Brian P. Higgins
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View article: Patient-reported vision impairment in low luminance relates to visual function in age-related macular degeneration: A MACUSTAR study report
Patient-reported vision impairment in low luminance relates to visual function in age-related macular degeneration: A MACUSTAR study report Open
Early stages of age-related macular degeneration (AMD) can lead to a number of visual function deficits, but the patient relevance of these deficits is largely unknown. We therefore investigated how bilateral visual function domains affect…
View article: Regulatory T cell stability determines the efficiency of bile duct regeneration during cholangitis
Regulatory T cell stability determines the efficiency of bile duct regeneration during cholangitis Open
Background and Aims Cholangiopathies such as Primary Sclerosing Cholangitis (PSC) cause damage to the bile ducts and fibrosis with no effective cure. A reduction and impairment in the function of regulatory T cells (Tregs) occurs in PSC. Y…
View article: Longitudinal Imaging of the Parafoveal Cone Mosaic in Congenital Achromatopsia
Longitudinal Imaging of the Parafoveal Cone Mosaic in Congenital Achromatopsia Open
Proprietary or commercial disclosures may be found in the Footnotes and Disclosures at the end of this article.
View article: In Vivo Assessment of Retinal Phenotypes in Axenfeld–Rieger Syndrome
In Vivo Assessment of Retinal Phenotypes in Axenfeld–Rieger Syndrome Open
These findings implicate PITX2 in the development of the posterior segment, particularly the fovea, in humans. The identified posterior segment phenotypes may contribute to visual acuity deficits in individuals with PITX2-ARS.
View article: Longitudinal Assessment of OCT-Based Measures of Foveal Cone Structure in Achromatopsia
Longitudinal Assessment of OCT-Based Measures of Foveal Cone Structure in Achromatopsia Open
ACHM appears to be a generally stable condition, at least over the follow-up period assessed here. As cones are the cellular targets for emerging gene therapies, stable EZ and ONL thickness demonstrate therapeutic potential for ACHM, altho…
View article: Assessing the Sensitivity of OCT-A Retinal Vasculature Metrics
Assessing the Sensitivity of OCT-A Retinal Vasculature Metrics Open
Quantitative metrics vary in their ability to detect vascular abnormalities in OCT-A images. Metric choice in screening studies will need to balance expected capillary abnormalities and the quality of the OCT-A images being used.
View article: Automated image processing pipeline for adaptive optics scanning light ophthalmoscopy
Automated image processing pipeline for adaptive optics scanning light ophthalmoscopy Open
To mitigate the substantial post-processing burden associated with adaptive optics scanning light ophthalmoscopy (AOSLO), we have developed an open-source, automated AOSLO image processing pipeline with both “live” and “full” modes. The li…
Intraobserver Repeatability and Interobserver Reproducibility of Ellipsoid Zone Measurements in Retinitis Pigmentosa Open
We describe repeatability and reproducibility of a method for measuring EZ width in patients with RP or Usher syndrome. This approach could facilitate measurement of retinal band thickness and/or intensity.
View article: REPEATABILITY AND LONGITUDINAL ASSESSMENT OF FOVEAL CONE STRUCTURE IN CNGB3-ASSOCIATED ACHROMATOPSIA
REPEATABILITY AND LONGITUDINAL ASSESSMENT OF FOVEAL CONE STRUCTURE IN CNGB3-ASSOCIATED ACHROMATOPSIA Open
Purpose: Congenital achromatopsia is an autosomal recessive disease causing substantial reduction or complete absence of cone function. Although believed to be a relatively stationary disorder, questions remain regarding the stability of c…
View article: Residual Foveal Cone Structure in <i>CNGB3</i>-Associated Achromatopsia
Residual Foveal Cone Structure in <i>CNGB3</i>-Associated Achromatopsia Open
The degree of residual foveal cone structure varies greatly among subjects with CNGB3-associated ACHM. Such measurements may be useful in estimating the therapeutic potential of a given retina, providing affected individuals and physicians…
View article: PHOTORECEPTOR INNER SEGMENT MORPHOLOGY IN BEST VITELLIFORM MACULAR DYSTROPHY
PHOTORECEPTOR INNER SEGMENT MORPHOLOGY IN BEST VITELLIFORM MACULAR DYSTROPHY Open
Combined confocal and nonconfocal split-detector AOSLO imaging reveals substantial variability within clinical lesions in all stages of BVMD. Longitudinal cellular photoreceptor imaging could prove a powerful tool for understanding disease…
View article: Automatic detection of cone photoreceptors in split detector adaptive optics scanning light ophthalmoscope images
Automatic detection of cone photoreceptors in split detector adaptive optics scanning light ophthalmoscope images Open
Quantitative analysis of the cone photoreceptor mosaic in the living retina is potentially useful for early diagnosis and prognosis of many ocular diseases. Non-confocal split detector based adaptive optics scanning light ophthalmoscope (A…
View article: Assessing Photoreceptor Structure in Macular Hole using Split-detector Adaptive Optics Scanning Light Ophthalmoscopy
Assessing Photoreceptor Structure in Macular Hole using Split-detector Adaptive Optics Scanning Light Ophthalmoscopy Open
Introduction: Macular hole (MH) and vitreomacular traction (VMT) can involve disruption at the level of the photoreceptor interdigitation zone (IZ) and ellipsoid zone (EZ) with optical coherence tomography (OCT). Confocal adaptive optics s…