Ben Murcott
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View article: Colorectal cancer progression to metastasis is associated with dynamic genome-wide biphasic 5-hydroxymethylcytosine accumulation
Colorectal cancer progression to metastasis is associated with dynamic genome-wide biphasic 5-hydroxymethylcytosine accumulation Open
Background Colorectal cancer (CRC) progression from adenoma to adenocarcinoma is associated with global reduction in 5-methylcytosine (5mC) and 5-hydroxymethylcytosine (5hmC). DNA hypomethylation continues upon liver metastasis. Here we ex…
View article: <i>Strongyloides</i> questions—a research agenda for the future
<i>Strongyloides</i> questions—a research agenda for the future Open
The Strongyloides genus of parasitic nematodes have a fascinating life cycle and biology, but are also important pathogens of people and a World Health Organization-defined neglected tropical disease. Here, a community of Strongyloides res…
Supplementary Table 1 from <i>Strongyloides</i> questions – a research agenda for the future Open
Ninety three Strongyloides questions, group into 13 main questions, within two themes.
stepRNA: Identification of Dicer cleavage signatures and passenger strand lengths in small RNA sequences Open
The enzyme Dicer is a component of many small RNA (sRNA) pathways involved in RNA processing for post-transcriptional regulation, anti-viral response and control of transposable elements. Cleavage of double-stranded RNA by Dicer produces a…
piRNA-like small RNAs target transposable elements in a Clade IV parasitic nematode Open
The small RNA (sRNA) pathways identified in the model organism Caenorhabditis elegans are not widely conserved across nematodes. For example, the PIWI pathway and PIWI-interacting RNAs (piRNAs) are involved in regulating and silencing tran…