Bethan Lang
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View article: Coupled dynamic simulation of wind turbine structures and tuned liquid dampers based on Adams
Coupled dynamic simulation of wind turbine structures and tuned liquid dampers based on Adams Open
This study establishes a structural-TLD coupled dynamic simulation model based on the coupled vibration theory of elastic structures-fluids and Adams’ virtual prototype technology. The model’s accuracy and applicability were validated by c…
View article: Evolution and significance of neuronal surface autoantibodies after Japanese encephalitis
Evolution and significance of neuronal surface autoantibodies after Japanese encephalitis Open
NMDAR-antibody encephalitis can arise as a post-infectious 'relapse' following HSV encephalitis. We asked whether a similar condition might occur after Japanese Encephalitis (JE). Cell-based assays for antigen-specific antibodies and IgG b…
View article: A feline model of spontaneously occurring autoimmune limbic encephalitis
A feline model of spontaneously occurring autoimmune limbic encephalitis Open
Autoimmune encephalitis (AE) is an important cause of encephalitis in humans and occurs at a similar rate to infectious encephalitis. It is frequently associated with antibodies against the extracellular domain of neuronal proteins. Among …
View article: Dysphagia incidence in intensive care unit patients with coronavirus disease 2019: retrospective analysis following systematic dysphagia screening
Dysphagia incidence in intensive care unit patients with coronavirus disease 2019: retrospective analysis following systematic dysphagia screening Open
Objective Post-extubation dysphagia in critically ill patients is known to affect about 18 per cent of mixed medical-surgical intensive care unit patients. This study investigated the incidence of post-extubation dysphagia in adult intensi…
View article: A Flow Cytometric Assay to Detect Functional Ganglionic Acetylcholine Receptor Antibodies by Immunomodulation in Autoimmune Autonomic Ganglionopathy
A Flow Cytometric Assay to Detect Functional Ganglionic Acetylcholine Receptor Antibodies by Immunomodulation in Autoimmune Autonomic Ganglionopathy Open
Autoimmune Autonomic Ganglionopathy (AAG) is an uncommon immune-mediated neurological disease that results in failure of autonomic function and is associated with autoantibodies directed against the ganglionic acetylcholine receptor (gnACH…
View article: Clinical features which predict neuronal surface autoantibodies in new-onset focal epilepsy: implications for immunotherapies
Clinical features which predict neuronal surface autoantibodies in new-onset focal epilepsy: implications for immunotherapies Open
Objective To generate a score which clinically identifies surface-directed autoantibodies in adults with new-onset focal epilepsy, and evaluate the value of immunotherapy in this clinical setting. Methods Prospective clinical and autoantib…
View article: Systemic delivery of human GlyR IgG antibody induces GlyR internalization into motor neurons of brainstem and spinal cord with motor dysfunction in mice
Systemic delivery of human GlyR IgG antibody induces GlyR internalization into motor neurons of brainstem and spinal cord with motor dysfunction in mice Open
Aims Progressive encephalomyelitis with rigidity and myoclonus (PERM) is a life‐threatening condition often associated with highly raised serum antibodies to glycine receptors (GlyRs); these bind to the surface of large neurons and interne…
View article: Incidence and phenotypes of childhood-onset genetic epilepsies: a prospective population-based national cohort
Incidence and phenotypes of childhood-onset genetic epilepsies: a prospective population-based national cohort Open
Epilepsy is common in early childhood. In this age group it is associated with high rates of therapy-resistance, and with cognitive, motor, and behavioural comorbidity. A large number of genes, with wide ranging functions, are implicated i…
View article: Behaviour and neuropathology in mice injected with human contactin-associated protein 2 antibodies
Behaviour and neuropathology in mice injected with human contactin-associated protein 2 antibodies Open
Serum antibodies that bind to the surface of neurons or glia are associated with a wide range of rare but treatable CNS diseases. In many, if not most instances, the serum levels are higher than CSF levels yet most of the reported attempts…
View article: Acquired neuromyotonia in thymoma‐associated myasthenia gravis: a clinical and serological study
Acquired neuromyotonia in thymoma‐associated myasthenia gravis: a clinical and serological study Open
Background and purpose Acquired neuromyotonia can occur in patients with thymoma, alone or in association with myasthenia gravis ( MG ), but the clinical prognostic significance of such comorbidity is largely unknown. The clinico‐pathologi…
View article: Association of Leucine-Rich Glioma Inactivated Protein 1, Contactin-Associated Protein 2, and Contactin 2 Antibodies With Clinical Features and Patient-Reported Pain in Acquired Neuromyotonia
Association of Leucine-Rich Glioma Inactivated Protein 1, Contactin-Associated Protein 2, and Contactin 2 Antibodies With Clinical Features and Patient-Reported Pain in Acquired Neuromyotonia Open
The cohort study detailed underrecognized aspects of the clinical and serologic spectrum of NMT. The heterogeneity of clinical features and of specific antibodies limit associations, but the common existence of thymoma, pain, and autonomic…
View article: Glutamate receptor δ2 serum antibodies in pediatric opsoclonus myoclonus ataxia syndrome
Glutamate receptor δ2 serum antibodies in pediatric opsoclonus myoclonus ataxia syndrome Open
Autoantibodies to GluD2 are common in patients with OMAS, bind to surface determinants, and are potentially pathogenic.
