergoing anti‐reflux surgery Open
Background The role of high‐resolution esophageal impedance manometry (HRIM) for establishing risk for dysphagia after anti‐reflux surgery is unclear. We conducted a prospective study of children with primary gastroesophageal reflux (GER) …
Creation and Initial Validation of the International Dysphagia Diet Standardisation Initiative Functional Diet Scale Open
This initial validation study suggests that the International Dysphagia Diet Standardisation Initiative Functional Diet Scale has strong consensual and criterion validity and can be used reliably by clinicians to capture diet texture restr…
Pulse Arrival Time Accurately Detects Pacing-Induced Mechanical Alternans Open
Accurate cardiac risk stratification is crucial for preventing cardiac death, but still remains an unmet need.Mechanical alternans (MA), an oscillation of blood pressure that occurs on a beat-to-beat basis, has been recognized as a marker …
Lawlessness in the occupied Soviet territories during World War II Open
Members of both the German counterinsurgency forces and Soviet partisans terrorised the civilians of the occupied Soviet territories during World War II. At times, fighters of either force robbed, sexually assaulted and killed civilians. T…
View article: Development of International Terminology and Definitions for Texture-Modified Foods and Thickened Fluids Used in Dysphagia Management: The IDDSI Framework
Development of International Terminology and Definitions for Texture-Modified Foods and Thickened Fluids Used in Dysphagia Management: The IDDSI Framework Open
Dysphagia is estimated to affect ~8% of the world's population (~590 million people). Texture-modified foods and thickened drinks are commonly used to reduce the risks of choking and aspiration. The International Dysphagia Diet Standardisa…
Investigating a Novel Activation-Repolarisation Time Metric to Predict Localised Vulnerability to Reentry Using Computational Modelling Open
Exit sites associated with scar-related reentrant arrhythmias represent important targets for catheter ablation therapy. However, their accurate location in a safe and robust manner remains a significant clinical challenge. We recently pro…