View article: Correction: Myasthenia gravis seronegative for acetylcholine receptor antibodies in South Korea: Autoantibody profiles and clinical features
Correction: Myasthenia gravis seronegative for acetylcholine receptor antibodies in South Korea: Autoantibody profiles and clinical features Open
[This corrects the article DOI: 10.1371/journal.pone.0193723.].
View article: Hippocampal necrosis and sclerosis in cats: A retrospective study of 35 cases
Hippocampal necrosis and sclerosis in cats: A retrospective study of 35 cases Open
Hippocampal necrosis and hippocampal sclerosis in cats is a neuropathological entity which is a major concern in feline epilepsy. The aim of our study was to identify associated pathologic brain lesions possibly serving as aetiological tri…
View article: The Importance of Early Immunotherapy in patients with Faciobrachial Dystonic Seizures
The Importance of Early Immunotherapy in patients with Faciobrachial Dystonic Seizures Open
Faciobrachial dystonic seizures and limbic encephalitis closely associate with antibodies to leucine-rich glioma-inactivated 1 (LGI1). Here, we describe 103 consecutive patients with faciobrachial dystonic seizures and LGI1 antibodies to u…
View article: Myasthenia gravis seronegative for acetylcholine receptor antibodies in South Korea: Autoantibody profiles and clinical features
Myasthenia gravis seronegative for acetylcholine receptor antibodies in South Korea: Autoantibody profiles and clinical features Open
Acquired myasthenia gravis (MG) is a prototype autoimmune disease of the neuromuscular junction, caused in most patients by autoantibodies to the muscle nicotinic acetylcholine receptor (AChR). There seem to be ethnic and regional differen…
View article: Immune or Genetic-Mediated Disruption of CASPR2 Causes Pain Hypersensitivity Due to Enhanced Primary Afferent Excitability
Immune or Genetic-Mediated Disruption of CASPR2 Causes Pain Hypersensitivity Due to Enhanced Primary Afferent Excitability Open
Human autoantibodies to contactin-associated protein-like 2 (CASPR2) are often associated with neuropathic pain, and CASPR2 mutations have been linked to autism spectrum disorders, in which sensory dysfunction is increasingly recognized. H…
View article: The importance of early immunotherapy in patients with faciobrachial dystonic seizures
The importance of early immunotherapy in patients with faciobrachial dystonic seizures Open
Faciobrachial dystonic seizures and limbic encephalitis closely associate with antibodies to leucine-rich glioma-inactivated 1 (LGI1). Here, we describe 103 consecutive patients with faciobrachial dystonic seizures and LGI1 antibodies to u…
View article: Persistent microglial activation and synaptic loss with behavioral abnormalities in mouse offspring exposed to CASPR2-antibodies in utero
Persistent microglial activation and synaptic loss with behavioral abnormalities in mouse offspring exposed to CASPR2-antibodies in utero Open
Gestational transfer of maternal antibodies against fetal neuronal proteins may be relevant to some neurodevelopmental disorders, but until recently there were no proteins identified. We recently reported a fivefold increase in CASPR2-anti…
View article: Pathogenic potential of antibodies to the <scp> GABA <sub>B</sub> </scp> receptor
Pathogenic potential of antibodies to the <span> GABA <sub>B</sub> </span> receptor Open
Summary GABA B receptor ( GABA B R ) autoantibodies have been detected in the serum of immunotherapy‐responsive patients with autoimmune encephalitis. This study aimed to investigate the effect of immunoglobulin G (IgG) from a patient with…
View article: Intracellular and non-neuronal targets of voltage-gated potassium channel complex antibodies
Intracellular and non-neuronal targets of voltage-gated potassium channel complex antibodies Open
Objectives Autoantibodies against the extracellular domains of the voltage-gated potassium channel (VGKC) complex proteins, leucine-rich glioma-inactivated 1 (LGI1) and contactin-associated protein-2 (CASPR2), are found in patients with li…
View article: Stiff person syndrome in South Asia
Stiff person syndrome in South Asia Open
Diagnosis of stiff person syndrome remains clinical, supported by electromyography and serology for glutamic acid decarboxylase antibodies, facilitated by a high index of clinical suspicion. An autoimmune basis lends stiff person syndrome …
View article: Multiple sequential antibody-associated syndromes with a recurrent mutated neuroblastoma
Multiple sequential antibody-associated syndromes with a recurrent mutated neuroblastoma Open
A 5-year-old girl was diagnosed with opsoclonus-myoclonus syndrome (OMS) and a para-aortic neuroblastoma (NB) (figure 1A). Urinary catecholamines were elevated; NB biopsy confirmed no MYCN gene amplification. Serum showed Hu antibodies wit…
View article: Neuronal antibodies in pediatric epilepsy: Clinical features and long‐term outcomes of a historical cohort not treated with immunotherapy
Neuronal antibodies in pediatric epilepsy: Clinical features and long‐term outcomes of a historical cohort not treated with immunotherapy Open
Summary Objective In autoimmune encephalitis the etiologic role of neuronal cell‐surface antibodies is clear; patients diagnosed and treated early have better outcomes. Neuronal antibodies have also been described in patients with pediatri…
View article: Paediatric brainstem encephalitis associated with glial and neuronal autoantibodies
Paediatric brainstem encephalitis associated with glial and neuronal autoantibodies Open
Aim Central nervous system ( CNS ) autoantibodies have been reported in a range of neuroimmune diseases, but there has not been a systematic evaluation of autoantibodies in paediatric patients with brainstem encephalitis. Method Serum samp…